Amyloid-like protein 2 precursor - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot Q06335 (APLP2_MOUSE)

Last modified June 16, 2009. Version 81. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Amyloid-like protein 2
Alternative name(s):
    CDEI box-binding protein
      Short name=CDEBP

Gene names

Name:

Aplp2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	695 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Binds to the DNA 5'-GTCACATG-3'(CDEI box) which plays an important role in the early development of embryos.
Subunit structure	Interacts with CPEB1. Ref.5
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential. Nucleus Potential.
Sequence similarities	Belongs to the APP family.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane Nucleus
Domain	Signal Transmembrane
Ligand	DNA-binding
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	cellular copper ion homeostasis Inferred from mutant phenotype. Source: MGI embryonic development Inferred from genetic interaction. Source: MGI extracellular matrix organization Inferred from genetic interaction. Source: MGI forebrain development Inferred from genetic interaction. Source: MGI locomotory behavior Inferred from genetic interaction. Source: MGI mating behavior Inferred from genetic interaction. Source: MGI midbrain development Inferred from genetic interaction. Source: MGI neuromuscular process controlling balance Inferred from genetic interaction. Source: MGI regulation of epidermal growth factor receptor activity Inferred from genetic interaction. Source: MGI suckling behavior Inferred from genetic interaction. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.5 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
Aplp1	Q03157	1	EBI-446708,EBI-399929
App	P12023	1	EBI-446708,EBI-78814
Dab1	P97318	1	EBI-446708,EBI-81680

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

Potential

Chain

30 – 695

666

Amyloid-like protein 2

PRO_0000000208

Regions

Topological domain

30 – 624

595

Extracellular Potential

Transmembrane

625 – 648

Potential

Topological domain

649 – 695

Cytoplasmic Potential

Compositional bias

218 – 294

Asp/Glu-rich (highly acidic)

Compositional bias

218 – 231

Poly-Glu

Compositional bias

256 – 266

Poly-Glu

Amino acid modifications

Modified residue

682

Phosphotyrosine By similarity

Modified residue

687

Phosphotyrosine By similarity

Glycosylation

485

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

185 – 189

GMLLP → MACCC Ref.3

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Sequences

Sequence

Length

Mass (Da)

Tools

Q06335-1 [UniParc].

Last modified February 1, 1996. Version 3.
Checksum: BBF4B95AAB2A0311
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FASTA

695

78,944

        10         20         30         40         50         60 
MAATGTAAAA ATGKLLVLLL LGLTAPAAAL AGYIEALAAN AGTGFAVAEP QIAMLCGKLN 

        70         80         90        100        110        120 
MHVNIQTGKW EPDPTGTKSC LGTKEEVLQY CQEIYPELQI TNVMEANQPV NIDSWCRRDK 

       130        140        150        160        170        180 
RQCKSHIVIP FKCLVGEFVS DVLLVPDNCQ FFHQERMEVC EKHQRWHTLV KEACLTEGLT 

       190        200        210        220        230        240 
LYSYGMLLPC GVDQFHGTEY VCCPQTKTVD SDSTMSKEEE EEEEDEEDEE EDYDLDKSEF 

       250        260        270        280        290        300 
PTEADLEDFT EAAADEEEED EEEGEEVVED RDYYYDPFKG DDYNEENPTE PSSEGTISDK 

       310        320        330        340        350        360 
EIVHDVKVPP TPLPTNDVDV YLETSADDNE HARFQKAKEQ LEIRHRNRMD RVKKEWEEAE 

       370        380        390        400        410        420 
LQAKNLPKTE RQTLIQHFQA MVKALEKEAA SEKQQLVETH LARVEAMLND RRRIALENYL 

       430        440        450        460        470        480 
AALQSDPPRP HRILQALRRY VRAENKDRLH TIRHYQHVLA VDPEKAAQMK SQVMTHLHVI 

       490        500        510        520        530        540 
EERRNQSLTL LYKVPYVAQE IQEEIDELLQ EQRADMDQFT SSISENPVDV RVSSEESEEI 

       550        560        570        580        590        600 
PPFHPLHPFP SLSENEGSGM AEQDGGLIGA EEKVINSKNK MDENMVIDET LDVKEMIFNA 

       610        620        630        640        650        660 
ERVGGLEEEP ESVGPLREDF SLSSNALIGL LVIAVAIATV IVISLVMLRK RQYGTISHGI 

       670        680        690 
VEVDPMLTPE ERHLNKMQNH GYENPTYKYL EQMQI

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References

[1]	von der Kammer H. Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Fetal brain.
[2]	"The complete cDNA coding sequence for the mouse CDEI binding protein." Hanes J., von der Kammer H., Kristjansson G.I., Scheit K.H. Biochim. Biophys. Acta 1216:154-156(1993) [PubMed: 8218408] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-246.
[3]	"A murine sequence-specific DNA binding protein shows extensive local similarities to the amyloid precursor protein." Vidal F., Blangy A., Rassoulzadegan M., Cuzin F. Biochem. Biophys. Res. Commun. 189:1336-1341(1992) [PubMed: 1482349] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 185-695. Strain: BALB/c. Tissue: Heart.
[4]	"The mouse APLP2 gene. Chromosomal localization and promoter characterization." von Koch C.S., Lahiri D.K., Mammen A.L., Copeland N.G., Gilbert D.J., Jenkins N.A., Sisodia S.S. J. Biol. Chem. 270:25475-25480(1995) [PubMed: 7592716] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35. Strain: 129/Sv.
[5]	"Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation." Cao Q., Huang Y.-S., Kan M.-C., Richter J.D. Mol. Cell. Biol. 25:10930-10939(2005) [PubMed: 16314516] [Abstract] Cited for: INTERACTION WITH CPEB1.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	Z22592 mRNA. Translation: CAA80306.1. M97216 mRNA. Translation: AAA20039.1. U34291 Genomic DNA. Translation: AAC52318.1.
IPI	IPI00856197.
PIR	JC1404. S38344.
RefSeq	NP_001095925.1. NP_001095926.1.
UniGene	Mm.19133
3D structure databases
HSSP	HSSP built from PDB template 1MWP based on UniProtKB P05067.
SMR	Q06335. Positions 47-139.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q06335. 11 interactions.
PTM databases
PhosphoSite	Q06335.
Genome annotation databases
Ensembl	ENSMUSG00000031996. Mus musculus. [Contig view]
GeneID	11804.
KEGG	mmu:11804.
Organism-specific databases
MGI	MGI:88047. Aplp2.
Phylogenomic databases
HOVERGEN	Q06335.
Gene expression databases
ArrayExpress	Q06335.
Bgee	Q06335.
CleanEx	MM_APLP2.
GermOnline	ENSMUSG00000031996. Mus musculus.
Family and domain databases
InterPro	IPR008155. Amyloid_glyco. IPR011178. Amyloid_glyco_Cu-bd. IPR008154. Amyloid_glyco_extra. IPR019744. Amyloid_glyco_extracell_CS. IPR015849. Amyloid_glyco_heparin-bd. IPR019745. Amyloid_glyco_intracell_CS. IPR019543. APP_amyloid. [Graphical view]
Gene3D	G3DSA:3.30.1490.140. Amyloid_glyco_Cu-bd. 1 hit. G3DSA:3.90.570.10. Amyloid_glyco_heparin-bd. 1 hit.
Pfam	PF02177. A4_EXTRA. 1 hit. PF10515. APP_amyloid. 1 hit. [Graphical view]
PRINTS	PR00203. AMYLOIDA4.
SMART	SM00006. A4_EXTRA. 1 hit. [Graphical view]
PROSITE	PS00319. A4_EXTRA. 1 hit. PS00320. A4_INTRA. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	279659.
SOURCE	Search...

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Entry information

Entry name

APLP2_MOUSE

Accession

Primary (citable) accession number: Q06335

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents