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Q06190

- P2R3A_HUMAN

UniProt

Q06190 - P2R3A_HUMAN

Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

Gene

PPP2R3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi985 – 99612PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: IntAct
    3. protein phosphatase type 2A regulator activity Source: ProtInc

    GO - Biological processi

    1. eye photoreceptor cell differentiation Source: BHF-UCL
    2. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
    3. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
    4. positive regulation of protein catabolic process Source: BHF-UCL
    5. protein dephosphorylation Source: UniProtKB
    6. regulation of catalytic activity Source: GOC
    7. regulation of cell motility involved in somitogenic axis elongation Source: BHF-UCL
    8. somatic muscle development Source: BHF-UCL
    9. somite development Source: BHF-UCL
    10. Wnt signaling pathway involved in somitogenesis Source: BHF-UCL

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
    Alternative name(s):
    PP2A subunit B isoform PR72/PR130
    PP2A subunit B isoform R3 isoform
    PP2A subunit B isoforms B''-PR72/PR130
    PP2A subunit B isoforms B72/B130
    Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
    Gene namesi
    Name:PPP2R3A
    Synonyms:PPP2R3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:9307. PPP2R3A.

    Subcellular locationi

    GO - Cellular componenti

    1. protein phosphatase type 2A complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35523.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11501150Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alphaPRO_0000071443Add
    BLAST

    Proteomic databases

    MaxQBiQ06190.
    PaxDbiQ06190.
    PRIDEiQ06190.

    PTM databases

    PhosphoSiteiQ06190.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain, placenta, lung, muscle and kidney.

    Gene expression databases

    ArrayExpressiQ06190.
    BgeeiQ06190.
    CleanExiHS_PPP2R3A.
    GenevestigatoriQ06190.

    Organism-specific databases

    HPAiHPA035829.
    HPA035830.

    Interactioni

    Subunit structurei

    PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NKD1Q969G94EBI-949204,EBI-1538217

    Protein-protein interaction databases

    BioGridi111515. 6 interactions.
    DIPiDIP-29397N.
    IntActiQ06190. 7 interactions.
    MINTiMINT-2861926.
    STRINGi9606.ENSP00000264977.

    Structurei

    Secondary structure

    1
    1150
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi797 – 8059
    Beta strandi811 – 8133
    Helixi815 – 8184
    Helixi819 – 82810
    Turni830 – 8323
    Helixi833 – 8375
    Helixi839 – 85719
    Beta strandi861 – 8633
    Helixi867 – 8715
    Helixi875 – 8828
    Helixi888 – 8903
    Turni892 – 8954
    Helixi897 – 91014
    Beta strandi915 – 9195
    Helixi920 – 9234
    Turni924 – 9296
    Helixi933 – 9397
    Turni940 – 9445
    Helixi958 – 96912
    Helixi974 – 98411
    Beta strandi989 – 9924
    Helixi994 – 101017
    Helixi1018 – 102912
    Helixi1039 – 10457
    Helixi1048 – 10569
    Helixi1058 – 10625

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I5JX-ray2.09A786-1070[»]
    4I5KX-ray2.90A/B786-1070[»]
    ProteinModelPortaliQ06190.
    SMRiQ06190. Positions 706-1064.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini758 – 79336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini972 – 100736EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi670 – 69526Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG271066.
    HOGENOMiHOG000013216.
    HOVERGENiHBG000013.
    InParanoidiQ06190.
    KOiK11583.
    OMAiFQTIELQ.
    OrthoDBiEOG7XWPN3.
    PhylomeDBiQ06190.
    TreeFamiTF105554.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform PR130 (identifier: Q06190-1) [UniParc]FASTAAdd to Basket

    Also known as: 130 kDa

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAATYRLVVS TVNHYSSVVI DRRFEQAIHY CTGTCHTFTH GIDCIVVHHS     50
    VCADLLHIPV SQFKDADLNS MFLPHENGLS SAEGDYPQQA FTGIPRVKRG 100
    STFQNTYNLK DIAGEAISFA SGKIKEFSFE KLKNSNHAAY RKGRKVKSDS 150
    FNRRSVDLDL LCGHYNNDGN APSFGLLRSS SVEEKPLSHR NSLDTNLTSM 200
    FLQNFSEEDL VTQILEKHKI DNFSSGTDIK MCLDILLKCS EDLKKCTDII 250
    KQCIKKKSGS SISEGSGNDT ISSSETVYMN VMTRLASYLK KLPFEFMQSG 300
    NNEALDLTEL ISNMPSLQLT PFSPVFGTEQ PPKYEDVVQL SASDSGRFQT 350
    IELQNDKPNS RKMDTVQSIP NNSTNSLYNL EVNDPRTLKA VQVQSQSLTM 400
    NPLENVSSDD LMETLYIEEE SDGKKALDKG QKTENGPSHE LLKVNEHRAE 450
    FPEHATHLKK CPTPMQNEIG KIFEKSFVNL PKEDCKSKVS KFEEGDQRDF 500
    TNSSSQEEID KLLMDLESFS QKMETSLREP LAKGKNSNFL NSHSQLTGQT 550
    LVDLEPKSKV SSPIEKVSPS CLTRIIETNG HKIEEEDRAL LLRILESIED 600
    FAQELVECKS SRGSLSQEKE MMQILQETLT TSSQANLSVC RSPVGDKAKD 650
    TTSAVLIQQT PEVIKIQNKP EKKPGTPLPP PATSPSSPRP LSPVPHVNNV 700
    VNAPLSINIP RFYFPEGLPD TCSNHEQTLS RIETAFMDIE EQKADIYEMG 750
    KIAKVCGCPL YWKAPMFRAA GGEKTGFVTA QSFIAMWRKL LNNHHDDASK 800
    FICLLAKPNC SSLEQEDFIP LLQDVVDTHP GLTFLKDAPE FHSRYITTVI 850
    QRIFYTVNRS WSGKITSTEI RKSNFLQTLA LLEEEEDINQ ITDYFSYEHF 900
    YVIYCKFWEL DTDHDLYISQ ADLSRYNDQA SSSRIIERIF SGAVTRGKTI 950
    QKEGRMSYAD FVWFLISEED KRNPTSIEYW FRCMDVDGDG VLSMYELEYF 1000
    YEEQCERMEA MGIEPLPFHD LLCQMLDLVK PAVDGKITLR DLKRCRMAHI 1050
    FYDTFFNLEK YLDHEQRDPF AVQKDVENDG PEPSDWDRFA AEEYETLVAE 1100
    ESAQAQFQEG FEDYETDEPA SPSEFGNKSN KILSASLPEK CGKLQSVDEE 1150
    Length:1,150
    Mass (Da):130,278
    Last modified:June 1, 1994 - v1
    Checksum:i97A31BA4206518A3
    GO
    Isoform PR72 (identifier: Q06190-2) [UniParc]FASTAAdd to Basket

    Also known as: 72 kDa

    The sequence of this isoform differs from the canonical sequence as follows:
         1-621: Missing.
         622-665: MQILQETLTT...LIQQTPEVIK → MMIKETSLRR...KRLKSFQQTQ

    Show »
    Length:529
    Mass (Da):61,097
    Checksum:i3782D0D800A5F6D4
    GO
    Isoform 3 (identifier: Q06190-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-736: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:414
    Mass (Da):48,178
    Checksum:i3F0B982FF10C8AD9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671D → G.
    Corresponds to variant rs9814557 [ dbSNP | Ensembl ].
    VAR_051739
    Natural varianti67 – 671D → N.
    Corresponds to variant rs57374999 [ dbSNP | Ensembl ].
    VAR_061760
    Natural varianti108 – 1081N → S.
    Corresponds to variant rs36020282 [ dbSNP | Ensembl ].
    VAR_051740
    Natural varianti171 – 1711A → S.
    Corresponds to variant rs6779903 [ dbSNP | Ensembl ].
    VAR_051741
    Natural varianti481 – 4811P → A.
    Corresponds to variant rs34901937 [ dbSNP | Ensembl ].
    VAR_051742
    Natural varianti642 – 6421S → G.
    Corresponds to variant rs17197552 [ dbSNP | Ensembl ].
    VAR_051743
    Natural varianti695 – 6951P → L.
    Corresponds to variant rs9826032 [ dbSNP | Ensembl ].
    VAR_051744
    Natural varianti745 – 7451D → N.
    Corresponds to variant rs16843645 [ dbSNP | Ensembl ].
    VAR_022095

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 736736Missing in isoform 3. 1 PublicationVSP_045203Add
    BLAST
    Alternative sequencei1 – 621621Missing in isoform PR72. 2 PublicationsVSP_005107Add
    BLAST
    Alternative sequencei622 – 66544MQILQ…PEVIK → MMIKETSLRRDPDLRGELAF LARGCDFVLPSRFKKRLKSF QQTQ in isoform PR72. 2 PublicationsVSP_005108Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07590 mRNA. Translation: AAB02613.1.
    L12146 mRNA. Translation: AAB02614.1.
    AK293012 mRNA. Translation: BAF85701.1.
    AK298059 mRNA. Translation: BAG60353.1.
    AK316258 mRNA. Translation: BAH14629.1.
    AC072039 Genomic DNA. No translation available.
    AC092991 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79122.1.
    CH471052 Genomic DNA. Translation: EAW79123.1.
    AL389975 mRNA. Translation: CAB97532.1.
    CCDSiCCDS3087.1. [Q06190-1]
    CCDS3088.1. [Q06190-2]
    CCDS54642.1. [Q06190-3]
    PIRiA47114.
    B47114.
    RefSeqiNP_001177376.1. NM_001190447.1. [Q06190-3]
    NP_002709.2. NM_002718.4. [Q06190-1]
    NP_871626.1. NM_181897.2. [Q06190-2]
    XP_006713749.1. XM_006713686.1. [Q06190-1]
    UniGeneiHs.518155.

    Genome annotation databases

    EnsembliENST00000264977; ENSP00000264977; ENSG00000073711. [Q06190-1]
    ENST00000334546; ENSP00000334748; ENSG00000073711. [Q06190-2]
    ENST00000490467; ENSP00000419344; ENSG00000073711. [Q06190-3]
    GeneIDi5523.
    KEGGihsa:5523.
    UCSCiuc003eqv.2. human. [Q06190-1]
    uc003eqw.2. human. [Q06190-2]
    uc011blz.2. human.

    Polymorphism databases

    DMDMi543720.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07590 mRNA. Translation: AAB02613.1 .
    L12146 mRNA. Translation: AAB02614.1 .
    AK293012 mRNA. Translation: BAF85701.1 .
    AK298059 mRNA. Translation: BAG60353.1 .
    AK316258 mRNA. Translation: BAH14629.1 .
    AC072039 Genomic DNA. No translation available.
    AC092991 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79122.1 .
    CH471052 Genomic DNA. Translation: EAW79123.1 .
    AL389975 mRNA. Translation: CAB97532.1 .
    CCDSi CCDS3087.1. [Q06190-1 ]
    CCDS3088.1. [Q06190-2 ]
    CCDS54642.1. [Q06190-3 ]
    PIRi A47114.
    B47114.
    RefSeqi NP_001177376.1. NM_001190447.1. [Q06190-3 ]
    NP_002709.2. NM_002718.4. [Q06190-1 ]
    NP_871626.1. NM_181897.2. [Q06190-2 ]
    XP_006713749.1. XM_006713686.1. [Q06190-1 ]
    UniGenei Hs.518155.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I5J X-ray 2.09 A 786-1070 [» ]
    4I5K X-ray 2.90 A/B 786-1070 [» ]
    ProteinModelPortali Q06190.
    SMRi Q06190. Positions 706-1064.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111515. 6 interactions.
    DIPi DIP-29397N.
    IntActi Q06190. 7 interactions.
    MINTi MINT-2861926.
    STRINGi 9606.ENSP00000264977.

    PTM databases

    PhosphoSitei Q06190.

    Polymorphism databases

    DMDMi 543720.

    Proteomic databases

    MaxQBi Q06190.
    PaxDbi Q06190.
    PRIDEi Q06190.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264977 ; ENSP00000264977 ; ENSG00000073711 . [Q06190-1 ]
    ENST00000334546 ; ENSP00000334748 ; ENSG00000073711 . [Q06190-2 ]
    ENST00000490467 ; ENSP00000419344 ; ENSG00000073711 . [Q06190-3 ]
    GeneIDi 5523.
    KEGGi hsa:5523.
    UCSCi uc003eqv.2. human. [Q06190-1 ]
    uc003eqw.2. human. [Q06190-2 ]
    uc011blz.2. human.

    Organism-specific databases

    CTDi 5523.
    GeneCardsi GC03P135684.
    HGNCi HGNC:9307. PPP2R3A.
    HPAi HPA035829.
    HPA035830.
    MIMi 604944. gene.
    neXtProti NX_Q06190.
    PharmGKBi PA35523.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271066.
    HOGENOMi HOG000013216.
    HOVERGENi HBG000013.
    InParanoidi Q06190.
    KOi K11583.
    OMAi FQTIELQ.
    OrthoDBi EOG7XWPN3.
    PhylomeDBi Q06190.
    TreeFami TF105554.

    Miscellaneous databases

    GeneWikii PPP2R3A.
    GenomeRNAii 5523.
    NextBioi 21376.
    PROi Q06190.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q06190.
    Bgeei Q06190.
    CleanExi HS_PPP2R3A.
    Genevestigatori Q06190.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing."
      Hendrix P., Mayer-Jaekel R.E., Cron P., Goris J., Hofsteenge J., Merlevede W., Hemmings B.A.
      J. Biol. Chem. 268:15267-15276(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PR72 AND PR130), PARTIAL PROTEIN SEQUENCE, ALTERNATIVE SPLICING.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PR72; PR130 AND 3).
      Tissue: Lung, Tongue and Trachea.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 768-1150.

    Entry informationi

    Entry nameiP2R3A_HUMAN
    AccessioniPrimary (citable) accession number: Q06190
    Secondary accession number(s): A8KAE7
    , B4DNU1, B7ZAE3, Q06189, Q9NPQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3