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Q06318

- UTER_MOUSE

UniProt

Q06318 - UTER_MOUSE

Protein

Uteroglobin

Gene

Scgb1a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

    GO - Molecular functioni

    1. phospholipase A2 inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of interferon-gamma production Source: MGI
    2. negative regulation of interleukin-13 production Source: MGI
    3. negative regulation of interleukin-4 production Source: MGI
    4. negative regulation of interleukin-5 production Source: MGI
    5. negative regulation of T cell proliferation Source: MGI
    6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    7. regulation of inflammatory response Source: MGI
    8. regulation of mRNA stability Source: MGI
    9. response to cytokine Source: Ensembl
    10. response to drug Source: Ensembl
    11. response to fibroblast growth factor Source: Ensembl
    12. response to glucocorticoid Source: Ensembl
    13. response to lipopolysaccharide Source: Ensembl
    14. response to ozone Source: Ensembl
    15. response to silicon dioxide Source: Ensembl
    16. response to xenobiotic stimulus Source: Ensembl

    Keywords - Molecular functioni

    Phospholipase A2 inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uteroglobin
    Alternative name(s):
    Clara cell 17 kDa protein
    Clara cell phospholipid-binding protein
    Short name:
    CCPBP
    Clara cells 10 kDa secretory protein
    Short name:
    CC10
    PCB-binding protein
    Secretoglobin family 1A member 1
    Gene namesi
    Name:Scgb1a1
    Synonyms:Cc10, Ugb, Utg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:98919. Scgb1a1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: Ensembl
    3. intracellular Source: MGI
    4. nuclear envelope Source: Ensembl
    5. rough endoplasmic reticulum Source: Ensembl
    6. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 9675UteroglobinPRO_0000036366Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 – 24Interchain (with C-90)By similarity
    Disulfide bondi90 – 90Interchain (with C-24)By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ06318.
    PaxDbiQ06318.
    PRIDEiQ06318.

    PTM databases

    PhosphoSiteiQ06318.

    Expressioni

    Tissue specificityi

    Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

    Developmental stagei

    Appears on the eighteenth day of gestation in the airway epithelium.

    Inductioni

    By glucocorticoids.

    Gene expression databases

    ArrayExpressiQ06318.
    BgeeiQ06318.
    CleanExiMM_SCGB1A1.
    GenevestigatoriQ06318.

    Interactioni

    Subunit structurei

    Homodimer; antiparallel disulfide-linked.

    Protein-protein interaction databases

    IntActiQ06318. 1 interaction.
    MINTiMINT-4139704.
    STRINGi10090.ENSMUSP00000025554.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06318.
    SMRiQ06318. Positions 20-95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the secretoglobin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39130.
    HOGENOMiHOG000220914.
    HOVERGENiHBG018062.
    InParanoidiQ06318.
    OMAiFSPDQDM.
    OrthoDBiEOG77T17C.
    PhylomeDBiQ06318.
    TreeFamiTF338407.

    Family and domain databases

    InterProiIPR016126. Secretoglobin.
    IPR000329. Uteroglobin.
    [Graphical view]
    PfamiPF01099. Uteroglobin. 1 hit.
    [Graphical view]
    PRINTSiPR00486. UTEROGLOBIN.
    SMARTiSM00096. UTG. 1 hit.
    [Graphical view]
    SUPFAMiSSF48201. SSF48201. 1 hit.
    PROSITEiPS51311. SCGB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q06318-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIAITITVV MLSICCSSAS SDICPGFLQV LEALLMESES GYVASLKPFN   50
    PGSDLQNAGT QLKRLVDTLP QETRINIMKL TEKILTSPLC KQDLRF 96
    Length:96
    Mass (Da):10,519
    Last modified:June 1, 1994 - v1
    Checksum:i21103A8839497E6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04503 mRNA. Translation: AAA03625.1.
    L24372 Genomic DNA. Translation: AAA65446.1.
    X67702 mRNA. Translation: CAA47936.1.
    U01247 Unassigned DNA. Translation: AAA16141.1.
    BC027518 mRNA. Translation: AAH27518.1.
    CCDSiCCDS37911.1.
    PIRiA53025. UGMS.
    RefSeqiNP_035811.1. NM_011681.2.
    UniGeneiMm.2258.

    Genome annotation databases

    EnsembliENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653.
    GeneIDi22287.
    KEGGimmu:22287.
    UCSCiuc008gom.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04503 mRNA. Translation: AAA03625.1 .
    L24372 Genomic DNA. Translation: AAA65446.1 .
    X67702 mRNA. Translation: CAA47936.1 .
    U01247 Unassigned DNA. Translation: AAA16141.1 .
    BC027518 mRNA. Translation: AAH27518.1 .
    CCDSi CCDS37911.1.
    PIRi A53025. UGMS.
    RefSeqi NP_035811.1. NM_011681.2.
    UniGenei Mm.2258.

    3D structure databases

    ProteinModelPortali Q06318.
    SMRi Q06318. Positions 20-95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q06318. 1 interaction.
    MINTi MINT-4139704.
    STRINGi 10090.ENSMUSP00000025554.

    PTM databases

    PhosphoSitei Q06318.

    Proteomic databases

    MaxQBi Q06318.
    PaxDbi Q06318.
    PRIDEi Q06318.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025554 ; ENSMUSP00000025554 ; ENSMUSG00000024653 .
    GeneIDi 22287.
    KEGGi mmu:22287.
    UCSCi uc008gom.1. mouse.

    Organism-specific databases

    CTDi 7356.
    MGIi MGI:98919. Scgb1a1.

    Phylogenomic databases

    eggNOGi NOG39130.
    HOGENOMi HOG000220914.
    HOVERGENi HBG018062.
    InParanoidi Q06318.
    OMAi FSPDQDM.
    OrthoDBi EOG77T17C.
    PhylomeDBi Q06318.
    TreeFami TF338407.

    Miscellaneous databases

    ChiTaRSi SCGB1A1. mouse.
    NextBioi 302423.
    PROi Q06318.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q06318.
    Bgeei Q06318.
    CleanExi MM_SCGB1A1.
    Genevestigatori Q06318.

    Family and domain databases

    InterProi IPR016126. Secretoglobin.
    IPR000329. Uteroglobin.
    [Graphical view ]
    Pfami PF01099. Uteroglobin. 1 hit.
    [Graphical view ]
    PRINTSi PR00486. UTEROGLOBIN.
    SMARTi SM00096. UTG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48201. SSF48201. 1 hit.
    PROSITEi PS51311. SCGB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and tissue-specific expression of the cDNA for the mouse Clara cell 10 kD protein: comparison of endogenous expression to rabbit uteroglobin promoter-driven transgene expression."
      Margraf L.R., Finegold M.J., Stanley L.A., Major A., Hawkins H.K., DeMayo F.J.
      Am. J. Respir. Cell Mol. Biol. 9:231-238(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Structure and regulation of the murine Clara cell secretory protein gene."
      Stripp B.R., Huffman J.A., Bohinski R.J.
      Genomics 20:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Mouse Clara cell 10-kDa (CC10) protein: cDNA nucleotide sequence and molecular basis for the variation in progesterone binding of CC10 from different species."
      Singh G., Katyal S.L., Brown W.E., Kennedy A.L.
      Exp. Lung Res. 19:67-75(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22 AND 25-35.
      Tissue: Lung.
    4. "Cloning and characterization of the mouse Clara cell specific 10 kDa protein gene: comparison of the 5'-flanking region with the human rat and rabbit gene."
      Ray M.K., Magdaleno S., O'Malley B.W., Demayo F.J.
      Biochem. Biophys. Res. Commun. 197:163-171(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/Sv.
      Tissue: Lung.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.

    Entry informationi

    Entry nameiUTER_MOUSE
    AccessioniPrimary (citable) accession number: Q06318
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3