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Q06163 (TERT_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Telomerase reverse transcriptase

EC=2.7.7.49
Alternative name(s):
Telomerase catalytic subunit
Gene names
Name:EST2
Ordered Locus Names:YLR318W
ORF Names:L8543.12
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length884 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subcellular location

Nucleus. Chromosometelomere.

Miscellaneous

Deletion causes telomere shortening and senescence.

Sequence similarities

Belongs to the reverse transcriptase family. Telomerase subfamily.

Contains 1 reverse transcriptase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 884884Telomerase reverse transcriptase
PRO_0000054932

Regions

Domain422 – 725304Reverse transcriptase

Sites

Metal binding5301Magnesium; catalytic By similarity
Metal binding6701Magnesium; catalytic By similarity
Metal binding6711Magnesium; catalytic By similarity

Experimental info

Sequence conflict1621A → V in AAB64520. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q06163 [UniParc].

Last modified September 21, 2011. Version 2.
Checksum: 84540735E3CD40F5

FASTA884102,635
        10         20         30         40         50         60 
MKILFEFIQD KLDIDLQTNS TYKENLKCGH FNGLDEILTT CFALPNSRKI ALPCLPGDLS 

        70         80         90        100        110        120 
HKAVIDHCII YLLTGELYNN VLTFGYKIAR NEDVNNSLFC HSANVNVTLL KGAAWKMFHS 

       130        140        150        160        170        180 
LVGTYAFVDL LINYTVIQFN GQFFTQIVGN RCNEPHLPPK WAQRSSSSSA TAAQIKQLTE 

       190        200        210        220        230        240 
PVTNKQFLHK LNINSSSFFP YSKILPSSSS IKKLTDLREA IFPTNLVKIP QRLKVRINLT 

       250        260        270        280        290        300 
LQKLLKRHKR LNYVSILNSI CPPLEGTVLD LSHLSRQSPK ERVLKFIIVI LQKLLPQEMF 

       310        320        330        340        350        360 
GSKKNKGKII KNLNLLLSLP LNGYLPFDSL LKKLRLKDFR WLFISDIWFT KHNFENLNQL 

       370        380        390        400        410        420 
AICFISWLFR QLIPKIIQTF FYCTEISSTV TIVYFRHDTW NKLITPFIVE YFKTYLVENN 

       430        440        450        460        470        480 
VCRNHNSYTL SNFNHSKMRI IPKKSNNEFR IIAIPCRGAD EEEFTIYKEN HKNAIQPTQK 

       490        500        510        520        530        540 
ILEYLRNKRP TSFTKIYSPT QIADRIKEFK QRLLKKFNNV LPELYFMKFD VKSCYDSIPR 

       550        560        570        580        590        600 
MECMRILKDA LKNENGFFVR SQYFFNTNTG VLKLFNVVNA SRVPKPYELY IDNVRTVHLS 

       610        620        630        640        650        660 
NQDVINVVEM EIFKTALWVE DKCYIREDGL FQGSSLSAPI VDLVYDDLLE FYSEFKASPS 

       670        680        690        700        710        720 
QDTLILKLAD DFLIISTDQQ QVINIKKLAM GGFQKYNAKA NRDKILAVSS QSDDDTVIQF 

       730        740        750        760        770        780 
CAMHIFVKEL EVWKHSSTMN NFHIRSKSSK GIFRSLIALF NTRISYKTID TNLNSTNTVL 

       790        800        810        820        830        840 
MQIDHVVKNI SECYKSAFKD LSINVTQNMQ FHSFLQRIIE MTVSGCPITK CDPLIEYEVR 

       850        860        870        880 
FTILNGFLES LSSNTSKFKD NIILLRKEIQ HLQAYIYIYI HIVN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20618 Genomic DNA. Translation: AAB64520.1.
BK006945 Genomic DNA. Translation: DAA09627.2.
PIRS53396.
RefSeqNP_013422.2. NM_001182207.2.

3D structure databases

ProteinModelPortalQ06163.
SMRQ06163. Positions 183-412, 628-707.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31582. 40 interactions.
DIPDIP-7548N.
IntActQ06163. 4 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR318W; YLR318W; YLR318W.
GeneID851028.
KEGGsce:YLR318W.

Organism-specific databases

CYGDYLR318w.
SGDS000004310. EST2.

Phylogenomic databases

eggNOGNOG276584.
GeneTreeENSGT00390000018531.
HOGENOMHOG000141949.
KOK11126.
OMAVENATIN.
OrthoDBEOG7VTDWJ.

Enzyme and pathway databases

BioCycYEAST:G3O-32402-MONOMER.

Gene expression databases

GenevestigatorQ06163.

Family and domain databases

InterProIPR000477. RT_dom.
IPR021891. Telomerase_RBD.
IPR003545. Telomerase_RT.
[Graphical view]
PfamPF00078. RVT_1. 1 hit.
PF12009. Telomerase_RBD. 1 hit.
[Graphical view]
PRINTSPR01365. TELOMERASERT.
SMARTSM00975. Telomerase_RBD. 1 hit.
[Graphical view]
PROSITEPS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio967610.
PROQ06163.

Entry information

Entry nameTERT_YEAST
AccessionPrimary (citable) accession number: Q06163
Secondary accession number(s): D6VYW1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 21, 2011
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families