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Protein

Aspartic proteinase yapsin-7

Gene

YPS7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74By similarity1
Active sitei321By similarity1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: SGD

GO - Biological processi

  • fungal-type cell wall organization Source: SGD
  • protein catabolic process Source: GO_Central
  • proteolysis Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

BioCyciYEAST:G3O-29903-MONOMER

Protein family/group databases

MEROPSiA01.097

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase yapsin-7 (EC:3.4.23.-)
Gene namesi
Name:YPS7
Ordered Locus Names:YDR349C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR349C
SGDiS000002757 YPS7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 575LumenalSequence analysisAdd BLAST550
Transmembranei576 – 596HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000027056426 – 596Aspartic proteinase yapsin-7Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi552N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ06325
PaxDbiQ06325
PRIDEiQ06325

Interactioni

Protein-protein interaction databases

BioGridi32405, 75 interactors
DIPiDIP-5244N
IntActiQ06325, 3 interactors
STRINGi4932.YDR349C

Structurei

3D structure databases

ProteinModelPortaliQ06325
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 440Peptidase A1PROSITE-ProRule annotationAdd BLAST385

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075429
HOGENOMiHOG000141723
InParanoidiQ06325
OMAiYDTSRTT
OrthoDBiEOG092C4AA1

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 2 hits
PROSITEiView protein in PROSITE
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCLILWYLW LISTFQLEFA TASTANTTTT AKSGTSSSTE EPFPVLAVGK
60 70 80 90 100
DGRGNYYVNS TFGTPGQRQR LLVDIIQPYI NLVSGTSESH NEYSGVYHKH
110 120 130 140 150
PSYLMNDSTS SVPVSPGQIY EISFIDGRAV NCTLVTDDMN FTNVSSENSS
160 170 180 190 200
TALITDLMVT RDNVQFNSGS LSISNVSFFD IQSSNFKTSG LLGLSGKVTN
210 220 230 240 250
PGNAIDSSQY TEQSYFLSLL KDADIIESSS YSLWLAGDTS TYKTYRDPIS
260 270 280 290 300
NCGKLLLGGV DPSLFTGTLG KFDLIPYVDP VSNAVSVGYP IVPLGPIYIV
310 320 330 340 350
SNSGQSLNMT SKDFLSPALL DSTSSVSYLP TSTIIQIAVQ IAATYVESLD
360 370 380 390 400
RWLVQCSIAD MGVSLGFRLR ELTIEIPLRD LLSSTYDTST NSSMFFSSGQ
410 420 430 440 450
EACFLTLYAN TNTGVNILGE AFIKNIYMAM DLEDNTIAIA QAKKVEDDAV
460 470 480 490 500
TEETNETTAS TIIKKIKSGY IPYAKVMNSS NTRNLTLYPS YRSGYMFTVP
510 520 530 540 550
GQLTAAYSNG VITGAGRSFY DTSRASTSAR PSSTQFDSFS VSASEEWSNS
560 570 580 590
TNRTSSASGA GVRLSSPYTF NKDPAGHVTR IASLLLLSIF SILIVL
Length:596
Mass (Da):64,498
Last modified:November 1, 1996 - v1
Checksum:iE7F4C5BB33FC28CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299I → V in AAU09709 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA Translation: AAB64785.1
AY723792 Genomic DNA Translation: AAU09709.1
BK006938 Genomic DNA Translation: DAA12189.1
PIRiS61146
RefSeqiNP_010636.1, NM_001180657.1

Genome annotation databases

EnsemblFungiiYDR349C; YDR349C; YDR349C
GeneIDi851950
KEGGisce:YDR349C

Similar proteinsi

Entry informationi

Entry nameiYPS7_YEAST
AccessioniPrimary (citable) accession number: Q06325
Secondary accession number(s): D6VSX9, Q66RD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health