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Q06323

- PSME1_HUMAN

UniProt

Q06323 - PSME1_HUMAN

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Protein
Proteasome activator complex subunit 1
Gene
PSME1, IFI5111
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

GO - Molecular functioni

  1. endopeptidase activator activity Source: Ensembl

GO - Biological processi

  1. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
  2. G1/S transition of mitotic cell cycle Source: Reactome
  3. RNA metabolic process Source: Reactome
  4. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
  5. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  6. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  7. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  8. apoptotic process Source: Reactome
  9. cellular nitrogen compound metabolic process Source: Reactome
  10. gene expression Source: Reactome
  11. mRNA metabolic process Source: Reactome
  12. mitotic cell cycle Source: Reactome
  13. negative regulation of apoptotic process Source: Reactome
  14. negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  15. positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  16. protein polyubiquitination Source: Reactome
  17. regulation of apoptotic process Source: Reactome
  18. regulation of cellular amino acid metabolic process Source: Reactome
  19. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  20. small molecule metabolic process Source: Reactome
  21. viral process Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_111178. ER-Phagosome pathway.
REACT_1156. Orc1 removal from chromatin.
REACT_118656. Activation of NF-kappaB in B cells.
REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_13565. Regulation of ornithine decarboxylase (ODC).
REACT_150471. Separation of Sister Chromatids.
REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
REACT_200766. degradation of AXIN.
REACT_200841. degradation of DVL.
REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.
REACT_9031. Vpu mediated degradation of CD4.
REACT_9453. Vif-mediated degradation of APOBEC3G.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 1
Alternative name(s):
11S regulator complex subunit alpha
Short name:
REG-alpha
Activator of multicatalytic protease subunit 1
Interferon gamma up-regulated I-5111 protein
Short name:
IGUP I-5111
Proteasome activator 28 subunit alpha
Short name:
PA28a
Short name:
PA28alpha
Gene namesi
Name:PSME1
Synonyms:IFI5111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:9568. PSME1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: UniProt
  4. nucleoplasm Source: Reactome
  5. proteasome activator complex Source: InterPro
  6. proteasome complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Proteasome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33914.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Proteasome activator complex subunit 1
PRO_0000161779Add
BLAST

Proteomic databases

MaxQBiQ06323.
PaxDbiQ06323.
PRIDEiQ06323.

2D gel databases

DOSAC-COBS-2DPAGEQ06323.
OGPiQ06323.
SWISS-2DPAGEQ06323.

PTM databases

PhosphoSiteiQ06323.

Expressioni

Inductioni

By IFNG/IFN-gamma.

Gene expression databases

ArrayExpressiQ06323.
BgeeiQ06323.
CleanExiHS_PSME1.
GenevestigatoriQ06323.

Organism-specific databases

HPAiHPA006632.

Interactioni

Subunit structurei

Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers.1 Publication

Protein-protein interaction databases

BioGridi111692. 59 interactions.
IntActiQ06323. 20 interactions.
MINTiMINT-5002728.
STRINGi9606.ENSP00000372155.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 3023
Helixi32 – 4514
Helixi47 – 493
Helixi108 – 13730
Helixi148 – 19043
Helixi196 – 23237
Helixi234 – 2385

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AVOX-ray2.80A/C/E/G/I/K/M4-63[»]
B/D/F/H/J/L/N104-242[»]
ProteinModelPortaliQ06323.
SMRiQ06323. Positions 4-63, 104-242.

Miscellaneous databases

EvolutionaryTraceiQ06323.

Family & Domainsi

Sequence similaritiesi

Belongs to the PA28 family.

Phylogenomic databases

eggNOGiNOG265006.
HOGENOMiHOG000282822.
HOVERGENiHBG053745.
KOiK06696.
OMAiMINTQSE.
OrthoDBiEOG7GTT4C.
PhylomeDBiQ06323.
TreeFamiTF106236.

Family and domain databases

Gene3Di1.20.120.180. 1 hit.
1.20.5.120. 1 hit.
InterProiIPR009077. Proteasome_activ_pa28.
IPR003186. Proteasome_activ_pa28_C.
IPR003185. Proteasome_activ_pa28_N.
[Graphical view]
PANTHERiPTHR10660. PTHR10660. 1 hit.
PfamiPF02251. PA28_alpha. 1 hit.
PF02252. PA28_beta. 1 hit.
[Graphical view]
SUPFAMiSSF47216. SSF47216. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q06323-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAMLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN    50
EANLSNLKAP LDIPVPDPVK EKEKEERKKQ QEKEDKDEKK KGEDEDKGPP 100
CGPVNCNEKI VVLLQRLKPE IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV 150
AVQEKVFELM TSLHTKLEGF HTQISKYFSE RGDAVTKAAK QPHVGDYRQL 200
VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP RGETKGMIY 249
Length:249
Mass (Da):28,723
Last modified:November 1, 1995 - v1
Checksum:i5E27727E5A0B0AAB
GO
Isoform 2 (identifier: Q06323-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-249: AVLYDIILKNFEKLKKPRGETKGMIY → VRRQGQGRGGQRQLSQATHSLTLQARG

Note: Gene prediction based on EST data.

Show »
Length:250
Mass (Da):28,602
Checksum:iD860008F47D35F97
GO
Isoform 3 (identifier: Q06323-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-233: AVLYDIILKN → VRRLCYMTSS
     234-249: Missing.

Note: Gene prediction based on EST data.

Show »
Length:233
Mass (Da):26,870
Checksum:i4B9A7BFE858CC6D9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551S → N.
Corresponds to variant rs1803830 [ dbSNP | Ensembl ].
VAR_011993
Natural varianti244 – 2441T → K.
Corresponds to variant rs14930 [ dbSNP | Ensembl ].
VAR_011994

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei224 – 24926AVLYD…KGMIY → VRRQGQGRGGQRQLSQATHS LTLQARG in isoform 2.
VSP_046880Add
BLAST
Alternative sequencei224 – 23310AVLYDIILKN → VRRLCYMTSS in isoform 3.
VSP_055166
Alternative sequencei234 – 24916Missing in isoform 3.
VSP_055167Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07633 mRNA. Translation: AAA16521.1.
U10360 Genomic DNA. Translation: AAA53230.1.
AF078829 Genomic DNA. Translation: AAF02217.1.
BT019337 mRNA. Translation: AAV38144.1.
AK312211 mRNA. Translation: BAG35144.1.
CR456780 mRNA. Translation: CAG33061.1.
AL136295 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66105.1.
BC000352 mRNA. Translation: AAH00352.1.
BC007503 mRNA. Translation: AAH07503.1.
AB007137 Genomic DNA. Translation: BAA28836.1.
CCDSiCCDS41930.1. [Q06323-2]
CCDS9612.1. [Q06323-1]
PIRiA54859.
RefSeqiNP_001268457.1. NM_001281528.1.
NP_006254.1. NM_006263.3. [Q06323-1]
UniGeneiHs.75348.

Genome annotation databases

EnsembliENST00000206451; ENSP00000206451; ENSG00000092010. [Q06323-1]
ENST00000382708; ENSP00000372155; ENSG00000092010. [Q06323-2]
ENST00000561435; ENSP00000453976; ENSG00000092010.
GeneIDi5720.
KEGGihsa:5720.
UCSCiuc001wmg.3. human. [Q06323-1]

Polymorphism databases

DMDMi1170519.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07633 mRNA. Translation: AAA16521.1 .
U10360 Genomic DNA. Translation: AAA53230.1 .
AF078829 Genomic DNA. Translation: AAF02217.1 .
BT019337 mRNA. Translation: AAV38144.1 .
AK312211 mRNA. Translation: BAG35144.1 .
CR456780 mRNA. Translation: CAG33061.1 .
AL136295 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66105.1 .
BC000352 mRNA. Translation: AAH00352.1 .
BC007503 mRNA. Translation: AAH07503.1 .
AB007137 Genomic DNA. Translation: BAA28836.1 .
CCDSi CCDS41930.1. [Q06323-2 ]
CCDS9612.1. [Q06323-1 ]
PIRi A54859.
RefSeqi NP_001268457.1. NM_001281528.1.
NP_006254.1. NM_006263.3. [Q06323-1 ]
UniGenei Hs.75348.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AVO X-ray 2.80 A/C/E/G/I/K/M 4-63 [» ]
B/D/F/H/J/L/N 104-242 [» ]
ProteinModelPortali Q06323.
SMRi Q06323. Positions 4-63, 104-242.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111692. 59 interactions.
IntActi Q06323. 20 interactions.
MINTi MINT-5002728.
STRINGi 9606.ENSP00000372155.

PTM databases

PhosphoSitei Q06323.

Polymorphism databases

DMDMi 1170519.

2D gel databases

DOSAC-COBS-2DPAGE Q06323.
OGPi Q06323.
SWISS-2DPAGE Q06323.

Proteomic databases

MaxQBi Q06323.
PaxDbi Q06323.
PRIDEi Q06323.

Protocols and materials databases

DNASUi 5720.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000206451 ; ENSP00000206451 ; ENSG00000092010 . [Q06323-1 ]
ENST00000382708 ; ENSP00000372155 ; ENSG00000092010 . [Q06323-2 ]
ENST00000561435 ; ENSP00000453976 ; ENSG00000092010 .
GeneIDi 5720.
KEGGi hsa:5720.
UCSCi uc001wmg.3. human. [Q06323-1 ]

Organism-specific databases

CTDi 5720.
GeneCardsi GC14P024605.
HGNCi HGNC:9568. PSME1.
HPAi HPA006632.
MIMi 600654. gene.
neXtProti NX_Q06323.
PharmGKBi PA33914.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265006.
HOGENOMi HOG000282822.
HOVERGENi HBG053745.
KOi K06696.
OMAi MINTQSE.
OrthoDBi EOG7GTT4C.
PhylomeDBi Q06323.
TreeFami TF106236.

Enzyme and pathway databases

Reactomei REACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_111178. ER-Phagosome pathway.
REACT_1156. Orc1 removal from chromatin.
REACT_118656. Activation of NF-kappaB in B cells.
REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_13565. Regulation of ornithine decarboxylase (ODC).
REACT_150471. Separation of Sister Chromatids.
REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
REACT_200766. degradation of AXIN.
REACT_200841. degradation of DVL.
REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.
REACT_9031. Vpu mediated degradation of CD4.
REACT_9453. Vif-mediated degradation of APOBEC3G.

Miscellaneous databases

EvolutionaryTracei Q06323.
GeneWikii PSME1.
GenomeRNAii 5720.
NextBioi 22232.
PROi Q06323.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q06323.
Bgeei Q06323.
CleanExi HS_PSME1.
Genevestigatori Q06323.

Family and domain databases

Gene3Di 1.20.120.180. 1 hit.
1.20.5.120. 1 hit.
InterProi IPR009077. Proteasome_activ_pa28.
IPR003186. Proteasome_activ_pa28_C.
IPR003185. Proteasome_activ_pa28_N.
[Graphical view ]
PANTHERi PTHR10660. PTHR10660. 1 hit.
Pfami PF02251. PA28_alpha. 1 hit.
PF02252. PA28_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF47216. SSF47216. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111."
    Honore B., Leffers H., Madsen P., Celis J.E.
    Eur. J. Biochem. 218:421-430(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lung fibroblast.
  2. "Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease."
    Realini C., Dubiel W., Pratt G., Ferrell K., Rechsteiner M.
    J. Biol. Chem. 269:20727-20732(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Tissue: Blood.
  3. "Organization of the genes encoding the human proteasome activators PA28alpha and beta."
    McCusker D., Wilson M., Trowsdale J.
    Immunogenetics 49:438-445(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  10. "Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes."
    Kohda K., Ishibashi T., Shimbara N., Tanaka K., Matsuda Y., Kasahara M.
    J. Immunol. 160:4923-4935(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-118.
  11. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
    Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
    Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-35; 191-197 AND 199-209.
    Tissue: Keratinocyte.
  12. "The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer."
    Johnston S.C., Whitby F.G., Realini C., Rechsteiner M., Hill C.P.
    Protein Sci. 6:2469-2473(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  13. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
    Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.
    Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

Entry informationi

Entry nameiPSME1_HUMAN
AccessioniPrimary (citable) accession number: Q06323
Secondary accession number(s): A6NJG9
, H0YNE3, Q6IBM2, Q9UEF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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