Q06416 (P5F1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative POU domain, class 5, transcription factor 1B

Alternative name(s):
Octamer-binding protein 3-like
Octamer-binding transcription factor 3-like

Gene names

Name:	POU5F1B
Synonyms:	OTF3C, OTF3P1, POU5F1P1, POU5FLC20, POU5FLC8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Shows weak transcriptional activator activity. Ref.7
Subcellular location	Nucleus Ref.7.
Sequence similarities	Belongs to the POU transcription factor family. Class-5 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.
Caution	Could be the product of a pseudogene. Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. Two of them, localized on chromosomes 8 and 10 have been shown to be preferentially transcribed in cancer tissues and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Traceable author statement. Source: UniProtKB
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Putative POU domain, class 5, transcription factor 1B		PRO_0000100753
Regions
	Domain	138 – 212	75	POU-specific
	DNA binding	229 – 288	60	Homeobox
Natural variations
	Natural variant	33	1	L → R. Corresponds to variant rs1061394 [ dbSNP | Ensembl ].		VAR_067432
	Natural variant	69	1	L → F. Corresponds to variant rs1061395 [ dbSNP | Ensembl ].		VAR_067433
	Natural variant	176	1	G → E. Corresponds to variant rs6998061 [ dbSNP | Ensembl ].		VAR_067434
	Natural variant	182	1	K → T. Ref.3 Ref.5 Corresponds to variant rs13273814 [ dbSNP | Ensembl ].		VAR_067435
	Natural variant	214	1	N → D. Ref.3 Ref.5 Corresponds to variant rs13274084 [ dbSNP | Ensembl ].		VAR_067436
	Natural variant	238	1	E → Q. Corresponds to variant rs7002225 [ dbSNP | Ensembl ].		VAR_067437
	Natural variant	313	1	P → L. Corresponds to variant rs16897482 [ dbSNP | Ensembl ].		VAR_067438
Experimental info
	Sequence conflict	197	1	M → I in CAA77953. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q06416 [UniParc]. Last modified November 16, 2011. Version 2. Checksum: 9AF853B116FCB75A	FASTA	359	38,588
	10 20 30 40 50 60 MAGHLASDFA FSPPPGGGGD GPWGAEPGWV DPLTWLSFQG PPGGPGIGPG VGPGSEVWGI 70 80 90 100 110 120 PPCPPPYELC GGMAYCGPQV GVGLVPQGGL ETSQPESEAG VGVESNSNGA SPEPCTVPPG 130 140 150 160 170 180 AVKLEKEKLE QNPEKSQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLI LGVLFGKVFS 190 200 210 220 230 240 QKTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLMQAR KRKRTSIENR 250 260 270 280 290 300 VRGNLENLFL QCPKPTLQIS HIAQQLGLEK DVVRVWFCNR RQKGKRSSSD YAQREDFEAA 310 320 330 340 350 GSPFSGGPVS FPPAPGPHFG TPGYGSPHFT ALYSSVPFPE GEVFPPVSVI TLGSPMHSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues." Takeda J., Seino S., Bell G.I. Nucleic Acids Res. 20:4613-4620(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	"Emergence of young human genes after a burst of retroposition in primates." Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H. PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Identification and expression analysis of novel intron-less human POU5F1/OCT3 related POU domain genes." van Roozendaal K.E.P., Gillis A.J.M., van Asseldonk M., Oosterhuis J.W., Looijenga L.H.J., van Zoelen E.J.J. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-182 AND ASP-214. Tissue: Kidney.
[4]	"Differential expression of Oct-4 gene and pseudogene in normal and breast cancer cells." Zhao F.-Q., Buss K. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary cancer.
[5]	"Expression of OCT4 pseudogenes in two human somatic tumours: glioma and breast carcinoma." Zhao S., Yuan Q., Guo Y., Liu S., Zhang Y., Wang J., Liu H., Wang F., Liu K., Ling E.-A., Hao A. Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-182 AND ASP-214. Tissue: Glial tumor and Mammary cancer.
[6]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1." Panagopoulos I., Moeller E., Collin A., Mertens F. Oncol. Rep. 20:1029-1033(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z11901 Genomic DNA. Translation: CAA77953.1. DQ120688 Genomic DNA. Translation: ABB92462.1. AF268615 mRNA. Translation: AAG53083.1. AF268618 mRNA. Translation: AAG53085.1. DQ486513 mRNA. Translation: ABF29403.1. GU480878 mRNA. Translation: ADE48591.1. GU480883 mRNA. Translation: ADE48596.1. HQ122713 mRNA. Translation: ADW77354.1. HQ122716 mRNA. Translation: ADW77356.1. HQ122719 mRNA. Translation: ADW77359.1. HQ122750 mRNA. Translation: ADW77386.1. HQ122752 mRNA. Translation: ADW77388.1. HQ122785 mRNA. Translation: ADW77419.1. HQ122788 mRNA. Translation: ADW77422.1. HQ122790 mRNA. Translation: ADW77424.1. HQ122891 mRNA. Translation: ADW77511.1. HQ122892 mRNA. Translation: ADW77512.1. HQ122895 mRNA. Translation: ADW77514.1. HQ122898 mRNA. Translation: ADW77515.1. HQ122900 mRNA. Translation: ADW77516.1. HQ122902 mRNA. Translation: ADW77517.1. AC016883 Genomic DNA. No translation available.
IPI	IPI00183154.
RefSeq	NP_001153014.1. NM_001159542.1.
UniGene	Hs.450254.
3D structure databases
ProteinModelPortal	Q06416.
SMR	Q06416. Positions 140-288.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000375557.
PTM databases
PhosphoSite	Q06416.
Polymorphism databases
DMDM	28201858.
Proteomic databases
PaxDb	Q06416.
PRIDE	Q06416.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000391675; ENSP00000375557; ENSG00000212993. ENST00000465342; ENSP00000419298; ENSG00000212993.
GeneID	5462.
KEGG	hsa:5462.
Organism-specific databases
CTD	5462.
GeneCards	GC08P128426.
HGNC	HGNC:9223. POU5F1B.
neXtProt	NX_Q06416.
PharmGKB	PA33547.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG329627.
HOGENOM	HOG000089941.
InParanoid	Q06416.
KO	K09367.
OMA	QICHIAQ.
OrthoDB	EOG46MBK1.
PhylomeDB	Q06416.
Gene expression databases
ArrayExpress	Q06416.
Bgee	Q06416.
Genevestigator	Q06416.
GermOnline	ENSG00000204531. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit. 1.10.260.40. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR010982. Lambda_DNA-bd_dom. IPR013847. POU. IPR015585. POU_dom_5. IPR000327. POU_specific. [Graphical view]
PANTHER	PTHR11636:SF15. PTHR11636:SF15. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit. [Graphical view]
PRINTS	PR00028. POUDOMAIN.
SMART	SM00389. HOX. 1 hit. SM00352. POU. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit. SSF47413. Lambda_like_DNA. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS00465. POU_2. 1 hit. PS51179. POU_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5462.
NextBio	21141.

Entry information

Entry name

P5F1B_HUMAN

Accession

Primary (citable) accession number: Q06416
Secondary accession number(s): D5K9V4 , Q2VIK6, Q9BZV7, Q9BZV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	November 16, 2011
Last modified:	April 3, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.