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Protein

DOCK-like protein YLR422W

Gene

YLR422W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: SGD
  • mitophagy Source: SGD
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32482-MONOMER.
ReactomeiR-SCE-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
DOCK-like protein YLR422W
Gene namesi
Ordered Locus Names:YLR422W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR422W.
SGDiS000004414. YLR422W.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19321932DOCK-like protein YLR422WPRO_0000247776Add
BLAST

Proteomic databases

MaxQBiQ06409.

PTM databases

iPTMnetiQ06409.

Interactioni

Protein-protein interaction databases

BioGridi31681. 33 interactions.
DIPiDIP-6405N.
IntActiQ06409. 1 interaction.
MINTiMINT-697984.

Structurei

3D structure databases

ProteinModelPortaliQ06409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1410 – 1824415DHR-2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DOCK family.Curated
Contains 1 DHR-2 domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00610000085806.
HOGENOMiHOG000141938.
InParanoidiQ06409.
OMAiPFEHITS.
OrthoDBiEOG75QRC9.

Family and domain databases

InterProiIPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PfamiPF06920. DHR-2. 1 hit.
[Graphical view]
PROSITEiPS51651. DHR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQDSQRWL PTDRLIYGVL VKSFLPLQRY PELVYENSNY ANVYVGAEVY
60 70 80 90 100
VFEESVDKKW CRAYQCLRPF PEEFISNMNS ANDVLPDVKP KVVIFPRKYV
110 120 130 140 150
HFEAEKAVST MPFFKAPSAE DFKPLISKEC ESRSFCDSLY VSSTDDISTG
160 170 180 190 200
KPRKTPRPPF PFFRYQKRSF KDEMGPILSL ISSHVYSMYS IGEFSIYRKM
210 220 230 240 250
IKLYYDLDTI RFRLSMNLTT EAEKINLIRA ATSLRTKIAK FLSSTYRKNK
260 270 280 290 300
LIANSTPRNP DPYGFEGIFA RDIDTGELLS YEIDKLRTLV SSSMLCGLTN
310 320 330 340 350
NFPTVPVVES DDESSSNGLF GTVRSSILVN LKDLAWDPSI SDPKYQDLSI
360 370 380 390 400
CVYLRTKDEV LTESFTMTKS SNMESALDEI PAMLFKNILE TIVHKNKVYL
410 420 430 440 450
VVVLKETIAI TTETAPEISS YNISTEESSS HSPFSPFNSS TENKIDHVKK
460 470 480 490 500
GLAAGVINIS PVFKFYNGLS VANKAQRFNL YLYSSDSSDS QNFNSSKDAD
510 520 530 540 550
LGWGGLINKI IKDSSEGVSV NPRAVSLSVT VKEIIGKQEA EKVLSTSLVP
560 570 580 590 600
IRSIPTYFYD TMFSQAERIY LNLGRVSLYG LPAADTNIEN VTVQISCRNK
610 620 630 640 650
AVKFCKNKLE ERSGDWKFVS VRPNESIGES IRIEGVENMN EDETLRVLVY
660 670 680 690 700
LNGFLMAKSN IHIKKKNEII EYRKGTVFQI MSSKSVPLIH LELEASYFGR
710 720 730 740 750
RYNINPAITN FLVLQTKNVE FDQQLKEHYS VTLKQLNNVS FKDLLKHFDT
760 770 780 790 800
ILAHYLLLLE SVNEATDKKG PSSSLPNIVF SEFVKFLNLM LTHQENSRYW
810 820 830 840 850
FNRLYKKVMS KELECPNVAP ILIKHMTTIF DRSHSSWTRT GTAICRTILY
860 870 880 890 900
IIVLAIGSSH SDEMPNFSHF FRSLHKFLML ADEPIMADQI LLIESIPSML
910 920 930 940 950
ETMTNHCKVE DLVRFAIGLF ECCQEKEMNQ KMYSRPLSVR EEEYLNTKFN
960 970 980 990 1000
CLLKLINKKV LQNYLTNTES VDKLRLQFLS KTLEWLLTPY TPGDDKCFHV
1010 1020 1030 1040 1050
ESLRLVNSVF ITIIEDYKFD MLQRNLIRLL PYLCKSFVHL RRYCKKARLM
1060 1070 1080 1090 1100
RPRRVFTMLF PREIPCNYIP VDSIVNDEVV VEVLLELAII ICEITKIASS
1110 1120 1130 1140 1150
RFPSYQSFSE IINLCDKDTL FQSNFYSRQI TNENVYTITK TVFLFFKQDW
1160 1170 1180 1190 1200
FPGMKWLGVS ALLGRSSLIL LSLCKDYIIE NNSPSPSKES EKRVDMRLWA
1210 1220 1230 1240 1250
EYVKVILLVS NHKSASLTKL AITPRKAVYL ISGDLKKISA YILNECWDAL
1260 1270 1280 1290 1300
ATGHYNITYA KKYGLGALSD CQFELFVHNQ FLIREIFIFA FHRHIDATRI
1310 1320 1330 1340 1350
CCKILWGLGL NFWRIFGSLQ PAVNACIPEL FSAYQIGKLR LNDYELERFV
1360 1370 1380 1390 1400
SCLFFMMHVP DSDTFFPACM DFLRDLLGFL HIVNEIYKIP NQEEFDDDRT
1410 1420 1430 1440 1450
ARHIEMFEYL LEANRPELFH KMIYDLFIHF IQKKDFVQAA LSLELLAGTY
1460 1470 1480 1490 1500
AWDSNDTLEA ISFPPLPEQS SFERKEYLLK ESARNFSRGQ KPEKALAVYK
1510 1520 1530 1540 1550
DLIKAYDEIN YDLNGLAFVH DQIAGIYTRL QSIDRLVPTY FKVSFMGFGF
1560 1570 1580 1590 1600
PKSLRNKSFV FEGLPFEHIT SMHDRLLRSY HGSNIVHSQE EVDMLLMNPP
1610 1620 1630 1640 1650
MGKYIHVASV EPCLSISDNY NSSDKKSSIN NKVRMYIENR DLRTFSNSRR
1660 1670 1680 1690 1700
LPGAKGVTDL WVEEYTYHTM NTFPTLMNRS EIVKVTKSKL SPLENAIRSL
1710 1720 1730 1740 1750
QVKIQELYGL ENMCNKTLKD HGDVNDLFTE LSTNITGTIS APVNGGISQY
1760 1770 1780 1790 1800
KAFLEPSTSK QFSTDDLGRL TLAFDELVAV LGRCLTLHAE LLPSKDLKPS
1810 1820 1830 1840 1850
HDLLVRLFEE NFAEEIERYS RTLSEANRSR NNMITARIIS HKNPNKKASF
1860 1870 1880 1890 1900
SGRDHHTSGS NHSQFVLEHS DSFGPNSLLF GKYLTRTLSH SSTTSSLDKS
1910 1920 1930
GIVSGTSSTF LAGSQPNTNT DSQHKHDYSH SG
Length:1,932
Mass (Da):221,563
Last modified:November 1, 1996 - v1
Checksum:i1E9CE4AE6F8D3F94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20939 Genomic DNA. Translation: AAB67508.1.
BK006945 Genomic DNA. Translation: DAA09724.1.
PIRiS53409.
RefSeqiNP_013526.1. NM_001182310.1.

Genome annotation databases

EnsemblFungiiYLR422W; YLR422W; YLR422W.
GeneIDi851141.
KEGGisce:YLR422W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20939 Genomic DNA. Translation: AAB67508.1.
BK006945 Genomic DNA. Translation: DAA09724.1.
PIRiS53409.
RefSeqiNP_013526.1. NM_001182310.1.

3D structure databases

ProteinModelPortaliQ06409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31681. 33 interactions.
DIPiDIP-6405N.
IntActiQ06409. 1 interaction.
MINTiMINT-697984.

PTM databases

iPTMnetiQ06409.

Proteomic databases

MaxQBiQ06409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR422W; YLR422W; YLR422W.
GeneIDi851141.
KEGGisce:YLR422W.

Organism-specific databases

EuPathDBiFungiDB:YLR422W.
SGDiS000004414. YLR422W.

Phylogenomic databases

GeneTreeiENSGT00610000085806.
HOGENOMiHOG000141938.
InParanoidiQ06409.
OMAiPFEHITS.
OrthoDBiEOG75QRC9.

Enzyme and pathway databases

BioCyciYEAST:G3O-32482-MONOMER.
ReactomeiR-SCE-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiQ06409.

Family and domain databases

InterProiIPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PfamiPF06920. DHR-2. 1 hit.
[Graphical view]
PROSITEiPS51651. DHR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYL422_YEAST
AccessioniPrimary (citable) accession number: Q06409
Secondary accession number(s): D6VZ58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.