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Protein

Sterol 3-beta-glucosyltransferase

Gene

ATG26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in decane metabolism (By similarity). Involved in the biosynthesis of sterol glucoside. Not involved in autophagy-related pathways.By similarity2 Publications

Catalytic activityi

UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside.

GO - Molecular functioni

  • sterol 3-beta-glucosyltransferase activity Source: SGD

GO - Biological processi

  • ascospore-type prospore membrane assembly Source: SGD
  • flavonoid biosynthetic process Source: GO_Central
  • flavonoid glucuronidation Source: GO_Central
  • lipid glycosylation Source: InterPro
  • protein transport Source: UniProtKB-KW
  • sterol biosynthetic process Source: UniProtKB-KW
  • sterol metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Protein transport, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism, Transport

Enzyme and pathway databases

BioCyciYEAST:YLR189C-MONOMER.
BRENDAi2.4.1.173. 984.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 3-beta-glucosyltransferase (EC:2.4.1.173)
Alternative name(s):
Autophagy-related protein 26
UDP-glycosyltransferase 51
Gene namesi
Name:ATG26
Synonyms:UGT51
Ordered Locus Names:YLR189C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR189C.
SGDiS000004179. ATG26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11981198Sterol 3-beta-glucosyltransferasePRO_0000215616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761PhosphoserineCombined sources
Modified residuei693 – 6931PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06321.

PTM databases

iPTMnetiQ06321.

Interactioni

Protein-protein interaction databases

BioGridi31459. 35 interactions.
DIPiDIP-6644N.
IntActiQ06321. 3 interactions.
MINTiMINT-641026.

Structurei

3D structure databases

ProteinModelPortaliQ06321.
SMRiQ06321. Positions 826-1163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 23650GRAM 1Add
BLAST
Domaini238 – 33699PHPROSITE-ProRule annotationAdd
BLAST
Domaini570 – 63667GRAM 2Add
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family.Curated
Contains 2 GRAM domains.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000034145.
InParanoidiQ06321.
KOiK05841.
OMAiNKWRVET.
OrthoDBiEOG092C09PF.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004276. GlycoTrans_28_N.
IPR004182. GRAM.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF03033. Glyco_transf_28. 1 hit.
PF02893. GRAM. 1 hit.
PF00169. PH. 1 hit.
PF00201. UDPGT. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 2 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPITQIISAS DSEAGPKPSI SLVPDKPSEP ETSPRHHRLS RSLSKFKRWR
60 70 80 90 100
GRSNSSLSMG SSEQQELQDS PNEARSDDDE NGYNNDNADD LAKSKYMMKS
110 120 130 140 150
IAGLLTTASV YAGMNNAQEM NVLSQVDSEE SDSSDSFQEN IGRNEVKSKK
160 170 180 190 200
ENLKTKSHPE VPRLDKRKPT LFDFSITREK LSKDNVAKLR QRFCLDEQEP
210 220 230 240 250
FLNDFPAWLL KDVLVQGHIF ITTKHFLFFA YLPKNPRSVK MSGNLNIRTK
260 270 280 290 300
LIRSTRYWCV LKNHLFSMYT SSTELYFPVL TIDLREVQKI ETQKHTLNGS
310 320 330 340 350
ATKTFKLYTD ESTFKFNADS EFSAKSWVNA LKKEQFAAQN SENNSISLKI
360 370 380 390 400
PLPNIIEIDD QPIVNKALTL RLRALESSQT YAIDDFMFVF MDGSGSQVKE
410 420 430 440 450
SLGEQLAILQ KSGVNTLYYD IPAKKSKSSF GKETPATVEQ KNNGEDSKYL
460 470 480 490 500
NVPTSAVPSS ENGKKSRFRF RERSNSWFRR AKPLEDSQVE DVEEIYKDAA
510 520 530 540 550
NDIDSSVHST IHIHEQEDSQ EQTVAWKPSH LKNFAEMWAA KPIHYRNKFI
560 570 580 590 600
PFQKDDTYLI KETEEVSANE RFRYHFKFNK EKSLISTYYT YLNRNVPVYG
610 620 630 640 650
KIYVSNDTVC FRSLLPGSNT YMVLPLVDVE TCYKEKGFRF GYFVLVIVIH
660 670 680 690 700
GHEELFFEFS TEVARDDIER ILLKLLDNIY ASSAEGSNIS SASLGDVQHN
710 720 730 740 750
PDSAKLKLFE DKINAEGFEV PLMIDENPHY KTSIKPNKSY KFGLLTIGSR
760 770 780 790 800
GDVQPYIALG KGLIKEGHQV VIITHSEFRD FVESHGIQFE EIAGNPVELM
810 820 830 840 850
SLMVENESMN VKMLREASSK FRGWIDALLQ TSWEVCNRRK FDILIESPSA
860 870 880 890 900
MVGIHITEAL QIPYFRAFTM PWTRTRAYPH AFIVPDQKRG GNYNYLTHVL
910 920 930 940 950
FENVFWKGIS GQVNKWRVET LGLGKTNLFL LQQNNVPFLY NVSPTIFPPS
960 970 980 990 1000
IDFSEWVRVT GYWFLDDKST FKPPAELQEF ISEARSKGKK LVYIGFGSIV
1010 1020 1030 1040 1050
VSNAKEMTEA LVEAVMEADV YCILNKGWSE RLGDKAAKKT EVDLPRNILN
1060 1070 1080 1090 1100
IGNVPHDWLF PQVDAAVHHG GSGTTGASLR AGLPTVIKPF FGDQFFYAGR
1110 1120 1130 1140 1150
VEDIGVGIAL KKLNAQTLAD ALKVATTNKI MKDRAGLIKK KISKEDGIKT
1160 1170 1180 1190
AISAIYNELE YARSVTLSRV KTPRKKEENV DATKLTPAET TDEGWTMI
Length:1,198
Mass (Da):136,054
Last modified:November 1, 1996 - v1
Checksum:i74DED87BBBF75B51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17246 Genomic DNA. Translation: AAB67475.1.
BK006945 Genomic DNA. Translation: DAA09508.1.
PIRiS51434.
RefSeqiNP_013290.1. NM_001182076.1.

Genome annotation databases

EnsemblFungiiYLR189C; YLR189C; YLR189C.
GeneIDi850886.
KEGGisce:YLR189C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17246 Genomic DNA. Translation: AAB67475.1.
BK006945 Genomic DNA. Translation: DAA09508.1.
PIRiS51434.
RefSeqiNP_013290.1. NM_001182076.1.

3D structure databases

ProteinModelPortaliQ06321.
SMRiQ06321. Positions 826-1163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31459. 35 interactions.
DIPiDIP-6644N.
IntActiQ06321. 3 interactions.
MINTiMINT-641026.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiQ06321.

Proteomic databases

MaxQBiQ06321.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR189C; YLR189C; YLR189C.
GeneIDi850886.
KEGGisce:YLR189C.

Organism-specific databases

EuPathDBiFungiDB:YLR189C.
SGDiS000004179. ATG26.

Phylogenomic databases

HOGENOMiHOG000034145.
InParanoidiQ06321.
KOiK05841.
OMAiNKWRVET.
OrthoDBiEOG092C09PF.

Enzyme and pathway databases

BioCyciYEAST:YLR189C-MONOMER.
BRENDAi2.4.1.173. 984.

Miscellaneous databases

PROiQ06321.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004276. GlycoTrans_28_N.
IPR004182. GRAM.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF03033. Glyco_transf_28. 1 hit.
PF02893. GRAM. 1 hit.
PF00169. PH. 1 hit.
PF00201. UDPGT. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 2 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATG26_YEAST
AccessioniPrimary (citable) accession number: Q06321
Secondary accession number(s): D6VYJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.