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Protein

Lymphotoxin-alpha

Gene

Lta

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

GO - Biological processi

  • defense response to Gram-positive bacterium Source: Ensembl
  • humoral immune response Source: Ensembl
  • lymph node development Source: Ensembl
  • negative regulation of fibroblast proliferation Source: RGD
  • negative regulation of growth of symbiont in host Source: Ensembl
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
  • positive regulation of glial cell proliferation Source: RGD
  • positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  • positive regulation of interferon-gamma production Source: Ensembl
  • response to drug Source: RGD
  • response to hypoxia Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to nutrient Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-RNO-5668541. TNFR2 non-canonical NF-kB pathway.
R-RNO-5669034. TNFs bind their physiological receptors.
R-RNO-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotoxin-alpha
Short name:
LT-alpha
Alternative name(s):
TNF-beta
Tumor necrosis factor ligand superfamily member 1
Gene namesi
Name:Lta
Synonyms:Tnfb, Tnfsf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi3020. Lta.

Subcellular locationi

  • Secreted By similarity
  • Membrane By similarity

  • Note: The homotrimer is secreted. The heterotrimer is membrane-associated.By similarity

GO - Cellular componenti

  • extracellular space Source: RGD
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333By similarityAdd
BLAST
Chaini34 – 202169Lymphotoxin-alphaPRO_0000034471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ06332.
PRIDEiQ06332.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000838.
GenevisibleiQ06332. RN.

Interactioni

Subunit structurei

Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001111.

Structurei

3D structure databases

ProteinModelPortaliQ06332.
SMRiQ06332. Positions 59-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWT9. Eukaryota.
ENOG410YQC4. LUCA.
GeneTreeiENSGT00530000062992.
HOGENOMiHOG000048729.
HOVERGENiHBG012516.
InParanoidiQ06332.
KOiK05468.
OMAiFPKATPT.
OrthoDBiEOG091G0HIG.
PhylomeDBiQ06332.
TreeFamiTF332169.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002960. TNF_beta.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01236. TNFBETA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPLGRLHLL RVLSTPPVFL LGLLLALPLG AQGLSGVRFS ASRTAHQPPQ
60 70 80 90 100
KHLTHGLLKP AAHLVGYPSK QNSLLWRANT DRAFLRHGFS LNNNSLLIPT
110 120 130 140 150
SGLYFVYSQV VFSGESCSPR AIPTPIYLAH EVQLFSSQYP FHVPLLSAQK
160 170 180 190 200
SVYPGLQGPW VRSMYQGAVF LLSKGDQLST HTDGISHLHF SPSTVFFGAF

AL
Length:202
Mass (Da):22,112
Last modified:June 1, 1994 - v1
Checksum:iA56963CE33AE0C08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00981 Genomic DNA. Translation: AAA16276.1.
BX883046 Genomic DNA. Translation: CAE84004.1.
PIRiJN0869.
RefSeqiNP_542947.1. NM_080769.2.
UniGeneiRn.160577.

Genome annotation databases

EnsembliENSRNOT00000001111; ENSRNOP00000001111; ENSRNOG00000000838.
ENSRNOT00000088936; ENSRNOP00000069608; ENSRNOG00000000838.
GeneIDi25008.
KEGGirno:25008.
UCSCiRGD:3020. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00981 Genomic DNA. Translation: AAA16276.1.
BX883046 Genomic DNA. Translation: CAE84004.1.
PIRiJN0869.
RefSeqiNP_542947.1. NM_080769.2.
UniGeneiRn.160577.

3D structure databases

ProteinModelPortaliQ06332.
SMRiQ06332. Positions 59-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001111.

Proteomic databases

PaxDbiQ06332.
PRIDEiQ06332.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001111; ENSRNOP00000001111; ENSRNOG00000000838.
ENSRNOT00000088936; ENSRNOP00000069608; ENSRNOG00000000838.
GeneIDi25008.
KEGGirno:25008.
UCSCiRGD:3020. rat.

Organism-specific databases

CTDi4049.
RGDi3020. Lta.

Phylogenomic databases

eggNOGiENOG410IWT9. Eukaryota.
ENOG410YQC4. LUCA.
GeneTreeiENSGT00530000062992.
HOGENOMiHOG000048729.
HOVERGENiHBG012516.
InParanoidiQ06332.
KOiK05468.
OMAiFPKATPT.
OrthoDBiEOG091G0HIG.
PhylomeDBiQ06332.
TreeFamiTF332169.

Enzyme and pathway databases

ReactomeiR-RNO-5668541. TNFR2 non-canonical NF-kB pathway.
R-RNO-5669034. TNFs bind their physiological receptors.
R-RNO-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Miscellaneous databases

PROiQ06332.

Gene expression databases

BgeeiENSRNOG00000000838.
GenevisibleiQ06332. RN.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002960. TNF_beta.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01236. TNFBETA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNFB_RAT
AccessioniPrimary (citable) accession number: Q06332
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.