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Q06367

- CP1A1_CAVPO

UniProt

Q06367 - CP1A1_CAVPO

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Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei220 – 2201SubstrateBy similarity
Metal bindingi453 – 4531Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. vitamin D 24-hydroxylase activity Source: Ensembl

GO - Biological processi

  1. amine metabolic process Source: Ensembl
  2. cellular response to organic cyclic compound Source: Ensembl
  3. drug metabolic process Source: Ensembl
  4. heterocycle metabolic process Source: Ensembl
  5. hydrogen peroxide biosynthetic process Source: Ensembl
  6. response to toxic substance Source: Ensembl
  7. toxin metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:CYP1A1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Cytochrome P450 1A1PRO_0000051626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Constitutively expressed in liver.

Inductioni

By 3-methylcholanthrene (3MC).

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000014064.

Structurei

3D structure databases

ProteinModelPortaliQ06367.
SMRiQ06367. Positions 28-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ06367.
OrthoDBiEOG7RBZ85.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06367-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTSAMELLL TATIFCLVLW VVRIFRPQVP KGLKSPPGPW GWPLIGHMLT
60 70 80 90 100
LGKNPHLALT RLSARYGDVL QIRIGSTPVV VLSGLDTIRQ ALVRQGDDFK
110 120 130 140 150
GRPDLYSFTF ISDGQSMTFN PDSGPVWAAR RRLAQSALKS FSVASDPASV
160 170 180 190 200
SSCYLEEHVK KEAEYLIKKF QELMAGPGHF DPYRYVVVSV ANVISAICFG
210 220 230 240 250
QRYSHDDQQL LELIDLNNEF GEVTGSGNPS DFIPILRYLP SATMDTFKDL
260 270 280 290 300
NRRFSVFIQK MIKEHYKTFE KGHIRDITDS LIEHCQDRKL DKNANIQISD
310 320 330 340 350
QKIIGIVLDL FGAGFDTITT AISWSLLYLV MNPRIQKKIQ EELDTVIGRE
360 370 380 390 400
RQPQLADRPK LPYMEAFISE VFRYSSFMPF TIPHSTTKDT SLNGFYIPKG
410 420 430 440 450
CCIFVNQWQI NHDQKLWGDP SVFRPERFLS PDGTVDKALS EKVTIFGLGK
460 470 480 490 500
RRCLGEVIGR WEVFLFLAIL LQQLEFSTSP GVKIDMTPIY GLTMKYSRCE
510
HFQAQTRPFV LKCPEA
Length:516
Mass (Da):58,571
Last modified:November 1, 1996 - v1
Checksum:i026DD4DCAB6E39BA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21Missing AA sequence (PubMed:3718958)Curated
Sequence conflicti16 – 161C → W AA sequence (PubMed:3718958)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11043 mRNA. Translation: BAA01794.1.
PIRiS43414.
RefSeqiNP_001166411.1. NM_001172940.1.

Genome annotation databases

EnsembliENSCPOT00000015748; ENSCPOP00000014064; ENSCPOG00000015596.
GeneIDi100135512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11043 mRNA. Translation: BAA01794.1 .
PIRi S43414.
RefSeqi NP_001166411.1. NM_001172940.1.

3D structure databases

ProteinModelPortali Q06367.
SMRi Q06367. Positions 28-505.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000014064.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000015748 ; ENSCPOP00000014064 ; ENSCPOG00000015596 .
GeneIDi 100135512.

Organism-specific databases

CTDi 1543.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118992.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi Q06367.
OrthoDBi EOG7RBZ85.
TreeFami TF105095.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of guinea pig CYP1A1: complete primary structure and fast mobility of expressed protein on electrophoresis."
    Ohgiya S., Ishizaki K., Shinriki N.
    Biochim. Biophys. Acta 1216:237-244(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.
    Tissue: Liver.
  2. "Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450."
    Cheng K.C., Park S.S., Krutzsch H.C., Grantham P.H., Gelboin H.V., Friedman F.K.
    Biochemistry 25:2397-2402(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-24.
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_CAVPO
AccessioniPrimary (citable) accession number: Q06367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Constitutive expression of this enzyme in liver may be related to the sensitivity of guinea pig to TCDD.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3