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Protein

Uncharacterized oxidoreductase TDA5

Gene

TDA5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the resistance to DNA-damaging agents.2 Publications

Miscellaneous

Present with 2130 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei201SubstrateBy similarity1
Active sitei214Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 98NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciYEAST:G3O-32486-MONOMER
ReactomeiR-SCE-1660661 Sphingolipid de novo biosynthesis
R-SCE-193144 Estrogen biosynthesis
R-SCE-2187335 The retinoid cycle in cones (daylight vision)
R-SCE-5365859 RA biosynthesis pathway
R-SCE-8964572 Lipid particle organization

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized oxidoreductase TDA5 (EC:1.-.-.-)
Alternative name(s):
Topoisomerase I damage affected protein 5
Gene namesi
Name:TDA5
Ordered Locus Names:YLR426W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR426W
SGDiS000004418 TDA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002477781 – 326Uncharacterized oxidoreductase TDA5Add BLAST326

Proteomic databases

PaxDbiQ06417
PRIDEiQ06417
TopDownProteomicsiQ06417

Interactioni

Protein-protein interaction databases

BioGridi31686, 285 interactors
DIPiDIP-4567N
IntActiQ06417, 7 interactors
MINTiQ06417
STRINGi4932.YLR426W

Structurei

3D structure databases

ProteinModelPortaliQ06417
SMRiQ06417
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000148998
InParanoidiQ06417
OMAiYANFLPG
OrthoDBiEOG092C3QFN

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q06417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDCLCRWV VLPLLRYPLL VALVLRWSLS DSISICLTIY TLLINAFLIA
60 70 80 90 100
NSYIKRSGQV AWKSLREFKN GIVLITGGSK GLGRAIVSQL LQDYSNLTIL
110 120 130 140 150
NVDICPSSVR NTRVKDLICD LSDDEEVAAL LNLLKRKYKN EIRLIVNNAG
160 170 180 190 200
VRANFTGFNG MERDNLDKIF KINTFAPLQF IQELAPSRHS TRQCYIVNIA
210 220 230 240 250
SILGILTPAK VAAYAASKAA LIAFHQSYSF ELQNEGVRNI RTLLVTPGQL
260 270 280 290 300
NTEMFAGFKP PRQFFAPVID ITTLAAKIVR YCELGQRGQL NEPFYCSFAH
310 320
LLMCVPYSLQ RIVRSFSRID CCLPDE
Length:326
Mass (Da):36,677
Last modified:November 1, 1996 - v1
Checksum:i2663A29F1C6D7FD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20939 Genomic DNA Translation: AAB67505.1
BK006945 Genomic DNA Translation: DAA09728.1
PIRiS53413
RefSeqiNP_013530.1, NM_001182314.1

Genome annotation databases

EnsemblFungiiYLR426W; YLR426W; YLR426W
GeneIDi851146
KEGGisce:YLR426W

Similar proteinsi

Entry informationi

Entry nameiTDA5_YEAST
AccessioniPrimary (citable) accession number: Q06417
Secondary accession number(s): D6VZ62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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