ID   UTER_MOUSE              Reviewed;          96 AA.
AC   Q06318;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   24-JAN-2024, entry version 167.
DE   RecName: Full=Uteroglobin;
DE   AltName: Full=Club cell 17 kDa protein;
DE   AltName: Full=Club cell phospholipid-binding protein;
DE            Short=CCPBP;
DE   AltName: Full=Club cells 10 kDa secretory protein;
DE            Short=CC10;
DE   AltName: Full=PCB-binding protein;
DE   AltName: Full=Secretoglobin family 1A member 1;
DE   Flags: Precursor;
GN   Name=Scgb1a1; Synonyms=Cc10, Ugb, Utg;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RX   PubMed=8398159; DOI=10.1165/ajrcmb/9.3.231;
RA   Margraf L.R., Finegold M.J., Stanley L.A., Major A., Hawkins H.K.,
RA   DeMayo F.J.;
RT   "Cloning and tissue-specific expression of the cDNA for the mouse Clara
RT   cell 10 kD protein: comparison of endogenous expression to rabbit
RT   uteroglobin promoter-driven transgene expression.";
RL   Am. J. Respir. Cell Mol. Biol. 9:231-238(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8020953; DOI=10.1006/geno.1994.1123;
RA   Stripp B.R., Huffman J.A., Bohinski R.J.;
RT   "Structure and regulation of the murine Clara cell secretory protein
RT   gene.";
RL   Genomics 20:27-35(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 22 AND 25-35.
RC   TISSUE=Lung;
RX   PubMed=8440203; DOI=10.3109/01902149309071081;
RA   Singh G., Katyal S.L., Brown W.E., Kennedy A.L.;
RT   "Mouse Clara cell 10-kDa (CC10) protein: cDNA nucleotide sequence and
RT   molecular basis for the variation in progesterone binding of CC10 from
RT   different species.";
RL   Exp. Lung Res. 19:67-75(1993).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129/Sv; TISSUE=Lung;
RX   PubMed=7916613; DOI=10.1006/bbrc.1993.2455;
RA   Ray M.K., Magdaleno S., O'Malley B.W., Demayo F.J.;
RT   "Cloning and characterization of the mouse Clara cell specific 10 kDa
RT   protein gene: comparison of the 5'-flanking region with the human rat and
RT   rabbit gene.";
RL   Biochem. Biophys. Res. Commun. 197:163-171(1993).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Lung;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Binds phosphatidylcholine, phosphatidylinositol,
CC       polychlorinated biphenyls (PCB) and weakly progesterone, potent
CC       inhibitor of phospholipase A2.
CC   -!- SUBUNIT: Antiparallel homodimer; disulfide-linked (By similarity).
CC       Interaction with LMBR1L is controversial (By similarity).
CC       {ECO:0000250|UniProtKB:P11684}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Club cells (nonciliated cells of the surface
CC       epithelium of the pulmonary airways).
CC   -!- DEVELOPMENTAL STAGE: Appears on the eighteenth day of gestation in the
CC       airway epithelium.
CC   -!- INDUCTION: By glucocorticoids.
CC   -!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
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DR   EMBL; L04503; AAA03625.1; -; mRNA.
DR   EMBL; L24372; AAA65446.1; -; Genomic_DNA.
DR   EMBL; X67702; CAA47936.1; -; mRNA.
DR   EMBL; U01247; AAA16141.1; -; Unassigned_DNA.
DR   EMBL; BC027518; AAH27518.1; -; mRNA.
DR   CCDS; CCDS37911.1; -.
DR   PIR; A53025; UGMS.
DR   RefSeq; NP_035811.1; NM_011681.2.
DR   AlphaFoldDB; Q06318; -.
DR   SMR; Q06318; -.
DR   STRING; 10090.ENSMUSP00000025554; -.
DR   PhosphoSitePlus; Q06318; -.
DR   CPTAC; non-CPTAC-3520; -.
DR   PaxDb; 10090-ENSMUSP00000025554; -.
DR   PeptideAtlas; Q06318; -.
DR   ProteomicsDB; 275398; -.
DR   Antibodypedia; 14807; 518 antibodies from 37 providers.
DR   DNASU; 22287; -.
DR   Ensembl; ENSMUST00000025554.3; ENSMUSP00000025554.3; ENSMUSG00000024653.3.
DR   GeneID; 22287; -.
DR   KEGG; mmu:22287; -.
DR   UCSC; uc008gom.1; mouse.
DR   AGR; MGI:98919; -.
DR   CTD; 7356; -.
DR   MGI; MGI:98919; Scgb1a1.
DR   VEuPathDB; HostDB:ENSMUSG00000024653; -.
DR   eggNOG; ENOG502SXFT; Eukaryota.
DR   GeneTree; ENSGT00940000155073; -.
DR   HOGENOM; CLU_166234_1_0_1; -.
DR   InParanoid; Q06318; -.
DR   OMA; MKIAITI; -.
DR   OrthoDB; 4862909at2759; -.
DR   PhylomeDB; Q06318; -.
DR   TreeFam; TF338407; -.
DR   BioGRID-ORCS; 22287; 3 hits in 78 CRISPR screens.
DR   ChiTaRS; Scgb1a1; mouse.
DR   PRO; PR:Q06318; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q06318; Protein.
DR   Bgee; ENSMUSG00000024653; Expressed in right lung lobe and 53 other cell types or tissues.
DR   ExpressionAtlas; Q06318; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0005635; C:nuclear envelope; ISO:MGI.
DR   GO; GO:0030141; C:secretory granule; ISO:MGI.
DR   GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0097160; F:polychlorinated biphenyl binding; ISO:MGI.
DR   GO; GO:0032696; P:negative regulation of interleukin-13 production; IDA:MGI.
DR   GO; GO:0032713; P:negative regulation of interleukin-4 production; IDA:MGI.
DR   GO; GO:0032714; P:negative regulation of interleukin-5 production; IDA:MGI.
DR   GO; GO:0042130; P:negative regulation of T cell proliferation; IDA:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0032689; P:negative regulation of type II interferon production; IDA:MGI.
DR   GO; GO:0050727; P:regulation of inflammatory response; IDA:MGI.
DR   GO; GO:0043488; P:regulation of mRNA stability; IDA:MGI.
DR   GO; GO:0034097; P:response to cytokine; ISO:MGI.
DR   GO; GO:0071774; P:response to fibroblast growth factor; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0010193; P:response to ozone; IEA:Ensembl.
DR   GO; GO:0034021; P:response to silicon dioxide; IEA:Ensembl.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0042098; P:T cell proliferation; IDA:MGI.
DR   CDD; cd00633; Secretoglobin; 1.
DR   Gene3D; 1.10.210.10; Secretoglobin; 1.
DR   InterPro; IPR016126; Secretoglobin.
DR   InterPro; IPR043215; Secretoglobin_1C-like.
DR   InterPro; IPR035960; Secretoglobin_sf.
DR   InterPro; IPR000329; Uteroglobin.
DR   PANTHER; PTHR10136; SECRETOGLOBIN FAMILY 1 MEMBER; 1.
DR   PANTHER; PTHR10136:SF6; UTEROGLOBIN; 1.
DR   Pfam; PF01099; Uteroglobin; 1.
DR   PRINTS; PR00486; UTEROGLOBIN.
DR   SMART; SM00096; UTG; 1.
DR   SUPFAM; SSF48201; Uteroglobin-like; 1.
DR   PROSITE; PS51311; SCGB; 1.
DR   Genevisible; Q06318; MM.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Phospholipase A2 inhibitor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..96
FT                   /note="Uteroglobin"
FT                   /id="PRO_0000036366"
FT   DISULFID        24
FT                   /note="Interchain (with C-90)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        90
FT                   /note="Interchain (with C-24)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   96 AA;  10519 MW;  21103A8839497E6C CRC64;
     MKIAITITVV MLSICCSSAS SDICPGFLQV LEALLMESES GYVASLKPFN PGSDLQNAGT
     QLKRLVDTLP QETRINIMKL TEKILTSPLC KQDLRF
//