Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q06416 (P5F1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative POU domain, class 5, transcription factor 1B
Alternative name(s):
Octamer-binding protein 3-like
Octamer-binding transcription factor 3-like
Gene names
Name:POU5F1B
Synonyms:OTF3C, OTF3P1, POU5F1P1, POU5FLC20, POU5FLC8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Shows weak transcriptional activator activity. Ref.7

Subcellular location

Nucleus Ref.7.

Sequence similarities

Belongs to the POU transcription factor family. Class-5 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Caution

Could be the product of a pseudogene. Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. Two of them, localized on chromosomes 8 and 10 have been shown to be preferentially transcribed in cancer tissues and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Non-traceable author statement Ref.1. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Putative POU domain, class 5, transcription factor 1B
PRO_0000100753

Regions

Domain138 – 21275POU-specific
DNA binding229 – 28860Homeobox

Natural variations

Natural variant331L → R.
Corresponds to variant rs1061394 [ dbSNP | Ensembl ].
VAR_067432
Natural variant691L → F.
Corresponds to variant rs1061395 [ dbSNP | Ensembl ].
VAR_067433
Natural variant1761G → E.
Corresponds to variant rs6998061 [ dbSNP | Ensembl ].
VAR_067434
Natural variant1821K → T. Ref.3 Ref.5
Corresponds to variant rs13273814 [ dbSNP | Ensembl ].
VAR_067435
Natural variant2141N → D. Ref.3 Ref.5
Corresponds to variant rs13274084 [ dbSNP | Ensembl ].
VAR_067436
Natural variant2381E → Q.
Corresponds to variant rs7002225 [ dbSNP | Ensembl ].
VAR_067437
Natural variant3131P → L.
Corresponds to variant rs16897482 [ dbSNP | Ensembl ].
VAR_067438

Experimental info

Sequence conflict1971M → I in CAA77953. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q06416 [UniParc].

Last modified November 16, 2011. Version 2.
Checksum: 9AF853B116FCB75A

FASTA35938,588
        10         20         30         40         50         60 
MAGHLASDFA FSPPPGGGGD GPWGAEPGWV DPLTWLSFQG PPGGPGIGPG VGPGSEVWGI 

        70         80         90        100        110        120 
PPCPPPYELC GGMAYCGPQV GVGLVPQGGL ETSQPESEAG VGVESNSNGA SPEPCTVPPG 

       130        140        150        160        170        180 
AVKLEKEKLE QNPEKSQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLI LGVLFGKVFS 

       190        200        210        220        230        240 
QKTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLMQAR KRKRTSIENR 

       250        260        270        280        290        300 
VRGNLENLFL QCPKPTLQIS HIAQQLGLEK DVVRVWFCNR RQKGKRSSSD YAQREDFEAA 

       310        320        330        340        350 
GSPFSGGPVS FPPAPGPHFG TPGYGSPHFT ALYSSVPFPE GEVFPPVSVI TLGSPMHSN 

« Hide

References

« Hide 'large scale' references
[1]"Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues."
Takeda J., Seino S., Bell G.I.
Nucleic Acids Res. 20:4613-4620(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[2]"Emergence of young human genes after a burst of retroposition in primates."
Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Identification and expression analysis of novel intron-less human POU5F1/OCT3 related POU domain genes."
van Roozendaal K.E.P., Gillis A.J.M., van Asseldonk M., Oosterhuis J.W., Looijenga L.H.J., van Zoelen E.J.J.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-182 AND ASP-214.
Tissue: Kidney.
[4]"Differential expression of Oct-4 gene and pseudogene in normal and breast cancer cells."
Zhao F.-Q., Buss K.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mammary cancer.
[5]"Expression of OCT4 pseudogenes in two human somatic tumours: glioma and breast carcinoma."
Zhao S., Yuan Q., Guo Y., Liu S., Zhang Y., Wang J., Liu H., Wang F., Liu K., Ling E.-A., Hao A.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-182 AND ASP-214.
Tissue: Glial tumor and Mammary cancer.
[6]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1."
Panagopoulos I., Moeller E., Collin A., Mertens F.
Oncol. Rep. 20:1029-1033(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z11901 Genomic DNA. Translation: CAA77953.1.
DQ120688 Genomic DNA. Translation: ABB92462.1.
AF268615 mRNA. Translation: AAG53083.1.
AF268618 mRNA. Translation: AAG53085.1.
DQ486513 mRNA. Translation: ABF29403.1.
GU480878 mRNA. Translation: ADE48591.1.
GU480883 mRNA. Translation: ADE48596.1.
HQ122713 mRNA. Translation: ADW77354.1.
HQ122716 mRNA. Translation: ADW77356.1.
HQ122719 mRNA. Translation: ADW77359.1.
HQ122750 mRNA. Translation: ADW77386.1.
HQ122752 mRNA. Translation: ADW77388.1.
HQ122785 mRNA. Translation: ADW77419.1.
HQ122788 mRNA. Translation: ADW77422.1.
HQ122790 mRNA. Translation: ADW77424.1.
HQ122891 mRNA. Translation: ADW77511.1.
HQ122892 mRNA. Translation: ADW77512.1.
HQ122895 mRNA. Translation: ADW77514.1.
HQ122898 mRNA. Translation: ADW77515.1.
HQ122900 mRNA. Translation: ADW77516.1.
HQ122902 mRNA. Translation: ADW77517.1.
AC016883 Genomic DNA. No translation available.
RefSeqNP_001153014.1. NM_001159542.1.
UniGeneHs.450254.

3D structure databases

ProteinModelPortalQ06416.
SMRQ06416. Positions 140-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000375557.

PTM databases

PhosphoSiteQ06416.

Polymorphism databases

DMDM357528826.

Proteomic databases

PaxDbQ06416.
PRIDEQ06416.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000391675; ENSP00000375557; ENSG00000212993.
ENST00000465342; ENSP00000419298; ENSG00000212993.
GeneID5462.
KEGGhsa:5462.
UCSCuc003ysf.3. human.

Organism-specific databases

CTD5462.
GeneCardsGC08P128426.
HGNCHGNC:9223. POU5F1B.
neXtProtNX_Q06416.
PharmGKBPA33547.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG329627.
HOGENOMHOG000089941.
InParanoidQ06416.
KOK09367.
OrthoDBEOG7DJSMG.
PhylomeDBQ06416.
TreeFamTF316413.

Gene expression databases

ArrayExpressQ06416.
BgeeQ06416.
GenevestigatorQ06416.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5/6.
IPR000327. POU_specific.
[Graphical view]
PANTHERPTHR11636:SF15. PTHR11636:SF15. 1 hit.
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi5462.
NextBio21141.

Entry information

Entry nameP5F1B_HUMAN
AccessionPrimary (citable) accession number: Q06416
Secondary accession number(s): D5K9V4 expand/collapse secondary AC list , Q2VIK6, Q9BZV7, Q9BZV9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM