Autophagy-related protein 17 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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Q06410 (ATG17_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 85. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Autophagy-related protein 17

Gene names

Name:	ATG17
Synonyms:	APG17
Ordered Locus Names:	YLR423C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for autophagy. Functions with CIS1/ATG31 at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Ref.3 Ref.5 Ref.9 Ref.11
Subunit structure	Interacts with ATG1, ATG29 and CIS1/ATG31. Forms a complex with SNX4 and ATG20. Ref.3 Ref.5 Ref.9 Ref.11
Subcellular location	Cytoplasm. Preautophagosomal structure Ref.4 Ref.5 Ref.7 Ref.9 Ref.11.
Miscellaneous	Present with 358 molecules/cell in log phase SD medium. Ref.8
Sequence similarities	Belongs to the ATG17 family.

Ontologies

Keywords
Biological process	Autophagy
Cellular component	Cytoplasm
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of protein kinase activity Inferred from mutant phenotype Ref.3. Source: SGD autophagic vacuole assembly Inferred from mutant phenotype. Source: SGD mitochondrion degradation Inferred from mutant phenotype. Source: SGD peroxisome degradation Inferred from mutant phenotype. Source: SGD piecemeal microautophagy of nucleus Inferred from mutant phenotype. Source: SGD
Cellular component	pre-autophagosomal structure Inferred from direct assay. Source: SGD
Molecular function	protein complex scaffold Inferred from genetic interaction. Source: SGD protein kinase activator activity Inferred from mutant phenotype Ref.3. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
CIS1	Q12421	2	EBI-30856,EBI-34768
DAM1	P53267	3	EBI-30856,EBI-23268
IPI3	P53877	3	EBI-30856,EBI-29063
SNX4	P47057	3	EBI-30856,EBI-17610

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 417

417

Autophagy-related protein 17

PRO_0000124566

Regions

Coiled coil

146 – 221

Potential

Coiled coil

353 – 384

Potential

Amino acid modifications

Modified residue

405

Phosphoserine Ref.10

Modified residue

406

Phosphoserine Ref.10

Sequences

Sequence

Length

Mass (Da)

Tools

Q06410 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 71504B6C76549B75
Show »

FASTA

417

48,656

        10         20         30         40         50         60 
MNEADVTKFV NNARKTLTDA QLLCSSANLR IVDIKKKLSS WQLSISKLNF LIVGLRQQGK 

        70         80         90        100        110        120 
FLYTILKEGI GTKLIQKQWN QAVLVVLVDE MKYWQYEITS KVQRLDGIVN ELSISEKDDT 

       130        140        150        160        170        180 
DPSKLGDYIS RDNVNLLNDK LKEVPVIERQ IENIKLQYEN MVRKVNKELI DTKLTDVTQK 

       190        200        210        220        230        240 
FQSKFGIDNL METNVAEQFS RELTDLEKDL AEIMNSLTQH FDKTLLLQDK KIDNDEREEL 

       250        260        270        280        290        300 
FKVVQGDDKE LYNIFKTLHE VIDDVDKTIL NLGQFLQAKI KEKTELHSEV SEIINDFNRN 

       310        320        330        340        350        360 
LEYLLIFKDI SNLIDSFKNS CTQDIQTTKE LCEFYDNFEE SYGNLVLEAK RRKDVANRMK 

       370        380        390        400        410 
TILKDCEKQL QNLDAQDQEE RQNFIAENGT YLPETIWPGK IDDFSSLYTL NYNVKNP

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. Hoheisel J.D. Nature 387:87-90(1997) [PubMed: 9169871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Tor-mediated induction of autophagy via an Apg1 protein kinase complex." Kamada Y., Funakoshi T., Shintani T., Nagano K., Ohsumi M., Ohsumi Y. J. Cell Biol. 150:1507-1513(2000) [PubMed: 10995454] [Abstract] Cited for: FUNCTION, INTERACTION WITH ATG1.
[4]	"A protein interaction map for cell polarity development." Drees B.L., Sundin B.A., Brazeau E., Caviston J.P., Chen G.-C., Guo W., Kozminski K.G., Lau M.W., Moskow J.J., Tong A., Schenkman L.R., McKenzie A. III, Brennwald P.J., Longtine M., Bi E., Chan C., Novick P., Boone C. , Pringle J.R., Davis T.N., Fields S., Drubin D.G. J. Cell Biol. 154:549-571(2001) [PubMed: 11489916] [Abstract] Cited for: SUBCELLULAR LOCATION.
[5]	"Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy." Nice D.C. III, Sato T.K., Stromhaug P.E., Emr S.D., Klionsky D.J. J. Biol. Chem. 277:30198-30207(2002) [PubMed: 12048214] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ATG20 AND SNX4.
[6]	"A unified nomenclature for yeast autophagy-related genes." Klionsky D.J., Cregg J.M., Dunn W.A. Jr., Emr S.D., Sakai Y., Sandoval I.V., Sibirny A., Subramani S., Thumm M., Veenhuis M., Ohsumi Y. Dev. Cell 5:539-545(2003) [PubMed: 14536056] [Abstract] Cited for: NOMENCLATURE.
[7]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]	"Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae." Kabeya Y., Kawamata T., Suzuki K., Ohsumi Y. Biochem. Biophys. Res. Commun. 356:405-410(2007) [PubMed: 17362880] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CIS1.
[10]	"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed: 17287358] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-405 AND SER-406, MASS SPECTROMETRY.
[11]	"Organization of the pre-autophagosomal structure responsible for autophagosome formation." Kawamata T., Kamada Y., Kabeya Y., Sekito T., Ohsumi Y. Mol. Biol. Cell 19:2039-2050(2008) [PubMed: 18287526] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ATG29.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U20939 Genomic DNA. Translation: AAB67509.1. BK006945 Genomic DNA. Translation: DAA09725.1.
PIR	S53410.
RefSeq	NP_013527.1. NM_001182311.1.
3D structure databases
ProteinModelPortal	Q06410.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1490N.
IntAct	Q06410. 92 interactions.
MINT	MINT-403279.
STRING	Q06410.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YLR423C; YLR423C; YLR423C.
GeneID	851142.
KEGG	sce:YLR423C.
NMPDR	fig\|4932.3.peg.4557.
Organism-specific databases
CYGD	YLR423c.
SGD	S000004415. ATG17.
Phylogenomic databases
eggNOG	fuNOG08471.
GeneTree	EFGT00050000005656.
HOGENOM	HBG202587.
OMA	YLPENIW.
OrthoDB	EOG4SN4XX.
Gene expression databases
ArrayExpress	Q06410.
Genevestigator	Q06410.
GermOnline	YLR423C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR007240. Autophagy-rel_prot_17. [Graphical view]
KO	K08329.
Pfam	PF04108. APG17. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	967904.

Entry information

Entry name

ATG17_YEAST

Accession

Primary (citable) accession number: Q06410
Secondary accession number(s): D6VZ59

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents