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Q06350

- CHI2_YEAST

UniProt

Q06350 - CHI2_YEAST

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Protein

Sporulation-specific chitinase 2

Gene

CTS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei223 – 2231Proton donorPROSITE-ProRule annotation

GO - Molecular functioni

  1. chitinase activity Source: UniProtKB-EC

GO - Biological processi

  1. chitin catabolic process Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
  3. sporulation resulting in formation of a cellular spore Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation, Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29921-MONOMER.

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-specific chitinase 2 (EC:3.2.1.14)
Gene namesi
Name:CTS2
Ordered Locus Names:YDR371W
ORF Names:D9481.7
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR371w.
SGDiS000002779. CTS2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 511477Sporulation-specific chitinase 2PRO_0000011937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ06350.
PaxDbiQ06350.
PeptideAtlasiQ06350.

Expressioni

Gene expression databases

GenevestigatoriQ06350.

Interactioni

Protein-protein interaction databases

BioGridi32430. 9 interactions.
DIPiDIP-5251N.
IntActiQ06350. 2 interactions.
MINTiMINT-566526.
STRINGi4932.YDR371W.

Structurei

3D structure databases

ProteinModelPortaliQ06350.
SMRiQ06350. Positions 72-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3325.
GeneTreeiENSGT00550000074323.
HOGENOMiHOG000111627.
InParanoidiQ06350.
KOiK01183.
OMAiAYANESR.
OrthoDBiEOG7WQ826.

Family and domain databases

Gene3Di3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEiPS01095. CHITINASE_18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06350-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGHSAQHRS KSSLVSHLLI LLIFITIIIE MCLYNKIFKN QRSDDIRDNF
60 70 80 90 100
NNGGHRVPSN VQNHGTHIRD EAFISGVYYS NWSPYKPRFH FPHDINLKQV
110 120 130 140 150
SHIYYAFFKI NSRTGGIENT DSWSDLEMNL YKSLAIKNSE LIKESSNNSV
160 170 180 190 200
QNILPLGCIG ELFYLKNTCS DKKFKVIMSI GGWSDSENFK IIIKDDKLLQ
210 220 230 240 250
NFVDSSVETM FRLGFDGIDL DWEFPGNNES EPRGYLKLVR MLRLKLNSLE
260 270 280 290 300
SQIFGKRTED HFQLSIAAPA FKDKLFYLPI TEIDQYVDYW NMMTYDYYGS
310 320 330 340 350
WSETTGYHSN LFSETELNGN FAMHYMIDRF GVNSRKLVLG MAAYGRSFHI
360 370 380 390 400
KDNKFEPFNQ NTVLINKIFK GVGKPTKEID KADGKEGIWP YKNLPKIGTI
410 420 430 440 450
EQYDPKYVSA YCFDEKNSIF ISYDNTKSVK TKAEYVTHNN LGGGFWWESC
460 470 480 490 500
GEAYANESRS LINAFNEGLH FNVSSKPSIF QDVRVKKYYL NKYGDGGFLS
510
PYLKHLDSRK Q
Length:511
Mass (Da):59,118
Last modified:November 1, 1996 - v1
Checksum:i238FF79963BF0D63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28373 Genomic DNA. Translation: AAB64807.1.
BK006938 Genomic DNA. Translation: DAA12212.1.
PIRiS61166.
RefSeqiNP_010659.1. NM_001180679.1.

Genome annotation databases

EnsemblFungiiYDR371W; YDR371W; YDR371W.
GeneIDi851977.
KEGGisce:YDR371W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28373 Genomic DNA. Translation: AAB64807.1 .
BK006938 Genomic DNA. Translation: DAA12212.1 .
PIRi S61166.
RefSeqi NP_010659.1. NM_001180679.1.

3D structure databases

ProteinModelPortali Q06350.
SMRi Q06350. Positions 72-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32430. 9 interactions.
DIPi DIP-5251N.
IntActi Q06350. 2 interactions.
MINTi MINT-566526.
STRINGi 4932.YDR371W.

Protein family/group databases

CAZyi GH18. Glycoside Hydrolase Family 18.

Proteomic databases

MaxQBi Q06350.
PaxDbi Q06350.
PeptideAtlasi Q06350.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR371W ; YDR371W ; YDR371W .
GeneIDi 851977.
KEGGi sce:YDR371W.

Organism-specific databases

CYGDi YDR371w.
SGDi S000002779. CTS2.

Phylogenomic databases

eggNOGi COG3325.
GeneTreei ENSGT00550000074323.
HOGENOMi HOG000111627.
InParanoidi Q06350.
KOi K01183.
OMAi AYANESR.
OrthoDBi EOG7WQ826.

Enzyme and pathway databases

BioCyci YEAST:G3O-29921-MONOMER.

Miscellaneous databases

NextBioi 970115.

Gene expression databases

Genevestigatori Q06350.

Family and domain databases

Gene3Di 3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00704. Glyco_hydro_18. 1 hit.
[Graphical view ]
SMARTi SM00636. Glyco_18. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEi PS01095. CHITINASE_18. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCHI2_YEAST
AccessioniPrimary (citable) accession number: Q06350
Secondary accession number(s): D6VT02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3050 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3