Q06318 (UTER_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uteroglobin

Alternative name(s):
Clara cell 17 kDa protein
Clara cell phospholipid-binding protein
Short name=CCPBP
Clara cells 10 kDa secretory protein
Short name=CC10
PCB-binding protein
Secretoglobin family 1A member 1

Gene names

Name:	Scgb1a1
Synonyms:	Cc10, Ugb, Utg

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	96 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
Subunit structure	Homodimer; antiparallel disulfide-linked.
Subcellular location	Secreted.
Tissue specificity	Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
Developmental stage	Appears on the eighteenth day of gestation in the airway epithelium.
Induction	By glucocorticoids.
Sequence similarities	Belongs to the secretoglobin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Phospholipase A2 inhibitor
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of T cell proliferation Inferred from direct assay PubMed 15356574. Source: MGI negative regulation of interferon-gamma production Inferred from direct assay PubMed 15356574. Source: MGI negative regulation of interleukin-13 production Inferred from direct assay PubMed 15356574. Source: MGI negative regulation of interleukin-4 production Inferred from direct assay PubMed 15356574. Source: MGI negative regulation of interleukin-5 production Inferred from direct assay PubMed 15356574. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 15356574. Source: MGI regulation of inflammatory response Inferred from direct assay PubMed 15356574. Source: MGI regulation of mRNA stability Inferred from direct assay PubMed 15356574. Source: MGI response to cytokine stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to fibroblast growth factor stimulus Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to ozone Inferred from electronic annotation. Source: Compara response to silicon dioxide Inferred from electronic annotation. Source: Compara response to xenobiotic stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay PubMed 8813084. Source: MGI extracellular space Inferred from electronic annotation. Source: Compara nuclear envelope Inferred from electronic annotation. Source: Compara rough endoplasmic reticulum Inferred from electronic annotation. Source: Compara secretory granule Inferred from electronic annotation. Source: Compara
Molecular_function	phospholipase A2 inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 96	75	Uteroglobin		PRO_0000036366
Amino acid modifications
	Disulfide bond	24		Interchain (with C-90) By similarity
	Disulfide bond	90		Interchain (with C-24) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q06318 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 21103A8839497E6C	FASTA	96	10,519
	10 20 30 40 50 60 MKIAITITVV MLSICCSSAS SDICPGFLQV LEALLMESES GYVASLKPFN PGSDLQNAGT 70 80 90 QLKRLVDTLP QETRINIMKL TEKILTSPLC KQDLRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and tissue-specific expression of the cDNA for the mouse Clara cell 10 kD protein: comparison of endogenous expression to rabbit uteroglobin promoter-driven transgene expression." Margraf L.R., Finegold M.J., Stanley L.A., Major A., Hawkins H.K., DeMayo F.J. Am. J. Respir. Cell Mol. Biol. 9:231-238(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"Structure and regulation of the murine Clara cell secretory protein gene." Stripp B.R., Huffman J.A., Bohinski R.J. Genomics 20:27-35(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Mouse Clara cell 10-kDa (CC10) protein: cDNA nucleotide sequence and molecular basis for the variation in progesterone binding of CC10 from different species." Singh G., Katyal S.L., Brown W.E., Kennedy A.L. Exp. Lung Res. 19:67-75(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22 AND 25-35. Tissue: Lung.
[4]	"Cloning and characterization of the mouse Clara cell specific 10 kDa protein gene: comparison of the 5'-flanking region with the human rat and rabbit gene." Ray M.K., Magdaleno S., O'Malley B.W., Demayo F.J. Biochem. Biophys. Res. Commun. 197:163-171(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/Sv. Tissue: Lung.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L04503 mRNA. Translation: AAA03625.1. L24372 Genomic DNA. Translation: AAA65446.1. X67702 mRNA. Translation: CAA47936.1. U01247 Unassigned DNA. Translation: AAA16141.1. BC027518 mRNA. Translation: AAH27518.1.
IPI	IPI00113547.
PIR	UGMS. A53025.
RefSeq	NP_035811.1. NM_011681.2.
UniGene	Mm.2258.
3D structure databases
ProteinModelPortal	Q06318.
SMR	Q06318. Positions 20-95.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000025554.
PTM databases
PhosphoSite	Q06318.
Proteomic databases
PaxDb	Q06318.
PRIDE	Q06318.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653.
GeneID	22287.
KEGG	mmu:22287.
Organism-specific databases
CTD	7356.
MGI	MGI:98919. Scgb1a1.
Phylogenomic databases
eggNOG	NOG39130.
HOGENOM	HOG000220914.
HOVERGEN	HBG018062.
InParanoid	Q06318.
OMA	ASAEICP.
OrthoDB	EOG4XKV8P.
Gene expression databases
ArrayExpress	Q06318.
Bgee	Q06318.
CleanEx	MM_SCGB1A1.
Genevestigator	Q06318.
GermOnline	ENSMUSG00000024653. Mus musculus.
Family and domain databases
InterPro	IPR016126. Secretoglobin. IPR000329. Uteroglobin-like. IPR006039. Uteroglobin-like_fam. IPR006038. Uteroglobin-like_superfam. [Graphical view]
PANTHER	PTHR10136. PTHR10136. 1 hit.
Pfam	PF01099. Uteroglobin. 1 hit. [Graphical view]
PRINTS	PR00486. UTEROGLOBIN.
SMART	SM00096. UTG. 1 hit. [Graphical view]
SUPFAM	SSF48201. Secretoglobin. 1 hit.
PROSITE	PS51311. SCGB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SCGB1A1. mouse.
NextBio	302423.
SOURCE	Search...

Entry information

Entry name

UTER_MOUSE

Accession

Primary (citable) accession number: Q06318

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program