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Protein

Isocitrate dehydrogenase [NADP]

Gene

IDH1

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May supply 2-oxoglutarate for amino acid biosynthesis and ammonia assimilation via the glutamine synthetase/glutamate synthase (GS/GOGAT) pathway.By similarity

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+, Mn2+Note: Binds 1 Mg2+ or Mn2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80SubstrateBy similarity1
Binding sitei85NADPBy similarity1
Binding sitei112SubstrateBy similarity1
Binding sitei135SubstrateBy similarity1
Sitei142Critical for catalysisBy similarity1
Sitei215Critical for catalysisBy similarity1
Metal bindingi255Magnesium or manganeseBy similarity1
Binding sitei263NADPBy similarity1
Metal bindingi278Magnesium or manganeseBy similarity1
Binding sitei331NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 80NADPBy similarity3
Nucleotide bindingi313 – 318NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle
LigandMagnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:IDH1
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Chromosome 14

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835851 – 413Isocitrate dehydrogenase [NADP]Add BLAST413

Proteomic databases

PRIDEiQ06197
ProMEXiQ06197

Expressioni

Tissue specificityi

Leaves, nodules and roots with the relative amount of 1:3.4:7.7.

Gene expression databases

GenevisibleiQ06197 GM

Interactioni

Subunit structurei

Heterodimer.

Protein-protein interaction databases

STRINGi3847.GLYMA14G39160.2

Structurei

3D structure databases

ProteinModelPortaliQ06197
SMRiQ06197
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 103Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1526 Eukaryota
COG0538 LUCA
InParanoidiQ06197
KOiK00031
OMAiYLNTMDF
OrthoDBiEOG09370DQY

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q06197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFQKIKVA NPIVEMDGDE MTRVIWKSIK DKLILPFLEL DIKYYDLGLP
60 70 80 90 100
YRDETDDKVT IESAEATLKY NVAIKCATIT PDEARVKEFG LKSMWKSPNG
110 120 130 140 150
TIRNILNGTV FREPILCKNI PRLVPGWTKA ICIGRHAFGD QYRATDTVIK
160 170 180 190 200
GAGKLKLVFV PEGQGEETEF EVFNFTGEGG VSLAMYNTDE SIRSFAEASM
210 220 230 240 250
ATALEKKWPL YLSTKNTILK KYDGRFKDIF QEVYEASWKS KFEAAGIWYE
260 270 280 290 300
HRLIDDMVAY ALKSEGGYVW ACKNYDGDVQ SDFLAQGFGS LGLMTSVLVC
310 320 330 340 350
PDGKTIEAEA AHGTVTRHFR VHQKGGETST NSIASIFAWT RGLAHRAKLD
360 370 380 390 400
DNAKLLDFTE KLEAACIGVV EAGKMTKDLA LILHGSKLSR EHYLNTEEFI
410
DAVAAELSAR LSA
Length:413
Mass (Da):46,050
Last modified:October 1, 1996 - v2
Checksum:i78B90E53C6D686B5
GO

Sequence cautioni

The sequence AAA33978 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12157 mRNA Translation: AAA33978.1 Different initiation.
RefSeqiXP_014622642.1, XM_014767156.1
UniGeneiGma.8359

Genome annotation databases

EnsemblPlantsiKRH17285; KRH17285; GLYMA_14G211000
GeneIDi100791166
GrameneiKRH17285; KRH17285; GLYMA_14G211000
KEGGigmx:100791166

Similar proteinsi

Entry informationi

Entry nameiIDHC_SOYBN
AccessioniPrimary (citable) accession number: Q06197
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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