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Protein

Uteroglobin

Gene

Scgb1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Uteroglobin
Alternative name(s):
Clara cell 17 kDa protein
Clara cell phospholipid-binding protein
Short name:
CCPBP
Clara cells 10 kDa secretory protein
Short name:
CC10
PCB-binding protein
Secretoglobin family 1A member 1
Gene namesi
Name:Scgb1a1
Synonyms:Cc10, Ugb, Utg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:98919. Scgb1a1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • extracellular space Source: Ensembl
  • intracellular Source: MGI
  • nuclear envelope Source: Ensembl
  • rough endoplasmic reticulum Source: Ensembl
  • secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 9675UteroglobinPRO_0000036366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 – 24Interchain (with C-90)By similarity
Disulfide bondi90 – 90Interchain (with C-24)By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ06318.
PaxDbiQ06318.
PRIDEiQ06318.

PTM databases

PhosphoSiteiQ06318.

Expressioni

Tissue specificityi

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Developmental stagei

Appears on the eighteenth day of gestation in the airway epithelium.

Inductioni

By glucocorticoids.

Gene expression databases

BgeeiQ06318.
CleanExiMM_SCGB1A1.
ExpressionAtlasiQ06318. baseline and differential.
GenevisibleiQ06318. MM.

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked.

Protein-protein interaction databases

IntActiQ06318. 1 interaction.
MINTiMINT-4139704.
STRINGi10090.ENSMUSP00000025554.

Structurei

3D structure databases

ProteinModelPortaliQ06318.
SMRiQ06318. Positions 20-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39130.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiQ06318.
OMAiASAEICP.
OrthoDBiEOG77T17C.
PhylomeDBiQ06318.
TreeFamiTF338407.

Family and domain databases

InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAITITVV MLSICCSSAS SDICPGFLQV LEALLMESES GYVASLKPFN
60 70 80 90
PGSDLQNAGT QLKRLVDTLP QETRINIMKL TEKILTSPLC KQDLRF
Length:96
Mass (Da):10,519
Last modified:June 1, 1994 - v1
Checksum:i21103A8839497E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04503 mRNA. Translation: AAA03625.1.
L24372 Genomic DNA. Translation: AAA65446.1.
X67702 mRNA. Translation: CAA47936.1.
U01247 Unassigned DNA. Translation: AAA16141.1.
BC027518 mRNA. Translation: AAH27518.1.
CCDSiCCDS37911.1.
PIRiA53025. UGMS.
RefSeqiNP_035811.1. NM_011681.2.
UniGeneiMm.2258.

Genome annotation databases

EnsembliENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653.
GeneIDi22287.
KEGGimmu:22287.
UCSCiuc008gom.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04503 mRNA. Translation: AAA03625.1.
L24372 Genomic DNA. Translation: AAA65446.1.
X67702 mRNA. Translation: CAA47936.1.
U01247 Unassigned DNA. Translation: AAA16141.1.
BC027518 mRNA. Translation: AAH27518.1.
CCDSiCCDS37911.1.
PIRiA53025. UGMS.
RefSeqiNP_035811.1. NM_011681.2.
UniGeneiMm.2258.

3D structure databases

ProteinModelPortaliQ06318.
SMRiQ06318. Positions 20-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ06318. 1 interaction.
MINTiMINT-4139704.
STRINGi10090.ENSMUSP00000025554.

PTM databases

PhosphoSiteiQ06318.

Proteomic databases

MaxQBiQ06318.
PaxDbiQ06318.
PRIDEiQ06318.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653.
GeneIDi22287.
KEGGimmu:22287.
UCSCiuc008gom.1. mouse.

Organism-specific databases

CTDi7356.
MGIiMGI:98919. Scgb1a1.

Phylogenomic databases

eggNOGiNOG39130.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiQ06318.
OMAiASAEICP.
OrthoDBiEOG77T17C.
PhylomeDBiQ06318.
TreeFamiTF338407.

Miscellaneous databases

ChiTaRSiScgb1a1. mouse.
NextBioi302423.
PROiQ06318.
SOURCEiSearch...

Gene expression databases

BgeeiQ06318.
CleanExiMM_SCGB1A1.
ExpressionAtlasiQ06318. baseline and differential.
GenevisibleiQ06318. MM.

Family and domain databases

InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and tissue-specific expression of the cDNA for the mouse Clara cell 10 kD protein: comparison of endogenous expression to rabbit uteroglobin promoter-driven transgene expression."
    Margraf L.R., Finegold M.J., Stanley L.A., Major A., Hawkins H.K., DeMayo F.J.
    Am. J. Respir. Cell Mol. Biol. 9:231-238(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Structure and regulation of the murine Clara cell secretory protein gene."
    Stripp B.R., Huffman J.A., Bohinski R.J.
    Genomics 20:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Mouse Clara cell 10-kDa (CC10) protein: cDNA nucleotide sequence and molecular basis for the variation in progesterone binding of CC10 from different species."
    Singh G., Katyal S.L., Brown W.E., Kennedy A.L.
    Exp. Lung Res. 19:67-75(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22 AND 25-35.
    Tissue: Lung.
  4. "Cloning and characterization of the mouse Clara cell specific 10 kDa protein gene: comparison of the 5'-flanking region with the human rat and rabbit gene."
    Ray M.K., Magdaleno S., O'Malley B.W., Demayo F.J.
    Biochem. Biophys. Res. Commun. 197:163-171(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
    Tissue: Lung.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiUTER_MOUSE
AccessioniPrimary (citable) accession number: Q06318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 22, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.