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Protein

Uncharacterized oxidoreductase TDA5

Gene

TDA5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the resistance to DNA-damaging agents.2 Publications

Miscellaneous

Present with 2130 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei201SubstrateBy similarity1
Active sitei214Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 98NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciYEAST:G3O-32486-MONOMER.
ReactomeiR-SCE-193144. Estrogen biosynthesis.
R-SCE-2187335. The retinoid cycle in cones (daylight vision).
R-SCE-5365859. RA biosynthesis pathway.
R-SCE-8964572. Lipid particle organization.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized oxidoreductase TDA5 (EC:1.-.-.-)
Alternative name(s):
Topoisomerase I damage affected protein 5
Gene namesi
Name:TDA5
Ordered Locus Names:YLR426W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR426W.
SGDiS000004418. TDA5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002477781 – 326Uncharacterized oxidoreductase TDA5Add BLAST326

Proteomic databases

PRIDEiQ06417.
TopDownProteomicsiQ06417.

Interactioni

Protein-protein interaction databases

BioGridi31686. 274 interactors.
DIPiDIP-4567N.
IntActiQ06417. 6 interactors.
MINTiMINT-510149.
STRINGi4932.YLR426W.

Structurei

3D structure databases

ProteinModelPortaliQ06417.
SMRiQ06417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00540000069900.
InParanoidiQ06417.
OMAiYANFLPG.
OrthoDBiEOG092C3QFN.

Family and domain databases

InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDCLCRWV VLPLLRYPLL VALVLRWSLS DSISICLTIY TLLINAFLIA
60 70 80 90 100
NSYIKRSGQV AWKSLREFKN GIVLITGGSK GLGRAIVSQL LQDYSNLTIL
110 120 130 140 150
NVDICPSSVR NTRVKDLICD LSDDEEVAAL LNLLKRKYKN EIRLIVNNAG
160 170 180 190 200
VRANFTGFNG MERDNLDKIF KINTFAPLQF IQELAPSRHS TRQCYIVNIA
210 220 230 240 250
SILGILTPAK VAAYAASKAA LIAFHQSYSF ELQNEGVRNI RTLLVTPGQL
260 270 280 290 300
NTEMFAGFKP PRQFFAPVID ITTLAAKIVR YCELGQRGQL NEPFYCSFAH
310 320
LLMCVPYSLQ RIVRSFSRID CCLPDE
Length:326
Mass (Da):36,677
Last modified:November 1, 1996 - v1
Checksum:i2663A29F1C6D7FD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20939 Genomic DNA. Translation: AAB67505.1.
BK006945 Genomic DNA. Translation: DAA09728.1.
PIRiS53413.
RefSeqiNP_013530.1. NM_001182314.1.

Genome annotation databases

EnsemblFungiiYLR426W; YLR426W; YLR426W.
GeneIDi851146.
KEGGisce:YLR426W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTDA5_YEAST
AccessioniPrimary (citable) accession number: Q06417
Secondary accession number(s): D6VZ62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names