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Protein

Uteroglobin

Gene

Scgb1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPhospholipase A2 inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Uteroglobin
Alternative name(s):
Clara cell 17 kDa protein
Clara cell phospholipid-binding protein
Short name:
CCPBP
Clara cells 10 kDa secretory protein
Short name:
CC10
PCB-binding protein
Secretoglobin family 1A member 1
Gene namesi
Name:Scgb1a1
Synonyms:Cc10, Ugb, Utg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:98919. Scgb1a1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • intracellular Source: MGI
  • nuclear envelope Source: Ensembl
  • rough endoplasmic reticulum Source: Ensembl
  • secretory granule Source: Ensembl

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003636622 – 96UteroglobinAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24Interchain (with C-90)By similarity
Disulfide bondi90Interchain (with C-24)By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ06318.
PeptideAtlasiQ06318.
PRIDEiQ06318.

PTM databases

PhosphoSitePlusiQ06318.

Expressioni

Tissue specificityi

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Developmental stagei

Appears on the eighteenth day of gestation in the airway epithelium.

Inductioni

By glucocorticoids.

Gene expression databases

BgeeiENSMUSG00000024653.
CleanExiMM_SCGB1A1.
ExpressionAtlasiQ06318. baseline and differential.
GenevisibleiQ06318. MM.

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked.

Protein-protein interaction databases

IntActiQ06318. 1 interactor.
MINTiMINT-4139704.
STRINGi10090.ENSMUSP00000025554.

Structurei

3D structure databases

ProteinModelPortaliQ06318.
SMRiQ06318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J459. Eukaryota.
ENOG4111966. LUCA.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiQ06318.
OMAiASAEICP.
OrthoDBiEOG091G15B2.
PhylomeDBiQ06318.
TreeFamiTF338407.

Family and domain databases

CDDicd00633. Secretoglobin. 1 hit.
Gene3Di1.10.210.10. 1 hit.
InterProiView protein in InterPro
IPR016126. Secretoglobin.
IPR000329. Uteroglobin.
PfamiView protein in Pfam
PF01099. Uteroglobin. 1 hit.
PRINTSiPR00486. UTEROGLOBIN.
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiView protein in PROSITE
PS51311. SCGB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAITITVV MLSICCSSAS SDICPGFLQV LEALLMESES GYVASLKPFN
60 70 80 90
PGSDLQNAGT QLKRLVDTLP QETRINIMKL TEKILTSPLC KQDLRF
Length:96
Mass (Da):10,519
Last modified:June 1, 1994 - v1
Checksum:i21103A8839497E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04503 mRNA. Translation: AAA03625.1.
L24372 Genomic DNA. Translation: AAA65446.1.
X67702 mRNA. Translation: CAA47936.1.
U01247 Unassigned DNA. Translation: AAA16141.1.
BC027518 mRNA. Translation: AAH27518.1.
CCDSiCCDS37911.1.
PIRiA53025. UGMS.
RefSeqiNP_035811.1. NM_011681.2.
UniGeneiMm.2258.

Genome annotation databases

EnsembliENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653.
GeneIDi22287.
KEGGimmu:22287.
UCSCiuc008gom.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiUTER_MOUSE
AccessioniPrimary (citable) accession number: Q06318
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: August 30, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families