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Protein

Gastric inhibitory polypeptide

Gene

Gip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

GO - Molecular functioni

  • receptor binding Source: RGD

GO - Biological processi

  • adult locomotory behavior Source: Ensembl
  • digestive system development Source: RGD
  • endocrine pancreas development Source: Ensembl
  • exploration behavior Source: Ensembl
  • female pregnancy Source: RGD
  • long-term synaptic potentiation Source: RGD
  • memory Source: Ensembl
  • positive regulation of cAMP-mediated signaling Source: RGD
  • positive regulation of glucagon secretion Source: RGD
  • positive regulation of glucose transport Source: RGD
  • positive regulation of insulin secretion Source: RGD
  • positive regulation of synaptic transmission Source: RGD
  • regulation of insulin secretion Source: RGD
  • response to acidic pH Source: RGD
  • response to amino acid Source: RGD
  • response to axon injury Source: RGD
  • response to carbohydrate Source: RGD
  • response to drug Source: RGD
  • response to glucose Source: RGD
  • response to lipid Source: RGD
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to selenium ion Source: RGD
  • response to starvation Source: RGD
  • sensory perception of pain Source: Ensembl
  • triglyceride homeostasis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide
Short name:
GIP
Alternative name(s):
Glucose-dependent insulinotropic polypeptide
Gene namesi
Name:Gip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2709. Gip.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: RGD
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Propeptidei22 – 4221PRO_0000011220Add
BLAST
Peptidei44 – 8542Gastric inhibitory polypeptidePRO_0000011221Add
BLAST
Propeptidei87 – 14458PRO_0000011222Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ06145.
PRIDEiQ06145.

Expressioni

Tissue specificityi

Highly expressed in the duodenum and jejunum.

Gene expression databases

GenevisibleiQ06145. RN.

Interactioni

GO - Molecular functioni

  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008481.

Structurei

3D structure databases

ProteinModelPortaliQ06145.
SMRiQ06145. Positions 44-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JC1A. Eukaryota.
ENOG4111BXQ. LUCA.
GeneTreeiENSGT00390000005121.
HOGENOMiHOG000112725.
HOVERGENiHBG005839.
InParanoidiQ06145.
KOiK05258.
OMAiLAWMVDQ.
OrthoDBiEOG7C8GKZ.
PhylomeDBiQ06145.
TreeFamiTF332333.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVALKTCSLL LVLLFLAVGL GEKEEVEFRS HAKFAGPRPR GPRYAEGTFI
60 70 80 90 100
SDYSIAMDKI RQQDFVNWLL AQKGKKNDWK HNLTQREARA LELAGQSQRN
110 120 130 140
EEKEAQGSSL PKSLSDEDVL RDLLIQELLA WMADQAELCR LRSQ
Length:144
Mass (Da):16,401
Last modified:November 1, 1995 - v2
Checksum:i091D7617459C6032
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66724 Genomic DNA. Translation: CAA47256.1.
Z19564 mRNA. Translation: CAA79621.1.
L08831 mRNA. Translation: AAA41225.1.
M92916 mRNA. Translation: AAA41237.1.
PIRiJN0589.
RefSeqiNP_062604.1. NM_019630.3.
UniGeneiRn.10446.

Genome annotation databases

EnsembliENSRNOT00000008481; ENSRNOP00000008481; ENSRNOG00000006306.
GeneIDi25040.
KEGGirno:25040.
UCSCiRGD:2709. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66724 Genomic DNA. Translation: CAA47256.1.
Z19564 mRNA. Translation: CAA79621.1.
L08831 mRNA. Translation: AAA41225.1.
M92916 mRNA. Translation: AAA41237.1.
PIRiJN0589.
RefSeqiNP_062604.1. NM_019630.3.
UniGeneiRn.10446.

3D structure databases

ProteinModelPortaliQ06145.
SMRiQ06145. Positions 44-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008481.

Proteomic databases

PaxDbiQ06145.
PRIDEiQ06145.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008481; ENSRNOP00000008481; ENSRNOG00000006306.
GeneIDi25040.
KEGGirno:25040.
UCSCiRGD:2709. rat.

Organism-specific databases

CTDi2695.
RGDi2709. Gip.

Phylogenomic databases

eggNOGiENOG410JC1A. Eukaryota.
ENOG4111BXQ. LUCA.
GeneTreeiENSGT00390000005121.
HOGENOMiHOG000112725.
HOVERGENiHBG005839.
InParanoidiQ06145.
KOiK05258.
OMAiLAWMVDQ.
OrthoDBiEOG7C8GKZ.
PhylomeDBiQ06145.
TreeFamiTF332333.

Enzyme and pathway databases

ReactomeiR-RNO-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Miscellaneous databases

PROiQ06145.

Gene expression databases

GenevisibleiQ06145. RN.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of rat gastric inhibitory peptide cDNA."
    Sharma S.K., Austin C., Howard A., Lo G., Nicholl C.G., Legon S.
    J. Mol. Endocrinol. 9:265-272(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Duodenum.
  2. "Glucose-dependent insulinotropic peptide: structure of the precursor and tissue-specific expression in rat."
    Tseng C.C., Jarboe L.A., Landau S.B., Williams E.K., Wolfe M.
    Proc. Natl. Acad. Sci. U.S.A. 90:1992-1996(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Jejunum.
  3. "Molecular cloning of rat glucose-dependent insulinotropic peptide (GIP)."
    Higashimoto Y., Liddle R.A., Simchock J.
    Biochim. Biophys. Acta 1132:72-74(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Intestine.
  4. "Isolation and characterization of the gene encoding rat glucose-dependent insulinotropic peptide."
    Higashimoto Y., Liddle R.A.
    Biochem. Biophys. Res. Commun. 193:182-190(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiGIP_RAT
AccessioniPrimary (citable) accession number: Q06145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.