Regenerating islet-derived protein 3-alpha precursor

Contribute

Send feedback

Read comments (?) or add your own

Q06141 (REG3A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 112. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Regenerating islet-derived protein 3-alpha
Short name=REG-3-alpha

Alternative name(s):
Human proislet peptide
Pancreatitis-associated protein 1
Regenerating islet-derived protein III-alpha
Short name=Reg III-alpha

Gene names

Name:	REG3A
Synonyms:	HIP, PAP, PAP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Might be a stress protein involved in the control of bacterial proliferation.
Subcellular location	Secreted. Note: Found in the apical region of pancreatic acinar cells.
Tissue specificity	Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. Ref.2
Induction	Appears in pancreatic juice after induction of pancreatic inflammation.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Biological process	Acute phase Inflammatory response
Cellular component	Secreted
Domain	Signal
Ligand	Lectin
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	acute-phase response Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Traceable author statement. Source: ProtInc heterophilic cell-cell adhesion Traceable author statement. Source: ProtInc multicellular organismal development Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Traceable author statement. Source: ProtInc extracellular space Traceable author statement. Source: ProtInc soluble fraction Traceable author statement. Source: ProtInc
Molecular function	sugar binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

By similarity

Chain

27 – 175

149

Regenerating islet-derived protein 3-alpha

PRO_0000017429

Regions

Domain

38 – 173

136

C-type lectin

Amino acid modifications

Disulfide bond

40 ↔ 51

By similarity

Disulfide bond

68 ↔ 171

By similarity

Disulfide bond

146 ↔ 163

By similarity

Experimental info

Sequence conflict

173 – 175

FTD → VH in AAA36415. Ref.2

Secondary structure

175

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q06141 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: C51149FAC22EB68C
Show »

FASTA

175

19,395

        10         20         30         40         50         60 
MLPPMALPSV SWMLLSCLML LSQVQGEEPQ RELPSARIRC PKGSKAYGSH CYALFLSPKS 

        70         80         90        100        110        120 
WTDADLACQK RPSGNLVSVL SGAEGSFVSS LVKSIGNSYS YVWIGLHDPT QGTEPNGEGW 

       130        140        150        160        170 
EWSSSDVMNY FAWERNPSTI SSPGHCASLS RSTAFLRWKD YNCNVRLPYV CKFTD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP)." Itoh T., Teraoka H. Biochim. Biophys. Acta 1172:184-186(1993) [PubMed: 7679928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas and Small intestine.
[2]	"Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases." Orelle B., Keim V., Masciotra L., Dagorn J.-C., Iovanna J.-L. J. Clin. Invest. 90:2284-2291(1992) [PubMed: 1469087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Pancreas.
[3]	"A novel gene (HIP) activated in human primary liver cancer." Lasserre C., Christa L., Simon M.T., Vernier P., Brechot C. Cancer Res. 52:5089-5095(1992) [PubMed: 1325291] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[4]	"Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene." Dusetti N.J., Frigerio J.-M., Fox M.F., Swallow D.M., Dagorn J.-C., Iovanna J.L. Genomics 19:108-114(1994) [PubMed: 8188210] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[5]	"Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer." Lasserre C., Simon M.T., Ishikawa H., Diriong S., Nguyen V.C., Christa L., Vernier P., Brechot C. Eur. J. Biochem. 224:29-38(1994) [PubMed: 8076648] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

Pancreatitis-associated protein 1

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D13510 mRNA. Translation: BAA02728.1.
M84337 mRNA. Translation: AAA36415.1.
S51768 mRNA. Translation: AAB24642.1.
X68641 mRNA. Translation: CAA48605.1.
L15533 Genomic DNA. Translation: AAA60020.1.
BC036776 mRNA. Translation: AAH36776.1.

IPI

IPI00029039.

PIR

A49616.

RefSeq

NP_002571.1. NM_002580.2.
NP_620354.1. NM_138937.2.
NP_620355.1. NM_138938.2.

UniGene

Hs.567312.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UV0	X-ray	1.78	A	27-175	[»]
2GO0	NMR	-	A	39-175	[»]

ProteinModelPortal

Q06141.

SMR

Q06141. Positions 39-175.

ModBase

Search...

Protein-protein interaction databases

STRING

Q06141.

Polymorphism databases

DMDM

464341.

Proteomic databases

PeptideAtlas

Q06141.

PRIDE

Q06141.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000305165; ENSP00000304311; ENSG00000172016.
ENST00000393878; ENSP00000377456; ENSG00000172016.
ENST00000409839; ENSP00000386630; ENSG00000172016.

GeneID

5068.

KEGG

hsa:5068.

UCSC

uc002sod.1. human.

Organism-specific databases

CTD

5068.

GeneCards

GC02M079384.

H-InvDB

HIX0023997.

HGNC

HGNC:8601. REG3A.

MIM

167805. gene.

neXtProt

NX_Q06141.

PharmGKB

PA32931.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG12669.

HOGENOM

HBG283257.

HOVERGEN

HBG004151.

InParanoid

Q06141.

OMA

SPGHCAS.

OrthoDB

EOG4TTGK0.

PhylomeDB

Q06141.

Gene expression databases

ArrayExpress

Q06141.

Bgee

Q06141.

CleanEx

HS_REG3A.

Genevestigator

Q06141.

GermOnline

ENSG00000172016. Homo sapiens.

Family and domain databases

InterPro

IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR003990. Pancreatis_ac.
[Graphical view]

Gene3D

G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.

Pfam

PF00059. Lectin_C. 1 hit.
[Graphical view]

PRINTS

PR01504. PNCREATITSAP.

SMART

SM00034. CLECT. 1 hit.
[Graphical view]

SUPFAM

SSF56436. C-type_lectin_fold. 1 hit.

PROSITE

PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

19526.

PMAP-CutDB

Q06141.

SOURCE

Search...

Entry information

Entry name

REG3A_HUMAN

Accession

Primary (citable) accession number: Q06141

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	January 25, 2012
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents