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Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

CACNG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

GO - Molecular functioni

  • voltage-gated calcium channel activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5576893 Phase 2 - plateau phase

Protein family/group databases

TCDBi8.A.16.1.1 the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene namesi
Name:CACNG1
Synonyms:CACNLG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108878.4
HGNCiHGNC:1405 CACNG1
MIMi114209 gene
neXtProtiNX_Q06432

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 29HelicalSequence analysisAdd BLAST19
Transmembranei105 – 129HelicalSequence analysisAdd BLAST25
Transmembranei140 – 155HelicalSequence analysisAdd BLAST16
Transmembranei180 – 204HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108878
PharmGKBiPA26015

Chemistry databases

ChEMBLiCHEMBL2363032
DrugBankiDB00343 Diltiazem
DB00898 Ethanol
DB04842 Fluspirilene
DB00308 Ibutilide
DB00528 Lercanidipine
DB00653 Magnesium Sulfate
DB01054 Nitrendipine
DB00421 Spironolactone

Polymorphism and mutation databases

BioMutaiCACNG1
DMDMi1168946

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646691 – 222Voltage-dependent calcium channel gamma-1 subunitAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ06432
PeptideAtlasiQ06432
PRIDEiQ06432

PTM databases

iPTMnetiQ06432
PhosphoSitePlusiQ06432

Expressioni

Tissue specificityi

Skeletal muscle.

Gene expression databases

BgeeiENSG00000108878
CleanExiHS_CACNG1
GenevisibleiQ06432 HS

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
A8KA833EBI-9686780,EBI-10174961

Protein-protein interaction databases

BioGridi107240, 16 interactors
IntActiQ06432, 2 interactors
STRINGi9606.ENSP00000226021

Structurei

3D structure databases

ProteinModelPortaliQ06432
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH0I Eukaryota
ENOG4111J5G LUCA
GeneTreeiENSGT00390000007786
HOGENOMiHOG000293219
HOVERGENiHBG003868
InParanoidiQ06432
KOiK04866
OMAiEKNCSYF
OrthoDBiEOG091G0IU0
PhylomeDBiQ06432
TreeFamiTF331651

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR005421 VDCC_g1su
IPR008368 VDCC_gsu
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
PRINTSiPR01792 VDCCGAMMA
PR01601 VDCCGAMMA1

Sequencei

Sequence statusi: Complete.

Q06432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTKMLKVR VTLFCILAGI VLAMTAVVTD HWAVLSPHME HHNTTCEAAH
60 70 80 90 100
FGLWRICTKR IPMDDSKTCG PITLPGEKNC SYFRHFNPGE SSEIFEFTTQ
110 120 130 140 150
KEYSISAAAI AIFSLGFIIL GSLCVLLSLG KKRDYLLRPA SMFYAFAGLC
160 170 180 190 200
ILVSVEVMRQ SVKRMIDSED TVWIEYYYSW SFACACAAFI LLFLGGLALL
210 220
LFSLPRMPRN PWESCMDAEP EH
Length:222
Mass (Da):25,028
Last modified:November 1, 1995 - v1
Checksum:iEFEC34266CFC47CB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012063196G → S. Corresponds to variant dbSNP:rs1799938Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07738 mRNA Translation: AAA51904.1
AK313852 mRNA Translation: BAG36580.1
CH471099 Genomic DNA Translation: EAW89022.1
BC069493 mRNA Translation: AAH69493.1
BC113486 mRNA Translation: AAI13487.1
BC113492 mRNA Translation: AAI13493.1
Z19603 Genomic DNA Translation: CAA79671.1
Z19587 Genomic DNA Translation: CAB62573.1 Sequence problems.
CCDSiCCDS11668.1
PIRiA46658
RefSeqiNP_000718.1, NM_000727.3
UniGeneiHs.147989

Genome annotation databases

EnsembliENST00000226021; ENSP00000226021; ENSG00000108878
GeneIDi786
KEGGihsa:786
UCSCiuc002jfu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCG1_HUMAN
AccessioniPrimary (citable) accession number: Q06432
Secondary accession number(s): B2R9N3, Q14D59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health