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Protein

Lymphotoxin-alpha

Gene

Lta

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

GO - Molecular functioni

GO - Biological processi

  • defense response to Gram-positive bacterium Source: Ensembl
  • humoral immune response Source: Ensembl
  • lymph node development Source: Ensembl
  • negative regulation of fibroblast proliferation Source: RGD
  • negative regulation of growth of symbiont in host Source: Ensembl
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
  • positive regulation of glial cell proliferation Source: RGD
  • positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  • positive regulation of interferon-gamma production Source: Ensembl
  • response to drug Source: RGD
  • response to hypoxia Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to nutrient Source: RGD

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-RNO-5668541 TNFR2 non-canonical NF-kB pathway
R-RNO-5669034 TNFs bind their physiological receptors
R-RNO-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotoxin-alpha
Short name:
LT-alpha
Alternative name(s):
TNF-beta
Tumor necrosis factor ligand superfamily member 1
Gene namesi
Name:Lta
Synonyms:Tnfb, Tnfsf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi3020 Lta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33By similarityAdd BLAST33
ChainiPRO_000003447134 – 202Lymphotoxin-alphaAdd BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ06332
PRIDEiQ06332

Expressioni

Gene expression databases

BgeeiENSRNOG00000000838
GenevisibleiQ06332 RN

Interactioni

Subunit structurei

Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001111

Structurei

3D structure databases

ProteinModelPortaliQ06332
SMRiQ06332
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWT9 Eukaryota
ENOG410YQC4 LUCA
GeneTreeiENSGT00530000062992
HOGENOMiHOG000048729
HOVERGENiHBG012516
InParanoidiQ06332
KOiK05468
OMAiQYPFHVP
OrthoDBiEOG091G0HIG
PhylomeDBiQ06332
TreeFamiTF332169

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002960 TNF_beta
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01236 TNFBETA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPLGRLHLL RVLSTPPVFL LGLLLALPLG AQGLSGVRFS ASRTAHQPPQ
60 70 80 90 100
KHLTHGLLKP AAHLVGYPSK QNSLLWRANT DRAFLRHGFS LNNNSLLIPT
110 120 130 140 150
SGLYFVYSQV VFSGESCSPR AIPTPIYLAH EVQLFSSQYP FHVPLLSAQK
160 170 180 190 200
SVYPGLQGPW VRSMYQGAVF LLSKGDQLST HTDGISHLHF SPSTVFFGAF

AL
Length:202
Mass (Da):22,112
Last modified:June 1, 1994 - v1
Checksum:iA56963CE33AE0C08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00981 Genomic DNA Translation: AAA16276.1
BX883046 Genomic DNA Translation: CAE84004.1
PIRiJN0869
RefSeqiNP_542947.1, NM_080769.2
XP_017457036.1, XM_017601547.1
UniGeneiRn.160577

Genome annotation databases

EnsembliENSRNOT00000001111; ENSRNOP00000001111; ENSRNOG00000000838
ENSRNOT00000088936; ENSRNOP00000069608; ENSRNOG00000000838
GeneIDi25008
KEGGirno:25008
UCSCiRGD:3020 rat

Similar proteinsi

Entry informationi

Entry nameiTNFB_RAT
AccessioniPrimary (citable) accession number: Q06332
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health