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Protein

Aspartic proteinase yapsin-7

Gene

YPS7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741By similarity
Active sitei321 – 3211By similarity

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: SGD

GO - Biological processi

  • fungal-type cell wall organization Source: SGD
  • protein catabolic process Source: GO_Central
  • proteolysis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BioCyciYEAST:G3O-29903-MONOMER.

Protein family/group databases

MEROPSiA01.097.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase yapsin-7 (EC:3.4.23.-)
Gene namesi
Name:YPS7
Ordered Locus Names:YDR349C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR349C.
SGDiS000002757. YPS7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 575550LumenalSequence analysisAdd
BLAST
Transmembranei576 – 59621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 596571Aspartic proteinase yapsin-7PRO_0000270564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence analysis
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence analysis
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence analysis
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence analysis
Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence analysis
Glycosylationi552 – 5521N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ06325.

Interactioni

Protein-protein interaction databases

BioGridi32405. 44 interactions.
DIPiDIP-5244N.
MINTiMINT-554357.

Structurei

3D structure databases

ProteinModelPortaliQ06325.
SMRiQ06325. Positions 161-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 440385Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075429.
HOGENOMiHOG000141723.
InParanoidiQ06325.
OMAiYDTSRTT.
OrthoDBiEOG790G92.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 2 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 2 hits.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCLILWYLW LISTFQLEFA TASTANTTTT AKSGTSSSTE EPFPVLAVGK
60 70 80 90 100
DGRGNYYVNS TFGTPGQRQR LLVDIIQPYI NLVSGTSESH NEYSGVYHKH
110 120 130 140 150
PSYLMNDSTS SVPVSPGQIY EISFIDGRAV NCTLVTDDMN FTNVSSENSS
160 170 180 190 200
TALITDLMVT RDNVQFNSGS LSISNVSFFD IQSSNFKTSG LLGLSGKVTN
210 220 230 240 250
PGNAIDSSQY TEQSYFLSLL KDADIIESSS YSLWLAGDTS TYKTYRDPIS
260 270 280 290 300
NCGKLLLGGV DPSLFTGTLG KFDLIPYVDP VSNAVSVGYP IVPLGPIYIV
310 320 330 340 350
SNSGQSLNMT SKDFLSPALL DSTSSVSYLP TSTIIQIAVQ IAATYVESLD
360 370 380 390 400
RWLVQCSIAD MGVSLGFRLR ELTIEIPLRD LLSSTYDTST NSSMFFSSGQ
410 420 430 440 450
EACFLTLYAN TNTGVNILGE AFIKNIYMAM DLEDNTIAIA QAKKVEDDAV
460 470 480 490 500
TEETNETTAS TIIKKIKSGY IPYAKVMNSS NTRNLTLYPS YRSGYMFTVP
510 520 530 540 550
GQLTAAYSNG VITGAGRSFY DTSRASTSAR PSSTQFDSFS VSASEEWSNS
560 570 580 590
TNRTSSASGA GVRLSSPYTF NKDPAGHVTR IASLLLLSIF SILIVL
Length:596
Mass (Da):64,498
Last modified:November 1, 1996 - v1
Checksum:iE7F4C5BB33FC28CA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991I → V in AAU09709 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA. Translation: AAB64785.1.
AY723792 Genomic DNA. Translation: AAU09709.1.
BK006938 Genomic DNA. Translation: DAA12189.1.
PIRiS61146.
RefSeqiNP_010636.1. NM_001180657.1.

Genome annotation databases

EnsemblFungiiYDR349C; YDR349C; YDR349C.
GeneIDi851950.
KEGGisce:YDR349C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA. Translation: AAB64785.1.
AY723792 Genomic DNA. Translation: AAU09709.1.
BK006938 Genomic DNA. Translation: DAA12189.1.
PIRiS61146.
RefSeqiNP_010636.1. NM_001180657.1.

3D structure databases

ProteinModelPortaliQ06325.
SMRiQ06325. Positions 161-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32405. 44 interactions.
DIPiDIP-5244N.
MINTiMINT-554357.

Protein family/group databases

MEROPSiA01.097.

Proteomic databases

MaxQBiQ06325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR349C; YDR349C; YDR349C.
GeneIDi851950.
KEGGisce:YDR349C.

Organism-specific databases

EuPathDBiFungiDB:YDR349C.
SGDiS000002757. YPS7.

Phylogenomic databases

GeneTreeiENSGT00550000075429.
HOGENOMiHOG000141723.
InParanoidiQ06325.
OMAiYDTSRTT.
OrthoDBiEOG790G92.

Enzyme and pathway databases

BioCyciYEAST:G3O-29903-MONOMER.

Miscellaneous databases

PROiQ06325.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 2 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 2 hits.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae."
    Krysan D.J., Ting E.L., Abeijon C., Kroos L., Fuller R.S.
    Eukaryot. Cell 4:1364-1374(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiYPS7_YEAST
AccessioniPrimary (citable) accession number: Q06325
Secondary accession number(s): D6VSX9, Q66RD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.