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Q06348

- PRRX2_MOUSE

UniProt

Q06348 - PRRX2_MOUSE

Protein

Paired mesoderm homeobox protein 2

Gene

Prrx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi98 – 15760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. HMG box domain binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. artery morphogenesis Source: MGI
    2. cartilage development Source: MGI
    3. embryonic cranial skeleton morphogenesis Source: MGI
    4. embryonic limb morphogenesis Source: MGI
    5. embryonic skeletal system morphogenesis Source: MGI
    6. inner ear morphogenesis Source: MGI
    7. middle ear morphogenesis Source: MGI
    8. positive regulation of mesenchymal cell proliferation Source: MGI
    9. positive regulation of smoothened signaling pathway Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired mesoderm homeobox protein 2
    Short name:
    PRX-2
    Alternative name(s):
    Homeobox protein S8
    Gene namesi
    Name:Prrx2
    Synonyms:Prx2, S8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:98218. Prrx2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 247247Paired mesoderm homeobox protein 2PRO_0000049256Add
    BLAST

    Proteomic databases

    PRIDEiQ06348.

    PTM databases

    PhosphoSiteiQ06348.

    Expressioni

    Tissue specificityi

    In the embryo, expressed in craniofacial mesenchyme, limb, heart, somites and sclerotomes. Absent from central and peripheral nervous systems, splanchnopleure and ectodermal derivatives.

    Gene expression databases

    CleanExiMM_PRRX2.
    GenevestigatoriQ06348.

    Interactioni

    Protein-protein interaction databases

    BioGridi203059. 1 interaction.
    IntActiQ06348. 1 interaction.
    MINTiMINT-1782155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06348.
    SMRiQ06348. Positions 98-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi224 – 23714OARAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 96Poly-Ala

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG309174.
    HOGENOMiHOG000231518.
    HOVERGENiHBG021349.
    InParanoidiQ06348.
    KOiK09329.
    PhylomeDBiQ06348.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003654. OAR_dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06348-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSAAAAFAL DPPAPGPGPP PAPGDCAQAR KNFSVSHLLD LEEVAAAGRR    50
    AAGPVSGPAE ARVGAAREPS GGSSGTEAAP QDGDCPSPGR GTKRKKKQRR 100
    NRTTFNSSQL QALERVFERT HYPDAFVREE LARRVNLSEA RVQVWFQNRR 150
    AKFRRNERAM LATRSASLLK SYGQEAAIEQ PVAPRPTTMS PDYLSWPASS 200
    PYSSVPPYSP GGSSPATPGV NMANSIASLR LKAKEFSLHH SQVPTVN 247
    Length:247
    Mass (Da):26,427
    Last modified:June 1, 1998 - v2
    Checksum:i640FFC2E7FC2F61B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52875 mRNA. Translation: CAA37055.1.
    X14572 mRNA. Translation: CAA32710.1. Sequence problems.
    CCDSiCCDS15888.1.
    PIRiI48410. S18038.
    RefSeqiNP_033142.2. NM_009116.2.
    UniGeneiMm.1802.

    Genome annotation databases

    GeneIDi20204.
    KEGGimmu:20204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52875 mRNA. Translation: CAA37055.1 .
    X14572 mRNA. Translation: CAA32710.1 . Sequence problems.
    CCDSi CCDS15888.1.
    PIRi I48410. S18038.
    RefSeqi NP_033142.2. NM_009116.2.
    UniGenei Mm.1802.

    3D structure databases

    ProteinModelPortali Q06348.
    SMRi Q06348. Positions 98-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203059. 1 interaction.
    IntActi Q06348. 1 interaction.
    MINTi MINT-1782155.

    PTM databases

    PhosphoSitei Q06348.

    Proteomic databases

    PRIDEi Q06348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 20204.
    KEGGi mmu:20204.

    Organism-specific databases

    CTDi 51450.
    MGIi MGI:98218. Prrx2.

    Phylogenomic databases

    eggNOGi NOG309174.
    HOGENOMi HOG000231518.
    HOVERGENi HBG021349.
    InParanoidi Q06348.
    KOi K09329.
    PhylomeDBi Q06348.

    Miscellaneous databases

    NextBioi 297791.
    PROi Q06348.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PRRX2.
    Genevestigatori Q06348.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003654. OAR_dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Meijlink F., ten Berge D., Brouwer A., Bleys R.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme."
      Opstelten D.-J.E., Vogels R., Robert B., Kalkhoven E., Zwartkruis F., de Laaf L., Destree O.H., Deschamps J., Lawson K.A., Meijlink F.
      Mech. Dev. 34:29-41(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-247.
      Tissue: Spleen.
    3. "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
      Kongsuwan K., Webb E., Housiaux P., Adams J.M.
      EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-157.

    Entry informationi

    Entry nameiPRRX2_MOUSE
    AccessioniPrimary (citable) accession number: Q06348
    Secondary accession number(s): Q61651
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3