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Q06432

- CCG1_HUMAN

UniProt

Q06432 - CCG1_HUMAN

Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

CACNG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

    GO - Molecular functioni

    1. voltage-gated calcium channel activity Source: ProtInc

    GO - Biological processi

    1. muscle contraction Source: ProtInc
    2. sarcoplasmic reticulum calcium ion transport Source: Ensembl
    3. transport Source: ProtInc

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Protein family/group databases

    TCDBi8.A.16.1.1. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-1 subunit
    Alternative name(s):
    Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
    Gene namesi
    Name:CACNG1
    Synonyms:CACNLG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:1405. CACNG1.

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated calcium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26015.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Voltage-dependent calcium channel gamma-1 subunitPRO_0000164669Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ06432.
    PRIDEiQ06432.

    Expressioni

    Tissue specificityi

    Skeletal muscle.

    Gene expression databases

    BgeeiQ06432.
    CleanExiHS_CACNG1.
    GenevestigatoriQ06432.

    Organism-specific databases

    HPAiHPA054153.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000226021.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06432.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 2919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12925HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 15516HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20425HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47450.
    HOGENOMiHOG000293219.
    HOVERGENiHBG003868.
    InParanoidiQ06432.
    KOiK04866.
    OMAiWAVLSPH.
    OrthoDBiEOG7WQ7TF.
    PhylomeDBiQ06432.
    TreeFamiTF331651.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR005421. VDCC_g1su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF13903. Claudin_2. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01601. VDCCGAMMA1.

    Sequencei

    Sequence statusi: Complete.

    Q06432-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQTKMLKVR VTLFCILAGI VLAMTAVVTD HWAVLSPHME HHNTTCEAAH    50
    FGLWRICTKR IPMDDSKTCG PITLPGEKNC SYFRHFNPGE SSEIFEFTTQ 100
    KEYSISAAAI AIFSLGFIIL GSLCVLLSLG KKRDYLLRPA SMFYAFAGLC 150
    ILVSVEVMRQ SVKRMIDSED TVWIEYYYSW SFACACAAFI LLFLGGLALL 200
    LFSLPRMPRN PWESCMDAEP EH 222
    Length:222
    Mass (Da):25,028
    Last modified:November 1, 1995 - v1
    Checksum:iEFEC34266CFC47CB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti196 – 1961G → S.
    Corresponds to variant rs1799938 [ dbSNP | Ensembl ].
    VAR_012063

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07738 mRNA. Translation: AAA51904.1.
    AK313852 mRNA. Translation: BAG36580.1.
    CH471099 Genomic DNA. Translation: EAW89022.1.
    BC069493 mRNA. Translation: AAH69493.1.
    BC113486 mRNA. Translation: AAI13487.1.
    BC113492 mRNA. Translation: AAI13493.1.
    Z19603 Genomic DNA. Translation: CAA79671.1.
    Z19587 Genomic DNA. Translation: CAB62573.1. Sequence problems.
    CCDSiCCDS11668.1.
    PIRiA46658.
    RefSeqiNP_000718.1. NM_000727.3.
    UniGeneiHs.147989.

    Genome annotation databases

    EnsembliENST00000226021; ENSP00000226021; ENSG00000108878.
    GeneIDi786.
    KEGGihsa:786.
    UCSCiuc002jfu.3. human.

    Polymorphism databases

    DMDMi1168946.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07738 mRNA. Translation: AAA51904.1 .
    AK313852 mRNA. Translation: BAG36580.1 .
    CH471099 Genomic DNA. Translation: EAW89022.1 .
    BC069493 mRNA. Translation: AAH69493.1 .
    BC113486 mRNA. Translation: AAI13487.1 .
    BC113492 mRNA. Translation: AAI13493.1 .
    Z19603 Genomic DNA. Translation: CAA79671.1 .
    Z19587 Genomic DNA. Translation: CAB62573.1 . Sequence problems.
    CCDSi CCDS11668.1.
    PIRi A46658.
    RefSeqi NP_000718.1. NM_000727.3.
    UniGenei Hs.147989.

    3D structure databases

    ProteinModelPortali Q06432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000226021.

    Chemistry

    BindingDBi Q06432.
    ChEMBLi CHEMBL2363032.
    DrugBanki DB00381. Amlodipine.
    DB00343. Diltiazem.
    DB00308. Ibutilide.
    DB00528. Lercanidipine.
    DB00653. Magnesium Sulfate.
    DB00393. Nimodipine.
    DB01054. Nitrendipine.
    DB00661. Verapamil.

    Protein family/group databases

    TCDBi 8.A.16.1.1. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    Polymorphism databases

    DMDMi 1168946.

    Proteomic databases

    PaxDbi Q06432.
    PRIDEi Q06432.

    Protocols and materials databases

    DNASUi 786.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000226021 ; ENSP00000226021 ; ENSG00000108878 .
    GeneIDi 786.
    KEGGi hsa:786.
    UCSCi uc002jfu.3. human.

    Organism-specific databases

    CTDi 786.
    GeneCardsi GC17P065040.
    HGNCi HGNC:1405. CACNG1.
    HPAi HPA054153.
    MIMi 114209. gene.
    neXtProti NX_Q06432.
    PharmGKBi PA26015.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47450.
    HOGENOMi HOG000293219.
    HOVERGENi HBG003868.
    InParanoidi Q06432.
    KOi K04866.
    OMAi WAVLSPH.
    OrthoDBi EOG7WQ7TF.
    PhylomeDBi Q06432.
    TreeFami TF331651.

    Miscellaneous databases

    GeneWikii CACNG1.
    GenomeRNAii 786.
    NextBioi 3202.
    PROi Q06432.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q06432.
    CleanExi HS_CACNG1.
    Genevestigatori Q06432.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR005421. VDCC_g1su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF13903. Claudin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01601. VDCCGAMMA1.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location."
      Powers P.A., Liu S., Hogan K., Gregg R.G.
      J. Biol. Chem. 268:9275-9279(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal skeletal muscle.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus."
      Iles D.E., Segers B., Weghuis D.O., Suikerbuijk R., Wieringa B.
      Cytogenet. Cell Genet. 64:227-230(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 102-147 AND 174-222.

    Entry informationi

    Entry nameiCCG1_HUMAN
    AccessioniPrimary (citable) accession number: Q06432
    Secondary accession number(s): B2R9N3, Q14D59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3