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Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

CACNG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

GO - Molecular functioni

  • voltage-gated calcium channel activity Source: ProtInc

GO - Biological processi

  • muscle contraction Source: ProtInc
  • sarcoplasmic reticulum calcium ion transport Source: Ensembl
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Protein family/group databases

TCDBi8.A.16.1.1. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene namesi
Name:CACNG1
Synonyms:CACNLG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:1405. CACNG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 2919HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12925HelicalSequence AnalysisAdd
BLAST
Transmembranei140 – 15516HelicalSequence AnalysisAdd
BLAST
Transmembranei180 – 20425HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • voltage-gated calcium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26015.

Chemistry

DrugBankiDB00343. Diltiazem.
DB04842. Fluspirilene.
DB00308. Ibutilide.
DB00528. Lercanidipine.
DB00653. Magnesium Sulfate.
DB01054. Nitrendipine.
DB00421. Spironolactone.

Polymorphism and mutation databases

BioMutaiCACNG1.
DMDMi1168946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Voltage-dependent calcium channel gamma-1 subunitPRO_0000164669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ06432.
PRIDEiQ06432.

Expressioni

Tissue specificityi

Skeletal muscle.

Gene expression databases

BgeeiQ06432.
CleanExiHS_CACNG1.
GenevestigatoriQ06432.

Organism-specific databases

HPAiHPA054153.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
A8KA833EBI-9686780,EBI-10174961

Protein-protein interaction databases

BioGridi107240. 1 interaction.
IntActiQ06432. 1 interaction.
STRINGi9606.ENSP00000226021.

Structurei

3D structure databases

ProteinModelPortaliQ06432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47450.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiQ06432.
KOiK04866.
OMAiHNTTCEA.
OrthoDBiEOG7WQ7TF.
PhylomeDBiQ06432.
TreeFamiTF331651.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.

Sequencei

Sequence statusi: Complete.

Q06432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTKMLKVR VTLFCILAGI VLAMTAVVTD HWAVLSPHME HHNTTCEAAH
60 70 80 90 100
FGLWRICTKR IPMDDSKTCG PITLPGEKNC SYFRHFNPGE SSEIFEFTTQ
110 120 130 140 150
KEYSISAAAI AIFSLGFIIL GSLCVLLSLG KKRDYLLRPA SMFYAFAGLC
160 170 180 190 200
ILVSVEVMRQ SVKRMIDSED TVWIEYYYSW SFACACAAFI LLFLGGLALL
210 220
LFSLPRMPRN PWESCMDAEP EH
Length:222
Mass (Da):25,028
Last modified:November 1, 1995 - v1
Checksum:iEFEC34266CFC47CB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti196 – 1961G → S.
Corresponds to variant rs1799938 [ dbSNP | Ensembl ].
VAR_012063

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07738 mRNA. Translation: AAA51904.1.
AK313852 mRNA. Translation: BAG36580.1.
CH471099 Genomic DNA. Translation: EAW89022.1.
BC069493 mRNA. Translation: AAH69493.1.
BC113486 mRNA. Translation: AAI13487.1.
BC113492 mRNA. Translation: AAI13493.1.
Z19603 Genomic DNA. Translation: CAA79671.1.
Z19587 Genomic DNA. Translation: CAB62573.1. Sequence problems.
CCDSiCCDS11668.1.
PIRiA46658.
RefSeqiNP_000718.1. NM_000727.3.
UniGeneiHs.147989.

Genome annotation databases

EnsembliENST00000226021; ENSP00000226021; ENSG00000108878.
GeneIDi786.
KEGGihsa:786.
UCSCiuc002jfu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07738 mRNA. Translation: AAA51904.1.
AK313852 mRNA. Translation: BAG36580.1.
CH471099 Genomic DNA. Translation: EAW89022.1.
BC069493 mRNA. Translation: AAH69493.1.
BC113486 mRNA. Translation: AAI13487.1.
BC113492 mRNA. Translation: AAI13493.1.
Z19603 Genomic DNA. Translation: CAA79671.1.
Z19587 Genomic DNA. Translation: CAB62573.1. Sequence problems.
CCDSiCCDS11668.1.
PIRiA46658.
RefSeqiNP_000718.1. NM_000727.3.
UniGeneiHs.147989.

3D structure databases

ProteinModelPortaliQ06432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107240. 1 interaction.
IntActiQ06432. 1 interaction.
STRINGi9606.ENSP00000226021.

Chemistry

BindingDBiQ06432.
ChEMBLiCHEMBL2363032.
DrugBankiDB00343. Diltiazem.
DB04842. Fluspirilene.
DB00308. Ibutilide.
DB00528. Lercanidipine.
DB00653. Magnesium Sulfate.
DB01054. Nitrendipine.
DB00421. Spironolactone.

Protein family/group databases

TCDBi8.A.16.1.1. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Polymorphism and mutation databases

BioMutaiCACNG1.
DMDMi1168946.

Proteomic databases

PaxDbiQ06432.
PRIDEiQ06432.

Protocols and materials databases

DNASUi786.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226021; ENSP00000226021; ENSG00000108878.
GeneIDi786.
KEGGihsa:786.
UCSCiuc002jfu.3. human.

Organism-specific databases

CTDi786.
GeneCardsiGC17P065040.
HGNCiHGNC:1405. CACNG1.
HPAiHPA054153.
MIMi114209. gene.
neXtProtiNX_Q06432.
PharmGKBiPA26015.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47450.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiQ06432.
KOiK04866.
OMAiHNTTCEA.
OrthoDBiEOG7WQ7TF.
PhylomeDBiQ06432.
TreeFamiTF331651.

Miscellaneous databases

GeneWikiiCACNG1.
GenomeRNAii786.
NextBioi3202.
PROiQ06432.
SOURCEiSearch...

Gene expression databases

BgeeiQ06432.
CleanExiHS_CACNG1.
GenevestigatoriQ06432.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location."
    Powers P.A., Liu S., Hogan K., Gregg R.G.
    J. Biol. Chem. 268:9275-9279(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal skeletal muscle.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus."
    Iles D.E., Segers B., Weghuis D.O., Suikerbuijk R., Wieringa B.
    Cytogenet. Cell Genet. 64:227-230(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 102-147 AND 174-222.

Entry informationi

Entry nameiCCG1_HUMAN
AccessioniPrimary (citable) accession number: Q06432
Secondary accession number(s): B2R9N3, Q14D59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.