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Protein

Sporulation-specific chitinase 2

Gene

CTS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 3050 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei223Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • chitin catabolic process Source: GO_Central
  • polysaccharide catabolic process Source: UniProtKB-KW
  • sporulation resulting in formation of a cellular spore Source: SGD

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation, Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29921-MONOMER.
ReactomeiR-SCE-6798695. Neutrophil degranulation.
R-SCE-71387. Metabolism of carbohydrates.

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-specific chitinase 2 (EC:3.2.1.14)
Gene namesi
Name:CTS2
Ordered Locus Names:YDR371W
ORF Names:D9481.7
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR371W.
SGDiS000002779. CTS2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001193735 – 511Sporulation-specific chitinase 2Add BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi472N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ06350.
PRIDEiQ06350.

Interactioni

Protein-protein interaction databases

BioGridi32430. 67 interactors.
DIPiDIP-5251N.
IntActiQ06350. 2 interactors.
MINTiMINT-566526.
STRINGi4932.YDR371W.

Structurei

3D structure databases

ProteinModelPortaliQ06350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00550000074323.
HOGENOMiHOG000111627.
InParanoidiQ06350.
KOiK01183.
OMAiTYSPNFA.
OrthoDBiEOG092C2AAM.

Family and domain databases

InterProiView protein in InterPro
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00704. Glyco_hydro_18. 1 hit.
SMARTiView protein in SMART
SM00636. Glyco_18. 1 hit.
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEiView protein in PROSITE
PS01095. CHITINASE_18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGHSAQHRS KSSLVSHLLI LLIFITIIIE MCLYNKIFKN QRSDDIRDNF
60 70 80 90 100
NNGGHRVPSN VQNHGTHIRD EAFISGVYYS NWSPYKPRFH FPHDINLKQV
110 120 130 140 150
SHIYYAFFKI NSRTGGIENT DSWSDLEMNL YKSLAIKNSE LIKESSNNSV
160 170 180 190 200
QNILPLGCIG ELFYLKNTCS DKKFKVIMSI GGWSDSENFK IIIKDDKLLQ
210 220 230 240 250
NFVDSSVETM FRLGFDGIDL DWEFPGNNES EPRGYLKLVR MLRLKLNSLE
260 270 280 290 300
SQIFGKRTED HFQLSIAAPA FKDKLFYLPI TEIDQYVDYW NMMTYDYYGS
310 320 330 340 350
WSETTGYHSN LFSETELNGN FAMHYMIDRF GVNSRKLVLG MAAYGRSFHI
360 370 380 390 400
KDNKFEPFNQ NTVLINKIFK GVGKPTKEID KADGKEGIWP YKNLPKIGTI
410 420 430 440 450
EQYDPKYVSA YCFDEKNSIF ISYDNTKSVK TKAEYVTHNN LGGGFWWESC
460 470 480 490 500
GEAYANESRS LINAFNEGLH FNVSSKPSIF QDVRVKKYYL NKYGDGGFLS
510
PYLKHLDSRK Q
Length:511
Mass (Da):59,118
Last modified:November 1, 1996 - v1
Checksum:i238FF79963BF0D63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28373 Genomic DNA. Translation: AAB64807.1.
BK006938 Genomic DNA. Translation: DAA12212.1.
PIRiS61166.
RefSeqiNP_010659.1. NM_001180679.1.

Genome annotation databases

EnsemblFungiiYDR371W; YDR371W; YDR371W.
GeneIDi851977.
KEGGisce:YDR371W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCHI2_YEAST
AccessioniPrimary (citable) accession number: Q06350
Secondary accession number(s): D6VT02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names