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Q06348

- PRRX2_MOUSE

UniProt

Q06348 - PRRX2_MOUSE

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Protein
Paired mesoderm homeobox protein 2
Gene
Prrx2, Prx2, S8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi98 – 15760Homeobox
Add
BLAST

GO - Molecular functioni

  1. HMG box domain binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. artery morphogenesis Source: MGI
  2. cartilage development Source: MGI
  3. embryonic cranial skeleton morphogenesis Source: MGI
  4. embryonic limb morphogenesis Source: MGI
  5. embryonic skeletal system morphogenesis Source: MGI
  6. inner ear morphogenesis Source: MGI
  7. middle ear morphogenesis Source: MGI
  8. positive regulation of mesenchymal cell proliferation Source: MGI
  9. positive regulation of smoothened signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2
Short name:
PRX-2
Alternative name(s):
Homeobox protein S8
Gene namesi
Name:Prrx2
Synonyms:Prx2, S8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:98218. Prrx2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Paired mesoderm homeobox protein 2
PRO_0000049256Add
BLAST

Proteomic databases

PRIDEiQ06348.

PTM databases

PhosphoSiteiQ06348.

Expressioni

Tissue specificityi

In the embryo, expressed in craniofacial mesenchyme, limb, heart, somites and sclerotomes. Absent from central and peripheral nervous systems, splanchnopleure and ectodermal derivatives.

Gene expression databases

CleanExiMM_PRRX2.
GenevestigatoriQ06348.

Interactioni

Protein-protein interaction databases

BioGridi203059. 1 interaction.
IntActiQ06348. 1 interaction.
MINTiMINT-1782155.

Structurei

3D structure databases

ProteinModelPortaliQ06348.
SMRiQ06348. Positions 98-154.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi224 – 23714OAR
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 96Poly-Ala

Sequence similaritiesi

Belongs to the paired homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG309174.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiQ06348.
KOiK09329.
PhylomeDBiQ06348.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06348-1 [UniParc]FASTAAdd to Basket

« Hide

MDSAAAAFAL DPPAPGPGPP PAPGDCAQAR KNFSVSHLLD LEEVAAAGRR    50
AAGPVSGPAE ARVGAAREPS GGSSGTEAAP QDGDCPSPGR GTKRKKKQRR 100
NRTTFNSSQL QALERVFERT HYPDAFVREE LARRVNLSEA RVQVWFQNRR 150
AKFRRNERAM LATRSASLLK SYGQEAAIEQ PVAPRPTTMS PDYLSWPASS 200
PYSSVPPYSP GGSSPATPGV NMANSIASLR LKAKEFSLHH SQVPTVN 247
Length:247
Mass (Da):26,427
Last modified:June 1, 1998 - v2
Checksum:i640FFC2E7FC2F61B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52875 mRNA. Translation: CAA37055.1.
X14572 mRNA. Translation: CAA32710.1. Sequence problems.
CCDSiCCDS15888.1.
PIRiI48410. S18038.
RefSeqiNP_033142.2. NM_009116.2.
UniGeneiMm.1802.

Genome annotation databases

GeneIDi20204.
KEGGimmu:20204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52875 mRNA. Translation: CAA37055.1 .
X14572 mRNA. Translation: CAA32710.1 . Sequence problems.
CCDSi CCDS15888.1.
PIRi I48410. S18038.
RefSeqi NP_033142.2. NM_009116.2.
UniGenei Mm.1802.

3D structure databases

ProteinModelPortali Q06348.
SMRi Q06348. Positions 98-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203059. 1 interaction.
IntActi Q06348. 1 interaction.
MINTi MINT-1782155.

PTM databases

PhosphoSitei Q06348.

Proteomic databases

PRIDEi Q06348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 20204.
KEGGi mmu:20204.

Organism-specific databases

CTDi 51450.
MGIi MGI:98218. Prrx2.

Phylogenomic databases

eggNOGi NOG309174.
HOGENOMi HOG000231518.
HOVERGENi HBG021349.
InParanoidi Q06348.
KOi K09329.
PhylomeDBi Q06348.

Miscellaneous databases

NextBioi 297791.
PROi Q06348.
SOURCEi Search...

Gene expression databases

CleanExi MM_PRRX2.
Genevestigatori Q06348.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Meijlink F., ten Berge D., Brouwer A., Bleys R.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme."
    Opstelten D.-J.E., Vogels R., Robert B., Kalkhoven E., Zwartkruis F., de Laaf L., Destree O.H., Deschamps J., Lawson K.A., Meijlink F.
    Mech. Dev. 34:29-41(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-247.
    Tissue: Spleen.
  3. "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
    Kongsuwan K., Webb E., Housiaux P., Adams J.M.
    EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-157.

Entry informationi

Entry nameiPRRX2_MOUSE
AccessioniPrimary (citable) accession number: Q06348
Secondary accession number(s): Q61651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi