Reviewed, UniProtKB/Swiss-Prot Q06204 (YL446_YEAST)

Names and origin

Protein names

Recommended name:
    Putative hexokinase YLR446W
    EC=2.7.1.1

Gene names

Ordered Locus Names:

YLR446W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q05789	1	EBI-37403,EBI-35873
PRP6	P19735	1	EBI-37403,EBI-227

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Putative hexokinase YLR446W		PRO_0000268190
Regions
	Region	132 – 154	23	Glucose-binding Potential
Experimental info
	Sequence conflict	52	1	K → E in AAT92658. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q06204-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 704555676B3DA755	FASTA	433	48,969
	10 20 30 40 50 60 MTIESTLARE LESLILPADS IVNVVDQFQE ELLSRLQTNT ISMLPQCLVP DKRSRWNPED 70 80 90 100 110 120 KILTIDFGGT RLKFAIISLP QIVIEYNDAF ELTYNIVDSN FFNQIIYTIC TRLAANGYIK 130 140 150 160 170 180 KKNESSEASK FFVSVTFSFP LNPEGEVVAM GKGFVMTDTL QGSTVKQLIQ SSFHRIISEN 190 200 210 220 230 240 IEEFFCTMNV CHVINDAIAV SLTSKFICEN DSISLIIGTG TNACFEVPYG YLPPFKRDAL 250 260 270 280 290 300 RETLPSSYNK ETLNFKHVLI NSEIGFIGKN VIALQPFDIH GAISYEMPLE CVTSGKWLPL 310 320 330 340 350 360 SLKNILLQYN IIPKNFPVEF NGELVCQLAE DCTNAWFENE HYALICQIAR LLIKRAAFYV 370 380 390 400 410 420 AAIVQAIDII TGCKNYNFIH IGYVGSFLHN SNFYREQIKY YSSIHIKLQF LNHSNLLGAA 430 IATYLNKSDN QVQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D. Nature 387:87-90(1997) [PubMed: 9169871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U22382 Genomic DNA. Translation: AAB67530.1. AY692639 Genomic DNA. Translation: AAT92658.1.
PIR	S55968.
RefSeq	NP_013551.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4630N.
IntAct	Q06204. 8 interactions.
STRING	Q06204.
Proteomic databases
PRIDE	Q06204.
Genome annotation databases
Ensembl	YLR446W; YLR446W; YLR446W; Saccharomyces cerevisiae. [Genome view]
GeneID	851167.
GenomeReviews	Gene locus YLR446W in contig Y13138_GR.
KEGG	sce:YLR446W.
NMPDR	fig|4932.3.peg.4582.
Organism-specific databases
CYGD	YLR446w.
SGD	S000004438. YLR446W.
Phylogenomic databases
HOGENOM	Q06204.
OMA	VAMGKGF.
Enzyme and pathway databases
BRENDA	2.7.1.1. 250.
Gene expression databases
ArrayExpress	Q06204.
Genevestigator	Q06204.
GermOnline	YLR446W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR019807. Hexokinase_CS. [Graphical view]
PANTHER	PTHR19443. Hexokinase. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	967969.

Entry information

Entry name

YL446_YEAST

Accession

Primary (citable) accession number: Q06204
Secondary accession number(s): Q6B2U1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)