Q06432 (CCG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel gamma-1 subunit

Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma

Gene names

Name:	CACNG1
Synonyms:	CACNLG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.
Subunit structure	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Skeletal muscle.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	muscle contraction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	voltage-gated calcium channel complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	voltage-gated calcium channel activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Voltage-dependent calcium channel gamma-1 subunit		PRO_0000164669
Regions
	Transmembrane	11 – 29	19	Helical; Potential
	Transmembrane	105 – 129	25	Helical; Potential
	Transmembrane	140 – 155	16	Helical; Potential
	Transmembrane	180 – 204	25	Helical; Potential
Amino acid modifications
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	196	1	G → S. Corresponds to variant rs1799938 [ dbSNP | Ensembl ].		VAR_012063

Sequences

	Sequence		Length	Mass (Da)
	Q06432 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: EFEC34266CFC47CB	FASTA	222	25,028
	10 20 30 40 50 60 MSQTKMLKVR VTLFCILAGI VLAMTAVVTD HWAVLSPHME HHNTTCEAAH FGLWRICTKR 70 80 90 100 110 120 IPMDDSKTCG PITLPGEKNC SYFRHFNPGE SSEIFEFTTQ KEYSISAAAI AIFSLGFIIL 130 140 150 160 170 180 GSLCVLLSLG KKRDYLLRPA SMFYAFAGLC ILVSVEVMRQ SVKRMIDSED TVWIEYYYSW 190 200 210 220 SFACACAAFI LLFLGGLALL LFSLPRMPRN PWESCMDAEP EH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location." Powers P.A., Liu S., Hogan K., Gregg R.G. J. Biol. Chem. 268:9275-9279(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal skeletal muscle.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus." Iles D.E., Segers B., Weghuis D.O., Suikerbuijk R., Wieringa B. Cytogenet. Cell Genet. 64:227-230(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 102-147 AND 174-222.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L07738 mRNA. Translation: AAA51904.1. AK313852 mRNA. Translation: BAG36580.1. CH471099 Genomic DNA. Translation: EAW89022.1. BC069493 mRNA. Translation: AAH69493.1. BC113486 mRNA. Translation: AAI13487.1. BC113492 mRNA. Translation: AAI13493.1. Z19603 Genomic DNA. Translation: CAA79671.1. Z19587 Genomic DNA. Translation: CAB62573.1. Sequence problems.
IPI	IPI00030935.
PIR	A46658.
RefSeq	NP_000718.1. NM_000727.3.
UniGene	Hs.147989.
3D structure databases
ProteinModelPortal	Q06432.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000226021.
Protein family/group databases
TCDB	8.A.16.1.1. Ca+ channel auxiliary subunit gamma1-gamma8 (CCAgamma) family.
Polymorphism databases
DMDM	1168946.
Proteomic databases
PaxDb	Q06432.
PRIDE	Q06432.
Protocols and materials databases
DNASU	786.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000226021; ENSP00000226021; ENSG00000108878.
GeneID	786.
KEGG	hsa:786.
UCSC	uc002jfu.3. human.
Organism-specific databases
CTD	786.
GeneCards	GC17P065040.
HGNC	HGNC:1405. CACNG1.
MIM	114209. gene.
neXtProt	NX_Q06432.
PharmGKB	PA26015.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47450.
HOGENOM	HOG000293219.
HOVERGEN	HBG003868.
InParanoid	Q06432.
KO	K04866.
OMA	WAVLSPH.
OrthoDB	EOG49PB0K.
PhylomeDB	Q06432.
Gene expression databases
Bgee	Q06432.
CleanEx	HS_CACNG1.
Genevestigator	Q06432.
GermOnline	ENSG00000108878. Homo sapiens.
Family and domain databases
InterPro	IPR005421. VDCC_g1su. IPR008368. VDCC_gsu. [Graphical view]
PRINTS	PR01792. VDCCGAMMA. PR01601. VDCCGAMMA1.
ProtoNet	Search...
Other
BindingDB	Q06432.
DrugBank	DB00381. Amlodipine. DB00343. Diltiazem. DB00308. Ibutilide. DB00528. Lercanidipine. DB00653. Magnesium Sulfate. DB00393. Nimodipine. DB01054. Nitrendipine. DB00661. Verapamil.
GenomeRNAi	786.
NextBio	3202.
SOURCE	Search...

Entry information

Entry name

CCG1_HUMAN

Accession

Primary (citable) accession number: Q06432
Secondary accession number(s): B2R9N3, Q14D59

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.