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Protein

Calcium-binding protein 39

Gene

Cab39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 39
Alternative name(s):
MO25alpha
Protein Mo25
Gene namesi
Name:Cab39
Synonyms:Mo25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107438. Cab39.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Calcium-binding protein 39PRO_0000209825Add
BLAST

Proteomic databases

EPDiQ06138.
MaxQBiQ06138.
PaxDbiQ06138.
PRIDEiQ06138.

PTM databases

iPTMnetiQ06138.
PhosphoSiteiQ06138.

Expressioni

Developmental stagei

Transcribed during early mouse development. Detected at all developmental stages from the egg through the blastocyst, most abundant at the 2-cell stage.

Gene expression databases

BgeeiQ06138.
CleanExiMM_CAB39.
ExpressionAtlasiQ06138. baseline and differential.
GenevisibleiQ06138. MM.

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198428. 1 interaction.
IntActiQ06138. 1 interaction.
MINTiMINT-4089580.
STRINGi10090.ENSMUSP00000095270.

Structurei

3D structure databases

ProteinModelPortaliQ06138.
SMRiQ06138. Positions 2-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mo25 family.Curated

Phylogenomic databases

eggNOGiKOG1566. Eukaryota.
ENOG410XP4S. LUCA.
GeneTreeiENSGT00390000004360.
HOGENOMiHOG000234711.
HOVERGENiHBG050757.
InParanoidiQ06138.
KOiK08272.
OMAiKVFSHYQ.
OrthoDBiEOG7CK371.
TreeFamiTF314910.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]
PANTHERiPTHR10182. PTHR10182. 1 hit.
PfamiPF08569. Mo25. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06138-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM
60 70 80 90 100
KEILYGTNEK EPQTEAVAQL AQELYNSGLL GTLVADLQLI DFEGKKDVAQ
110 120 130 140 150
IFNNILRRQI GTRTPTVEYI CTQQNILFML LKGYESPEIA LNCGIMLREC
160 170 180 190 200
IRHEPLAKII LWSEQFYDFF RYVEMSTFDI ASDAFATFKD LLTRHKLLSA
210 220 230 240 250
EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR HNFTIMTKYI
260 270 280 290 300
SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQT
310 320 330 340
KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRAAQQE A
Length:341
Mass (Da):39,843
Last modified:July 27, 2011 - v2
Checksum:iE7FECA529D6FE811
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti332 – 3321D → N in AAB24801 (PubMed:8418809).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51858 mRNA. Translation: AAB24801.1.
AK144665 mRNA. Translation: BAE25997.1.
CH466520 Genomic DNA. Translation: EDL40253.1.
CH466520 Genomic DNA. Translation: EDL40254.1.
CH466520 Genomic DNA. Translation: EDL40256.1.
BC020041 mRNA. Translation: AAH20041.1.
CCDSiCCDS15112.1.
RefSeqiNP_598542.3. NM_133781.4.
XP_006529153.1. XM_006529090.2.
XP_006529154.1. XM_006529091.1.
XP_011246209.1. XM_011247907.1.
UniGeneiMm.26135.

Genome annotation databases

EnsembliENSMUST00000097666; ENSMUSP00000095270; ENSMUSG00000036707.
ENSMUST00000113360; ENSMUSP00000108987; ENSMUSG00000036707.
GeneIDi12283.
KEGGimmu:12283.
UCSCiuc007bum.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51858 mRNA. Translation: AAB24801.1.
AK144665 mRNA. Translation: BAE25997.1.
CH466520 Genomic DNA. Translation: EDL40253.1.
CH466520 Genomic DNA. Translation: EDL40254.1.
CH466520 Genomic DNA. Translation: EDL40256.1.
BC020041 mRNA. Translation: AAH20041.1.
CCDSiCCDS15112.1.
RefSeqiNP_598542.3. NM_133781.4.
XP_006529153.1. XM_006529090.2.
XP_006529154.1. XM_006529091.1.
XP_011246209.1. XM_011247907.1.
UniGeneiMm.26135.

3D structure databases

ProteinModelPortaliQ06138.
SMRiQ06138. Positions 2-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198428. 1 interaction.
IntActiQ06138. 1 interaction.
MINTiMINT-4089580.
STRINGi10090.ENSMUSP00000095270.

PTM databases

iPTMnetiQ06138.
PhosphoSiteiQ06138.

Proteomic databases

EPDiQ06138.
MaxQBiQ06138.
PaxDbiQ06138.
PRIDEiQ06138.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097666; ENSMUSP00000095270; ENSMUSG00000036707.
ENSMUST00000113360; ENSMUSP00000108987; ENSMUSG00000036707.
GeneIDi12283.
KEGGimmu:12283.
UCSCiuc007bum.2. mouse.

Organism-specific databases

CTDi51719.
MGIiMGI:107438. Cab39.

Phylogenomic databases

eggNOGiKOG1566. Eukaryota.
ENOG410XP4S. LUCA.
GeneTreeiENSGT00390000004360.
HOGENOMiHOG000234711.
HOVERGENiHBG050757.
InParanoidiQ06138.
KOiK08272.
OMAiKVFSHYQ.
OrthoDBiEOG7CK371.
TreeFamiTF314910.

Enzyme and pathway databases

ReactomeiR-MMU-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Miscellaneous databases

ChiTaRSiCab39. mouse.
PROiQ06138.
SOURCEiSearch...

Gene expression databases

BgeeiQ06138.
CleanExiMM_CAB39.
ExpressionAtlasiQ06138. baseline and differential.
GenevisibleiQ06138. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]
PANTHERiPTHR10182. PTHR10182. 1 hit.
PfamiPF08569. Mo25. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel mRNA sequence expressed in cleavage stage mouse embryos."
    Miyamoto H., Matsushiro A., Nozaki M.
    Mol. Reprod. Dev. 34:1-7(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  5. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 97-107; 197-209 AND 269-279, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCAB39_MOUSE
AccessioniPrimary (citable) accession number: Q06138
Secondary accession number(s): Q8VDZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.