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Q06432 (CCG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene names
Name:CACNG1
Synonyms:CACNLG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

Subunit structure

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Skeletal muscle.

Sequence similarities

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Voltage-dependent calcium channel gamma-1 subunit
PRO_0000164669

Regions

Transmembrane11 – 2919Helical; Potential
Transmembrane105 – 12925Helical; Potential
Transmembrane140 – 15516Helical; Potential
Transmembrane180 – 20425Helical; Potential

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential

Natural variations

Natural variant1961G → S.
Corresponds to variant rs1799938 [ dbSNP | Ensembl ].
VAR_012063

Sequences

Sequence LengthMass (Da)Tools
Q06432 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: EFEC34266CFC47CB

FASTA22225,028
        10         20         30         40         50         60 
MSQTKMLKVR VTLFCILAGI VLAMTAVVTD HWAVLSPHME HHNTTCEAAH FGLWRICTKR 

        70         80         90        100        110        120 
IPMDDSKTCG PITLPGEKNC SYFRHFNPGE SSEIFEFTTQ KEYSISAAAI AIFSLGFIIL 

       130        140        150        160        170        180 
GSLCVLLSLG KKRDYLLRPA SMFYAFAGLC ILVSVEVMRQ SVKRMIDSED TVWIEYYYSW 

       190        200        210        220 
SFACACAAFI LLFLGGLALL LFSLPRMPRN PWESCMDAEP EH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location."
Powers P.A., Liu S., Hogan K., Gregg R.G.
J. Biol. Chem. 268:9275-9279(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal skeletal muscle.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus."
Iles D.E., Segers B., Weghuis D.O., Suikerbuijk R., Wieringa B.
Cytogenet. Cell Genet. 64:227-230(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 102-147 AND 174-222.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L07738 mRNA. Translation: AAA51904.1.
AK313852 mRNA. Translation: BAG36580.1.
CH471099 Genomic DNA. Translation: EAW89022.1.
BC069493 mRNA. Translation: AAH69493.1.
BC113486 mRNA. Translation: AAI13487.1.
BC113492 mRNA. Translation: AAI13493.1.
Z19603 Genomic DNA. Translation: CAA79671.1.
Z19587 Genomic DNA. Translation: CAB62573.1. Sequence problems.
CCDSCCDS11668.1.
PIRA46658.
RefSeqNP_000718.1. NM_000727.3.
UniGeneHs.147989.

3D structure databases

ProteinModelPortalQ06432.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000226021.

Chemistry

BindingDBQ06432.
ChEMBLCHEMBL2363032.
DrugBankDB00381. Amlodipine.
DB00343. Diltiazem.
DB00308. Ibutilide.
DB00528. Lercanidipine.
DB00653. Magnesium Sulfate.
DB00393. Nimodipine.
DB01054. Nitrendipine.
DB00661. Verapamil.

Protein family/group databases

TCDB8.A.16.1.1. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Polymorphism databases

DMDM1168946.

Proteomic databases

PaxDbQ06432.
PRIDEQ06432.

Protocols and materials databases

DNASU786.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000226021; ENSP00000226021; ENSG00000108878.
GeneID786.
KEGGhsa:786.
UCSCuc002jfu.3. human.

Organism-specific databases

CTD786.
GeneCardsGC17P065040.
HGNCHGNC:1405. CACNG1.
HPAHPA054153.
MIM114209. gene.
neXtProtNX_Q06432.
PharmGKBPA26015.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47450.
HOGENOMHOG000293219.
HOVERGENHBG003868.
InParanoidQ06432.
KOK04866.
OMAWAVLSPH.
OrthoDBEOG7WQ7TF.
PhylomeDBQ06432.
TreeFamTF331651.

Gene expression databases

BgeeQ06432.
CleanExHS_CACNG1.
GenevestigatorQ06432.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.
ProtoNetSearch...

Other

GeneWikiCACNG1.
GenomeRNAi786.
NextBio3202.
PROQ06432.
SOURCESearch...

Entry information

Entry nameCCG1_HUMAN
AccessionPrimary (citable) accession number: Q06432
Secondary accession number(s): B2R9N3, Q14D59
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM