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Protein

Amyloid-like protein 2

Gene

Aplp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein (By similarity). Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular copper ion homeostasis Source: MGI
  • cholesterol metabolic process Source: MGI
  • extracellular matrix organization Source: MGI
  • forebrain development Source: MGI
  • locomotory behavior Source: MGI
  • mating behavior Source: MGI
  • midbrain development Source: MGI
  • neuromuscular process controlling balance Source: MGI
  • regulation of epidermal growth factor-activated receptor activity Source: MGI
  • regulation of protein binding Source: MGI
  • suckling behavior Source: MGI

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-like protein 2
Short name:
APLP-2
Alternative name(s):
CDEI box-binding protein
Short name:
CDEBP
Gene namesi
Name:Aplp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88047 Aplp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 636ExtracellularSequence analysisAdd BLAST605
Transmembranei637 – 660HelicalSequence analysisAdd BLAST24
Topological domaini661 – 707CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000000020832 – 707Amyloid-like protein 2Add BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216PhosphoserineBy similarity1
Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei534PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ06335
PaxDbiQ06335
PeptideAtlasiQ06335
PRIDEiQ06335

PTM databases

iPTMnetiQ06335
PhosphoSitePlusiQ06335

Expressioni

Gene expression databases

BgeeiENSMUSG00000031996
CleanExiMM_APLP2
ExpressionAtlasiQ06335 baseline and differential
GenevisibleiQ06335 MM

Interactioni

Subunit structurei

Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AppP120233EBI-446708,EBI-78814

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198154, 4 interactors
IntActiQ06335, 12 interactors
MINTiQ06335
STRINGi10090.ENSMUSP00000072428

Structurei

3D structure databases

ProteinModelPortaliQ06335
SMRiQ06335
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni693 – 707Interaction with DAB21 PublicationAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi694 – 699NPXY motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 294Asp/Glu-rich (highly acidic)Add BLAST77
Compositional biasi218 – 231Poly-GluAdd BLAST14
Compositional biasi256 – 266Poly-GluAdd BLAST11

Sequence similaritiesi

Belongs to the APP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3540 Eukaryota
ENOG410ZW2A LUCA
GeneTreeiENSGT00530000063252
HOGENOMiHOG000232190
HOVERGENiHBG000051
InParanoidiQ06335
KOiK08117

Family and domain databases

Gene3Di1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
InterProiView protein in InterPro
IPR036669 Amyloid_Cu-bd_sf
IPR008155 Amyloid_glyco
IPR011178 Amyloid_glyco_Cu-bd
IPR024329 Amyloid_glyco_E2_domain
IPR008154 Amyloid_glyco_extra
IPR019744 Amyloid_glyco_extracell_CS
IPR015849 Amyloid_glyco_heparin-bd
IPR036454 Amyloid_glyco_heparin-bd_sf
IPR019745 Amyloid_glyco_intracell_CS
IPR019543 APP_amyloid_C
IPR036176 E2_sf
IPR011993 PH-like_dom_sf
PANTHERiPTHR23103 PTHR23103, 2 hits
PfamiView protein in Pfam
PF10515 APP_amyloid, 1 hit
PF12924 APP_Cu_bd, 1 hit
PF12925 APP_E2, 1 hit
PF02177 APP_N, 1 hit
PRINTSiPR00203 AMYLOIDA4
SMARTiView protein in SMART
SM00006 A4_EXTRA, 1 hit
SUPFAMiSSF109843 SSF109843, 1 hit
SSF56491 SSF56491, 1 hit
SSF89811 SSF89811, 1 hit
PROSITEiView protein in PROSITE
PS00319 A4_EXTRA, 1 hit
PS00320 A4_INTRA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q06335-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATGTAAAA ATGKLLVLLL LGLTAPAAAL AGYIEALAAN AGTGFAVAEP
60 70 80 90 100
QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC LGTKEEVLQY CQEIYPELQI
110 120 130 140 150
TNVMEANQPV NIDSWCRRDK RQCKSHIVIP FKCLVGEFVS DVLLVPDNCQ
160 170 180 190 200
FFHQERMEVC EKHQRWHTLV KEACLTEGLT LYSYGMLLPC GVDQFHGTEY
210 220 230 240 250
VCCPQTKTVD SDSTMSKEEE EEEEDEEDEE EDYDLDKSEF PTEADLEDFT
260 270 280 290 300
EAAADEEEED EEEGEEVVED RDYYYDPFKG DDYNEENPTE PSSEGTISDK
310 320 330 340 350
EIVHDVKVPP TPLPTNDVDV YFETSADDNE HARFQKAKEQ LEIRHRNRMD
360 370 380 390 400
RVKKEWEEAE LQAKNLPKTE RQTLIQHFQA MVKALEKEAA SEKQQLVETH
410 420 430 440 450
LARVEAMLND RRRIALENYL AALQSDPPRP HRILQALRRY VRAENKDRLH
460 470 480 490 500
TIRHYQHVLA VDPEKAAQMK SQVMTHLHVI EERRNQSLSL LYKVPYVAQE
510 520 530 540 550
IQEEIDELLQ EQRADMDQFT SSISENPVDV RVSSEESEEI PPFHPLHPFP
560 570 580 590 600
SLSENEDTQP ELYHPMKKGS GMAEQDGGLI GAEEKVINSK NKMDENMVID
610 620 630 640 650
ETLDVKEMIF NAERVGGLEE EPESVGPLRE DFSLSSNALI GLLVIAVAIA
660 670 680 690 700
TVIVISLVML RKRQYGTISH GIVEVDPMLT PEERHLNKMQ NHGYENPTYK

YLEQMQI
Length:707
Mass (Da):80,467
Last modified:June 28, 2011 - v4
Checksum:iBBB8C3E25A6CC503
GO
Isoform 2 (identifier: Q06335-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-568: Missing.

Show »
Length:695
Mass (Da):78,998
Checksum:iADB62430849EF6AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55F → L in CAA80306 (Ref. 1) Curated1
Sequence conflicti185 – 189GMLLP → MACCC in AAA20039 (PubMed:1482349).Curated5
Sequence conflicti322F → L in CAA80306 (Ref. 1) Curated1
Sequence conflicti322F → L in AAA20039 (PubMed:1482349).Curated1
Sequence conflicti489S → T in CAA80306 (Ref. 1) Curated1
Sequence conflicti489S → T in AAA20039 (PubMed:1482349).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041386557 – 568Missing in isoform 2. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22592 mRNA Translation: CAA80306.1
BC051999 mRNA Translation: AAH51999.1
M97216 mRNA Translation: AAA20039.1
U34291 Genomic DNA Translation: AAC52318.1
CCDSiCCDS52748.1 [Q06335-1]
PIRiJC1404
S38344
RefSeqiNP_001095926.1, NM_001102456.1 [Q06335-1]
UniGeneiMm.19133

Genome annotation databases

EnsembliENSMUST00000079758; ENSMUSP00000078694; ENSMUSG00000031996 [Q06335-1]
ENSMUST00000217641; ENSMUSP00000149023; ENSMUSG00000031996 [Q06335-2]
GeneIDi11804
KEGGimmu:11804
UCSCiuc009orl.1 mouse [Q06335-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAPLP2_MOUSE
AccessioniPrimary (citable) accession number: Q06335
Secondary accession number(s): Q80US7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 153 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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