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Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

Gene

PPP2R3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi985 – 99612PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein phosphatase type 2A regulator activity Source: ProtInc

GO - Biological processi

  1. eye photoreceptor cell differentiation Source: BHF-UCL
  2. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  3. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  4. positive regulation of protein catabolic process Source: BHF-UCL
  5. protein dephosphorylation Source: UniProtKB
  6. regulation of cell motility involved in somitogenic axis elongation Source: BHF-UCL
  7. regulation of protein phosphatase type 2A activity Source: GOC
  8. somatic muscle development Source: BHF-UCL
  9. somite development Source: BHF-UCL
  10. Wnt signaling pathway involved in somitogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Alternative name(s):
PP2A subunit B isoform PR72/PR130
PP2A subunit B isoform R3 isoform
PP2A subunit B isoforms B''-PR72/PR130
PP2A subunit B isoforms B72/B130
Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
Gene namesi
Name:PPP2R3A
Synonyms:PPP2R3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9307. PPP2R3A.

Subcellular locationi

GO - Cellular componenti

  1. protein phosphatase type 2A complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35523.

Polymorphism and mutation databases

BioMutaiPPP2R3A.
DMDMi543720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11501150Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alphaPRO_0000071443Add
BLAST

Proteomic databases

MaxQBiQ06190.
PaxDbiQ06190.
PRIDEiQ06190.

PTM databases

PhosphoSiteiQ06190.

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, muscle and kidney.

Gene expression databases

BgeeiQ06190.
CleanExiHS_PPP2R3A.
GenevestigatoriQ06190.

Organism-specific databases

HPAiHPA035829.
HPA035830.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Binary interactionsi

WithEntry#Exp.IntActNotes
NKD1Q969G94EBI-949204,EBI-1538217

Protein-protein interaction databases

BioGridi111515. 9 interactions.
DIPiDIP-29397N.
IntActiQ06190. 7 interactions.
MINTiMINT-2861926.
STRINGi9606.ENSP00000264977.

Structurei

Secondary structure

1
1150
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi797 – 8059Combined sources
Beta strandi811 – 8133Combined sources
Helixi815 – 8184Combined sources
Helixi819 – 82810Combined sources
Turni830 – 8323Combined sources
Helixi833 – 8375Combined sources
Helixi839 – 85719Combined sources
Beta strandi861 – 8633Combined sources
Helixi867 – 8715Combined sources
Helixi875 – 8828Combined sources
Helixi888 – 8903Combined sources
Turni892 – 8954Combined sources
Helixi897 – 91014Combined sources
Beta strandi915 – 9195Combined sources
Helixi920 – 9234Combined sources
Turni924 – 9296Combined sources
Helixi933 – 9397Combined sources
Turni940 – 9445Combined sources
Helixi958 – 96912Combined sources
Helixi974 – 98411Combined sources
Beta strandi989 – 9924Combined sources
Helixi994 – 101017Combined sources
Helixi1018 – 102912Combined sources
Helixi1039 – 10457Combined sources
Helixi1048 – 10569Combined sources
Helixi1058 – 10625Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I5JX-ray2.09A786-1070[»]
4I5KX-ray2.90A/B786-1070[»]
ProteinModelPortaliQ06190.
SMRiQ06190. Positions 719-1065.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini758 – 79336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini972 – 100736EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi670 – 69526Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG271066.
GeneTreeiENSGT00530000063265.
HOGENOMiHOG000013216.
HOVERGENiHBG000013.
KOiK11583.
OMAiFQTIELQ.
OrthoDBiEOG7XWPN3.
PhylomeDBiQ06190.
TreeFamiTF105554.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PR130 (identifier: Q06190-1) [UniParc]FASTAAdd to basket

Also known as: 130 kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATYRLVVS TVNHYSSVVI DRRFEQAIHY CTGTCHTFTH GIDCIVVHHS
60 70 80 90 100
VCADLLHIPV SQFKDADLNS MFLPHENGLS SAEGDYPQQA FTGIPRVKRG
110 120 130 140 150
STFQNTYNLK DIAGEAISFA SGKIKEFSFE KLKNSNHAAY RKGRKVKSDS
160 170 180 190 200
FNRRSVDLDL LCGHYNNDGN APSFGLLRSS SVEEKPLSHR NSLDTNLTSM
210 220 230 240 250
FLQNFSEEDL VTQILEKHKI DNFSSGTDIK MCLDILLKCS EDLKKCTDII
260 270 280 290 300
KQCIKKKSGS SISEGSGNDT ISSSETVYMN VMTRLASYLK KLPFEFMQSG
310 320 330 340 350
NNEALDLTEL ISNMPSLQLT PFSPVFGTEQ PPKYEDVVQL SASDSGRFQT
360 370 380 390 400
IELQNDKPNS RKMDTVQSIP NNSTNSLYNL EVNDPRTLKA VQVQSQSLTM
410 420 430 440 450
NPLENVSSDD LMETLYIEEE SDGKKALDKG QKTENGPSHE LLKVNEHRAE
460 470 480 490 500
FPEHATHLKK CPTPMQNEIG KIFEKSFVNL PKEDCKSKVS KFEEGDQRDF
510 520 530 540 550
TNSSSQEEID KLLMDLESFS QKMETSLREP LAKGKNSNFL NSHSQLTGQT
560 570 580 590 600
LVDLEPKSKV SSPIEKVSPS CLTRIIETNG HKIEEEDRAL LLRILESIED
610 620 630 640 650
FAQELVECKS SRGSLSQEKE MMQILQETLT TSSQANLSVC RSPVGDKAKD
660 670 680 690 700
TTSAVLIQQT PEVIKIQNKP EKKPGTPLPP PATSPSSPRP LSPVPHVNNV
710 720 730 740 750
VNAPLSINIP RFYFPEGLPD TCSNHEQTLS RIETAFMDIE EQKADIYEMG
760 770 780 790 800
KIAKVCGCPL YWKAPMFRAA GGEKTGFVTA QSFIAMWRKL LNNHHDDASK
810 820 830 840 850
FICLLAKPNC SSLEQEDFIP LLQDVVDTHP GLTFLKDAPE FHSRYITTVI
860 870 880 890 900
QRIFYTVNRS WSGKITSTEI RKSNFLQTLA LLEEEEDINQ ITDYFSYEHF
910 920 930 940 950
YVIYCKFWEL DTDHDLYISQ ADLSRYNDQA SSSRIIERIF SGAVTRGKTI
960 970 980 990 1000
QKEGRMSYAD FVWFLISEED KRNPTSIEYW FRCMDVDGDG VLSMYELEYF
1010 1020 1030 1040 1050
YEEQCERMEA MGIEPLPFHD LLCQMLDLVK PAVDGKITLR DLKRCRMAHI
1060 1070 1080 1090 1100
FYDTFFNLEK YLDHEQRDPF AVQKDVENDG PEPSDWDRFA AEEYETLVAE
1110 1120 1130 1140 1150
ESAQAQFQEG FEDYETDEPA SPSEFGNKSN KILSASLPEK CGKLQSVDEE
Length:1,150
Mass (Da):130,278
Last modified:June 1, 1994 - v1
Checksum:i97A31BA4206518A3
GO
Isoform PR72 (identifier: Q06190-2) [UniParc]FASTAAdd to basket

Also known as: 72 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-621: Missing.
     622-665: MQILQETLTT...LIQQTPEVIK → MMIKETSLRR...KRLKSFQQTQ

Show »
Length:529
Mass (Da):61,097
Checksum:i3782D0D800A5F6D4
GO
Isoform 3 (identifier: Q06190-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-736: Missing.

Note: No experimental confirmation available.

Show »
Length:414
Mass (Da):48,178
Checksum:i3F0B982FF10C8AD9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671D → G.
Corresponds to variant rs9814557 [ dbSNP | Ensembl ].
VAR_051739
Natural varianti67 – 671D → N.
Corresponds to variant rs57374999 [ dbSNP | Ensembl ].
VAR_061760
Natural varianti108 – 1081N → S.
Corresponds to variant rs36020282 [ dbSNP | Ensembl ].
VAR_051740
Natural varianti171 – 1711A → S.
Corresponds to variant rs6779903 [ dbSNP | Ensembl ].
VAR_051741
Natural varianti481 – 4811P → A.
Corresponds to variant rs34901937 [ dbSNP | Ensembl ].
VAR_051742
Natural varianti642 – 6421S → G.
Corresponds to variant rs17197552 [ dbSNP | Ensembl ].
VAR_051743
Natural varianti695 – 6951P → L.
Corresponds to variant rs9826032 [ dbSNP | Ensembl ].
VAR_051744
Natural varianti745 – 7451D → N.
Corresponds to variant rs16843645 [ dbSNP | Ensembl ].
VAR_022095

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 736736Missing in isoform 3. 1 PublicationVSP_045203Add
BLAST
Alternative sequencei1 – 621621Missing in isoform PR72. 2 PublicationsVSP_005107Add
BLAST
Alternative sequencei622 – 66544MQILQ…PEVIK → MMIKETSLRRDPDLRGELAF LARGCDFVLPSRFKKRLKSF QQTQ in isoform PR72. 2 PublicationsVSP_005108Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07590 mRNA. Translation: AAB02613.1.
L12146 mRNA. Translation: AAB02614.1.
AK293012 mRNA. Translation: BAF85701.1.
AK298059 mRNA. Translation: BAG60353.1.
AK316258 mRNA. Translation: BAH14629.1.
AC072039 Genomic DNA. No translation available.
AC092991 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79122.1.
CH471052 Genomic DNA. Translation: EAW79123.1.
AL389975 mRNA. Translation: CAB97532.1.
CCDSiCCDS3087.1. [Q06190-1]
CCDS3088.1. [Q06190-2]
CCDS54642.1. [Q06190-3]
PIRiA47114.
B47114.
RefSeqiNP_001177376.1. NM_001190447.1. [Q06190-3]
NP_002709.2. NM_002718.4. [Q06190-1]
NP_871626.1. NM_181897.2. [Q06190-2]
XP_006713749.1. XM_006713686.2. [Q06190-1]
UniGeneiHs.518155.

Genome annotation databases

EnsembliENST00000264977; ENSP00000264977; ENSG00000073711. [Q06190-1]
ENST00000334546; ENSP00000334748; ENSG00000073711. [Q06190-2]
ENST00000490467; ENSP00000419344; ENSG00000073711. [Q06190-3]
GeneIDi5523.
KEGGihsa:5523.
UCSCiuc003eqv.2. human. [Q06190-1]
uc003eqw.2. human. [Q06190-2]
uc011blz.2. human.

Polymorphism and mutation databases

BioMutaiPPP2R3A.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07590 mRNA. Translation: AAB02613.1.
L12146 mRNA. Translation: AAB02614.1.
AK293012 mRNA. Translation: BAF85701.1.
AK298059 mRNA. Translation: BAG60353.1.
AK316258 mRNA. Translation: BAH14629.1.
AC072039 Genomic DNA. No translation available.
AC092991 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79122.1.
CH471052 Genomic DNA. Translation: EAW79123.1.
AL389975 mRNA. Translation: CAB97532.1.
CCDSiCCDS3087.1. [Q06190-1]
CCDS3088.1. [Q06190-2]
CCDS54642.1. [Q06190-3]
PIRiA47114.
B47114.
RefSeqiNP_001177376.1. NM_001190447.1. [Q06190-3]
NP_002709.2. NM_002718.4. [Q06190-1]
NP_871626.1. NM_181897.2. [Q06190-2]
XP_006713749.1. XM_006713686.2. [Q06190-1]
UniGeneiHs.518155.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I5JX-ray2.09A786-1070[»]
4I5KX-ray2.90A/B786-1070[»]
ProteinModelPortaliQ06190.
SMRiQ06190. Positions 719-1065.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111515. 9 interactions.
DIPiDIP-29397N.
IntActiQ06190. 7 interactions.
MINTiMINT-2861926.
STRINGi9606.ENSP00000264977.

PTM databases

PhosphoSiteiQ06190.

Polymorphism and mutation databases

BioMutaiPPP2R3A.
DMDMi543720.

Proteomic databases

MaxQBiQ06190.
PaxDbiQ06190.
PRIDEiQ06190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264977; ENSP00000264977; ENSG00000073711. [Q06190-1]
ENST00000334546; ENSP00000334748; ENSG00000073711. [Q06190-2]
ENST00000490467; ENSP00000419344; ENSG00000073711. [Q06190-3]
GeneIDi5523.
KEGGihsa:5523.
UCSCiuc003eqv.2. human. [Q06190-1]
uc003eqw.2. human. [Q06190-2]
uc011blz.2. human.

Organism-specific databases

CTDi5523.
GeneCardsiGC03P135684.
HGNCiHGNC:9307. PPP2R3A.
HPAiHPA035829.
HPA035830.
MIMi604944. gene.
neXtProtiNX_Q06190.
PharmGKBiPA35523.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG271066.
GeneTreeiENSGT00530000063265.
HOGENOMiHOG000013216.
HOVERGENiHBG000013.
KOiK11583.
OMAiFQTIELQ.
OrthoDBiEOG7XWPN3.
PhylomeDBiQ06190.
TreeFamiTF105554.

Miscellaneous databases

GeneWikiiPPP2R3A.
GenomeRNAii5523.
NextBioi21376.
PROiQ06190.
SOURCEiSearch...

Gene expression databases

BgeeiQ06190.
CleanExiHS_PPP2R3A.
GenevestigatoriQ06190.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing."
    Hendrix P., Mayer-Jaekel R.E., Cron P., Goris J., Hofsteenge J., Merlevede W., Hemmings B.A.
    J. Biol. Chem. 268:15267-15276(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PR72 AND PR130), PARTIAL PROTEIN SEQUENCE, ALTERNATIVE SPLICING.
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PR72; PR130 AND 3).
    Tissue: Lung, Tongue and Trachea.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 768-1150.

Entry informationi

Entry nameiP2R3A_HUMAN
AccessioniPrimary (citable) accession number: Q06190
Secondary accession number(s): A8KAE7
, B4DNU1, B7ZAE3, Q06189, Q9NPQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 29, 2015
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.