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Q06348 (PRRX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired mesoderm homeobox protein 2

Short name=PRX-2
Alternative name(s):
Homeobox protein S8
Gene names
Name:Prrx2
Synonyms:Prx2, S8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Tissue specificity

In the embryo, expressed in craniofacial mesenchyme, limb, heart, somites and sclerotomes. Absent from central and peripheral nervous systems, splanchnopleure and ectodermal derivatives.

Sequence similarities

Belongs to the paired homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processartery morphogenesis

Inferred from genetic interaction PubMed 10664157. Source: MGI

cartilage development

Inferred from genetic interaction PubMed 9876178. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from genetic interaction PubMed 9729491. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction PubMed 9729491PubMed 9882503. Source: MGI

embryonic skeletal system morphogenesis

Inferred from genetic interaction PubMed 11532916PubMed 9729491PubMed 9876178. Source: MGI

inner ear morphogenesis

Inferred from genetic interaction PubMed 9729491. Source: MGI

middle ear morphogenesis

Inferred from genetic interaction PubMed 9729491. Source: MGI

positive regulation of mesenchymal cell proliferation

Inferred from genetic interaction PubMed 11532916. Source: MGI

positive regulation of smoothened signaling pathway

Inferred from genetic interaction PubMed 11532916. Source: MGI

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionHMG box domain binding

Inferred from physical interaction PubMed 16582099. Source: UniProtKB

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247Paired mesoderm homeobox protein 2
PRO_0000049256

Regions

DNA binding98 – 15760Homeobox
Motif224 – 23714OAR
Compositional bias4 – 96Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
Q06348 [UniParc].

Last modified June 1, 1998. Version 2.
Checksum: 640FFC2E7FC2F61B

FASTA24726,427
        10         20         30         40         50         60 
MDSAAAAFAL DPPAPGPGPP PAPGDCAQAR KNFSVSHLLD LEEVAAAGRR AAGPVSGPAE 

        70         80         90        100        110        120 
ARVGAAREPS GGSSGTEAAP QDGDCPSPGR GTKRKKKQRR NRTTFNSSQL QALERVFERT 

       130        140        150        160        170        180 
HYPDAFVREE LARRVNLSEA RVQVWFQNRR AKFRRNERAM LATRSASLLK SYGQEAAIEQ 

       190        200        210        220        230        240 
PVAPRPTTMS PDYLSWPASS PYSSVPPYSP GGSSPATPGV NMANSIASLR LKAKEFSLHH 


SQVPTVN 

« Hide

References

[1]Meijlink F., ten Berge D., Brouwer A., Bleys R.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme."
Opstelten D.-J.E., Vogels R., Robert B., Kalkhoven E., Zwartkruis F., de Laaf L., Destree O.H., Deschamps J., Lawson K.A., Meijlink F.
Mech. Dev. 34:29-41(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-247.
Tissue: Spleen.
[3]"Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
Kongsuwan K., Webb E., Housiaux P., Adams J.M.
EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-157.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52875 mRNA. Translation: CAA37055.1.
X14572 mRNA. Translation: CAA32710.1. Sequence problems.
PIRS18038. I48410.
RefSeqNP_033142.2. NM_009116.2.
UniGeneMm.1802.

3D structure databases

ProteinModelPortalQ06348.
SMRQ06348. Positions 98-154.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203059. 1 interaction.
IntActQ06348. 1 interaction.
MINTMINT-1782155.

PTM databases

PhosphoSiteQ06348.

Proteomic databases

PRIDEQ06348.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID20204.
KEGGmmu:20204.

Organism-specific databases

CTD51450.
MGIMGI:98218. Prrx2.

Phylogenomic databases

eggNOGNOG309174.
HOGENOMHOG000231518.
HOVERGENHBG021349.
InParanoidQ06348.
KOK09329.
PhylomeDBQ06348.

Gene expression databases

CleanExMM_PRRX2.
GenevestigatorQ06348.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297791.
PROQ06348.
SOURCESearch...

Entry information

Entry namePRRX2_MOUSE
AccessionPrimary (citable) accession number: Q06348
Secondary accession number(s): Q61651
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot