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Q06318

- UTER_MOUSE

UniProt

Q06318 - UTER_MOUSE

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Protein

Uteroglobin

Gene

Scgb1a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

GO - Molecular functioni

  1. phospholipase A2 inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of interferon-gamma production Source: MGI
  2. negative regulation of interleukin-13 production Source: MGI
  3. negative regulation of interleukin-4 production Source: MGI
  4. negative regulation of interleukin-5 production Source: MGI
  5. negative regulation of T cell proliferation Source: MGI
  6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  7. regulation of inflammatory response Source: MGI
  8. regulation of mRNA stability Source: MGI
  9. response to cytokine Source: Ensembl
  10. response to drug Source: Ensembl
  11. response to fibroblast growth factor Source: Ensembl
  12. response to glucocorticoid Source: Ensembl
  13. response to lipopolysaccharide Source: Ensembl
  14. response to ozone Source: Ensembl
  15. response to silicon dioxide Source: Ensembl
  16. response to xenobiotic stimulus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Uteroglobin
Alternative name(s):
Clara cell 17 kDa protein
Clara cell phospholipid-binding protein
Short name:
CCPBP
Clara cells 10 kDa secretory protein
Short name:
CC10
PCB-binding protein
Secretoglobin family 1A member 1
Gene namesi
Name:Scgb1a1
Synonyms:Cc10, Ugb, Utg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:98919. Scgb1a1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: Ensembl
  3. intracellular Source: MGI
  4. nuclear envelope Source: Ensembl
  5. rough endoplasmic reticulum Source: Ensembl
  6. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 9675UteroglobinPRO_0000036366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 – 24Interchain (with C-90)By similarity
Disulfide bondi90 – 90Interchain (with C-24)By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ06318.
PaxDbiQ06318.
PRIDEiQ06318.

PTM databases

PhosphoSiteiQ06318.

Expressioni

Tissue specificityi

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Developmental stagei

Appears on the eighteenth day of gestation in the airway epithelium.

Inductioni

By glucocorticoids.

Gene expression databases

BgeeiQ06318.
CleanExiMM_SCGB1A1.
ExpressionAtlasiQ06318. baseline and differential.
GenevestigatoriQ06318.

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked.

Protein-protein interaction databases

IntActiQ06318. 1 interaction.
MINTiMINT-4139704.
STRINGi10090.ENSMUSP00000025554.

Structurei

3D structure databases

ProteinModelPortaliQ06318.
SMRiQ06318. Positions 20-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39130.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiQ06318.
OMAiFSPDQDM.
OrthoDBiEOG77T17C.
PhylomeDBiQ06318.
TreeFamiTF338407.

Family and domain databases

InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06318-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIAITITVV MLSICCSSAS SDICPGFLQV LEALLMESES GYVASLKPFN
60 70 80 90
PGSDLQNAGT QLKRLVDTLP QETRINIMKL TEKILTSPLC KQDLRF
Length:96
Mass (Da):10,519
Last modified:June 1, 1994 - v1
Checksum:i21103A8839497E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04503 mRNA. Translation: AAA03625.1.
L24372 Genomic DNA. Translation: AAA65446.1.
X67702 mRNA. Translation: CAA47936.1.
U01247 Unassigned DNA. Translation: AAA16141.1.
BC027518 mRNA. Translation: AAH27518.1.
CCDSiCCDS37911.1.
PIRiA53025. UGMS.
RefSeqiNP_035811.1. NM_011681.2.
UniGeneiMm.2258.

Genome annotation databases

EnsembliENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653.
GeneIDi22287.
KEGGimmu:22287.
UCSCiuc008gom.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04503 mRNA. Translation: AAA03625.1 .
L24372 Genomic DNA. Translation: AAA65446.1 .
X67702 mRNA. Translation: CAA47936.1 .
U01247 Unassigned DNA. Translation: AAA16141.1 .
BC027518 mRNA. Translation: AAH27518.1 .
CCDSi CCDS37911.1.
PIRi A53025. UGMS.
RefSeqi NP_035811.1. NM_011681.2.
UniGenei Mm.2258.

3D structure databases

ProteinModelPortali Q06318.
SMRi Q06318. Positions 20-95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q06318. 1 interaction.
MINTi MINT-4139704.
STRINGi 10090.ENSMUSP00000025554.

PTM databases

PhosphoSitei Q06318.

Proteomic databases

MaxQBi Q06318.
PaxDbi Q06318.
PRIDEi Q06318.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025554 ; ENSMUSP00000025554 ; ENSMUSG00000024653 .
GeneIDi 22287.
KEGGi mmu:22287.
UCSCi uc008gom.1. mouse.

Organism-specific databases

CTDi 7356.
MGIi MGI:98919. Scgb1a1.

Phylogenomic databases

eggNOGi NOG39130.
HOGENOMi HOG000220914.
HOVERGENi HBG018062.
InParanoidi Q06318.
OMAi FSPDQDM.
OrthoDBi EOG77T17C.
PhylomeDBi Q06318.
TreeFami TF338407.

Miscellaneous databases

ChiTaRSi Scgb1a1. mouse.
NextBioi 302423.
PROi Q06318.
SOURCEi Search...

Gene expression databases

Bgeei Q06318.
CleanExi MM_SCGB1A1.
ExpressionAtlasi Q06318. baseline and differential.
Genevestigatori Q06318.

Family and domain databases

InterProi IPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view ]
Pfami PF01099. Uteroglobin. 1 hit.
[Graphical view ]
PRINTSi PR00486. UTEROGLOBIN.
SMARTi SM00096. UTG. 1 hit.
[Graphical view ]
SUPFAMi SSF48201. SSF48201. 1 hit.
PROSITEi PS51311. SCGB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and tissue-specific expression of the cDNA for the mouse Clara cell 10 kD protein: comparison of endogenous expression to rabbit uteroglobin promoter-driven transgene expression."
    Margraf L.R., Finegold M.J., Stanley L.A., Major A., Hawkins H.K., DeMayo F.J.
    Am. J. Respir. Cell Mol. Biol. 9:231-238(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Structure and regulation of the murine Clara cell secretory protein gene."
    Stripp B.R., Huffman J.A., Bohinski R.J.
    Genomics 20:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Mouse Clara cell 10-kDa (CC10) protein: cDNA nucleotide sequence and molecular basis for the variation in progesterone binding of CC10 from different species."
    Singh G., Katyal S.L., Brown W.E., Kennedy A.L.
    Exp. Lung Res. 19:67-75(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22 AND 25-35.
    Tissue: Lung.
  4. "Cloning and characterization of the mouse Clara cell specific 10 kDa protein gene: comparison of the 5'-flanking region with the human rat and rabbit gene."
    Ray M.K., Magdaleno S., O'Malley B.W., Demayo F.J.
    Biochem. Biophys. Res. Commun. 197:163-171(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
    Tissue: Lung.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiUTER_MOUSE
AccessioniPrimary (citable) accession number: Q06318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3