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Reviewed, UniProtKB/Swiss-Prot Q06418 (TYRO3_HUMAN)

Last modified November 25, 2008. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tyrosine-protein kinase receptor TYRO3
    EC=2.7.10.1
Alternative name(s):
    Tyrosine-protein kinase RSE
    Tyrosine-protein kinase SKY
    Tyrosine-protein kinase DTK
    Tyrosine-protein kinase byk
Gene names
Name: TYRO3
Synonyms: BYK, DTK, RSE, SKY
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length890 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May be involved in cell adhesion processes, particularly in the central nervous system. In case of filovirus infection, seems to function as a cell entry factor.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Monomer and homodimer. Interacts with GAS6.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Abundant in the brain and lower levels in other tissues.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

Contains 2 fibronectin type-III domains.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4040 Potential
Chain41 – 890850Tyrosine-protein kinase receptor TYRO3
PRO_0000024478

Regions

Topological domain41 – 429389Extracellular Potential
Transmembrane430 – 45021 Potential
Topological domain451 – 890440Cytoplasmic Potential
Domain41 – 12888Ig-like C2-type 1
Domain139 – 22082Ig-like C2-type 2
Domain225 – 31793Fibronectin type-III 1
Domain322 – 41392Fibronectin type-III 2
Domain518 – 790273Protein kinase
Nucleotide binding524 – 5329ATP By similarity

Sites

Active site6551Proton acceptor By similarity
Binding site5501ATP By similarity

Amino acid modifications

Modified residue6851Phosphotyrosine By similarity
Modified residue6861Phosphotyrosine; by autocatalysis By similarity
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation2301N-linked (GlcNAc...) Potential
Glycosylation2401N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation3801N-linked (GlcNAc...) Potential
Disulfide bond64 ↔ 117
Disulfide bond160 ↔ 203

Natural variations

Natural variant211P → L: dbSNP rs17854578.
VAR_045886
Natural variant3461I → N: dbSNP rs12148316.
VAR_045887
Natural variant5421G → S: dbSNP rs17857363.
VAR_045888
Natural variant8151A → V: dbSNP rs1042057.
VAR_045889
Natural variant8191L → M: dbSNP rs17854579.
VAR_045890
Natural variant8241R → G: dbSNP rs17857364.
VAR_045891
Natural variant8311A → T
VAR_041876

Experimental info

Mutagenesis991I → R: Abolishes dimerization
Sequence conflict29 – 368Missing in AAC50070. Ref.3
Sequence conflict2851L → F in BAA21781. Ref.4
Sequence conflict2931N → I in BAA21781. Ref.4
Sequence conflict3411E → V in BAA21781. Ref.4
Sequence conflict8121E → D in BAA21781. Ref.4

Secondary structure

................................... 890
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q06418-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F9EC675077C4E8F1

FASTA89096,905
        10         20         30         40         50         60 
MALRRSMGRP GLPPLPLPPP PRLGLLLAAL ASLLLPESAA AGLKLMGAPV KLTVSQGQPV 

        70         80         90        100        110        120 
KLNCSVEGME EPDIQWVKDG AVVQNLDQLY IPVSEQHWIG FLSLKSVERS DAGRYWCQVE 

       130        140        150        160        170        180 
DGGETEISQP VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IVWWRGTTKI 

       190        200        210        220        230        240 
GGPAPSPSVL NVTGVTQSTM FSCEAHNLKG LASSRTATVH LQALPAAPFN ITVTKLSSSN 

       250        260        270        280        290        300 
ASVAWMPGAD GRALLQSCTV QVTQAPGGWE VLAVVVPVPP FTCLLRDLVP ATNYSLRVRC 

       310        320        330        340        350        360 
ANALGPSPYA DWVPFQTKGL APASAPQNLH AIRTDSGLIL EWEEVIPEAP LEGPLGPYKL 

       370        380        390        400        410        420 
SWVQDNGTQD ELTVEGTRAN LTGWDPQKDL IVRVCVSNAV GCGPWSQPLV VSSHDRAGQQ 

       430        440        450        460        470        480 
GPPHSRTSWV PVVLGVLTAL VTAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA 

       490        500        510        520        530        540 
RSFNRERPER IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE 

       550        560        570        580        590        600 
DGSFVKVAVK MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM 

       610        620        630        640        650        660 
VILPFMKHGD LHAFLLASRI GENPFNLPLQ TLIRFMVDIA CGMEYLSSRN FIHRDLAARN 

       670        680        690        700        710        720 
CMLAEDMTVC VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VQSDVWAFGV 

       730        740        750        760        770        780 
TMWEIMTRGQ TPYAGIENAE IYNYLIGGNR LKQPPECMED VYDLMYQCWS ADPKQRPSFT 

       790        800        810        820        830        840 
CLRMELENIL GQLSVLSASQ DPLYINIERA EEPTAGGSLE LPGRDQPYSG AGDGSGMGAV 

       850        860        870        880        890 
GGTPSDCRYI LTPGGLAEQP GQAEHQPESP LNETQRLLLL QQGLLPHSSC 

« Hide

References

« Hide 'large scale' references
[1]"RSE, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain."
Mark M.R., Scadden D.T., Wang Z., Gu Q., Goddard A., Godowski P.J.
J. Biol. Chem. 269:10720-10728(1994) [PubMed: 7511603] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain."
Ohashi K., Mizuno K., Kuma K., Miyata T., Nakamura T.
Oncogene 9:699-705(1994) [PubMed: 8108112] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Isolation and characterization of the human DTK receptor tyrosine kinase."
Crosier K.E., Hall L.R., Lewis P.M., Morris C.M., Wood C.R., Morris J.C., Crosier P.S.
Growth Factors 11:137-144(1994) [PubMed: 7857658] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-815.
Tissue: Brain.
[4]"A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress."
Kajii Y., Ninomiya D., Kato M., Mizuguchi M., Saji M., Katsumoto T., Ohno K., Takashima S., Onodera K.
Biol. Cell 88:45-54(1996) [PubMed: 9175267] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-21; SER-542; MET-819 AND GLY-824.
Tissue: Skin and Testis.
[6]"The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25."
Polvi A., Armstrong E., Lai C., Lemke G., Huebner K., Spritz R.A., Giuda L.C., Nicholls R.D., Alitalo K.
Gene 134:289-293(1993) [PubMed: 8262388] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 519-720.
[7]"Tyro3 family-mediated cell entry of Ebola and Marburg viruses."
Shimojima M., Takada A., Ebihara H., Neumann G., Fujioka K., Irimura T., Jones S., Feldmann H., Kawaoka Y.
J. Virol. 80:10109-10116(2006) [PubMed: 17005688] [Abstract]
Cited for: FUNCTION AS CELL ENTRY FACTOR IN FILOVIRUS INFECTION.
[8]"Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family."
Heiring C., Dahlbaeck B., Muller Y.A.
J. Biol. Chem. 279:6952-6958(2004) [PubMed: 14623883] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 41-222, SUBUNIT, INTERACTION WITH GAS6, MUTAGENESIS OF ILE-99, DISULFIDE BONDS.
[9]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed: 17344846] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-831.

Cross-references

Sequence databases

U05682 mRNA. Translation: AAA19236.1.
D17517 mRNA. Translation: BAA04467.1.
U18934 mRNA. Translation: AAC50070.1.
D50479 mRNA. Translation: BAA21781.1. Different initiation.
BC049368 mRNA. Translation: AAH49368.1.
BC051756 mRNA. Translation: AAH51756.1.
X72886 mRNA. Translation: CAA51396.1.
PIRA53743.
I38912.
RefSeqNP_006284.2.
UniGeneHs.381282

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1RHFX-ray1.96A/B41-222[»]
ModBaseSearch...

PTM databases

PhosphoSiteQ06418.

Genome annotation databases

EnsemblENSG00000092445. Homo sapiens. [Contig view]
GeneID7301.
KEGGhsa:7301.

Organism-specific databases

H-InvDBHIX0012156.
HGNCHGNC:12446. TYRO3.
HPAHPA007654.
MIM600341. gene.
PharmGKBPA37097.
GenAtlasSearch...
GeneCardsSearch...