Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sterol 3-beta-glucosyltransferase

Gene

ATG26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in decane metabolism (By similarity). Involved in the biosynthesis of sterol glucoside. Not involved in autophagy-related pathways.By similarity2 Publications

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside.

GO - Molecular functioni

GO - Biological processi

  • ascospore-type prospore membrane assembly Source: SGD
  • carbohydrate metabolic process Source: InterPro
  • lipid glycosylation Source: InterPro
  • protein transport Source: UniProtKB-KW
  • sterol biosynthetic process Source: UniProtKB-KW
  • sterol metabolic process Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Protein transport, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism, Transport

Enzyme and pathway databases

BioCyciYEAST:YLR189C-MONOMER.
BRENDAi2.4.1.173. 984.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 3-beta-glucosyltransferase (EC:2.4.1.173)
Alternative name(s):
Autophagy-related protein 26
UDP-glycosyltransferase 51
Gene namesi
Name:ATG26
Synonyms:UGT51
Ordered Locus Names:YLR189C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR189C.
SGDiS000004179. ATG26.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156161 – 1198Sterol 3-beta-glucosyltransferaseAdd BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphoserineCombined sources1
Modified residuei693PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06321.
PRIDEiQ06321.

PTM databases

iPTMnetiQ06321.

Interactioni

Protein-protein interaction databases

BioGridi31459. 70 interactors.
DIPiDIP-6644N.
IntActiQ06321. 11 interactors.
MINTiMINT-641026.
STRINGi4932.YLR189C.

Structurei

Secondary structure

11198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi741 – 745Combined sources5
Helixi750 – 765Combined sources16
Beta strandi769 – 774Combined sources6
Helixi776 – 778Combined sources3
Helixi779 – 784Combined sources6
Beta strandi788 – 791Combined sources4
Helixi797 – 805Combined sources9
Helixi810 – 839Combined sources30
Beta strandi842 – 846Combined sources5
Helixi848 – 850Combined sources3
Helixi853 – 860Combined sources8
Beta strandi864 – 870Combined sources7
Beta strandi876 – 878Combined sources3
Helixi891 – 919Combined sources29
Helixi928 – 931Combined sources4
Helixi933 – 935Combined sources3
Beta strandi938 – 940Combined sources3
Turni944 – 946Combined sources3
Beta strandi957 – 959Combined sources3
Helixi975 – 986Combined sources12
Beta strandi990 – 995Combined sources6
Beta strandi998 – 1000Combined sources3
Helixi1004 – 1017Combined sources14
Beta strandi1020 – 1025Combined sources6
Beta strandi1028 – 1031Combined sources4
Beta strandi1048 – 1050Combined sources3
Helixi1056 – 1059Combined sources4
Helixi1060 – 1062Combined sources3
Beta strandi1063 – 1068Combined sources6
Helixi1072 – 1080Combined sources9
Beta strandi1085 – 1087Combined sources3
Helixi1093 – 1103Combined sources11
Beta strandi1106 – 1109Combined sources4
Helixi1115 – 1127Combined sources13
Helixi1129 – 1144Combined sources16
Helixi1147 – 1169Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GL5X-ray1.90A/B722-1198[»]
ProteinModelPortaliQ06321.
SMRiQ06321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 236GRAM 1Add BLAST50
Domaini238 – 336PHPROSITE-ProRule annotationAdd BLAST99
Domaini570 – 636GRAM 2Add BLAST67

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000034145.
InParanoidiQ06321.
KOiK05841.
OMAiWEATHSE.
OrthoDBiEOG092C09PF.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiView protein in InterPro
IPR004276. GlycoTrans_28_N.
IPR004182. GRAM.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR002213. UDP_glucos_trans.
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiView protein in Pfam
PF03033. Glyco_transf_28. 1 hit.
PF02893. GRAM. 1 hit.
PF00169. PH. 1 hit.
PF00201. UDPGT. 1 hit.
SMARTiView protein in SMART
SM00568. GRAM. 2 hits.
SM00233. PH. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50003. PH_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPITQIISAS DSEAGPKPSI SLVPDKPSEP ETSPRHHRLS RSLSKFKRWR
60 70 80 90 100
GRSNSSLSMG SSEQQELQDS PNEARSDDDE NGYNNDNADD LAKSKYMMKS
110 120 130 140 150
IAGLLTTASV YAGMNNAQEM NVLSQVDSEE SDSSDSFQEN IGRNEVKSKK
160 170 180 190 200
ENLKTKSHPE VPRLDKRKPT LFDFSITREK LSKDNVAKLR QRFCLDEQEP
210 220 230 240 250
FLNDFPAWLL KDVLVQGHIF ITTKHFLFFA YLPKNPRSVK MSGNLNIRTK
260 270 280 290 300
LIRSTRYWCV LKNHLFSMYT SSTELYFPVL TIDLREVQKI ETQKHTLNGS
310 320 330 340 350
ATKTFKLYTD ESTFKFNADS EFSAKSWVNA LKKEQFAAQN SENNSISLKI
360 370 380 390 400
PLPNIIEIDD QPIVNKALTL RLRALESSQT YAIDDFMFVF MDGSGSQVKE
410 420 430 440 450
SLGEQLAILQ KSGVNTLYYD IPAKKSKSSF GKETPATVEQ KNNGEDSKYL
460 470 480 490 500
NVPTSAVPSS ENGKKSRFRF RERSNSWFRR AKPLEDSQVE DVEEIYKDAA
510 520 530 540 550
NDIDSSVHST IHIHEQEDSQ EQTVAWKPSH LKNFAEMWAA KPIHYRNKFI
560 570 580 590 600
PFQKDDTYLI KETEEVSANE RFRYHFKFNK EKSLISTYYT YLNRNVPVYG
610 620 630 640 650
KIYVSNDTVC FRSLLPGSNT YMVLPLVDVE TCYKEKGFRF GYFVLVIVIH
660 670 680 690 700
GHEELFFEFS TEVARDDIER ILLKLLDNIY ASSAEGSNIS SASLGDVQHN
710 720 730 740 750
PDSAKLKLFE DKINAEGFEV PLMIDENPHY KTSIKPNKSY KFGLLTIGSR
760 770 780 790 800
GDVQPYIALG KGLIKEGHQV VIITHSEFRD FVESHGIQFE EIAGNPVELM
810 820 830 840 850
SLMVENESMN VKMLREASSK FRGWIDALLQ TSWEVCNRRK FDILIESPSA
860 870 880 890 900
MVGIHITEAL QIPYFRAFTM PWTRTRAYPH AFIVPDQKRG GNYNYLTHVL
910 920 930 940 950
FENVFWKGIS GQVNKWRVET LGLGKTNLFL LQQNNVPFLY NVSPTIFPPS
960 970 980 990 1000
IDFSEWVRVT GYWFLDDKST FKPPAELQEF ISEARSKGKK LVYIGFGSIV
1010 1020 1030 1040 1050
VSNAKEMTEA LVEAVMEADV YCILNKGWSE RLGDKAAKKT EVDLPRNILN
1060 1070 1080 1090 1100
IGNVPHDWLF PQVDAAVHHG GSGTTGASLR AGLPTVIKPF FGDQFFYAGR
1110 1120 1130 1140 1150
VEDIGVGIAL KKLNAQTLAD ALKVATTNKI MKDRAGLIKK KISKEDGIKT
1160 1170 1180 1190
AISAIYNELE YARSVTLSRV KTPRKKEENV DATKLTPAET TDEGWTMI
Length:1,198
Mass (Da):136,054
Last modified:November 1, 1996 - v1
Checksum:i74DED87BBBF75B51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17246 Genomic DNA. Translation: AAB67475.1.
BK006945 Genomic DNA. Translation: DAA09508.1.
PIRiS51434.
RefSeqiNP_013290.1. NM_001182076.1.

Genome annotation databases

EnsemblFungiiYLR189C; YLR189C; YLR189C.
GeneIDi850886.
KEGGisce:YLR189C.

Similar proteinsi

Entry informationi

Entry nameiATG26_YEAST
AccessioniPrimary (citable) accession number: Q06321
Secondary accession number(s): D6VYJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names