Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W

Gene

YLR345W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Synthesis and degradation of fructose 2,6-bisphosphate.By similarity

Miscellaneous

Present with 3380 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei173Proton donor/acceptorBy similarity1
Binding sitei237Fructose 6-phosphateBy similarity1
Binding sitei298Fructose 2,6-bisphosphateBy similarity1
Sitei298Transition state stabilizerBy similarity1
Binding sitei433Fructose 2,6-bisphosphateBy similarity1
Sitei459Transition state stabilizerBy similarity1
Binding sitei464Fructose 2,6-bisphosphateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi90 – 98ATPBy similarity9
Nucleotide bindingi212 – 217ATPBy similarity6
Nucleotide bindingi415 – 418ATPBy similarity4
Nucleotide bindingi460 – 464ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

  • fructose 2,6-bisphosphate metabolic process Source: SGD
  • fructose metabolic process Source: InterPro
  • regulation of glycolytic process Source: SGD

Keywordsi

Molecular functionHydrolase, Kinase, Multifunctional enzyme, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32421-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W
Including the following 2 domains:
6-phosphofructo-2-kinase (EC:2.7.1.105)
Fructose-2,6-bisphosphatase (EC:3.1.3.46)
Gene namesi
Ordered Locus Names:YLR345W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR345W
SGDiS000004337 YLR345W

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002681851 – 509Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345WAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06137
PaxDbiQ06137
PRIDEiQ06137

PTM databases

iPTMnetiQ06137

Expressioni

Inductioni

Expression is under the control of the RFX1 transcription factor.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31608, 94 interactors
DIPiDIP-1500N
IntActiQ06137, 15 interactors
MINTiQ06137
STRINGi4932.YLR345W

Structurei

3D structure databases

ProteinModelPortaliQ06137
SMRiQ06137
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 2916-phosphofructo-2-kinaseBy similarityAdd BLAST286
Regioni292 – 466Fructose-2,6-bisphosphataseBy similarityAdd BLAST175

Sequence similaritiesi

In the C-terminal section; belongs to the phosphoglycerate mutase family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000075979
HOGENOMiHOG000200602
InParanoidiQ06137
KOiK19030
OMAiMAPAQLY
OrthoDBiEOG092C2NC6

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR003094 6Pfruct_kin
IPR013079 6Phosfructo_kin
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR027417 P-loop_NTPase
PANTHERiPTHR10606 PTHR10606, 1 hit
PfamiView protein in Pfam
PF01591 6PF2K, 1 hit
PF00300 His_Phos_1, 1 hit
PRINTSiPR00991 6PFRUCTKNASE
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53254 SSF53254, 1 hit

Sequencei

Sequence statusi: Complete.

Q06137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNVLSDDEE LLNGLGSEIM KPSRQGNHMA RTVKRWVNKE RATTADLKNV
60 70 80 90 100
NIDGVHGPVN TESYISPGQL YSTDSGNLFH AGRILVVLVG LPATSKTLLS
110 120 130 140 150
VAITRYTRWL GVRTKSFHFS EYKESAKNIP SDYFCVVPTS KEGVAFVEKL
160 170 180 190 200
RMQMLNDILA FFNDLSGQLA IYDALNIRKI DRKNLETTFS EIGVKVLFIE
210 220 230 240 250
SIVSDQEIMN RNIALALESN DYKGLSTDEA IDEYMRRLSV NEPYYEMMTH
260 270 280 290 300
DEELSYIKYI NLGKQIIVKD NIHGYLVNKI VFFLMNLRQK KGCVYFARCG
310 320 330 340 350
TSDKDNYIHD EELNEEGIHY SQVLKDFVLQ RIKQKRQAKK NSDSLVEVID
360 370 380 390 400
GSHDEDLKTS LIVWTGPRKR THDTALFFSK EGIKVQQRSE LRQLNPGSIA
410 420 430 440 450
DLTDQQIMDK FPSEYKESLK DPYHFRFPRA ESYHDLAVRM EPLLLEMEHT
460 470 480 490 500
SKDILIIAHE STLRVLYGYL MACTCVELPN LNFTRDKLVE ISFSPFCNTV

ELLNIPLTS
Length:509
Mass (Da):58,386
Last modified:November 1, 1996 - v1
Checksum:i29718CA8ECA8EB4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19028 Genomic DNA Translation: AAB67253.1
BK006945 Genomic DNA Translation: DAA09650.1
PIRiS51348
RefSeqiNP_013449.1, NM_001182234.1

Genome annotation databases

EnsemblFungiiYLR345W; YLR345W; YLR345W
GeneIDi851059
KEGGisce:YLR345W

Similar proteinsi

Entry informationi

Entry nameiYL345_YEAST
AccessioniPrimary (citable) accession number: Q06137
Secondary accession number(s): D6VYY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health