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Protein

Inner kinetochore subunit NKP2

Gene

NKP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.1 Publication

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromosome segregation Source: SGD
  • meiotic cell cycle Source: UniProtKB-KW

Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-32401-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Inner kinetochore subunit NKP2Curated
Alternative name(s):
Constitutive centromere-associated network protein NKP2Curated
Non-essential kinetochore protein 2
Gene namesi
Name:NKP2
Ordered Locus Names:YLR315W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR315W
SGDiS000004307 NKP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968681 – 153Inner kinetochore subunit NKP2Add BLAST153

Proteomic databases

PaxDbiQ06162
PRIDEiQ06162

Interactioni

Subunit structurei

Component of the inner kinetochore constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:22561346). NKP1 interacts directly with OKP1 and AME1 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NKP1Q124933EBI-34256,EBI-35840

Protein-protein interaction databases

BioGridi31580, 250 interactors
DIPiDIP-1939N
IntActiQ06162, 8 interactors
MINTiQ06162
STRINGi4932.YLR315W

Structurei

3D structure databases

ProteinModelPortaliQ06162
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili86 – 128Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the NKP2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ06162
OMAiHESEPDE
OrthoDBiEOG092C5Z03

Family and domain databases

InterProiView protein in InterPro
IPR018565 Nkp2/Cnl2
PANTHERiPTHR28064 PTHR28064, 1 hit
PfamiView protein in Pfam
PF09447 Cnl2_NKP2, 1 hit

Sequencei

Sequence statusi: Complete.

Q06162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSEQLLHNY VSDSLLTTLI SFQEFKQQLQ SYTSDEQQLQ HWYELLQARD
60 70 80 90 100
ARVTSELEAR IKQFFITLRS RLLRFLESEQ LSHSLSLETL IDALYKINDL
110 120 130 140 150
LQQRLQILDD AIQEKTSELA EFENMVRSPS AGDNAIPGLL QIIQSYINLL

EEN
Length:153
Mass (Da):17,862
Last modified:November 1, 1996 - v1
Checksum:i1445E11838649D70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20618 Genomic DNA Translation: AAB64519.1
AY692848 Genomic DNA Translation: AAT92867.1
BK006945 Genomic DNA Translation: DAA09625.1
PIRiS53394
RefSeqiNP_013419.1, NM_001182204.1

Genome annotation databases

EnsemblFungiiYLR315W; YLR315W; YLR315W
GeneIDi851025
KEGGisce:YLR315W

Similar proteinsi

Entry informationi

Entry nameiNKP2_YEAST
AccessioniPrimary (citable) accession number: Q06162
Secondary accession number(s): D6VYV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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