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Reviewed, UniProtKB/Swiss-Prot Q06190 (P2R3A_HUMAN)

Last modified February 9, 2010. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Alternative name(s):
    Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
    PP2A subunit B isoforms B''-PR72/PR130
    PP2A subunit B isoforms B72/B130
    PP2A subunit B isoform PR72/PR130
    PP2A subunit B isoform R3 isoform
Gene names
Name: PPP2R3A
Synonyms: PPP2R3
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1150 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Tissue specificity

Expressed in heart, brain, placenta, lung, muscle and kidney.

Sequence similarities

Contains 2 EF-hand domains.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

NKD1Q969G92EBI-949204,EBI-1538217
NKD1Q969G91EBI-949210,EBI-1538217

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform PR130 (identifier: Q06190-1)

Also known as: 130 kDa;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PR72 (identifier: Q06190-2)

Also known as: 72 kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-621: Missing.
     622-665: MQILQETLTT...LIQQTPEVIK → MMIKETSLRR...KRLKSFQQTQ

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11501150Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
PRO_0000071443

Regions

Domain758 – 79336EF-hand 1
Domain972 – 100736EF-hand 2
Calcium binding985 – 99612 Potential
Compositional bias670 – 69526Pro-rich

Natural variations

Alternative sequence1 – 621621Missing in isoform PR72.
VSP_005107
Alternative sequence622 – 66544MQILQ…PEVIK → MMIKETSLRRDPDLRGELAF LARGCDFVLPSRFKKRLKSF QQTQ in isoform PR72.
VSP_005108
Natural variant671D → G: dbSNP rs9814557.
VAR_051739
Natural variant671D → N: dbSNP rs57374999.
VAR_061760
Natural variant1081N → S: dbSNP rs36020282.
VAR_051740
Natural variant1711A → S: dbSNP rs6779903.
VAR_051741
Natural variant4811P → A: dbSNP rs34901937.
VAR_051742
Natural variant6421S → G: dbSNP rs17197552.
VAR_051743
Natural variant6951P → L: dbSNP rs9826032.
VAR_051744
Natural variant7451D → N: dbSNP rs16843645.
VAR_022095

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Sequences

Sequence LengthMass (Da)Tools
Isoform PR130 (130 kDa) [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 97A31BA4206518A3

FASTA1,150130,278
        10         20         30         40         50         60 
MAATYRLVVS TVNHYSSVVI DRRFEQAIHY CTGTCHTFTH GIDCIVVHHS VCADLLHIPV 

        70         80         90        100        110        120 
SQFKDADLNS MFLPHENGLS SAEGDYPQQA FTGIPRVKRG STFQNTYNLK DIAGEAISFA 

       130        140        150        160        170        180 
SGKIKEFSFE KLKNSNHAAY RKGRKVKSDS FNRRSVDLDL LCGHYNNDGN APSFGLLRSS 

       190        200        210        220        230        240 
SVEEKPLSHR NSLDTNLTSM FLQNFSEEDL VTQILEKHKI DNFSSGTDIK MCLDILLKCS 

       250        260        270        280        290        300 
EDLKKCTDII KQCIKKKSGS SISEGSGNDT ISSSETVYMN VMTRLASYLK KLPFEFMQSG 

       310        320        330        340        350        360 
NNEALDLTEL ISNMPSLQLT PFSPVFGTEQ PPKYEDVVQL SASDSGRFQT IELQNDKPNS 

       370        380        390        400        410        420 
RKMDTVQSIP NNSTNSLYNL EVNDPRTLKA VQVQSQSLTM NPLENVSSDD LMETLYIEEE 

       430        440        450        460        470        480 
SDGKKALDKG QKTENGPSHE LLKVNEHRAE FPEHATHLKK CPTPMQNEIG KIFEKSFVNL 

       490        500        510        520        530        540 
PKEDCKSKVS KFEEGDQRDF TNSSSQEEID KLLMDLESFS QKMETSLREP LAKGKNSNFL 

       550        560        570        580        590        600 
NSHSQLTGQT LVDLEPKSKV SSPIEKVSPS CLTRIIETNG HKIEEEDRAL LLRILESIED 

       610        620        630        640        650        660 
FAQELVECKS SRGSLSQEKE MMQILQETLT TSSQANLSVC RSPVGDKAKD TTSAVLIQQT 

       670        680        690        700        710        720 
PEVIKIQNKP EKKPGTPLPP PATSPSSPRP LSPVPHVNNV VNAPLSINIP RFYFPEGLPD 

       730        740        750        760        770        780 
TCSNHEQTLS RIETAFMDIE EQKADIYEMG KIAKVCGCPL YWKAPMFRAA GGEKTGFVTA 

       790        800        810        820        830        840 
QSFIAMWRKL LNNHHDDASK FICLLAKPNC SSLEQEDFIP LLQDVVDTHP GLTFLKDAPE 

       850        860        870        880        890        900 
FHSRYITTVI QRIFYTVNRS WSGKITSTEI RKSNFLQTLA LLEEEEDINQ ITDYFSYEHF 

       910        920        930        940        950        960 
YVIYCKFWEL DTDHDLYISQ ADLSRYNDQA SSSRIIERIF SGAVTRGKTI QKEGRMSYAD 

       970        980        990       1000       1010       1020 
FVWFLISEED KRNPTSIEYW FRCMDVDGDG VLSMYELEYF YEEQCERMEA MGIEPLPFHD 

      1030       1040       1050       1060       1070       1080 
LLCQMLDLVK PAVDGKITLR DLKRCRMAHI FYDTFFNLEK YLDHEQRDPF AVQKDVENDG 

      1090       1100       1110       1120       1130       1140 
PEPSDWDRFA AEEYETLVAE ESAQAQFQEG FEDYETDEPA SPSEFGNKSN KILSASLPEK 

      1150 
CGKLQSVDEE

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Isoform PR72 (72 kDa).

Checksum: 3782D0D800A5F6D4
Show »

FASTA52961,097

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References

« Hide 'large scale' references
[1]"Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing."
Hendrix P., Mayer-Jaekel R.E., Cron P., Goris J., Hofsteenge J., Merlevede W., Hemmings B.A.
J. Biol. Chem. 268:15267-15276(1993) [PubMed: 8392071] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, ALTERNATIVE SPLICING.
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PR72 AND PR130).
Tissue: Tongue and Trachea.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]The European IMAGE consortium
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 768-1150.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L07590 mRNA. Translation: AAB02613.1.
L12146 mRNA. Translation: AAB02614.1.
AK293012 mRNA. Translation: BAF85701.1.
AK316258 mRNA. Translation: BAH14629.1.
CH471052 Genomic DNA. Translation: EAW79122.1.
CH471052 Genomic DNA. Translation: EAW79123.1.
AL389975 mRNA. Translation: CAB97532.1.
IPIIPI00029144.
IPI00218930.
PIRA47114.
B47114.
RefSeqNP_002709.2.
NP_871626.1.
UniGeneHs.518155

3D structure databases

SMRQ06190. Positions 889-1049.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29397N.
IntActQ06190. 6 interactions.
STRINGQ06190.

PTM databases

PhosphoSiteQ06190.

Proteomic databases

PRIDEQ06190.

Genome annotation databases

EnsemblENST00000264977; ENSP00000264977; ENSG00000073711; Homo sapiens. [Genome view]
GeneID5523.
KEGGhsa:5523.
UCSCuc003eqv.1. human.
uc003eqw.1. human.

Organism-specific databases

CTD5523.
GeneCardsGC03P137167.
H-InvDBHIX0030765.
HGNCHGNC:9307. PPP2R3A.
MIM604944. gene.
PharmGKBPA35523.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG280542.
HOVERGENQ06190.
InParanoidQ06190.
OMAHYNNDGN.
OrthoDBEOG9QZB63.
PhylomeDBQ06190.

Gene expression databases

ArrayExpressQ06190.
BgeeQ06190.
CleanExHS_PPP2R3A.
GenevestigatorQ06190.
GermOnlineENSG00000073711. Homo sapiens.

Family and domain databases

InterProIPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR018249. EF_HAND_2.
[Graphical view]
Gene3DG3DSA:1.10.238.10. EF-Hand_type. 1 hit.
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio21376.
SOURCESearch...

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Entry information

Entry nameP2R3A_HUMAN
AccessionPrimary (citable) accession number: Q06190
Secondary accession number(s): A8KAE7 expand/collapse secondary AC list , B7ZAE3, Q06189, Q9NPQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 9, 2010
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents