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Protein

Paired mesoderm homeobox protein 2

Gene

Prrx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi98 – 157HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • HMG box domain binding Source: UniProtKB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • artery morphogenesis Source: MGI
  • cartilage development Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • inner ear morphogenesis Source: MGI
  • middle ear morphogenesis Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of smoothened signaling pathway Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2
Short name:
PRX-2
Alternative name(s):
Homeobox protein S8
Gene namesi
Name:Prrx2
Synonyms:Prx2, S8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98218 Prrx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492561 – 247Paired mesoderm homeobox protein 2Add BLAST247

Proteomic databases

MaxQBiQ06348
PaxDbiQ06348
PRIDEiQ06348

PTM databases

PhosphoSitePlusiQ06348

Expressioni

Tissue specificityi

In the embryo, expressed in craniofacial mesenchyme, limb, heart, somites and sclerotomes. Absent from central and peripheral nervous systems, splanchnopleure and ectodermal derivatives.

Gene expression databases

CleanExiMM_PRRX2

Interactioni

GO - Molecular functioni

  • HMG box domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi203059, 1 interactor
IntActiQ06348, 1 interactor
MINTiQ06348
STRINGi10090.ENSMUSP00000040332

Structurei

3D structure databases

ProteinModelPortaliQ06348
SMRiQ06348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi224 – 237OARPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 9Poly-Ala6

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
HOGENOMiHOG000231518
HOVERGENiHBG021349
InParanoidiQ06348
KOiK09329
PhylomeDBiQ06348

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequencei

Sequence statusi: Complete.

Q06348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAAAAFAL DPPAPGPGPP PAPGDCAQAR KNFSVSHLLD LEEVAAAGRR
60 70 80 90 100
AAGPVSGPAE ARVGAAREPS GGSSGTEAAP QDGDCPSPGR GTKRKKKQRR
110 120 130 140 150
NRTTFNSSQL QALERVFERT HYPDAFVREE LARRVNLSEA RVQVWFQNRR
160 170 180 190 200
AKFRRNERAM LATRSASLLK SYGQEAAIEQ PVAPRPTTMS PDYLSWPASS
210 220 230 240
PYSSVPPYSP GGSSPATPGV NMANSIASLR LKAKEFSLHH SQVPTVN
Length:247
Mass (Da):26,427
Last modified:June 1, 1998 - v2
Checksum:i640FFC2E7FC2F61B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52875 mRNA Translation: CAA37055.1
X14572 mRNA Translation: CAA32710.1 Sequence problems.
CCDSiCCDS15888.1
PIRiI48410 S18038
RefSeqiNP_033142.2, NM_009116.2
UniGeneiMm.1802

Genome annotation databases

GeneIDi20204
KEGGimmu:20204

Similar proteinsi

Entry informationi

Entry nameiPRRX2_MOUSE
AccessioniPrimary (citable) accession number: Q06348
Secondary accession number(s): Q61651
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health