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Protein

ADP-ribosylation factor-binding protein GGA1

Gene

GGA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of membrane traffic through the trans-Golgi network.

GO - Molecular functioni

  • ubiquitin binding Source: SGD

GO - Biological processi

  • Golgi to endosome transport Source: SGD
  • Golgi to vacuole transport Source: SGD
  • protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29909-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-binding protein GGA1
Alternative name(s):
Golgi-localized, gamma ear-containing, ARF-binding protein 1
Gene namesi
Name:GGA1
Ordered Locus Names:YDR358W
ORF Names:D9476.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR358W.
SGDiS000002766. GGA1.

Subcellular locationi

GO - Cellular componenti

  • clathrin adaptor complex Source: InterPro
  • cytosol Source: GOC
  • trans-Golgi network Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557ADP-ribosylation factor-binding protein GGA1PRO_0000212686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei348 – 3481PhosphothreonineCombined sources
Modified residuei353 – 3531PhosphoserineCombined sources
Modified residuei357 – 3571PhosphoserineCombined sources
Modified residuei378 – 3781PhosphoserineCombined sources
Modified residuei394 – 3941PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06336.
TopDownProteomicsiQ06336.

PTM databases

iPTMnetiQ06336.

Interactioni

Subunit structurei

Binds to ARF1 and ARF2.

GO - Molecular functioni

  • ubiquitin binding Source: SGD

Protein-protein interaction databases

BioGridi32414. 63 interactions.
IntActiQ06336. 5 interactions.
MINTiMINT-4482199.

Structurei

3D structure databases

ProteinModelPortaliQ06336.
SMRiQ06336. Positions 20-178, 444-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 165137VHSPROSITE-ProRule annotationAdd
BLAST
Domaini192 – 317126GATPROSITE-ProRule annotationAdd
BLAST
Domaini440 – 556117GAEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GAE domain.PROSITE-ProRule annotation
Contains 1 GAT domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00700000104396.
HOGENOMiHOG000209783.
InParanoidiQ06336.
OMAiSHIAEKH.
OrthoDBiEOG092C1LW8.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
2.60.40.1230. 1 hit.
InterProiIPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF02883. Alpha_adaptinC2. 1 hit.
PF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
PS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQRIELTSE PVRKPRSTES SLLRKIQRAC RSTLPEPDLG LNLDVADYIN
60 70 80 90 100
SKQGATPREA VLAIEKLVNN GDTQAAVFAL SLLDVLVKNC GYSIHLQISR
110 120 130 140 150
KEFLNDLVKR FPEQPPLRYS KVQQMILEAI EEWYQTICKH ASYKDDLQYI
160 170 180 190 200
NDMHKLLKYK GYTFPKVGSE NLAVLRPNDQ LRTPSELQEE QERAQAAKLE
210 220 230 240 250
ELLRSGKPDD LKEANKLMKI MAGFKDDTKV AVKQAINNEL NKLKRKADLF
260 270 280 290 300
NEMLTSADEP DLENEAIQEL YGDLKSAQPK FKKLIEEERD DDALVSNLSK
310 320 330 340 350
FNDLVIQLLK RYKSIKGMKE EELNVPDTNE PAKELNLIDF DDDTTANTPS
360 370 380 390 400
VTSPSKSLQP FDDLLGDFNK VSLSSPKSPQ ENDTVVDILG DAHSKSSGID
410 420 430 440 450
LLDFDSQPGE SKTALSAYSN SIVLPNGLLN SSSNSKEITA QSQRHILNQS
460 470 480 490 500
DHLRIDYELT RESMTKLRLV IFYSNISSDP ITNFALLVAS PKGTTLSLQP
510 520 530 540 550
QSGNMLQSNS RDGIKQIASV EGISVNLGKP IKLKWKANYC TKGDSKEESG

TTSLPTI
Length:557
Mass (Da):62,320
Last modified:November 1, 1996 - v1
Checksum:iDBA76787F998DBD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA. Translation: AAB64793.1.
BK006938 Genomic DNA. Translation: DAA12197.1.
PIRiS61154.
RefSeqiNP_010645.1. NM_001180666.1.

Genome annotation databases

EnsemblFungiiYDR358W; YDR358W; YDR358W.
GeneIDi851960.
KEGGisce:YDR358W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA. Translation: AAB64793.1.
BK006938 Genomic DNA. Translation: DAA12197.1.
PIRiS61154.
RefSeqiNP_010645.1. NM_001180666.1.

3D structure databases

ProteinModelPortaliQ06336.
SMRiQ06336. Positions 20-178, 444-557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32414. 63 interactions.
IntActiQ06336. 5 interactions.
MINTiMINT-4482199.

PTM databases

iPTMnetiQ06336.

Proteomic databases

MaxQBiQ06336.
TopDownProteomicsiQ06336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR358W; YDR358W; YDR358W.
GeneIDi851960.
KEGGisce:YDR358W.

Organism-specific databases

EuPathDBiFungiDB:YDR358W.
SGDiS000002766. GGA1.

Phylogenomic databases

GeneTreeiENSGT00700000104396.
HOGENOMiHOG000209783.
InParanoidiQ06336.
OMAiSHIAEKH.
OrthoDBiEOG092C1LW8.

Enzyme and pathway databases

BioCyciYEAST:G3O-29909-MONOMER.

Miscellaneous databases

PROiQ06336.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
2.60.40.1230. 1 hit.
InterProiIPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF02883. Alpha_adaptinC2. 1 hit.
PF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
PS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGGA1_YEAST
AccessioniPrimary (citable) accession number: Q06336
Secondary accession number(s): D6VSY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 656 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.