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Protein

Transcription factor tau 91 kDa subunit

Gene

TFC6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with TFC3 in DNA binding.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi6 – 18A.T hookAdd BLAST13

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29912-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor tau 91 kDa subunit
Alternative name(s):
TFIIIC 91 kDa subunit
Transcription factor C subunit 6
Gene namesi
Name:TFC6
Ordered Locus Names:YDR362C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR362C.
SGDiS000002770. TFC6.

Subcellular locationi

GO - Cellular componenti

  • transcription factor TFIIIC complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524831 – 672Transcription factor tau 91 kDa subunitAdd BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi375 ↔ 3831 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ06339.
PRIDEiQ06339.

PTM databases

iPTMnetiQ06339.

Interactioni

Subunit structurei

Heterodimer with TFC8. Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker. Interacts with TFC1, TFC3, TFC4 and directly with TFC8.5 Publications

Protein-protein interaction databases

BioGridi32417. 22 interactors.
DIPiDIP-2952N.
IntActiQ06339. 6 interactors.
MINTiMINT-477678.

Structurei

Secondary structure

1672
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi167 – 174Combined sources8
Helixi178 – 191Combined sources14
Helixi200 – 203Combined sources4
Beta strandi218 – 220Combined sources3
Helixi223 – 225Combined sources3
Turni226 – 230Combined sources5
Helixi241 – 244Combined sources4
Beta strandi253 – 258Combined sources6
Beta strandi261 – 266Combined sources6
Beta strandi270 – 272Combined sources3
Helixi273 – 275Combined sources3
Beta strandi283 – 287Combined sources5
Beta strandi298 – 300Combined sources3
Beta strandi308 – 318Combined sources11
Beta strandi339 – 347Combined sources9
Turni348 – 350Combined sources3
Beta strandi353 – 361Combined sources9
Beta strandi365 – 371Combined sources7
Beta strandi378 – 381Combined sources4
Beta strandi383 – 388Combined sources6
Beta strandi393 – 397Combined sources5
Beta strandi402 – 409Combined sources8
Beta strandi415 – 418Combined sources4
Turni421 – 423Combined sources3
Beta strandi425 – 440Combined sources16
Beta strandi443 – 449Combined sources7
Beta strandi457 – 461Combined sources5
Beta strandi463 – 465Combined sources3
Beta strandi467 – 473Combined sources7
Beta strandi481 – 486Combined sources6
Beta strandi489 – 494Combined sources6
Helixi496 – 498Combined sources3
Helixi499 – 502Combined sources4
Beta strandi504 – 508Combined sources5
Beta strandi517 – 520Combined sources4
Turni521 – 524Combined sources4
Beta strandi525 – 529Combined sources5
Beta strandi531 – 539Combined sources9
Beta strandi547 – 551Combined sources5
Beta strandi556 – 560Combined sources5
Beta strandi569 – 572Combined sources4
Turni573 – 575Combined sources3
Beta strandi576 – 578Combined sources3
Turni586 – 588Combined sources3
Beta strandi601 – 604Combined sources4
Beta strandi609 – 611Combined sources3
Beta strandi613 – 616Combined sources4
Beta strandi645 – 647Combined sources3
Turni651 – 655Combined sources5
Beta strandi656 – 660Combined sources5
Beta strandi664 – 670Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J04X-ray3.20B/D159-672[»]
ProteinModelPortaliQ06339.
SMRiQ06339.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06339.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 158Required for DNA-bindingAdd BLAST158
Regioni159 – 672Sufficient for interaction with TFC81 PublicationAdd BLAST514

Sequence similaritiesi

Contains 1 A.T hook DNA-binding domain.Curated

Phylogenomic databases

HOGENOMiHOG000001063.
InParanoidiQ06339.
KOiK15205.
OMAiRLWKWDY.
OrthoDBiEOG092C2605.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.

Sequencei

Sequence statusi: Complete.

Q06339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVIPAKKRG RPRKSVVAEV PYDSLASPVS ENSGSKRPRR NASKKAVANF
60 70 80 90 100
AQLVHAGRDD VINTTQVNNV DDTDDDDFVL NDEGDGEESD NVEIEFENEL
110 120 130 140 150
ESTKNEVADL NSSGSGASVR PSGRRNTVQK LRLKKNSTKN MKSSSPGSSL
160 170 180 190 200
GQKGRPIRLL KDLSSARDKI ERIYGLNKEK LLLLAKVKEG FETSVFDFPF
210 220 230 240 250
KNIQPDSPYF VCLDPPCKKE SAYNKVIGDK NRTVYHEINK TEFENMIKLR
260 270 280 290 300
TKRLKLLIGE VDAEVSTGDK IEFPVLANGK RRGFIYNVGG LVTDIAWLNI
310 320 330 340 350
EENTDIGKDI QYLAVAVSQY MDEPLNEHLE MFDKEKHSSC IQIFKMNTST
360 370 380 390 400
LHCVKVQTIV HSFGEVWDLK WHEGCHAPHL VGCLSFVSQE GTINFLEIID
410 420 430 440 450
NATDVHVFKM CEKPSLTLSL ADSLITTFDF LSPTTVVCGF KNGFVAEFDL
460 470 480 490 500
TDPEVPSFYD QVHDSYILSV STAYSDFEDT VVSTVAVDGY FYIFNPKDIA
510 520 530 540 550
TTKTTVSRFR GSNLVPVVYC PQIYSYIYSD GASSLRAVPS RAAFAVHPLV
560 570 580 590 600
SRETTITAIG VSRLHPMVLA GSADGSLIIT NAARRLLHGI KNSSATQKSL
610 620 630 640 650
RLWKWDYSIK DDKYRIDSSY EVYPLTVNDV SKAKIDAHGI NITCTKWNET
660 670
SAGGKCYAFS NSAGLLTLEY LS
Length:672
Mass (Da):74,709
Last modified:November 1, 1996 - v1
Checksum:i744D6D6A1923B076
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA. Translation: AAB64796.1.
BK006938 Genomic DNA. Translation: DAA12200.1.
PIRiS61157.
RefSeqiNP_010649.1. NM_001180670.1.

Genome annotation databases

EnsemblFungiiYDR362C; YDR362C; YDR362C.
GeneIDi851964.
KEGGisce:YDR362C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA. Translation: AAB64796.1.
BK006938 Genomic DNA. Translation: DAA12200.1.
PIRiS61157.
RefSeqiNP_010649.1. NM_001180670.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J04X-ray3.20B/D159-672[»]
ProteinModelPortaliQ06339.
SMRiQ06339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32417. 22 interactors.
DIPiDIP-2952N.
IntActiQ06339. 6 interactors.
MINTiMINT-477678.

PTM databases

iPTMnetiQ06339.

Proteomic databases

MaxQBiQ06339.
PRIDEiQ06339.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR362C; YDR362C; YDR362C.
GeneIDi851964.
KEGGisce:YDR362C.

Organism-specific databases

EuPathDBiFungiDB:YDR362C.
SGDiS000002770. TFC6.

Phylogenomic databases

HOGENOMiHOG000001063.
InParanoidiQ06339.
KOiK15205.
OMAiRLWKWDY.
OrthoDBiEOG092C2605.

Enzyme and pathway databases

BioCyciYEAST:G3O-29912-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ06339.
PROiQ06339.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTFC6_YEAST
AccessioniPrimary (citable) accession number: Q06339
Secondary accession number(s): D6VSZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1130 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.