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Q06367 (CP1A1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A1

EC=1.14.14.1
Alternative name(s):
CYPIA1
Gene names
Name:CYP1A1
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Constitutively expressed in liver.

Induction

By 3-methylcholanthrene (3MC).

Miscellaneous

Constitutive expression of this enzyme in liver may be related to the sensitivity of guinea pig to TCDD.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 516516Cytochrome P450 1A1
PRO_0000051626

Sites

Metal binding4531Iron (heme axial ligand) By similarity
Binding site2201Substrate By similarity

Experimental info

Sequence conflict21Missing AA sequence Ref.2
Sequence conflict161C → W AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q06367 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 026DD4DCAB6E39BA

FASTA51658,571
        10         20         30         40         50         60 
MSTSAMELLL TATIFCLVLW VVRIFRPQVP KGLKSPPGPW GWPLIGHMLT LGKNPHLALT 

        70         80         90        100        110        120 
RLSARYGDVL QIRIGSTPVV VLSGLDTIRQ ALVRQGDDFK GRPDLYSFTF ISDGQSMTFN 

       130        140        150        160        170        180 
PDSGPVWAAR RRLAQSALKS FSVASDPASV SSCYLEEHVK KEAEYLIKKF QELMAGPGHF 

       190        200        210        220        230        240 
DPYRYVVVSV ANVISAICFG QRYSHDDQQL LELIDLNNEF GEVTGSGNPS DFIPILRYLP 

       250        260        270        280        290        300 
SATMDTFKDL NRRFSVFIQK MIKEHYKTFE KGHIRDITDS LIEHCQDRKL DKNANIQISD 

       310        320        330        340        350        360 
QKIIGIVLDL FGAGFDTITT AISWSLLYLV MNPRIQKKIQ EELDTVIGRE RQPQLADRPK 

       370        380        390        400        410        420 
LPYMEAFISE VFRYSSFMPF TIPHSTTKDT SLNGFYIPKG CCIFVNQWQI NHDQKLWGDP 

       430        440        450        460        470        480 
SVFRPERFLS PDGTVDKALS EKVTIFGLGK RRCLGEVIGR WEVFLFLAIL LQQLEFSTSP 

       490        500        510 
GVKIDMTPIY GLTMKYSRCE HFQAQTRPFV LKCPEA 

« Hide

References

[1]"Molecular cloning of guinea pig CYP1A1: complete primary structure and fast mobility of expressed protein on electrophoresis."
Ohgiya S., Ishizaki K., Shinriki N.
Biochim. Biophys. Acta 1216:237-244(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hartley.
Tissue: Liver.
[2]"Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450."
Cheng K.C., Park S.S., Krutzsch H.C., Grantham P.H., Gelboin H.V., Friedman F.K.
Biochemistry 25:2397-2402(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-24.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D11043 mRNA. Translation: BAA01794.1.
PIRS43414.
RefSeqNP_001166411.1. NM_001172940.1.

3D structure databases

ProteinModelPortalQ06367.
SMRQ06367. Positions 28-505.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000014064.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000015748; ENSCPOP00000014064; ENSCPOG00000015596.
GeneID100135512.

Organism-specific databases

CTD1543.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117317.
HOGENOMHOG000036991.
HOVERGENHBG106944.
InParanoidQ06367.
OrthoDBEOG7RBZ85.
TreeFamTF105095.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_CAVPO
AccessionPrimary (citable) accession number: Q06367
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families