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Protein

Putative POU domain, class 5, transcription factor 1B

Gene

POU5F1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein uncertaini

Functioni

Shows weak transcriptional activator activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative POU domain, class 5, transcription factor 1B
Alternative name(s):
Oct4-pg1
Octamer-binding protein 3-like
Octamer-binding transcription factor 3-like
Gene namesi
Name:POU5F1B
Synonyms:OCT4PG1, OTF3C, OTF3P1, POU5F1P1, POU5FLC20, POU5FLC8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9223. POU5F1B.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5462.
OpenTargetsiENSG00000212993.
PharmGKBiPA33547.

Polymorphism and mutation databases

BioMutaiPOU5F1B.
DMDMi357528826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007531 – 359Putative POU domain, class 5, transcription factor 1BAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111PhosphoserineBy similarity1
Modified residuei235PhosphothreonineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei288PhosphoserineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei354PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ06416.
MaxQBiQ06416.
PaxDbiQ06416.
PeptideAtlasiQ06416.
PRIDEiQ06416.

PTM databases

iPTMnetiQ06416.
PhosphoSitePlusiQ06416.

Expressioni

Tissue specificityi

Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues.2 Publications

Gene expression databases

BgeeiENSG00000212993.
GenevisibleiQ06416. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375557.

Structurei

3D structure databases

ProteinModelPortaliQ06416.
SMRiQ06416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 212POU-specificPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000089941.
InParanoidiQ06416.
KOiK09367.
OrthoDBiEOG091G0U0S.
PhylomeDBiQ06416.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR015585. POU_dom_5.
[Graphical view]
PANTHERiPTHR11636:SF86. PTHR11636:SF86. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGHLASDFA FSPPPGGGGD GPWGAEPGWV DPLTWLSFQG PPGGPGIGPG
60 70 80 90 100
VGPGSEVWGI PPCPPPYELC GGMAYCGPQV GVGLVPQGGL ETSQPESEAG
110 120 130 140 150
VGVESNSNGA SPEPCTVPPG AVKLEKEKLE QNPEKSQDIK ALQKELEQFA
160 170 180 190 200
KLLKQKRITL GYTQADVGLI LGVLFGKVFS QKTICRFEAL QLSFKNMCKL
210 220 230 240 250
RPLLQKWVEE ADNNENLQEI CKAETLMQAR KRKRTSIENR VRGNLENLFL
260 270 280 290 300
QCPKPTLQIS HIAQQLGLEK DVVRVWFCNR RQKGKRSSSD YAQREDFEAA
310 320 330 340 350
GSPFSGGPVS FPPAPGPHFG TPGYGSPHFT ALYSSVPFPE GEVFPPVSVI

TLGSPMHSN
Length:359
Mass (Da):38,588
Last modified:November 16, 2011 - v2
Checksum:i9AF853B116FCB75A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10A → T in ADE48599 (PubMed:21341266).Curated1
Sequence conflicti13P → L in ADE48609 (PubMed:21341266).Curated1
Sequence conflicti13P → L in ADW77452 (PubMed:21341266).Curated1
Sequence conflicti14P → T in ADW77351 (PubMed:21341266).Curated1
Sequence conflicti23 – 25WGA → GGP in ADE48566 (PubMed:21341266).Curated3
Sequence conflicti23 – 25WGA → GGP in ADE48597 (PubMed:21341266).Curated3
Sequence conflicti31D → G in ADE48567 (PubMed:21341266).Curated1
Sequence conflicti31D → V in ADE48570 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77415 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77416 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77417 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77420 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77421 (PubMed:21341266).Curated1
Sequence conflicti39Q → R in ADE48583 (PubMed:21341266).Curated1
Sequence conflicti76C → R in ADW77445 (PubMed:21341266).Curated1
Sequence conflicti79Q → H in ADW77469 (PubMed:21341266).Curated1
Sequence conflicti91E → V in ADE48610 (PubMed:21341266).Curated1
Sequence conflicti91E → V in ADW77455 (PubMed:21341266).Curated1
Sequence conflicti106N → S in ADE48612 (PubMed:21341266).Curated1
Sequence conflicti107S → Y in ADW77513 (PubMed:21341266).Curated1
Sequence conflicti107S → Y in ADW77518 (PubMed:21341266).Curated1
Sequence conflicti129L → Q in ADE48580 (PubMed:21341266).Curated1
Sequence conflicti130E → G in ADW77492 (PubMed:21341266).Curated1
Sequence conflicti132N → D in ADW77447 (PubMed:21341266).Curated1
Sequence conflicti138D → G in ADE48599 (PubMed:21341266).Curated1
Sequence conflicti150A → T in ADE48616 (PubMed:21341266).Curated1
Sequence conflicti152L → F in ADW77351 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77490 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77499 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77502 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77503 (PubMed:21341266).Curated1
Sequence conflicti160L → P in ADW77417 (PubMed:21341266).Curated1
Sequence conflicti163T → A in ADE48580 (PubMed:21341266).Curated1
Sequence conflicti169L → F in ADW77415 (PubMed:21341266).Curated1
Sequence conflicti169L → F in ADW77420 (PubMed:21341266).Curated1
Sequence conflicti169L → F in ADW77421 (PubMed:21341266).Curated1
Sequence conflicti169L → P in ADE48561 (PubMed:21341266).Curated1
Sequence conflicti169L → R in ADE48583 (PubMed:21341266).Curated1
Sequence conflicti196N → D in ADW77492 (PubMed:21341266).Curated1
Sequence conflicti197M → I in CAA77953 (PubMed:1408763).Curated1
Sequence conflicti201R → W in ADE48615 (PubMed:21341266).Curated1
Sequence conflicti208V → E in ADW77493 (PubMed:21341266).Curated1
Sequence conflicti208V → E in ADW77501 (PubMed:21341266).Curated1
Sequence conflicti208V → E in ADW77506 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADE48593 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77355 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77358 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77387 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77418 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77423 (PubMed:21341266).Curated1
Sequence conflicti235T → A in ADW77518 (PubMed:21341266).Curated1
Sequence conflicti235T → A in ADW77513 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77488 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77496 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77504 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77507 (PubMed:21341266).Curated1
Sequence conflicti246E → G in ADW77492 (PubMed:21341266).Curated1
Sequence conflicti249F → L in ADW77474 (PubMed:21341266).Curated1
Sequence conflicti249F → L in ADW77481 (PubMed:21341266).Curated1
Sequence conflicti250L → P in ADE48580 (PubMed:21341266).Curated1
Sequence conflicti250L → Q in ADW77475 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77488 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77496 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77504 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77507 (PubMed:21341266).Curated1
Sequence conflicti264Q → H in ADE48609 (PubMed:21341266).Curated1
Sequence conflicti264Q → H in ADW77452 (PubMed:21341266).Curated1
Sequence conflicti264Q → L in ADW77477 (PubMed:21341266).Curated1
Sequence conflicti264Q → L in ADW77476 (PubMed:21341266).Curated1
Sequence conflicti264Q → L in ADW77467 (PubMed:21341266).Curated1
Sequence conflicti272V → M in ADW77472 (PubMed:21341266).Curated1
Sequence conflicti272V → M in ADW77479 (PubMed:21341266).Curated1
Sequence conflicti276 – 278WFC → CFG in ADW77495 (PubMed:21341266).Curated3
Sequence conflicti282Q → R in ADW77494 (PubMed:21341266).Curated1
Sequence conflicti284G → S in ADW77469 (PubMed:21341266).Curated1
Sequence conflicti295E → V in ADE48583 (PubMed:21341266).Curated1
Sequence conflicti318H → Q in ADW77444 (PubMed:21341266).Curated1
Sequence conflicti318H → Q in ADW77445 (PubMed:21341266).Curated1
Sequence conflicti321T → I in ADW77476 (PubMed:21341266).Curated1
Sequence conflicti321T → I in ADW77467 (PubMed:21341266).Curated1
Sequence conflicti321T → I in ADW77477 (PubMed:21341266).Curated1
Sequence conflicti326S → G in ADW77444 (PubMed:21341266).Curated1
Sequence conflicti326S → G in ADW77445 (PubMed:21341266).Curated1
Sequence conflicti331A → T in ADW77447 (PubMed:21341266).Curated1
Sequence conflicti331A → T in ADW77448 (PubMed:21341266).Curated1
Sequence conflicti331A → T in ADW77451 (PubMed:21341266).Curated1
Sequence conflicti340E → V in ADE48570 (PubMed:21341266).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06743233L → R.1 PublicationCorresponds to variant rs1061394dbSNPEnsembl.1
Natural variantiVAR_06743369L → F.Corresponds to variant rs1061395dbSNPEnsembl.1
Natural variantiVAR_067434176G → E.1 PublicationCorresponds to variant rs6998061dbSNPEnsembl.1
Natural variantiVAR_067435182K → T.2 PublicationsCorresponds to variant rs13273814dbSNPEnsembl.1
Natural variantiVAR_067436214N → D.2 PublicationsCorresponds to variant rs13274084dbSNPEnsembl.1
Natural variantiVAR_067437238E → Q.1 PublicationCorresponds to variant rs7002225dbSNPEnsembl.1
Natural variantiVAR_067438313P → L.Corresponds to variant rs556361752dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11901 Genomic DNA. Translation: CAA77953.1.
DQ120688 Genomic DNA. Translation: ABB92462.1.
AF268615 mRNA. Translation: AAG53083.1.
AF268618 mRNA. Translation: AAG53085.1.
DQ486513 mRNA. Translation: ABF29403.1.
GU480835 mRNA. Translation: ADE48561.1.
GU480840 mRNA. Translation: ADE48566.1.
GU480841 mRNA. Translation: ADE48567.1.
GU480842 mRNA. Translation: ADE48568.1.
GU480845 mRNA. Translation: ADE48570.1.
GU480864 mRNA. Translation: ADE48580.1.
GU480868 mRNA. Translation: ADE48583.1.
GU480878 mRNA. Translation: ADE48591.1.
GU480880 mRNA. Translation: ADE48593.1.
GU480883 mRNA. Translation: ADE48596.1.
GU480886 mRNA. Translation: ADE48597.1.
GU480889 mRNA. Translation: ADE48599.1.
GU480896 mRNA. Translation: ADE48604.1.
GU480902 mRNA. Translation: ADE48606.1.
GU480905 mRNA. Translation: ADE48609.1.
GU480906 mRNA. Translation: ADE48610.1.
GU480908 mRNA. Translation: ADE48612.1.
GU480911 mRNA. Translation: ADE48614.1.
GU480912 mRNA. Translation: ADE48615.1.
GU480913 mRNA. Translation: ADE48616.1.
HQ122710 mRNA. Translation: ADW77351.1.
HQ122711 mRNA. Translation: ADW77352.1.
HQ122712 mRNA. Translation: ADW77353.1.
HQ122713 mRNA. Translation: ADW77354.1.
HQ122714 mRNA. Translation: ADW77355.1.
HQ122716 mRNA. Translation: ADW77356.1.
HQ122717 mRNA. Translation: ADW77357.1.
HQ122718 mRNA. Translation: ADW77358.1.
HQ122719 mRNA. Translation: ADW77359.1.
HQ122721 mRNA. Translation: ADW77360.1.
HQ122749 mRNA. Translation: ADW77385.1.
HQ122750 mRNA. Translation: ADW77386.1.
HQ122751 mRNA. Translation: ADW77387.1.
HQ122752 mRNA. Translation: ADW77388.1.
HQ122781 mRNA. Translation: ADW77415.1.
HQ122782 mRNA. Translation: ADW77416.1.
HQ122783 mRNA. Translation: ADW77417.1.
HQ122784 mRNA. Translation: ADW77418.1.
HQ122785 mRNA. Translation: ADW77419.1.
HQ122786 mRNA. Translation: ADW77420.1.
HQ122787 mRNA. Translation: ADW77421.1.
HQ122788 mRNA. Translation: ADW77422.1.
HQ122789 mRNA. Translation: ADW77423.1.
HQ122790 mRNA. Translation: ADW77424.1.
HQ122816 mRNA. Translation: ADW77444.1.
HQ122817 mRNA. Translation: ADW77445.1.
HQ122818 mRNA. Translation: ADW77446.1.
HQ122819 mRNA. Translation: ADW77447.1.
HQ122820 mRNA. Translation: ADW77448.1.
HQ122821 mRNA. Translation: ADW77449.1.
HQ122822 mRNA. Translation: ADW77450.1.
HQ122823 mRNA. Translation: ADW77451.1.
HQ122824 mRNA. Translation: ADW77452.1.
HQ122825 mRNA. Translation: ADW77453.1.
HQ122826 mRNA. Translation: ADW77454.1.
HQ122827 mRNA. Translation: ADW77455.1.
HQ122841 mRNA. Translation: ADW77467.1.
HQ122842 mRNA. Translation: ADW77468.1.
HQ122843 mRNA. Translation: ADW77469.1.
HQ122844 mRNA. Translation: ADW77470.1.
HQ122845 mRNA. Translation: ADW77471.1.
HQ122846 mRNA. Translation: ADW77472.1.
HQ122848 mRNA. Translation: ADW77473.1.
HQ122849 mRNA. Translation: ADW77474.1.
HQ122851 mRNA. Translation: ADW77475.1.
HQ122852 mRNA. Translation: ADW77476.1.
HQ122853 mRNA. Translation: ADW77477.1.
HQ122854 mRNA. Translation: ADW77478.1.
HQ122855 mRNA. Translation: ADW77479.1.
HQ122856 mRNA. Translation: ADW77480.1.
HQ122857 mRNA. Translation: ADW77481.1.
HQ122864 mRNA. Translation: ADW77487.1.
HQ122865 mRNA. Translation: ADW77488.1.
HQ122866 mRNA. Translation: ADW77489.1.
HQ122867 mRNA. Translation: ADW77490.1.
HQ122868 mRNA. Translation: ADW77491.1.
HQ122869 mRNA. Translation: ADW77492.1.
HQ122870 mRNA. Translation: ADW77493.1.
HQ122871 mRNA. Translation: ADW77494.1.
HQ122874 mRNA. Translation: ADW77495.1.
HQ122876 mRNA. Translation: ADW77496.1.
HQ122877 mRNA. Translation: ADW77497.1.
HQ122878 mRNA. Translation: ADW77498.1.
HQ122879 mRNA. Translation: ADW77499.1.
HQ122880 mRNA. Translation: ADW77500.1.
HQ122881 mRNA. Translation: ADW77501.1.
HQ122882 mRNA. Translation: ADW77502.1.
HQ122883 mRNA. Translation: ADW77503.1.
HQ122884 mRNA. Translation: ADW77504.1.
HQ122885 mRNA. Translation: ADW77505.1.
HQ122886 mRNA. Translation: ADW77506.1.
HQ122887 mRNA. Translation: ADW77507.1.
HQ122891 mRNA. Translation: ADW77511.1.
HQ122892 mRNA. Translation: ADW77512.1.
HQ122893 mRNA. Translation: ADW77513.1.
HQ122895 mRNA. Translation: ADW77514.1.
HQ122898 mRNA. Translation: ADW77515.1.
HQ122900 mRNA. Translation: ADW77516.1.
HQ122902 mRNA. Translation: ADW77517.1.
HQ122903 mRNA. Translation: ADW77518.1.
AC016883 Genomic DNA. No translation available.
CCDSiCCDS55274.1.
RefSeqiNP_001153014.1. NM_001159542.1.
UniGeneiHs.450254.

Genome annotation databases

EnsembliENST00000465342; ENSP00000419298; ENSG00000212993.
GeneIDi5462.
KEGGihsa:5462.
UCSCiuc003ysf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11901 Genomic DNA. Translation: CAA77953.1.
DQ120688 Genomic DNA. Translation: ABB92462.1.
AF268615 mRNA. Translation: AAG53083.1.
AF268618 mRNA. Translation: AAG53085.1.
DQ486513 mRNA. Translation: ABF29403.1.
GU480835 mRNA. Translation: ADE48561.1.
GU480840 mRNA. Translation: ADE48566.1.
GU480841 mRNA. Translation: ADE48567.1.
GU480842 mRNA. Translation: ADE48568.1.
GU480845 mRNA. Translation: ADE48570.1.
GU480864 mRNA. Translation: ADE48580.1.
GU480868 mRNA. Translation: ADE48583.1.
GU480878 mRNA. Translation: ADE48591.1.
GU480880 mRNA. Translation: ADE48593.1.
GU480883 mRNA. Translation: ADE48596.1.
GU480886 mRNA. Translation: ADE48597.1.
GU480889 mRNA. Translation: ADE48599.1.
GU480896 mRNA. Translation: ADE48604.1.
GU480902 mRNA. Translation: ADE48606.1.
GU480905 mRNA. Translation: ADE48609.1.
GU480906 mRNA. Translation: ADE48610.1.
GU480908 mRNA. Translation: ADE48612.1.
GU480911 mRNA. Translation: ADE48614.1.
GU480912 mRNA. Translation: ADE48615.1.
GU480913 mRNA. Translation: ADE48616.1.
HQ122710 mRNA. Translation: ADW77351.1.
HQ122711 mRNA. Translation: ADW77352.1.
HQ122712 mRNA. Translation: ADW77353.1.
HQ122713 mRNA. Translation: ADW77354.1.
HQ122714 mRNA. Translation: ADW77355.1.
HQ122716 mRNA. Translation: ADW77356.1.
HQ122717 mRNA. Translation: ADW77357.1.
HQ122718 mRNA. Translation: ADW77358.1.
HQ122719 mRNA. Translation: ADW77359.1.
HQ122721 mRNA. Translation: ADW77360.1.
HQ122749 mRNA. Translation: ADW77385.1.
HQ122750 mRNA. Translation: ADW77386.1.
HQ122751 mRNA. Translation: ADW77387.1.
HQ122752 mRNA. Translation: ADW77388.1.
HQ122781 mRNA. Translation: ADW77415.1.
HQ122782 mRNA. Translation: ADW77416.1.
HQ122783 mRNA. Translation: ADW77417.1.
HQ122784 mRNA. Translation: ADW77418.1.
HQ122785 mRNA. Translation: ADW77419.1.
HQ122786 mRNA. Translation: ADW77420.1.
HQ122787 mRNA. Translation: ADW77421.1.
HQ122788 mRNA. Translation: ADW77422.1.
HQ122789 mRNA. Translation: ADW77423.1.
HQ122790 mRNA. Translation: ADW77424.1.
HQ122816 mRNA. Translation: ADW77444.1.
HQ122817 mRNA. Translation: ADW77445.1.
HQ122818 mRNA. Translation: ADW77446.1.
HQ122819 mRNA. Translation: ADW77447.1.
HQ122820 mRNA. Translation: ADW77448.1.
HQ122821 mRNA. Translation: ADW77449.1.
HQ122822 mRNA. Translation: ADW77450.1.
HQ122823 mRNA. Translation: ADW77451.1.
HQ122824 mRNA. Translation: ADW77452.1.
HQ122825 mRNA. Translation: ADW77453.1.
HQ122826 mRNA. Translation: ADW77454.1.
HQ122827 mRNA. Translation: ADW77455.1.
HQ122841 mRNA. Translation: ADW77467.1.
HQ122842 mRNA. Translation: ADW77468.1.
HQ122843 mRNA. Translation: ADW77469.1.
HQ122844 mRNA. Translation: ADW77470.1.
HQ122845 mRNA. Translation: ADW77471.1.
HQ122846 mRNA. Translation: ADW77472.1.
HQ122848 mRNA. Translation: ADW77473.1.
HQ122849 mRNA. Translation: ADW77474.1.
HQ122851 mRNA. Translation: ADW77475.1.
HQ122852 mRNA. Translation: ADW77476.1.
HQ122853 mRNA. Translation: ADW77477.1.
HQ122854 mRNA. Translation: ADW77478.1.
HQ122855 mRNA. Translation: ADW77479.1.
HQ122856 mRNA. Translation: ADW77480.1.
HQ122857 mRNA. Translation: ADW77481.1.
HQ122864 mRNA. Translation: ADW77487.1.
HQ122865 mRNA. Translation: ADW77488.1.
HQ122866 mRNA. Translation: ADW77489.1.
HQ122867 mRNA. Translation: ADW77490.1.
HQ122868 mRNA. Translation: ADW77491.1.
HQ122869 mRNA. Translation: ADW77492.1.
HQ122870 mRNA. Translation: ADW77493.1.
HQ122871 mRNA. Translation: ADW77494.1.
HQ122874 mRNA. Translation: ADW77495.1.
HQ122876 mRNA. Translation: ADW77496.1.
HQ122877 mRNA. Translation: ADW77497.1.
HQ122878 mRNA. Translation: ADW77498.1.
HQ122879 mRNA. Translation: ADW77499.1.
HQ122880 mRNA. Translation: ADW77500.1.
HQ122881 mRNA. Translation: ADW77501.1.
HQ122882 mRNA. Translation: ADW77502.1.
HQ122883 mRNA. Translation: ADW77503.1.
HQ122884 mRNA. Translation: ADW77504.1.
HQ122885 mRNA. Translation: ADW77505.1.
HQ122886 mRNA. Translation: ADW77506.1.
HQ122887 mRNA. Translation: ADW77507.1.
HQ122891 mRNA. Translation: ADW77511.1.
HQ122892 mRNA. Translation: ADW77512.1.
HQ122893 mRNA. Translation: ADW77513.1.
HQ122895 mRNA. Translation: ADW77514.1.
HQ122898 mRNA. Translation: ADW77515.1.
HQ122900 mRNA. Translation: ADW77516.1.
HQ122902 mRNA. Translation: ADW77517.1.
HQ122903 mRNA. Translation: ADW77518.1.
AC016883 Genomic DNA. No translation available.
CCDSiCCDS55274.1.
RefSeqiNP_001153014.1. NM_001159542.1.
UniGeneiHs.450254.

3D structure databases

ProteinModelPortaliQ06416.
SMRiQ06416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000375557.

PTM databases

iPTMnetiQ06416.
PhosphoSitePlusiQ06416.

Polymorphism and mutation databases

BioMutaiPOU5F1B.
DMDMi357528826.

Proteomic databases

EPDiQ06416.
MaxQBiQ06416.
PaxDbiQ06416.
PeptideAtlasiQ06416.
PRIDEiQ06416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000465342; ENSP00000419298; ENSG00000212993.
GeneIDi5462.
KEGGihsa:5462.
UCSCiuc003ysf.4. human.

Organism-specific databases

CTDi5462.
DisGeNETi5462.
GeneCardsiPOU5F1B.
HGNCiHGNC:9223. POU5F1B.
MIMi615739. gene.
neXtProtiNX_Q06416.
OpenTargetsiENSG00000212993.
PharmGKBiPA33547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000089941.
InParanoidiQ06416.
KOiK09367.
OrthoDBiEOG091G0U0S.
PhylomeDBiQ06416.
TreeFamiTF316413.

Miscellaneous databases

GenomeRNAii5462.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000212993.
GenevisibleiQ06416. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR015585. POU_dom_5.
[Graphical view]
PANTHERiPTHR11636:SF86. PTHR11636:SF86. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP5F1B_HUMAN
AccessioniPrimary (citable) accession number: Q06416
Secondary accession number(s): D5K9S4
, D5K9S9, D5K9T0, D5K9T1, D5K9T3, D5K9U3, D5K9U6, D5K9V4, D5K9V6, D5K9W0, D5K9W2, D5K9W7, D5K9X2, D5K9X3, D5K9X5, D5K9X8, D5K9X9, E9LRB1, E9LRB2, E9LRH5, E9LRH6, E9LRH7, E9LRK4, E9LRK5, E9LRK7, E9LRK8, E9LRM7, E9LRM9, E9LRN2, E9LRN4, E9LRN5, E9LRP8, E9LRQ0, E9LRQ2, E9LRQ3, E9LRQ4, E9LRQ5, E9LRS3, Q2VIK6, Q9BZV7, Q9BZV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: November 16, 2011
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. Two of them, localized on chromosomes 8 and 10 have been shown to be preferentially transcribed in cancer tissues and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.