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Protein

Aspartic proteinase yapsin-7

Gene

YPS7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74By similarity1
Active sitei321By similarity1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: SGD

GO - Biological processi

  • fungal-type cell wall organization Source: SGD
  • protein catabolic process Source: GO_Central
  • proteolysis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BioCyciYEAST:G3O-29903-MONOMER.

Protein family/group databases

MEROPSiA01.097.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase yapsin-7 (EC:3.4.23.-)
Gene namesi
Name:YPS7
Ordered Locus Names:YDR349C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR349C.
SGDiS000002757. YPS7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 575LumenalSequence analysisAdd BLAST550
Transmembranei576 – 596HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000027056426 – 596Aspartic proteinase yapsin-7Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1
Glycosylationi308N-linked (GlcNAc...)Sequence analysis1
Glycosylationi391N-linked (GlcNAc...)Sequence analysis1
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1
Glycosylationi484N-linked (GlcNAc...)Sequence analysis1
Glycosylationi549N-linked (GlcNAc...)Sequence analysis1
Glycosylationi552N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ06325.
PRIDEiQ06325.

Interactioni

Protein-protein interaction databases

BioGridi32405. 44 interactors.
DIPiDIP-5244N.
MINTiMINT-554357.

Structurei

3D structure databases

ProteinModelPortaliQ06325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 440Peptidase A1PROSITE-ProRule annotationAdd BLAST385

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075429.
HOGENOMiHOG000141723.
InParanoidiQ06325.
OMAiYDTSRTT.
OrthoDBiEOG092C4AA1.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 2 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 2 hits.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCLILWYLW LISTFQLEFA TASTANTTTT AKSGTSSSTE EPFPVLAVGK
60 70 80 90 100
DGRGNYYVNS TFGTPGQRQR LLVDIIQPYI NLVSGTSESH NEYSGVYHKH
110 120 130 140 150
PSYLMNDSTS SVPVSPGQIY EISFIDGRAV NCTLVTDDMN FTNVSSENSS
160 170 180 190 200
TALITDLMVT RDNVQFNSGS LSISNVSFFD IQSSNFKTSG LLGLSGKVTN
210 220 230 240 250
PGNAIDSSQY TEQSYFLSLL KDADIIESSS YSLWLAGDTS TYKTYRDPIS
260 270 280 290 300
NCGKLLLGGV DPSLFTGTLG KFDLIPYVDP VSNAVSVGYP IVPLGPIYIV
310 320 330 340 350
SNSGQSLNMT SKDFLSPALL DSTSSVSYLP TSTIIQIAVQ IAATYVESLD
360 370 380 390 400
RWLVQCSIAD MGVSLGFRLR ELTIEIPLRD LLSSTYDTST NSSMFFSSGQ
410 420 430 440 450
EACFLTLYAN TNTGVNILGE AFIKNIYMAM DLEDNTIAIA QAKKVEDDAV
460 470 480 490 500
TEETNETTAS TIIKKIKSGY IPYAKVMNSS NTRNLTLYPS YRSGYMFTVP
510 520 530 540 550
GQLTAAYSNG VITGAGRSFY DTSRASTSAR PSSTQFDSFS VSASEEWSNS
560 570 580 590
TNRTSSASGA GVRLSSPYTF NKDPAGHVTR IASLLLLSIF SILIVL
Length:596
Mass (Da):64,498
Last modified:November 1, 1996 - v1
Checksum:iE7F4C5BB33FC28CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299I → V in AAU09709 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA. Translation: AAB64785.1.
AY723792 Genomic DNA. Translation: AAU09709.1.
BK006938 Genomic DNA. Translation: DAA12189.1.
PIRiS61146.
RefSeqiNP_010636.1. NM_001180657.1.

Genome annotation databases

EnsemblFungiiYDR349C; YDR349C; YDR349C.
GeneIDi851950.
KEGGisce:YDR349C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA. Translation: AAB64785.1.
AY723792 Genomic DNA. Translation: AAU09709.1.
BK006938 Genomic DNA. Translation: DAA12189.1.
PIRiS61146.
RefSeqiNP_010636.1. NM_001180657.1.

3D structure databases

ProteinModelPortaliQ06325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32405. 44 interactors.
DIPiDIP-5244N.
MINTiMINT-554357.

Protein family/group databases

MEROPSiA01.097.

Proteomic databases

MaxQBiQ06325.
PRIDEiQ06325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR349C; YDR349C; YDR349C.
GeneIDi851950.
KEGGisce:YDR349C.

Organism-specific databases

EuPathDBiFungiDB:YDR349C.
SGDiS000002757. YPS7.

Phylogenomic databases

GeneTreeiENSGT00550000075429.
HOGENOMiHOG000141723.
InParanoidiQ06325.
OMAiYDTSRTT.
OrthoDBiEOG092C4AA1.

Enzyme and pathway databases

BioCyciYEAST:G3O-29903-MONOMER.

Miscellaneous databases

PROiQ06325.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 2 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 2 hits.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYPS7_YEAST
AccessioniPrimary (citable) accession number: Q06325
Secondary accession number(s): D6VSX9, Q66RD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.