Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gastric inhibitory polypeptide

Gene

Gip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • receptor binding Source: RGD

GO - Biological processi

  • adult locomotory behavior Source: RGD
  • digestive system development Source: RGD
  • endocrine pancreas development Source: RGD
  • exploration behavior Source: RGD
  • female pregnancy Source: RGD
  • long-term synaptic potentiation Source: RGD
  • memory Source: RGD
  • positive regulation of cAMP-mediated signaling Source: RGD
  • positive regulation of glucagon secretion Source: RGD
  • positive regulation of glucose transmembrane transport Source: RGD
  • positive regulation of insulin secretion Source: RGD
  • positive regulation of synaptic transmission Source: RGD
  • regulation of insulin secretion Source: RGD
  • response to acidic pH Source: RGD
  • response to amino acid Source: RGD
  • response to axon injury Source: RGD
  • response to carbohydrate Source: RGD
  • response to drug Source: RGD
  • response to glucose Source: RGD
  • response to lipid Source: RGD
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to selenium ion Source: RGD
  • response to starvation Source: RGD
  • sensory perception of pain Source: RGD
  • triglyceride homeostasis Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
R-RNO-418555 G alpha (s) signalling events
R-RNO-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide
Short name:
GIP
Alternative name(s):
Glucose-dependent insulinotropic polypeptide
Gene namesi
Name:Gip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2709 Gip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PropeptideiPRO_000001122022 – 42Add BLAST21
PeptideiPRO_000001122144 – 85Gastric inhibitory polypeptideAdd BLAST42
PropeptideiPRO_000001122287 – 144Add BLAST58

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ06145
PRIDEiQ06145

Expressioni

Tissue specificityi

Highly expressed in the duodenum and jejunum.

Gene expression databases

BgeeiENSRNOG00000006306
GenevisibleiQ06145 RN

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008481

Structurei

3D structure databases

ProteinModelPortaliQ06145
SMRiQ06145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JC1A Eukaryota
ENOG4111BXQ LUCA
GeneTreeiENSGT00390000005121
HOGENOMiHOG000112725
HOVERGENiHBG005839
InParanoidiQ06145
KOiK05258
OMAiLAWMVDQ
OrthoDBiEOG091G153X
PhylomeDBiQ06145
TreeFamiTF332333

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVALKTCSLL LVLLFLAVGL GEKEEVEFRS HAKFAGPRPR GPRYAEGTFI
60 70 80 90 100
SDYSIAMDKI RQQDFVNWLL AQKGKKNDWK HNLTQREARA LELAGQSQRN
110 120 130 140
EEKEAQGSSL PKSLSDEDVL RDLLIQELLA WMADQAELCR LRSQ
Length:144
Mass (Da):16,401
Last modified:November 1, 1995 - v2
Checksum:i091D7617459C6032
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66724 Genomic DNA Translation: CAA47256.1
Z19564 mRNA Translation: CAA79621.1
L08831 mRNA Translation: AAA41225.1
M92916 mRNA Translation: AAA41237.1
PIRiJN0589
RefSeqiNP_062604.1, NM_019630.3
UniGeneiRn.10446

Genome annotation databases

EnsembliENSRNOT00000008481; ENSRNOP00000008481; ENSRNOG00000006306
GeneIDi25040
KEGGirno:25040
UCSCiRGD:2709 rat

Similar proteinsi

Entry informationi

Entry nameiGIP_RAT
AccessioniPrimary (citable) accession number: Q06145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health