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Protein

Paired mesoderm homeobox protein 2

Gene

Prrx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi98 – 157HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • HMG box domain binding Source: UniProtKB
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • artery morphogenesis Source: MGI
  • cartilage development Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • inner ear morphogenesis Source: MGI
  • middle ear morphogenesis Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of smoothened signaling pathway Source: MGI
  • regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2
Short name:
PRX-2
Alternative name(s):
Homeobox protein S8
Gene namesi
Name:Prrx2
Synonyms:Prx2, S8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98218. Prrx2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492561 – 247Paired mesoderm homeobox protein 2Add BLAST247

Proteomic databases

PaxDbiQ06348.
PRIDEiQ06348.

PTM databases

PhosphoSitePlusiQ06348.

Expressioni

Tissue specificityi

In the embryo, expressed in craniofacial mesenchyme, limb, heart, somites and sclerotomes. Absent from central and peripheral nervous systems, splanchnopleure and ectodermal derivatives.

Gene expression databases

CleanExiMM_PRRX2.

Interactioni

GO - Molecular functioni

  • HMG box domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi203059. 1 interactor.
IntActiQ06348. 1 interactor.
MINTiMINT-1782155.
STRINGi10090.ENSMUSP00000040332.

Structurei

3D structure databases

ProteinModelPortaliQ06348.
SMRiQ06348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi224 – 237OARPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 9Poly-Ala6

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiQ06348.
KOiK09329.
PhylomeDBiQ06348.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAAAAFAL DPPAPGPGPP PAPGDCAQAR KNFSVSHLLD LEEVAAAGRR
60 70 80 90 100
AAGPVSGPAE ARVGAAREPS GGSSGTEAAP QDGDCPSPGR GTKRKKKQRR
110 120 130 140 150
NRTTFNSSQL QALERVFERT HYPDAFVREE LARRVNLSEA RVQVWFQNRR
160 170 180 190 200
AKFRRNERAM LATRSASLLK SYGQEAAIEQ PVAPRPTTMS PDYLSWPASS
210 220 230 240
PYSSVPPYSP GGSSPATPGV NMANSIASLR LKAKEFSLHH SQVPTVN
Length:247
Mass (Da):26,427
Last modified:June 1, 1998 - v2
Checksum:i640FFC2E7FC2F61B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52875 mRNA. Translation: CAA37055.1.
X14572 mRNA. Translation: CAA32710.1. Sequence problems.
CCDSiCCDS15888.1.
PIRiI48410. S18038.
RefSeqiNP_033142.2. NM_009116.2.
UniGeneiMm.1802.

Genome annotation databases

GeneIDi20204.
KEGGimmu:20204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52875 mRNA. Translation: CAA37055.1.
X14572 mRNA. Translation: CAA32710.1. Sequence problems.
CCDSiCCDS15888.1.
PIRiI48410. S18038.
RefSeqiNP_033142.2. NM_009116.2.
UniGeneiMm.1802.

3D structure databases

ProteinModelPortaliQ06348.
SMRiQ06348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203059. 1 interactor.
IntActiQ06348. 1 interactor.
MINTiMINT-1782155.
STRINGi10090.ENSMUSP00000040332.

PTM databases

PhosphoSitePlusiQ06348.

Proteomic databases

PaxDbiQ06348.
PRIDEiQ06348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20204.
KEGGimmu:20204.

Organism-specific databases

CTDi51450.
MGIiMGI:98218. Prrx2.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiQ06348.
KOiK09329.
PhylomeDBiQ06348.

Miscellaneous databases

PROiQ06348.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PRRX2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRRX2_MOUSE
AccessioniPrimary (citable) accession number: Q06348
Secondary accession number(s): Q61651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.