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Q06323

- PSME1_HUMAN

UniProt

Q06323 - PSME1_HUMAN

Protein

Proteasome activator complex subunit 1

Gene

PSME1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

    GO - Molecular functioni

    1. endopeptidase activator activity Source: Ensembl

    GO - Biological processi

    1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. apoptotic process Source: Reactome
    6. cellular nitrogen compound metabolic process Source: Reactome
    7. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
    8. G1/S transition of mitotic cell cycle Source: Reactome
    9. gene expression Source: Reactome
    10. mitotic cell cycle Source: Reactome
    11. mRNA metabolic process Source: Reactome
    12. negative regulation of apoptotic process Source: Reactome
    13. negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    14. positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    15. protein polyubiquitination Source: Reactome
    16. regulation of apoptotic process Source: Reactome
    17. regulation of cellular amino acid metabolic process Source: Reactome
    18. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    19. RNA metabolic process Source: Reactome
    20. small molecule metabolic process Source: Reactome
    21. viral process Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_111178. ER-Phagosome pathway.
    REACT_1156. Orc1 removal from chromatin.
    REACT_118656. Activation of NF-kappaB in B cells.
    REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
    REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_13565. Regulation of ornithine decarboxylase (ODC).
    REACT_150471. Separation of Sister Chromatids.
    REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_200766. degradation of AXIN.
    REACT_200841. degradation of DVL.
    REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
    REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_9031. Vpu mediated degradation of CD4.
    REACT_9453. Vif-mediated degradation of APOBEC3G.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome activator complex subunit 1
    Alternative name(s):
    11S regulator complex subunit alpha
    Short name:
    REG-alpha
    Activator of multicatalytic protease subunit 1
    Interferon gamma up-regulated I-5111 protein
    Short name:
    IGUP I-5111
    Proteasome activator 28 subunit alpha
    Short name:
    PA28a
    Short name:
    PA28alpha
    Gene namesi
    Name:PSME1
    Synonyms:IFI5111
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:9568. PSME1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. extracellular vesicular exosome Source: UniProt
    4. nucleoplasm Source: Reactome
    5. proteasome activator complex Source: InterPro
    6. proteasome complex Source: ProtInc

    Keywords - Cellular componenti

    Proteasome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33914.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249Proteasome activator complex subunit 1PRO_0000161779Add
    BLAST

    Proteomic databases

    MaxQBiQ06323.
    PaxDbiQ06323.
    PRIDEiQ06323.

    2D gel databases

    DOSAC-COBS-2DPAGEQ06323.
    OGPiQ06323.
    SWISS-2DPAGEQ06323.

    PTM databases

    PhosphoSiteiQ06323.

    Expressioni

    Inductioni

    By IFNG/IFN-gamma.

    Gene expression databases

    ArrayExpressiQ06323.
    BgeeiQ06323.
    CleanExiHS_PSME1.
    GenevestigatoriQ06323.

    Organism-specific databases

    HPAiHPA006632.

    Interactioni

    Subunit structurei

    Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers.1 Publication

    Protein-protein interaction databases

    BioGridi111692. 60 interactions.
    IntActiQ06323. 20 interactions.
    MINTiMINT-5002728.
    STRINGi9606.ENSP00000372155.

    Structurei

    Secondary structure

    1
    249
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi8 – 3023
    Helixi32 – 4514
    Helixi47 – 493
    Helixi108 – 13730
    Helixi148 – 19043
    Helixi196 – 23237
    Helixi234 – 2385

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AVOX-ray2.80A/C/E/G/I/K/M4-63[»]
    B/D/F/H/J/L/N104-242[»]
    ProteinModelPortaliQ06323.
    SMRiQ06323. Positions 4-63, 104-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ06323.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PA28 family.Curated

    Phylogenomic databases

    eggNOGiNOG265006.
    HOGENOMiHOG000282822.
    HOVERGENiHBG053745.
    KOiK06696.
    OMAiMINTQSE.
    OrthoDBiEOG7GTT4C.
    PhylomeDBiQ06323.
    TreeFamiTF106236.

    Family and domain databases

    Gene3Di1.20.120.180. 1 hit.
    1.20.5.120. 1 hit.
    InterProiIPR009077. Proteasome_activ_pa28.
    IPR003186. Proteasome_activ_pa28_C.
    IPR003185. Proteasome_activ_pa28_N.
    [Graphical view]
    PANTHERiPTHR10660. PTHR10660. 1 hit.
    PfamiPF02251. PA28_alpha. 1 hit.
    PF02252. PA28_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF47216. SSF47216. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q06323-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN    50
    EANLSNLKAP LDIPVPDPVK EKEKEERKKQ QEKEDKDEKK KGEDEDKGPP 100
    CGPVNCNEKI VVLLQRLKPE IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV 150
    AVQEKVFELM TSLHTKLEGF HTQISKYFSE RGDAVTKAAK QPHVGDYRQL 200
    VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP RGETKGMIY 249
    Length:249
    Mass (Da):28,723
    Last modified:November 1, 1995 - v1
    Checksum:i5E27727E5A0B0AAB
    GO
    Isoform 2 (identifier: Q06323-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         224-249: AVLYDIILKNFEKLKKPRGETKGMIY → VRRQGQGRGGQRQLSQATHSLTLQARG

    Note: Gene prediction based on EST data.

    Show »
    Length:250
    Mass (Da):28,602
    Checksum:iD860008F47D35F97
    GO
    Isoform 3 (identifier: Q06323-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         224-233: AVLYDIILKN → VRRLCYMTSS
         234-249: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:233
    Mass (Da):26,870
    Checksum:i4B9A7BFE858CC6D9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551S → N.
    Corresponds to variant rs1803830 [ dbSNP | Ensembl ].
    VAR_011993
    Natural varianti244 – 2441T → K.
    Corresponds to variant rs14930 [ dbSNP | Ensembl ].
    VAR_011994

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei224 – 24926AVLYD…KGMIY → VRRQGQGRGGQRQLSQATHS LTLQARG in isoform 2. CuratedVSP_046880Add
    BLAST
    Alternative sequencei224 – 23310AVLYDIILKN → VRRLCYMTSS in isoform 3. CuratedVSP_055166
    Alternative sequencei234 – 24916Missing in isoform 3. CuratedVSP_055167Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07633 mRNA. Translation: AAA16521.1.
    U10360 Genomic DNA. Translation: AAA53230.1.
    AF078829 Genomic DNA. Translation: AAF02217.1.
    BT019337 mRNA. Translation: AAV38144.1.
    AK312211 mRNA. Translation: BAG35144.1.
    CR456780 mRNA. Translation: CAG33061.1.
    AL136295 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66105.1.
    BC000352 mRNA. Translation: AAH00352.1.
    BC007503 mRNA. Translation: AAH07503.1.
    AB007137 Genomic DNA. Translation: BAA28836.1.
    CCDSiCCDS41930.1. [Q06323-2]
    CCDS61415.1. [Q06323-3]
    CCDS9612.1. [Q06323-1]
    PIRiA54859.
    RefSeqiNP_001268457.1. NM_001281528.1.
    NP_006254.1. NM_006263.3. [Q06323-1]
    UniGeneiHs.75348.

    Genome annotation databases

    EnsembliENST00000206451; ENSP00000206451; ENSG00000092010. [Q06323-1]
    ENST00000382708; ENSP00000372155; ENSG00000092010. [Q06323-2]
    ENST00000561435; ENSP00000453976; ENSG00000092010. [Q06323-3]
    GeneIDi5720.
    KEGGihsa:5720.
    UCSCiuc001wmg.3. human. [Q06323-1]

    Polymorphism databases

    DMDMi1170519.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07633 mRNA. Translation: AAA16521.1 .
    U10360 Genomic DNA. Translation: AAA53230.1 .
    AF078829 Genomic DNA. Translation: AAF02217.1 .
    BT019337 mRNA. Translation: AAV38144.1 .
    AK312211 mRNA. Translation: BAG35144.1 .
    CR456780 mRNA. Translation: CAG33061.1 .
    AL136295 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66105.1 .
    BC000352 mRNA. Translation: AAH00352.1 .
    BC007503 mRNA. Translation: AAH07503.1 .
    AB007137 Genomic DNA. Translation: BAA28836.1 .
    CCDSi CCDS41930.1. [Q06323-2 ]
    CCDS61415.1. [Q06323-3 ]
    CCDS9612.1. [Q06323-1 ]
    PIRi A54859.
    RefSeqi NP_001268457.1. NM_001281528.1.
    NP_006254.1. NM_006263.3. [Q06323-1 ]
    UniGenei Hs.75348.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AVO X-ray 2.80 A/C/E/G/I/K/M 4-63 [» ]
    B/D/F/H/J/L/N 104-242 [» ]
    ProteinModelPortali Q06323.
    SMRi Q06323. Positions 4-63, 104-242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111692. 60 interactions.
    IntActi Q06323. 20 interactions.
    MINTi MINT-5002728.
    STRINGi 9606.ENSP00000372155.

    PTM databases

    PhosphoSitei Q06323.

    Polymorphism databases

    DMDMi 1170519.

    2D gel databases

    DOSAC-COBS-2DPAGE Q06323.
    OGPi Q06323.
    SWISS-2DPAGE Q06323.

    Proteomic databases

    MaxQBi Q06323.
    PaxDbi Q06323.
    PRIDEi Q06323.

    Protocols and materials databases

    DNASUi 5720.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000206451 ; ENSP00000206451 ; ENSG00000092010 . [Q06323-1 ]
    ENST00000382708 ; ENSP00000372155 ; ENSG00000092010 . [Q06323-2 ]
    ENST00000561435 ; ENSP00000453976 ; ENSG00000092010 . [Q06323-3 ]
    GeneIDi 5720.
    KEGGi hsa:5720.
    UCSCi uc001wmg.3. human. [Q06323-1 ]

    Organism-specific databases

    CTDi 5720.
    GeneCardsi GC14P024605.
    HGNCi HGNC:9568. PSME1.
    HPAi HPA006632.
    MIMi 600654. gene.
    neXtProti NX_Q06323.
    PharmGKBi PA33914.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265006.
    HOGENOMi HOG000282822.
    HOVERGENi HBG053745.
    KOi K06696.
    OMAi MINTQSE.
    OrthoDBi EOG7GTT4C.
    PhylomeDBi Q06323.
    TreeFami TF106236.

    Enzyme and pathway databases

    Reactomei REACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_111178. ER-Phagosome pathway.
    REACT_1156. Orc1 removal from chromatin.
    REACT_118656. Activation of NF-kappaB in B cells.
    REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
    REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_13565. Regulation of ornithine decarboxylase (ODC).
    REACT_150471. Separation of Sister Chromatids.
    REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_200766. degradation of AXIN.
    REACT_200841. degradation of DVL.
    REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
    REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_9031. Vpu mediated degradation of CD4.
    REACT_9453. Vif-mediated degradation of APOBEC3G.

    Miscellaneous databases

    EvolutionaryTracei Q06323.
    GeneWikii PSME1.
    GenomeRNAii 5720.
    NextBioi 22232.
    PROi Q06323.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q06323.
    Bgeei Q06323.
    CleanExi HS_PSME1.
    Genevestigatori Q06323.

    Family and domain databases

    Gene3Di 1.20.120.180. 1 hit.
    1.20.5.120. 1 hit.
    InterProi IPR009077. Proteasome_activ_pa28.
    IPR003186. Proteasome_activ_pa28_C.
    IPR003185. Proteasome_activ_pa28_N.
    [Graphical view ]
    PANTHERi PTHR10660. PTHR10660. 1 hit.
    Pfami PF02251. PA28_alpha. 1 hit.
    PF02252. PA28_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47216. SSF47216. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111."
      Honore B., Leffers H., Madsen P., Celis J.E.
      Eur. J. Biochem. 218:421-430(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lung fibroblast.
    2. "Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease."
      Realini C., Dubiel W., Pratt G., Ferrell K., Rechsteiner M.
      J. Biol. Chem. 269:20727-20732(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Tissue: Blood.
    3. "Organization of the genes encoding the human proteasome activators PA28alpha and beta."
      McCusker D., Wilson M., Trowsdale J.
      Immunogenetics 49:438-445(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Spleen.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    10. "Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes."
      Kohda K., Ishibashi T., Shimbara N., Tanaka K., Matsuda Y., Kasahara M.
      J. Immunol. 160:4923-4935(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-118.
    11. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
      Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
      Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-35; 191-197 AND 199-209.
      Tissue: Keratinocyte.
    12. "The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer."
      Johnston S.C., Whitby F.G., Realini C., Rechsteiner M., Hill C.P.
      Protein Sci. 6:2469-2473(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    13. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
      Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.
      Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

    Entry informationi

    Entry nameiPSME1_HUMAN
    AccessioniPrimary (citable) accession number: Q06323
    Secondary accession number(s): A6NJG9
    , H0YNE3, Q6IBM2, Q9UEF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3