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Q06316 (BLAC_AMYLA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:bla
OrganismAmycolatopsis lactamdurans (Nocardia lactamdurans)
Taxonomic identifier1913 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeAmycolatopsis

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Active on penicillins but not on cephalosporins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Secreted.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 302273Beta-lactamase
PRO_0000017006

Regions

Region247 – 2493Substrate binding By similarity

Sites

Active site851Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q06316 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: B7D6550AAE88B4F4

FASTA30232,084
        10         20         30         40         50         60 
MADRRRVHAW ARARPAAPEP APPTPSAAAP SVAPGPAATP PDPAVEQEFT RLQTQYDARL 

        70         80         90        100        110        120 
GLYAVDTGSG ESVAFRADER FAFASTFKAL AAAAVLDSTT PQQLDQVVRY SKDELLENSP 

       130        140        150        160        170        180 
ITKDHVATGM TLRELCDAAV RFSDNTAGNL LLKHVGGPQG LDAALTAVGD EVTSADRWEP 

       190        200        210        220        230        240 
ELNSAVPGDV RDTSTPRALA HDLRQFVLGD ALAEDDRALL TDWLRRNTTG GTVIRAGVPA 

       250        260        270        280        290        300 
DWVVGDKTGS GYYGGRNDIA VLWPPNRAPI VMAVMTSREE PRAKRADALL ADAARVAVTA 


LG 

« Hide

References

[1]"Genes for a beta-lactamase, a penicillin-binding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocardia lactamdurans."
Coque J.J.R., Liras P., Martin J.F.
EMBO J. 12:631-639(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LC411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z13971 Genomic DNA. Translation: CAA78373.1.
PIRS36188.

3D structure databases

ProteinModelPortalQ06316.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_AMYLA
AccessionPrimary (citable) accession number: Q06316
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 11, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families