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Q06318 (UTER_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uteroglobin
Alternative name(s):
Clara cell 17 kDa protein
Clara cell phospholipid-binding protein
Short name=CCPBP
Clara cells 10 kDa secretory protein
Short name=CC10
PCB-binding protein
Secretoglobin family 1A member 1
Gene names
Name:Scgb1a1
Synonyms:Cc10, Ugb, Utg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length96 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Subunit structure

Homodimer; antiparallel disulfide-linked.

Subcellular location

Secreted.

Tissue specificity

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Developmental stage

Appears on the eighteenth day of gestation in the airway epithelium.

Induction

By glucocorticoids.

Sequence similarities

Belongs to the secretoglobin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionPhospholipase A2 inhibitor
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of T cell proliferation

Inferred from direct assay PubMed 15356574. Source: MGI

negative regulation of interferon-gamma production

Inferred from direct assay PubMed 15356574. Source: MGI

negative regulation of interleukin-13 production

Inferred from direct assay PubMed 15356574. Source: MGI

negative regulation of interleukin-4 production

Inferred from direct assay PubMed 15356574. Source: MGI

negative regulation of interleukin-5 production

Inferred from direct assay PubMed 15356574. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15356574. Source: MGI

regulation of inflammatory response

Inferred from direct assay PubMed 15356574. Source: MGI

regulation of mRNA stability

Inferred from direct assay PubMed 15356574. Source: MGI

response to cytokine

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to fibroblast growth factor

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to ozone

Inferred from electronic annotation. Source: Ensembl

response to silicon dioxide

Inferred from electronic annotation. Source: Ensembl

response to xenobiotic stimulus

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 8813084. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

intracellular

Inferred from direct assay PubMed 11724907. Source: MGI

nuclear envelope

Inferred from electronic annotation. Source: Ensembl

rough endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

secretory granule

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionphospholipase A2 inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 9675Uteroglobin
PRO_0000036366

Amino acid modifications

Disulfide bond24Interchain (with C-90) By similarity
Disulfide bond90Interchain (with C-24) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q06318 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 21103A8839497E6C

FASTA9610,519
        10         20         30         40         50         60 
MKIAITITVV MLSICCSSAS SDICPGFLQV LEALLMESES GYVASLKPFN PGSDLQNAGT 

        70         80         90 
QLKRLVDTLP QETRINIMKL TEKILTSPLC KQDLRF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and tissue-specific expression of the cDNA for the mouse Clara cell 10 kD protein: comparison of endogenous expression to rabbit uteroglobin promoter-driven transgene expression."
Margraf L.R., Finegold M.J., Stanley L.A., Major A., Hawkins H.K., DeMayo F.J.
Am. J. Respir. Cell Mol. Biol. 9:231-238(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"Structure and regulation of the murine Clara cell secretory protein gene."
Stripp B.R., Huffman J.A., Bohinski R.J.
Genomics 20:27-35(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Mouse Clara cell 10-kDa (CC10) protein: cDNA nucleotide sequence and molecular basis for the variation in progesterone binding of CC10 from different species."
Singh G., Katyal S.L., Brown W.E., Kennedy A.L.
Exp. Lung Res. 19:67-75(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22 AND 25-35.
Tissue: Lung.
[4]"Cloning and characterization of the mouse Clara cell specific 10 kDa protein gene: comparison of the 5'-flanking region with the human rat and rabbit gene."
Ray M.K., Magdaleno S., O'Malley B.W., Demayo F.J.
Biochem. Biophys. Res. Commun. 197:163-171(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/Sv.
Tissue: Lung.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L04503 mRNA. Translation: AAA03625.1.
L24372 Genomic DNA. Translation: AAA65446.1.
X67702 mRNA. Translation: CAA47936.1.
U01247 Unassigned DNA. Translation: AAA16141.1.
BC027518 mRNA. Translation: AAH27518.1.
PIRUGMS. A53025.
RefSeqNP_035811.1. NM_011681.2.
UniGeneMm.2258.

3D structure databases

ProteinModelPortalQ06318.
SMRQ06318. Positions 20-95.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ06318. 1 interaction.
MINTMINT-4139704.
STRING10090.ENSMUSP00000025554.

PTM databases

PhosphoSiteQ06318.

Proteomic databases

PaxDbQ06318.
PRIDEQ06318.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653.
GeneID22287.
KEGGmmu:22287.
UCSCuc008gom.1. mouse.

Organism-specific databases

CTD7356.
MGIMGI:98919. Scgb1a1.

Phylogenomic databases

eggNOGNOG39130.
HOGENOMHOG000220914.
HOVERGENHBG018062.
InParanoidQ06318.
OMAASAEICP.
OrthoDBEOG77T17C.
PhylomeDBQ06318.
TreeFamTF338407.

Gene expression databases

ArrayExpressQ06318.
BgeeQ06318.
CleanExMM_SCGB1A1.
GenevestigatorQ06318.

Family and domain databases

InterProIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSPR00486. UTEROGLOBIN.
SMARTSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMSSF48201. SSF48201. 1 hit.
PROSITEPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSCGB1A1. mouse.
NextBio302423.
PROQ06318.
SOURCESearch...

Entry information

Entry nameUTER_MOUSE
AccessionPrimary (citable) accession number: Q06318
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot