Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Miscellaneous

Constitutive expression of this enzyme in liver may be related to the sensitivity of guinea pig to TCDD.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220SubstrateBy similarity1
Metal bindingi453Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:CYP1A1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516261 – 516Cytochrome P450 1A1Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63O-linked (GlcNAc) serineBy similarity1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Constitutively expressed in liver.

Inductioni

By 3-methylcholanthrene (3MC).

Gene expression databases

BgeeiENSCPOG00000015596.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000014064.

Structurei

3D structure databases

ProteinModelPortaliQ06367.
SMRiQ06367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00880000137854.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ06367.
OMAiNNWQDYI.
OrthoDBiEOG091G0BT8.
TreeFamiTF105095.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSAMELLL TATIFCLVLW VVRIFRPQVP KGLKSPPGPW GWPLIGHMLT
60 70 80 90 100
LGKNPHLALT RLSARYGDVL QIRIGSTPVV VLSGLDTIRQ ALVRQGDDFK
110 120 130 140 150
GRPDLYSFTF ISDGQSMTFN PDSGPVWAAR RRLAQSALKS FSVASDPASV
160 170 180 190 200
SSCYLEEHVK KEAEYLIKKF QELMAGPGHF DPYRYVVVSV ANVISAICFG
210 220 230 240 250
QRYSHDDQQL LELIDLNNEF GEVTGSGNPS DFIPILRYLP SATMDTFKDL
260 270 280 290 300
NRRFSVFIQK MIKEHYKTFE KGHIRDITDS LIEHCQDRKL DKNANIQISD
310 320 330 340 350
QKIIGIVLDL FGAGFDTITT AISWSLLYLV MNPRIQKKIQ EELDTVIGRE
360 370 380 390 400
RQPQLADRPK LPYMEAFISE VFRYSSFMPF TIPHSTTKDT SLNGFYIPKG
410 420 430 440 450
CCIFVNQWQI NHDQKLWGDP SVFRPERFLS PDGTVDKALS EKVTIFGLGK
460 470 480 490 500
RRCLGEVIGR WEVFLFLAIL LQQLEFSTSP GVKIDMTPIY GLTMKYSRCE
510
HFQAQTRPFV LKCPEA
Length:516
Mass (Da):58,571
Last modified:November 1, 1996 - v1
Checksum:i026DD4DCAB6E39BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2Missing AA sequence (PubMed:3718958).Curated1
Sequence conflicti16C → W AA sequence (PubMed:3718958).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11043 mRNA. Translation: BAA01794.1.
PIRiS43414.
RefSeqiNP_001166411.1. NM_001172940.1.
XP_013000999.1. XM_013145545.1.

Genome annotation databases

EnsembliENSCPOT00000015748; ENSCPOP00000014064; ENSCPOG00000015596.
GeneIDi100135512.

Similar proteinsi

Entry informationi

Entry nameiCP1A1_CAVPO
AccessioniPrimary (citable) accession number: Q06367
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families