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Protein

Paired mesoderm homeobox protein 2

Gene

Prrx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi98 – 15760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. HMG box domain binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. artery morphogenesis Source: MGI
  2. cartilage development Source: MGI
  3. embryonic cranial skeleton morphogenesis Source: MGI
  4. embryonic limb morphogenesis Source: MGI
  5. embryonic skeletal system morphogenesis Source: MGI
  6. inner ear morphogenesis Source: MGI
  7. middle ear morphogenesis Source: MGI
  8. positive regulation of mesenchymal cell proliferation Source: MGI
  9. positive regulation of smoothened signaling pathway Source: MGI
  10. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2
Short name:
PRX-2
Alternative name(s):
Homeobox protein S8
Gene namesi
Name:Prrx2
Synonyms:Prx2, S8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:98218. Prrx2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Paired mesoderm homeobox protein 2PRO_0000049256Add
BLAST

Proteomic databases

PRIDEiQ06348.

PTM databases

PhosphoSiteiQ06348.

Expressioni

Tissue specificityi

In the embryo, expressed in craniofacial mesenchyme, limb, heart, somites and sclerotomes. Absent from central and peripheral nervous systems, splanchnopleure and ectodermal derivatives.

Gene expression databases

CleanExiMM_PRRX2.
GenevestigatoriQ06348.

Interactioni

Protein-protein interaction databases

BioGridi203059. 1 interaction.
IntActiQ06348. 1 interaction.
MINTiMINT-1782155.

Structurei

3D structure databases

ProteinModelPortaliQ06348.
SMRiQ06348. Positions 98-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi224 – 23714OARAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 96Poly-Ala

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG309174.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiQ06348.
KOiK09329.
PhylomeDBiQ06348.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06348-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSAAAAFAL DPPAPGPGPP PAPGDCAQAR KNFSVSHLLD LEEVAAAGRR
60 70 80 90 100
AAGPVSGPAE ARVGAAREPS GGSSGTEAAP QDGDCPSPGR GTKRKKKQRR
110 120 130 140 150
NRTTFNSSQL QALERVFERT HYPDAFVREE LARRVNLSEA RVQVWFQNRR
160 170 180 190 200
AKFRRNERAM LATRSASLLK SYGQEAAIEQ PVAPRPTTMS PDYLSWPASS
210 220 230 240
PYSSVPPYSP GGSSPATPGV NMANSIASLR LKAKEFSLHH SQVPTVN
Length:247
Mass (Da):26,427
Last modified:June 1, 1998 - v2
Checksum:i640FFC2E7FC2F61B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52875 mRNA. Translation: CAA37055.1.
X14572 mRNA. Translation: CAA32710.1. Sequence problems.
CCDSiCCDS15888.1.
PIRiI48410. S18038.
RefSeqiNP_033142.2. NM_009116.2.
UniGeneiMm.1802.

Genome annotation databases

GeneIDi20204.
KEGGimmu:20204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52875 mRNA. Translation: CAA37055.1.
X14572 mRNA. Translation: CAA32710.1. Sequence problems.
CCDSiCCDS15888.1.
PIRiI48410. S18038.
RefSeqiNP_033142.2. NM_009116.2.
UniGeneiMm.1802.

3D structure databases

ProteinModelPortaliQ06348.
SMRiQ06348. Positions 98-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203059. 1 interaction.
IntActiQ06348. 1 interaction.
MINTiMINT-1782155.

PTM databases

PhosphoSiteiQ06348.

Proteomic databases

PRIDEiQ06348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20204.
KEGGimmu:20204.

Organism-specific databases

CTDi51450.
MGIiMGI:98218. Prrx2.

Phylogenomic databases

eggNOGiNOG309174.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiQ06348.
KOiK09329.
PhylomeDBiQ06348.

Miscellaneous databases

NextBioi297791.
PROiQ06348.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PRRX2.
GenevestigatoriQ06348.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Meijlink F., ten Berge D., Brouwer A., Bleys R.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme."
    Opstelten D.-J.E., Vogels R., Robert B., Kalkhoven E., Zwartkruis F., de Laaf L., Destree O.H., Deschamps J., Lawson K.A., Meijlink F.
    Mech. Dev. 34:29-41(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-247.
    Tissue: Spleen.
  3. "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
    Kongsuwan K., Webb E., Housiaux P., Adams J.M.
    EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-157.

Entry informationi

Entry nameiPRRX2_MOUSE
AccessioniPrimary (citable) accession number: Q06348
Secondary accession number(s): Q61651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: January 7, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.