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Protein

ADP-ribosylation factor-binding protein GGA1

Gene

GGA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of membrane traffic through the trans-Golgi network.

GO - Molecular functioni

  • ubiquitin binding Source: SGD

GO - Biological processi

  • Golgi to endosome transport Source: SGD
  • Golgi to vacuole transport Source: SGD
  • protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29909-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-binding protein GGA1
Alternative name(s):
Golgi-localized, gamma ear-containing, ARF-binding protein 1
Gene namesi
Name:GGA1
Ordered Locus Names:YDR358W
ORF Names:D9476.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR358W.
SGDiS000002766. GGA1.

Subcellular locationi

GO - Cellular componenti

  • clathrin adaptor complex Source: InterPro
  • cytosol Source: GOC
  • trans-Golgi network Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126861 – 557ADP-ribosylation factor-binding protein GGA1Add BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei348PhosphothreonineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06336.
PRIDEiQ06336.
TopDownProteomicsiQ06336.

PTM databases

iPTMnetiQ06336.

Interactioni

Subunit structurei

Binds to ARF1 and ARF2.

GO - Molecular functioni

  • ubiquitin binding Source: SGD

Protein-protein interaction databases

BioGridi32414. 63 interactors.
IntActiQ06336. 5 interactors.
MINTiMINT-4482199.

Structurei

Secondary structure

1557
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi445 – 449Combined sources5
Beta strandi451 – 461Combined sources11
Beta strandi463 – 475Combined sources13
Beta strandi477 – 479Combined sources3
Beta strandi481 – 488Combined sources8
Beta strandi495 – 498Combined sources4
Beta strandi510 – 522Combined sources13
Helixi523 – 526Combined sources4
Beta strandi531 – 541Combined sources11
Beta strandi544 – 554Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CN1X-ray2.31A/B/C/D433-557[»]
5CN2X-ray2.25A/B433-557[»]
ProteinModelPortaliQ06336.
SMRiQ06336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 165VHSPROSITE-ProRule annotationAdd BLAST137
Domaini192 – 317GATPROSITE-ProRule annotationAdd BLAST126
Domaini440 – 556GAEPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Contains 1 GAE domain.PROSITE-ProRule annotation
Contains 1 GAT domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00860000133703.
HOGENOMiHOG000209783.
InParanoidiQ06336.
OMAiSHIAEKH.
OrthoDBiEOG092C1LW8.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
2.60.40.1230. 1 hit.
InterProiIPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF02883. Alpha_adaptinC2. 1 hit.
PF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
PS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQRIELTSE PVRKPRSTES SLLRKIQRAC RSTLPEPDLG LNLDVADYIN
60 70 80 90 100
SKQGATPREA VLAIEKLVNN GDTQAAVFAL SLLDVLVKNC GYSIHLQISR
110 120 130 140 150
KEFLNDLVKR FPEQPPLRYS KVQQMILEAI EEWYQTICKH ASYKDDLQYI
160 170 180 190 200
NDMHKLLKYK GYTFPKVGSE NLAVLRPNDQ LRTPSELQEE QERAQAAKLE
210 220 230 240 250
ELLRSGKPDD LKEANKLMKI MAGFKDDTKV AVKQAINNEL NKLKRKADLF
260 270 280 290 300
NEMLTSADEP DLENEAIQEL YGDLKSAQPK FKKLIEEERD DDALVSNLSK
310 320 330 340 350
FNDLVIQLLK RYKSIKGMKE EELNVPDTNE PAKELNLIDF DDDTTANTPS
360 370 380 390 400
VTSPSKSLQP FDDLLGDFNK VSLSSPKSPQ ENDTVVDILG DAHSKSSGID
410 420 430 440 450
LLDFDSQPGE SKTALSAYSN SIVLPNGLLN SSSNSKEITA QSQRHILNQS
460 470 480 490 500
DHLRIDYELT RESMTKLRLV IFYSNISSDP ITNFALLVAS PKGTTLSLQP
510 520 530 540 550
QSGNMLQSNS RDGIKQIASV EGISVNLGKP IKLKWKANYC TKGDSKEESG

TTSLPTI
Length:557
Mass (Da):62,320
Last modified:November 1, 1996 - v1
Checksum:iDBA76787F998DBD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA. Translation: AAB64793.1.
BK006938 Genomic DNA. Translation: DAA12197.1.
PIRiS61154.
RefSeqiNP_010645.1. NM_001180666.1.

Genome annotation databases

EnsemblFungiiYDR358W; YDR358W; YDR358W.
GeneIDi851960.
KEGGisce:YDR358W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA. Translation: AAB64793.1.
BK006938 Genomic DNA. Translation: DAA12197.1.
PIRiS61154.
RefSeqiNP_010645.1. NM_001180666.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CN1X-ray2.31A/B/C/D433-557[»]
5CN2X-ray2.25A/B433-557[»]
ProteinModelPortaliQ06336.
SMRiQ06336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32414. 63 interactors.
IntActiQ06336. 5 interactors.
MINTiMINT-4482199.

PTM databases

iPTMnetiQ06336.

Proteomic databases

MaxQBiQ06336.
PRIDEiQ06336.
TopDownProteomicsiQ06336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR358W; YDR358W; YDR358W.
GeneIDi851960.
KEGGisce:YDR358W.

Organism-specific databases

EuPathDBiFungiDB:YDR358W.
SGDiS000002766. GGA1.

Phylogenomic databases

GeneTreeiENSGT00860000133703.
HOGENOMiHOG000209783.
InParanoidiQ06336.
OMAiSHIAEKH.
OrthoDBiEOG092C1LW8.

Enzyme and pathway databases

BioCyciYEAST:G3O-29909-MONOMER.

Miscellaneous databases

PROiQ06336.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
2.60.40.1230. 1 hit.
InterProiIPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF02883. Alpha_adaptinC2. 1 hit.
PF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
PS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGGA1_YEAST
AccessioniPrimary (citable) accession number: Q06336
Secondary accession number(s): D6VSY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 656 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.