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Protein

Calcium-binding protein 39

Gene

Cab39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 39
Alternative name(s):
MO25alpha
Protein Mo25
Gene namesi
Name:Cab39
Synonyms:Mo25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107438 Cab39

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002098251 – 341Calcium-binding protein 39Add BLAST341

Proteomic databases

EPDiQ06138
MaxQBiQ06138
PaxDbiQ06138
PeptideAtlasiQ06138
PRIDEiQ06138

PTM databases

iPTMnetiQ06138
PhosphoSitePlusiQ06138

Expressioni

Developmental stagei

Transcribed during early mouse development. Detected at all developmental stages from the egg through the blastocyst, most abundant at the 2-cell stage.

Gene expression databases

BgeeiENSMUSG00000036707
CleanExiMM_CAB39
ExpressionAtlasiQ06138 baseline and differential
GenevisibleiQ06138 MM

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198428, 1 interactor
IntActiQ06138, 1 interactor
MINTiQ06138
STRINGi10090.ENSMUSP00000095270

Structurei

3D structure databases

ProteinModelPortaliQ06138
SMRiQ06138
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mo25 family.Curated

Phylogenomic databases

eggNOGiKOG1566 Eukaryota
ENOG410XP4S LUCA
GeneTreeiENSGT00390000004360
HOGENOMiHOG000234711
HOVERGENiHBG050757
InParanoidiQ06138
KOiK08272
OMAiKNYDRFF
OrthoDBiEOG091G0DTL
TreeFamiTF314910

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013878 Mo25
PANTHERiPTHR10182 PTHR10182, 1 hit
PfamiView protein in Pfam
PF08569 Mo25, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q06138-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM
60 70 80 90 100
KEILYGTNEK EPQTEAVAQL AQELYNSGLL GTLVADLQLI DFEGKKDVAQ
110 120 130 140 150
IFNNILRRQI GTRTPTVEYI CTQQNILFML LKGYESPEIA LNCGIMLREC
160 170 180 190 200
IRHEPLAKII LWSEQFYDFF RYVEMSTFDI ASDAFATFKD LLTRHKLLSA
210 220 230 240 250
EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR HNFTIMTKYI
260 270 280 290 300
SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQT
310 320 330 340
KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRAAQQE A
Length:341
Mass (Da):39,843
Last modified:July 27, 2011 - v2
Checksum:iE7FECA529D6FE811
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332D → N in AAB24801 (PubMed:8418809).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51858 mRNA Translation: AAB24801.1
AK144665 mRNA Translation: BAE25997.1
CH466520 Genomic DNA Translation: EDL40253.1
CH466520 Genomic DNA Translation: EDL40254.1
CH466520 Genomic DNA Translation: EDL40256.1
BC020041 mRNA Translation: AAH20041.1
CCDSiCCDS15112.1
RefSeqiNP_598542.3, NM_133781.4
XP_006529153.1, XM_006529090.3
XP_006529154.1, XM_006529091.2
XP_011246209.1, XM_011247907.2
XP_017168028.1, XM_017312539.1
UniGeneiMm.26135

Genome annotation databases

EnsembliENSMUST00000097666; ENSMUSP00000095270; ENSMUSG00000036707
ENSMUST00000113360; ENSMUSP00000108987; ENSMUSG00000036707
GeneIDi12283
KEGGimmu:12283
UCSCiuc007bum.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCAB39_MOUSE
AccessioniPrimary (citable) accession number: Q06138
Secondary accession number(s): Q8VDZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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