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Q06375 (PYRF_PICAN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifier870730 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Orotidine 5'-phosphate decarboxylase
PRO_0000134672

Regions

Region58 – 603Substrate binding By similarity
Region90 – 9910Substrate binding By similarity

Sites

Active site921Proton donor By similarity
Binding site361Substrate By similarity
Binding site2161Substrate By similarity
Binding site2341Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q06375 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 0934EF673B03A820

FASTA26329,275
        10         20         30         40         50         60 
MYKSYGERAK SHPSKVASRL LNLMESKQTN LCASVDVTKT QELLELLDKL GPYICLVKTH 

        70         80         90        100        110        120 
IDIVEDFSYE HTILPLQGLA KKHNFMIFED RKFADIGNTV KLQYKGGIYR TSKWADITNA 

       130        140        150        160        170        180 
HGVTGAGIVE GLKQAAEEST DEPRGLLMLA ELSSKGSLAT GEYTQKTVEI AKSDKEFVIG 

       190        200        210        220        230        240 
FIAQRDMGGR EEGFDWLIMT PGVGLDDKGD SLGQQYRTVD EVMQTGTDVI IVGRGLFGKG 

       250        260 
RDPEVEGKRY RNAGWEAYKR RIA 

« Hide

References

[1]"Cloning and sequencing of the ura3 locus of the methylotrophic yeast Hansenula polymorpha and its use for the generation of a deletion by gene replacement."
Merckelbach A., Goedecke S., Janowicz Z.A., Hollenberg C.P.
Appl. Microbiol. Biotechnol. 40:361-364(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL Y-5445.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69461 Genomic DNA. Translation: CAA49221.1.
PIRS31323.

3D structure databases

ProteinModelPortalQ06375.
SMRQ06375. Positions 4-261.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_PICAN
AccessionPrimary (citable) accession number: Q06375
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 16, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways