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Q06416

- P5F1B_HUMAN

UniProt

Q06416 - P5F1B_HUMAN

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Protein

Putative POU domain, class 5, transcription factor 1B

Gene

POU5F1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Protein uncertaini

Functioni

Shows weak transcriptional activator activity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi229 – 28860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative POU domain, class 5, transcription factor 1B
Alternative name(s):
Oct4-pg1
Octamer-binding protein 3-like
Octamer-binding transcription factor 3-like
Gene namesi
Name:POU5F1B
Synonyms:OCT4PG1, OTF3C, OTF3P1, POU5F1P1, POU5FLC20, POU5FLC8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:9223. POU5F1B.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Putative POU domain, class 5, transcription factor 1BPRO_0000100753Add
BLAST

Proteomic databases

PaxDbiQ06416.
PRIDEiQ06416.

PTM databases

PhosphoSiteiQ06416.

Expressioni

Tissue specificityi

Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues.2 Publications

Gene expression databases

BgeeiQ06416.
ExpressionAtlasiQ06416. baseline.
GenevestigatoriQ06416.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375557.

Structurei

3D structure databases

ProteinModelPortaliQ06416.
SMRiQ06416. Positions 140-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 21275POU-specificPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG329627.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000089941.
InParanoidiQ06416.
KOiK09367.
OrthoDBiEOG7DJSMG.
PhylomeDBiQ06416.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5.
IPR000327. POU_specific.
[Graphical view]
PANTHERiPTHR11636:SF15. PTHR11636:SF15. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06416-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGHLASDFA FSPPPGGGGD GPWGAEPGWV DPLTWLSFQG PPGGPGIGPG
60 70 80 90 100
VGPGSEVWGI PPCPPPYELC GGMAYCGPQV GVGLVPQGGL ETSQPESEAG
110 120 130 140 150
VGVESNSNGA SPEPCTVPPG AVKLEKEKLE QNPEKSQDIK ALQKELEQFA
160 170 180 190 200
KLLKQKRITL GYTQADVGLI LGVLFGKVFS QKTICRFEAL QLSFKNMCKL
210 220 230 240 250
RPLLQKWVEE ADNNENLQEI CKAETLMQAR KRKRTSIENR VRGNLENLFL
260 270 280 290 300
QCPKPTLQIS HIAQQLGLEK DVVRVWFCNR RQKGKRSSSD YAQREDFEAA
310 320 330 340 350
GSPFSGGPVS FPPAPGPHFG TPGYGSPHFT ALYSSVPFPE GEVFPPVSVI

TLGSPMHSN
Length:359
Mass (Da):38,588
Last modified:November 16, 2011 - v2
Checksum:i9AF853B116FCB75A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101A → T in ADE48599. (PubMed:21341266)Curated
Sequence conflicti13 – 131P → L in ADE48609. (PubMed:21341266)Curated
Sequence conflicti13 – 131P → L in ADW77452. (PubMed:21341266)Curated
Sequence conflicti14 – 141P → T in ADW77351. (PubMed:21341266)Curated
Sequence conflicti23 – 253WGA → GGP in ADE48566. (PubMed:21341266)Curated
Sequence conflicti23 – 253WGA → GGP in ADE48597. (PubMed:21341266)Curated
Sequence conflicti31 – 311D → G in ADE48567. (PubMed:21341266)Curated
Sequence conflicti31 – 311D → V in ADE48570. (PubMed:21341266)Curated
Sequence conflicti35 – 351W → R in ADW77415. (PubMed:21341266)Curated
Sequence conflicti35 – 351W → R in ADW77416. (PubMed:21341266)Curated
Sequence conflicti35 – 351W → R in ADW77417. (PubMed:21341266)Curated
Sequence conflicti35 – 351W → R in ADW77420. (PubMed:21341266)Curated
Sequence conflicti35 – 351W → R in ADW77421. (PubMed:21341266)Curated
Sequence conflicti39 – 391Q → R in ADE48583. (PubMed:21341266)Curated
Sequence conflicti76 – 761C → R in ADW77445. (PubMed:21341266)Curated
Sequence conflicti79 – 791Q → H in ADW77469. (PubMed:21341266)Curated
Sequence conflicti91 – 911E → V in ADE48610. (PubMed:21341266)Curated
Sequence conflicti91 – 911E → V in ADW77455. (PubMed:21341266)Curated
Sequence conflicti106 – 1061N → S in ADE48612. (PubMed:21341266)Curated
Sequence conflicti107 – 1071S → Y in ADW77513. (PubMed:21341266)Curated
Sequence conflicti107 – 1071S → Y in ADW77518. (PubMed:21341266)Curated
Sequence conflicti129 – 1291L → Q in ADE48580. (PubMed:21341266)Curated
Sequence conflicti130 – 1301E → G in ADW77492. (PubMed:21341266)Curated
Sequence conflicti132 – 1321N → D in ADW77447. (PubMed:21341266)Curated
Sequence conflicti138 – 1381D → G in ADE48599. (PubMed:21341266)Curated
Sequence conflicti150 – 1501A → T in ADE48616. (PubMed:21341266)Curated
Sequence conflicti152 – 1521L → F in ADW77351. (PubMed:21341266)Curated
Sequence conflicti155 – 1551Q → R in ADW77490. (PubMed:21341266)Curated
Sequence conflicti155 – 1551Q → R in ADW77499. (PubMed:21341266)Curated
Sequence conflicti155 – 1551Q → R in ADW77502. (PubMed:21341266)Curated
Sequence conflicti155 – 1551Q → R in ADW77503. (PubMed:21341266)Curated
Sequence conflicti160 – 1601L → P in ADW77417. (PubMed:21341266)Curated
Sequence conflicti163 – 1631T → A in ADE48580. (PubMed:21341266)Curated
Sequence conflicti169 – 1691L → F in ADW77415. (PubMed:21341266)Curated
Sequence conflicti169 – 1691L → F in ADW77420. (PubMed:21341266)Curated
Sequence conflicti169 – 1691L → F in ADW77421. (PubMed:21341266)Curated
Sequence conflicti169 – 1691L → P in ADE48561. (PubMed:21341266)Curated
Sequence conflicti169 – 1691L → R in ADE48583. (PubMed:21341266)Curated
Sequence conflicti196 – 1961N → D in ADW77492. (PubMed:21341266)Curated
Sequence conflicti197 – 1971M → I in CAA77953. (PubMed:1408763)Curated
Sequence conflicti201 – 2011R → W in ADE48615. (PubMed:21341266)Curated
Sequence conflicti208 – 2081V → E in ADW77493. (PubMed:21341266)Curated
Sequence conflicti208 – 2081V → E in ADW77501. (PubMed:21341266)Curated
Sequence conflicti208 – 2081V → E in ADW77506. (PubMed:21341266)Curated
Sequence conflicti211 – 2111A → T in ADE48593. (PubMed:21341266)Curated
Sequence conflicti211 – 2111A → T in ADW77355. (PubMed:21341266)Curated
Sequence conflicti211 – 2111A → T in ADW77358. (PubMed:21341266)Curated
Sequence conflicti211 – 2111A → T in ADW77387. (PubMed:21341266)Curated
Sequence conflicti211 – 2111A → T in ADW77418. (PubMed:21341266)Curated
Sequence conflicti211 – 2111A → T in ADW77423. (PubMed:21341266)Curated
Sequence conflicti235 – 2351T → A in ADW77518. (PubMed:21341266)Curated
Sequence conflicti235 – 2351T → A in ADW77513. (PubMed:21341266)Curated
Sequence conflicti241 – 2411V → M in ADW77488. (PubMed:21341266)Curated
Sequence conflicti241 – 2411V → M in ADW77496. (PubMed:21341266)Curated
Sequence conflicti241 – 2411V → M in ADW77504. (PubMed:21341266)Curated
Sequence conflicti241 – 2411V → M in ADW77507. (PubMed:21341266)Curated
Sequence conflicti246 – 2461E → G in ADW77492. (PubMed:21341266)Curated
Sequence conflicti249 – 2491F → L in ADW77474. (PubMed:21341266)Curated
Sequence conflicti249 – 2491F → L in ADW77481. (PubMed:21341266)Curated
Sequence conflicti250 – 2501L → P in ADE48580. (PubMed:21341266)Curated
Sequence conflicti250 – 2501L → Q in ADW77475. (PubMed:21341266)Curated
Sequence conflicti259 – 2591I → T in ADW77488. (PubMed:21341266)Curated
Sequence conflicti259 – 2591I → T in ADW77496. (PubMed:21341266)Curated
Sequence conflicti259 – 2591I → T in ADW77504. (PubMed:21341266)Curated
Sequence conflicti259 – 2591I → T in ADW77507. (PubMed:21341266)Curated
Sequence conflicti264 – 2641Q → H in ADE48609. (PubMed:21341266)Curated
Sequence conflicti264 – 2641Q → H in ADW77452. (PubMed:21341266)Curated
Sequence conflicti264 – 2641Q → L in ADW77477. (PubMed:21341266)Curated
Sequence conflicti264 – 2641Q → L in ADW77476. (PubMed:21341266)Curated
Sequence conflicti264 – 2641Q → L in ADW77467. (PubMed:21341266)Curated
Sequence conflicti272 – 2721V → M in ADW77472. (PubMed:21341266)Curated
Sequence conflicti272 – 2721V → M in ADW77479. (PubMed:21341266)Curated
Sequence conflicti276 – 2783WFC → CFG in ADW77495. (PubMed:21341266)Curated
Sequence conflicti282 – 2821Q → R in ADW77494. (PubMed:21341266)Curated
Sequence conflicti284 – 2841G → S in ADW77469. (PubMed:21341266)Curated
Sequence conflicti295 – 2951E → V in ADE48583. (PubMed:21341266)Curated
Sequence conflicti318 – 3181H → Q in ADW77444. (PubMed:21341266)Curated
Sequence conflicti318 – 3181H → Q in ADW77445. (PubMed:21341266)Curated
Sequence conflicti321 – 3211T → I in ADW77476. (PubMed:21341266)Curated
Sequence conflicti321 – 3211T → I in ADW77467. (PubMed:21341266)Curated
Sequence conflicti321 – 3211T → I in ADW77477. (PubMed:21341266)Curated
Sequence conflicti326 – 3261S → G in ADW77444. (PubMed:21341266)Curated
Sequence conflicti326 – 3261S → G in ADW77445. (PubMed:21341266)Curated
Sequence conflicti331 – 3311A → T in ADW77447. (PubMed:21341266)Curated
Sequence conflicti331 – 3311A → T in ADW77448. (PubMed:21341266)Curated
Sequence conflicti331 – 3311A → T in ADW77451. (PubMed:21341266)Curated
Sequence conflicti340 – 3401E → V in ADE48570. (PubMed:21341266)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331L → R.1 Publication
Corresponds to variant rs1061394 [ dbSNP | Ensembl ].
VAR_067432
Natural varianti69 – 691L → F.
Corresponds to variant rs1061395 [ dbSNP | Ensembl ].
VAR_067433
Natural varianti176 – 1761G → E.1 Publication
Corresponds to variant rs6998061 [ dbSNP | Ensembl ].
VAR_067434
Natural varianti182 – 1821K → T.2 Publications
Corresponds to variant rs13273814 [ dbSNP | Ensembl ].
VAR_067435
Natural varianti214 – 2141N → D.2 Publications
Corresponds to variant rs13274084 [ dbSNP | Ensembl ].
VAR_067436
Natural varianti238 – 2381E → Q.1 Publication
Corresponds to variant rs7002225 [ dbSNP | Ensembl ].
VAR_067437
Natural varianti313 – 3131P → L.
Corresponds to variant rs16897482 [ dbSNP | Ensembl ].
VAR_067438

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11901 Genomic DNA. Translation: CAA77953.1.
DQ120688 Genomic DNA. Translation: ABB92462.1.
AF268615 mRNA. Translation: AAG53083.1.
AF268618 mRNA. Translation: AAG53085.1.
DQ486513 mRNA. Translation: ABF29403.1.
GU480835 mRNA. Translation: ADE48561.1.
GU480840 mRNA. Translation: ADE48566.1.
GU480841 mRNA. Translation: ADE48567.1.
GU480842 mRNA. Translation: ADE48568.1.
GU480845 mRNA. Translation: ADE48570.1.
GU480864 mRNA. Translation: ADE48580.1.
GU480868 mRNA. Translation: ADE48583.1.
GU480878 mRNA. Translation: ADE48591.1.
GU480880 mRNA. Translation: ADE48593.1.
GU480883 mRNA. Translation: ADE48596.1.
GU480886 mRNA. Translation: ADE48597.1.
GU480889 mRNA. Translation: ADE48599.1.
GU480896 mRNA. Translation: ADE48604.1.
GU480902 mRNA. Translation: ADE48606.1.
GU480905 mRNA. Translation: ADE48609.1.
GU480906 mRNA. Translation: ADE48610.1.
GU480908 mRNA. Translation: ADE48612.1.
GU480911 mRNA. Translation: ADE48614.1.
GU480912 mRNA. Translation: ADE48615.1.
GU480913 mRNA. Translation: ADE48616.1.
HQ122710 mRNA. Translation: ADW77351.1.
HQ122711 mRNA. Translation: ADW77352.1.
HQ122712 mRNA. Translation: ADW77353.1.
HQ122713 mRNA. Translation: ADW77354.1.
HQ122714 mRNA. Translation: ADW77355.1.
HQ122716 mRNA. Translation: ADW77356.1.
HQ122717 mRNA. Translation: ADW77357.1.
HQ122718 mRNA. Translation: ADW77358.1.
HQ122719 mRNA. Translation: ADW77359.1.
HQ122721 mRNA. Translation: ADW77360.1.
HQ122749 mRNA. Translation: ADW77385.1.
HQ122750 mRNA. Translation: ADW77386.1.
HQ122751 mRNA. Translation: ADW77387.1.
HQ122752 mRNA. Translation: ADW77388.1.
HQ122781 mRNA. Translation: ADW77415.1.
HQ122782 mRNA. Translation: ADW77416.1.
HQ122783 mRNA. Translation: ADW77417.1.
HQ122784 mRNA. Translation: ADW77418.1.
HQ122785 mRNA. Translation: ADW77419.1.
HQ122786 mRNA. Translation: ADW77420.1.
HQ122787 mRNA. Translation: ADW77421.1.
HQ122788 mRNA. Translation: ADW77422.1.
HQ122789 mRNA. Translation: ADW77423.1.
HQ122790 mRNA. Translation: ADW77424.1.
HQ122816 mRNA. Translation: ADW77444.1.
HQ122817 mRNA. Translation: ADW77445.1.
HQ122818 mRNA. Translation: ADW77446.1.
HQ122819 mRNA. Translation: ADW77447.1.
HQ122820 mRNA. Translation: ADW77448.1.
HQ122821 mRNA. Translation: ADW77449.1.
HQ122822 mRNA. Translation: ADW77450.1.
HQ122823 mRNA. Translation: ADW77451.1.
HQ122824 mRNA. Translation: ADW77452.1.
HQ122825 mRNA. Translation: ADW77453.1.
HQ122826 mRNA. Translation: ADW77454.1.
HQ122827 mRNA. Translation: ADW77455.1.
HQ122841 mRNA. Translation: ADW77467.1.
HQ122842 mRNA. Translation: ADW77468.1.
HQ122843 mRNA. Translation: ADW77469.1.
HQ122844 mRNA. Translation: ADW77470.1.
HQ122845 mRNA. Translation: ADW77471.1.
HQ122846 mRNA. Translation: ADW77472.1.
HQ122848 mRNA. Translation: ADW77473.1.
HQ122849 mRNA. Translation: ADW77474.1.
HQ122851 mRNA. Translation: ADW77475.1.
HQ122852 mRNA. Translation: ADW77476.1.
HQ122853 mRNA. Translation: ADW77477.1.
HQ122854 mRNA. Translation: ADW77478.1.
HQ122855 mRNA. Translation: ADW77479.1.
HQ122856 mRNA. Translation: ADW77480.1.
HQ122857 mRNA. Translation: ADW77481.1.
HQ122864 mRNA. Translation: ADW77487.1.
HQ122865 mRNA. Translation: ADW77488.1.
HQ122866 mRNA. Translation: ADW77489.1.
HQ122867 mRNA. Translation: ADW77490.1.
HQ122868 mRNA. Translation: ADW77491.1.
HQ122869 mRNA. Translation: ADW77492.1.
HQ122870 mRNA. Translation: ADW77493.1.
HQ122871 mRNA. Translation: ADW77494.1.
HQ122874 mRNA. Translation: ADW77495.1.
HQ122876 mRNA. Translation: ADW77496.1.
HQ122877 mRNA. Translation: ADW77497.1.
HQ122878 mRNA. Translation: ADW77498.1.
HQ122879 mRNA. Translation: ADW77499.1.
HQ122880 mRNA. Translation: ADW77500.1.
HQ122881 mRNA. Translation: ADW77501.1.
HQ122882 mRNA. Translation: ADW77502.1.
HQ122883 mRNA. Translation: ADW77503.1.
HQ122884 mRNA. Translation: ADW77504.1.
HQ122885 mRNA. Translation: ADW77505.1.
HQ122886 mRNA. Translation: ADW77506.1.
HQ122887 mRNA. Translation: ADW77507.1.
HQ122891 mRNA. Translation: ADW77511.1.
HQ122892 mRNA. Translation: ADW77512.1.
HQ122893 mRNA. Translation: ADW77513.1.
HQ122895 mRNA. Translation: ADW77514.1.
HQ122898 mRNA. Translation: ADW77515.1.
HQ122900 mRNA. Translation: ADW77516.1.
HQ122902 mRNA. Translation: ADW77517.1.
HQ122903 mRNA. Translation: ADW77518.1.
AC016883 Genomic DNA. No translation available.
CCDSiCCDS55274.1.
RefSeqiNP_001153014.1. NM_001159542.1.
UniGeneiHs.450254.

Genome annotation databases

EnsembliENST00000465342; ENSP00000419298; ENSG00000212993.
GeneIDi5462.
KEGGihsa:5462.
UCSCiuc003ysf.3. human.

Polymorphism databases

DMDMi357528826.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11901 Genomic DNA. Translation: CAA77953.1 .
DQ120688 Genomic DNA. Translation: ABB92462.1 .
AF268615 mRNA. Translation: AAG53083.1 .
AF268618 mRNA. Translation: AAG53085.1 .
DQ486513 mRNA. Translation: ABF29403.1 .
GU480835 mRNA. Translation: ADE48561.1 .
GU480840 mRNA. Translation: ADE48566.1 .
GU480841 mRNA. Translation: ADE48567.1 .
GU480842 mRNA. Translation: ADE48568.1 .
GU480845 mRNA. Translation: ADE48570.1 .
GU480864 mRNA. Translation: ADE48580.1 .
GU480868 mRNA. Translation: ADE48583.1 .
GU480878 mRNA. Translation: ADE48591.1 .
GU480880 mRNA. Translation: ADE48593.1 .
GU480883 mRNA. Translation: ADE48596.1 .
GU480886 mRNA. Translation: ADE48597.1 .
GU480889 mRNA. Translation: ADE48599.1 .
GU480896 mRNA. Translation: ADE48604.1 .
GU480902 mRNA. Translation: ADE48606.1 .
GU480905 mRNA. Translation: ADE48609.1 .
GU480906 mRNA. Translation: ADE48610.1 .
GU480908 mRNA. Translation: ADE48612.1 .
GU480911 mRNA. Translation: ADE48614.1 .
GU480912 mRNA. Translation: ADE48615.1 .
GU480913 mRNA. Translation: ADE48616.1 .
HQ122710 mRNA. Translation: ADW77351.1 .
HQ122711 mRNA. Translation: ADW77352.1 .
HQ122712 mRNA. Translation: ADW77353.1 .
HQ122713 mRNA. Translation: ADW77354.1 .
HQ122714 mRNA. Translation: ADW77355.1 .
HQ122716 mRNA. Translation: ADW77356.1 .
HQ122717 mRNA. Translation: ADW77357.1 .
HQ122718 mRNA. Translation: ADW77358.1 .
HQ122719 mRNA. Translation: ADW77359.1 .
HQ122721 mRNA. Translation: ADW77360.1 .
HQ122749 mRNA. Translation: ADW77385.1 .
HQ122750 mRNA. Translation: ADW77386.1 .
HQ122751 mRNA. Translation: ADW77387.1 .
HQ122752 mRNA. Translation: ADW77388.1 .
HQ122781 mRNA. Translation: ADW77415.1 .
HQ122782 mRNA. Translation: ADW77416.1 .
HQ122783 mRNA. Translation: ADW77417.1 .
HQ122784 mRNA. Translation: ADW77418.1 .
HQ122785 mRNA. Translation: ADW77419.1 .
HQ122786 mRNA. Translation: ADW77420.1 .
HQ122787 mRNA. Translation: ADW77421.1 .
HQ122788 mRNA. Translation: ADW77422.1 .
HQ122789 mRNA. Translation: ADW77423.1 .
HQ122790 mRNA. Translation: ADW77424.1 .
HQ122816 mRNA. Translation: ADW77444.1 .
HQ122817 mRNA. Translation: ADW77445.1 .
HQ122818 mRNA. Translation: ADW77446.1 .
HQ122819 mRNA. Translation: ADW77447.1 .
HQ122820 mRNA. Translation: ADW77448.1 .
HQ122821 mRNA. Translation: ADW77449.1 .
HQ122822 mRNA. Translation: ADW77450.1 .
HQ122823 mRNA. Translation: ADW77451.1 .
HQ122824 mRNA. Translation: ADW77452.1 .
HQ122825 mRNA. Translation: ADW77453.1 .
HQ122826 mRNA. Translation: ADW77454.1 .
HQ122827 mRNA. Translation: ADW77455.1 .
HQ122841 mRNA. Translation: ADW77467.1 .
HQ122842 mRNA. Translation: ADW77468.1 .
HQ122843 mRNA. Translation: ADW77469.1 .
HQ122844 mRNA. Translation: ADW77470.1 .
HQ122845 mRNA. Translation: ADW77471.1 .
HQ122846 mRNA. Translation: ADW77472.1 .
HQ122848 mRNA. Translation: ADW77473.1 .
HQ122849 mRNA. Translation: ADW77474.1 .
HQ122851 mRNA. Translation: ADW77475.1 .
HQ122852 mRNA. Translation: ADW77476.1 .
HQ122853 mRNA. Translation: ADW77477.1 .
HQ122854 mRNA. Translation: ADW77478.1 .
HQ122855 mRNA. Translation: ADW77479.1 .
HQ122856 mRNA. Translation: ADW77480.1 .
HQ122857 mRNA. Translation: ADW77481.1 .
HQ122864 mRNA. Translation: ADW77487.1 .
HQ122865 mRNA. Translation: ADW77488.1 .
HQ122866 mRNA. Translation: ADW77489.1 .
HQ122867 mRNA. Translation: ADW77490.1 .
HQ122868 mRNA. Translation: ADW77491.1 .
HQ122869 mRNA. Translation: ADW77492.1 .
HQ122870 mRNA. Translation: ADW77493.1 .
HQ122871 mRNA. Translation: ADW77494.1 .
HQ122874 mRNA. Translation: ADW77495.1 .
HQ122876 mRNA. Translation: ADW77496.1 .
HQ122877 mRNA. Translation: ADW77497.1 .
HQ122878 mRNA. Translation: ADW77498.1 .
HQ122879 mRNA. Translation: ADW77499.1 .
HQ122880 mRNA. Translation: ADW77500.1 .
HQ122881 mRNA. Translation: ADW77501.1 .
HQ122882 mRNA. Translation: ADW77502.1 .
HQ122883 mRNA. Translation: ADW77503.1 .
HQ122884 mRNA. Translation: ADW77504.1 .
HQ122885 mRNA. Translation: ADW77505.1 .
HQ122886 mRNA. Translation: ADW77506.1 .
HQ122887 mRNA. Translation: ADW77507.1 .
HQ122891 mRNA. Translation: ADW77511.1 .
HQ122892 mRNA. Translation: ADW77512.1 .
HQ122893 mRNA. Translation: ADW77513.1 .
HQ122895 mRNA. Translation: ADW77514.1 .
HQ122898 mRNA. Translation: ADW77515.1 .
HQ122900 mRNA. Translation: ADW77516.1 .
HQ122902 mRNA. Translation: ADW77517.1 .
HQ122903 mRNA. Translation: ADW77518.1 .
AC016883 Genomic DNA. No translation available.
CCDSi CCDS55274.1.
RefSeqi NP_001153014.1. NM_001159542.1.
UniGenei Hs.450254.

3D structure databases

ProteinModelPortali Q06416.
SMRi Q06416. Positions 140-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000375557.

PTM databases

PhosphoSitei Q06416.

Polymorphism databases

DMDMi 357528826.

Proteomic databases

PaxDbi Q06416.
PRIDEi Q06416.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000465342 ; ENSP00000419298 ; ENSG00000212993 .
GeneIDi 5462.
KEGGi hsa:5462.
UCSCi uc003ysf.3. human.

Organism-specific databases

CTDi 5462.
GeneCardsi GC08P128426.
HGNCi HGNC:9223. POU5F1B.
MIMi 615739. gene.
neXtProti NX_Q06416.
PharmGKBi PA33547.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG329627.
GeneTreei ENSGT00760000118935.
HOGENOMi HOG000089941.
InParanoidi Q06416.
KOi K09367.
OrthoDBi EOG7DJSMG.
PhylomeDBi Q06416.
TreeFami TF316413.

Miscellaneous databases

GenomeRNAii 5462.
NextBioi 21141.
SOURCEi Search...

Gene expression databases

Bgeei Q06416.
ExpressionAtlasi Q06416. baseline.
Genevestigatori Q06416.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5.
IPR000327. POU_specific.
[Graphical view ]
PANTHERi PTHR11636:SF15. PTHR11636:SF15. 1 hit.
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues."
    Takeda J., Seino S., Bell G.I.
    Nucleic Acids Res. 20:4613-4620(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Emergence of young human genes after a burst of retroposition in primates."
    Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
    PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification and expression analysis of novel intron-less human POU5F1/OCT3 related POU domain genes."
    van Roozendaal K.E.P., Gillis A.J.M., van Asseldonk M., Oosterhuis J.W., Looijenga L.H.J., van Zoelen E.J.J.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-182 AND ASP-214.
    Tissue: Kidney.
  4. "Differential expression of Oct-4 gene and pseudogene in normal and breast cancer cells."
    Zhao F.-Q., Buss K.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary cancer.
  5. "Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma."
    Zhao S., Yuan Q., Hao H., Guo Y., Liu S., Zhang Y., Wang J., Liu H., Wang F., Liu K., Ling E.A., Hao A.
    J. Pathol. 223:672-682(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-33; GLU-176; THR-182; ASP-214 AND GLN-238, TISSUE SPECIFICITY.
    Tissue: Glial tumor and Mammary cancer.
  6. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: TISSUE SPECIFICITY.
  8. "The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1."
    Panagopoulos I., Moeller E., Collin A., Mertens F.
    Oncol. Rep. 20:1029-1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiP5F1B_HUMAN
AccessioniPrimary (citable) accession number: Q06416
Secondary accession number(s): D5K9S4
, D5K9S9, D5K9T0, D5K9T1, D5K9T3, D5K9U3, D5K9U6, D5K9V4, D5K9V6, D5K9W0, D5K9W2, D5K9W7, D5K9X2, D5K9X3, D5K9X5, D5K9X8, D5K9X9, E9LRB1, E9LRB2, E9LRH5, E9LRH6, E9LRH7, E9LRK4, E9LRK5, E9LRK7, E9LRK8, E9LRM7, E9LRM9, E9LRN2, E9LRN4, E9LRN5, E9LRP8, E9LRQ0, E9LRQ2, E9LRQ3, E9LRQ4, E9LRQ5, E9LRS3, Q2VIK6, Q9BZV7, Q9BZV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. Two of them, localized on chromosomes 8 and 10 have been shown to be preferentially transcribed in cancer tissues and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3