Reviewed, UniProtKB/Swiss-Prot Q06429 (1A11_ARATH)

Names and origin

Protein names

Recommended name:
    1-aminocyclopropane-1-carboxylate synthase-like protein 1

Gene names

Name:	ACS1
Synonyms:	ACC2
Ordered Locus Names:	At3g61510
ORF Names:	F2A19.110

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subunit structure	Homodimer By similarity.
Tissue specificity	Expressed in young leaves and flowers. Not expressed in roots. Ref.6
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Caution	Lacks the conserved tripeptide Ser/Thr-Asn-Pro in position 205 necessary for the ACS activity.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Ref.1 Inferred from electronic annotation. Source: InterPro identical protein binding Inferred from physical interaction. Source: IntAct pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring nitrogenous groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-2436157,EBI-2436157
ACS6	Q9SAR0	1	EBI-2436157,EBI-2356658

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	1-aminocyclopropane-1-carboxylate synthase-like protein 1		PRO_0000123896
Amino acid modifications
	Modified residue	273	1	N6-(pyridoxal phosphate)lysine By similarity
Experimental info
	Mutagenesis	205	1	S → TNPS: Restores ACS activity; when expressed in E.coli. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q06429-1 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 411E049B993DEEE1	FASTA	488	55,003
	10 20 30 40 50 60 MSQGACENQL LSKLALSDKH GEASPYFHGW KAYDNNPFHP THNPQGVIQM GLAENQLCSD 70 80 90 100 110 120 LIKEWIKENP QASICTAEGI DSFSDIAVFQ DYHGLKQFRQ AIATFMERAR GGRVRFEAER 130 140 150 160 170 180 VVMSGGATGA NETIMFCLAD PGDAFLVPTP YYAAFDRDLR WRTGVRIIPV ECSSSNNFQI 190 200 210 220 230 240 TKQALESAYL KAQETGIKIK GLIISNPLGT SLDRETLESL VSFINDKQIH LVCDEIYAAT 250 260 270 280 290 300 VFAEPGFISV AEIIQEMYYV NRDLIHIVYS LSKDMGLPGF RVGVVYSYND VVVSCARRMS 310 320 330 340 350 360 SFGLVSSQTQ SFLAAMLSDQ SFVDNFLVEV SKRVAKRHHM FTEGLEEMGI SCLRSNAGLF 370 380 390 400 410 420 VLMDLRHMLK DQTFDSEMAL WRVIINKVKI NVSPGSSFHC SEPGWFRVCF ANMDEDTLQI 430 440 450 460 470 480 ALERIKDFVV GDRANKNKNC NCICNNKREN KKRKSFQKNL KLSLSSMRYE EHVRSPKLMS PHSPLLRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of two members (ACS1 and ACS3) of the 1-aminocyclopropane-1-carboxylate synthase gene family of Arabidopsis thaliana." Liang X.-W., Oono Y., Shen N.F., Koehler C., Li K., Scolnik P.A., Theologis A. Gene 167:17-24(1995) [PubMed: 8566772] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ABSENCE OF ENZYME ACTIVITY, MUTAGENESIS OF SER-205. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"The 1-aminocyclopropane-1-carboxylate synthase gene family of Arabidopsis thaliana." Liang X.-W., Abel S., Keller J.A., Shen N.F., Theologis A. Proc. Natl. Acad. Sci. U.S.A. 89:11046-11050(1992) [PubMed: 1438312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 57-88.
[5]	"Cloning, genetic mapping, and expression analysis of an Arabidopsis thaliana gene that encodes 1-aminocyclopropane-1-carboxylate synthase." van der Straeten D., Rodrigues-Pousada R.A., Villarroel R., Hanley S., Goodman H.M., Van Montagu M. Proc. Natl. Acad. Sci. U.S.A. 89:9969-9973(1992) [PubMed: 1357670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-152. Strain: cv. C24. Tissue: Flower.
[6]	"Biochemical diversity among the 1-amino-cyclopropane-1-carboxylate synthase isozymes encoded by the Arabidopsis gene family." Yamagami T., Tsuchisaka A., Yamada K., Haddon W.F., Harden L.A., Theologis A. J. Biol. Chem. 278:49102-49112(2003) [PubMed: 12968022] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U26542 Genomic DNA. Translation: AAA96006.1. U26543 mRNA. Translation: AAB60312.1. AL132962 Genomic DNA. Translation: CAB71081.1. AY133715 mRNA. Translation: AAM91649.1. Z12615 mRNA. Translation: CAA78261.1.
IPI	IPI00520571.
PIR	B47199. T47943.
RefSeq	NP_191710.1.
UniGene	At.945
3D structure databases
SMR	Q06429. Positions 15-429.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q06429. 2 interactions.
STRING	Q06429.
Genome annotation databases
GeneID	825324.
GenomeReviews	Gene locus AT3G61510 in contig BA000014_GR.
KEGG	ath:AT3G61510.
NMPDR	fig|3702.1.peg.17526.
Organism-specific databases
GeneFarm	4048.
TAIR	At3g61510.
Phylogenomic databases
OMA	SNNFQIT
Gene expression databases
ArrayExpress	Q06429.
Genevestigator	Q06429.
GermOnline	AT3G61510. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015424. PyrdxlP-dep_Trfase_major. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

1A11_ARATH

Accession

Primary (citable) accession number: Q06429
Secondary accession number(s): Q43368, Q9S9C6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	November 24, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)