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Q06190 (P2R3A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Alternative name(s):
PP2A subunit B isoform PR72/PR130
PP2A subunit B isoform R3 isoform
PP2A subunit B isoforms B''-PR72/PR130
PP2A subunit B isoforms B72/B130
Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
Gene names
Name:PPP2R3A
Synonyms:PPP2R3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1150 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Tissue specificity

Expressed in heart, brain, placenta, lung, muscle and kidney.

Sequence similarities

Contains 2 EF-hand domains.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   LigandCalcium
Metal-binding
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway involved in somitogenesis

Inferred by curator PubMed 15687260. Source: BHF-UCL

eye photoreceptor cell differentiation

Inferred from genetic interaction PubMed 15687260. Source: BHF-UCL

negative regulation of canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 15687260. Source: BHF-UCL

positive regulation of canonical Wnt signaling pathway

Inferred from direct assay PubMed 16567647. Source: BHF-UCL

positive regulation of protein catabolic process

Inferred from mutant phenotype PubMed 15687260. Source: BHF-UCL

protein dephosphorylation

Inferred from sequence or structural similarity PubMed 1849734. Source: UniProtKB

regulation of catalytic activity

Traceable author statement Ref.1. Source: GOC

regulation of cell motility involved in somitogenic axis elongation

Inferred from genetic interaction PubMed 15687260. Source: BHF-UCL

somatic muscle development

Inferred from genetic interaction PubMed 15687260. Source: BHF-UCL

somite development

Inferred from sequence or structural similarity PubMed 16567647. Source: BHF-UCL

   Cellular_componentprotein phosphatase type 2A complex

Inferred from direct assay PubMed 17055435. Source: UniProtKB

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

protein phosphatase type 2A regulator activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NKD1Q969G94EBI-949204,EBI-1538217

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform PR130 (identifier: Q06190-1)

Also known as: 130 kDa;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PR72 (identifier: Q06190-2)

Also known as: 72 kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-621: Missing.
     622-665: MQILQETLTT...LIQQTPEVIK → MMIKETSLRR...KRLKSFQQTQ
Isoform 3 (identifier: Q06190-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-736: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11501150Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
PRO_0000071443

Regions

Domain758 – 79336EF-hand 1
Domain972 – 100736EF-hand 2
Calcium binding985 – 99612 Potential
Compositional bias670 – 69526Pro-rich

Natural variations

Alternative sequence1 – 736736Missing in isoform 3.
VSP_045203
Alternative sequence1 – 621621Missing in isoform PR72.
VSP_005107
Alternative sequence622 – 66544MQILQ…PEVIK → MMIKETSLRRDPDLRGELAF LARGCDFVLPSRFKKRLKSF QQTQ in isoform PR72.
VSP_005108
Natural variant671D → G.
Corresponds to variant rs9814557 [ dbSNP | Ensembl ].
VAR_051739
Natural variant671D → N.
Corresponds to variant rs57374999 [ dbSNP | Ensembl ].
VAR_061760
Natural variant1081N → S.
Corresponds to variant rs36020282 [ dbSNP | Ensembl ].
VAR_051740
Natural variant1711A → S.
Corresponds to variant rs6779903 [ dbSNP | Ensembl ].
VAR_051741
Natural variant4811P → A.
Corresponds to variant rs34901937 [ dbSNP | Ensembl ].
VAR_051742
Natural variant6421S → G.
Corresponds to variant rs17197552 [ dbSNP | Ensembl ].
VAR_051743
Natural variant6951P → L.
Corresponds to variant rs9826032 [ dbSNP | Ensembl ].
VAR_051744
Natural variant7451D → N.
Corresponds to variant rs16843645 [ dbSNP | Ensembl ].
VAR_022095

Secondary structure

................................................ 1150
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform PR130 (130 kDa) [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 97A31BA4206518A3

FASTA1,150130,278
        10         20         30         40         50         60 
MAATYRLVVS TVNHYSSVVI DRRFEQAIHY CTGTCHTFTH GIDCIVVHHS VCADLLHIPV 

        70         80         90        100        110        120 
SQFKDADLNS MFLPHENGLS SAEGDYPQQA FTGIPRVKRG STFQNTYNLK DIAGEAISFA 

       130        140        150        160        170        180 
SGKIKEFSFE KLKNSNHAAY RKGRKVKSDS FNRRSVDLDL LCGHYNNDGN APSFGLLRSS 

       190        200        210        220        230        240 
SVEEKPLSHR NSLDTNLTSM FLQNFSEEDL VTQILEKHKI DNFSSGTDIK MCLDILLKCS 

       250        260        270        280        290        300 
EDLKKCTDII KQCIKKKSGS SISEGSGNDT ISSSETVYMN VMTRLASYLK KLPFEFMQSG 

       310        320        330        340        350        360 
NNEALDLTEL ISNMPSLQLT PFSPVFGTEQ PPKYEDVVQL SASDSGRFQT IELQNDKPNS 

       370        380        390        400        410        420 
RKMDTVQSIP NNSTNSLYNL EVNDPRTLKA VQVQSQSLTM NPLENVSSDD LMETLYIEEE 

       430        440        450        460        470        480 
SDGKKALDKG QKTENGPSHE LLKVNEHRAE FPEHATHLKK CPTPMQNEIG KIFEKSFVNL 

       490        500        510        520        530        540 
PKEDCKSKVS KFEEGDQRDF TNSSSQEEID KLLMDLESFS QKMETSLREP LAKGKNSNFL 

       550        560        570        580        590        600 
NSHSQLTGQT LVDLEPKSKV SSPIEKVSPS CLTRIIETNG HKIEEEDRAL LLRILESIED 

       610        620        630        640        650        660 
FAQELVECKS SRGSLSQEKE MMQILQETLT TSSQANLSVC RSPVGDKAKD TTSAVLIQQT 

       670        680        690        700        710        720 
PEVIKIQNKP EKKPGTPLPP PATSPSSPRP LSPVPHVNNV VNAPLSINIP RFYFPEGLPD 

       730        740        750        760        770        780 
TCSNHEQTLS RIETAFMDIE EQKADIYEMG KIAKVCGCPL YWKAPMFRAA GGEKTGFVTA 

       790        800        810        820        830        840 
QSFIAMWRKL LNNHHDDASK FICLLAKPNC SSLEQEDFIP LLQDVVDTHP GLTFLKDAPE 

       850        860        870        880        890        900 
FHSRYITTVI QRIFYTVNRS WSGKITSTEI RKSNFLQTLA LLEEEEDINQ ITDYFSYEHF 

       910        920        930        940        950        960 
YVIYCKFWEL DTDHDLYISQ ADLSRYNDQA SSSRIIERIF SGAVTRGKTI QKEGRMSYAD 

       970        980        990       1000       1010       1020 
FVWFLISEED KRNPTSIEYW FRCMDVDGDG VLSMYELEYF YEEQCERMEA MGIEPLPFHD 

      1030       1040       1050       1060       1070       1080 
LLCQMLDLVK PAVDGKITLR DLKRCRMAHI FYDTFFNLEK YLDHEQRDPF AVQKDVENDG 

      1090       1100       1110       1120       1130       1140 
PEPSDWDRFA AEEYETLVAE ESAQAQFQEG FEDYETDEPA SPSEFGNKSN KILSASLPEK 

      1150 
CGKLQSVDEE 

« Hide

Isoform PR72 (72 kDa) [UniParc].

Checksum: 3782D0D800A5F6D4
Show »

FASTA52961,097
Isoform 3 [UniParc].

Checksum: 3F0B982FF10C8AD9
Show »

FASTA41448,178

References

« Hide 'large scale' references
[1]"Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing."
Hendrix P., Mayer-Jaekel R.E., Cron P., Goris J., Hofsteenge J., Merlevede W., Hemmings B.A.
J. Biol. Chem. 268:15267-15276(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PR72 AND PR130), PARTIAL PROTEIN SEQUENCE, ALTERNATIVE SPLICING.
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PR72; PR130 AND 3).
Tissue: Lung, Tongue and Trachea.
[3]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]The European IMAGE consortium
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 768-1150.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L07590 mRNA. Translation: AAB02613.1.
L12146 mRNA. Translation: AAB02614.1.
AK293012 mRNA. Translation: BAF85701.1.
AK298059 mRNA. Translation: BAG60353.1.
AK316258 mRNA. Translation: BAH14629.1.
AC072039 Genomic DNA. No translation available.
AC092991 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79122.1.
CH471052 Genomic DNA. Translation: EAW79123.1.
AL389975 mRNA. Translation: CAB97532.1.
PIRA47114.
B47114.
RefSeqNP_001177376.1. NM_001190447.1.
NP_002709.2. NM_002718.4.
NP_871626.1. NM_181897.2.
UniGeneHs.518155.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4I5JX-ray2.09A786-1070[»]
4I5KX-ray2.90A/B786-1070[»]
ProteinModelPortalQ06190.
SMRQ06190. Positions 706-1064.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111515. 6 interactions.
DIPDIP-29397N.
IntActQ06190. 7 interactions.
MINTMINT-2861926.
STRING9606.ENSP00000264977.

PTM databases

PhosphoSiteQ06190.

Polymorphism databases

DMDM543720.

Proteomic databases

PaxDbQ06190.
PRIDEQ06190.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264977; ENSP00000264977; ENSG00000073711. [Q06190-1]
ENST00000334546; ENSP00000334748; ENSG00000073711. [Q06190-2]
ENST00000490467; ENSP00000419344; ENSG00000073711. [Q06190-3]
GeneID5523.
KEGGhsa:5523.
UCSCuc003eqv.2. human. [Q06190-1]
uc003eqw.2. human. [Q06190-2]
uc011blz.2. human.

Organism-specific databases

CTD5523.
GeneCardsGC03P135684.
HGNCHGNC:9307. PPP2R3A.
HPAHPA035829.
HPA035830.
MIM604944. gene.
neXtProtNX_Q06190.
PharmGKBPA35523.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271066.
HOGENOMHOG000013216.
HOVERGENHBG000013.
InParanoidQ06190.
KOK11583.
OMAFQTIELQ.
OrthoDBEOG7XWPN3.
PhylomeDBQ06190.
TreeFamTF105554.

Gene expression databases

ArrayExpressQ06190.
BgeeQ06190.
CleanExHS_PPP2R3A.
GenevestigatorQ06190.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13499. EF-hand_7. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPPP2R3A.
GenomeRNAi5523.
NextBio21376.
PROQ06190.
SOURCESearch...

Entry information

Entry nameP2R3A_HUMAN
AccessionPrimary (citable) accession number: Q06190
Secondary accession number(s): A8KAE7 expand/collapse secondary AC list , B4DNU1, B7ZAE3, Q06189, Q9NPQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM