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Protein

Uncharacterized oxidoreductase TDA5

Gene

TDA5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the resistance to DNA-damaging agents.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei201 – 2011SubstrateBy similarity
Active sitei214 – 2141Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 9825NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciYEAST:G3O-32486-MONOMER.
ReactomeiR-SCE-193144. Estrogen biosynthesis.
R-SCE-2187335. The retinoid cycle in cones (daylight vision).
R-SCE-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized oxidoreductase TDA5 (EC:1.-.-.-)
Alternative name(s):
Topoisomerase I damage affected protein 5
Gene namesi
Name:TDA5
Ordered Locus Names:YLR426W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR426W.
SGDiS000004418. TDA5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Uncharacterized oxidoreductase TDA5PRO_0000247778Add
BLAST

Proteomic databases

TopDownProteomicsiQ06417.

Interactioni

Protein-protein interaction databases

BioGridi31686. 23 interactions.
DIPiDIP-4567N.
IntActiQ06417. 6 interactions.
MINTiMINT-510149.

Structurei

3D structure databases

ProteinModelPortaliQ06417.
SMRiQ06417. Positions 73-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00540000069900.
InParanoidiQ06417.
OMAiYANFLPG.
OrthoDBiEOG7MPRR7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDCLCRWV VLPLLRYPLL VALVLRWSLS DSISICLTIY TLLINAFLIA
60 70 80 90 100
NSYIKRSGQV AWKSLREFKN GIVLITGGSK GLGRAIVSQL LQDYSNLTIL
110 120 130 140 150
NVDICPSSVR NTRVKDLICD LSDDEEVAAL LNLLKRKYKN EIRLIVNNAG
160 170 180 190 200
VRANFTGFNG MERDNLDKIF KINTFAPLQF IQELAPSRHS TRQCYIVNIA
210 220 230 240 250
SILGILTPAK VAAYAASKAA LIAFHQSYSF ELQNEGVRNI RTLLVTPGQL
260 270 280 290 300
NTEMFAGFKP PRQFFAPVID ITTLAAKIVR YCELGQRGQL NEPFYCSFAH
310 320
LLMCVPYSLQ RIVRSFSRID CCLPDE
Length:326
Mass (Da):36,677
Last modified:November 1, 1996 - v1
Checksum:i2663A29F1C6D7FD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20939 Genomic DNA. Translation: AAB67505.1.
BK006945 Genomic DNA. Translation: DAA09728.1.
PIRiS53413.
RefSeqiNP_013530.1. NM_001182314.1.

Genome annotation databases

EnsemblFungiiYLR426W; YLR426W; YLR426W.
GeneIDi851146.
KEGGisce:YLR426W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20939 Genomic DNA. Translation: AAB67505.1.
BK006945 Genomic DNA. Translation: DAA09728.1.
PIRiS53413.
RefSeqiNP_013530.1. NM_001182314.1.

3D structure databases

ProteinModelPortaliQ06417.
SMRiQ06417. Positions 73-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31686. 23 interactions.
DIPiDIP-4567N.
IntActiQ06417. 6 interactions.
MINTiMINT-510149.

Proteomic databases

TopDownProteomicsiQ06417.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR426W; YLR426W; YLR426W.
GeneIDi851146.
KEGGisce:YLR426W.

Organism-specific databases

EuPathDBiFungiDB:YLR426W.
SGDiS000004418. TDA5.

Phylogenomic databases

GeneTreeiENSGT00540000069900.
InParanoidiQ06417.
OMAiYANFLPG.
OrthoDBiEOG7MPRR7.

Enzyme and pathway databases

BioCyciYEAST:G3O-32486-MONOMER.
ReactomeiR-SCE-193144. Estrogen biosynthesis.
R-SCE-2187335. The retinoid cycle in cones (daylight vision).
R-SCE-5365859. RA biosynthesis pathway.

Miscellaneous databases

NextBioi967915.
PROiQ06417.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents."
    Birrell G.W., Brown J.A., Wu H.I., Giaever G., Chu A.M., Davis R.W., Brown J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:8778-8783(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  6. "Genome-wide requirements for resistance to functionally distinct DNA-damaging agents."
    Lee W., St Onge R.P., Proctor M., Flaherty P., Jordan M.I., Arkin A.P., Davis R.W., Nislow C., Giaever G.
    PLoS Genet. 1:235-246(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. "Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage."
    Reid R.J., Gonzalez-Barrera S., Sunjevaric I., Alvaro D., Ciccone S., Wagner M., Rothstein R.
    Genome Res. 21:477-486(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTDA5_YEAST
AccessioniPrimary (citable) accession number: Q06417
Secondary accession number(s): D6VZ62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2130 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.