Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Suppressor of glycerol defect protein 1

Gene

SGD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in osmoregulatory glycerol response, probably through its interaction with PLC1 which regulates the expression of GDP1.2 Publications

GO - Molecular functioni

GO - Biological processi

  • hyperosmotic response Source: SGD
  • ribosomal small subunit biogenesis Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32415-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of glycerol defect protein 1
Gene namesi
Name:SGD1
Ordered Locus Names:YLR336C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR336C.
SGDiS000004328. SGD1.

Subcellular locationi

GO - Cellular componenti

  • FAL1-SGD1 complex Source: SGD
  • nucleolus Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 899899Suppressor of glycerol defect protein 1PRO_0000269652Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei736 – 7361PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06132.

PTM databases

iPTMnetiQ06132.

Interactioni

Subunit structurei

Interacts with PLC1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PLC1P323833EBI-34377,EBI-13485

Protein-protein interaction databases

BioGridi31600. 51 interactions.
DIPiDIP-6333N.
IntActiQ06132. 7 interactions.
MINTiMINT-709404.

Structurei

3D structure databases

ProteinModelPortaliQ06132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini335 – 540206MIF4GPROSITE-ProRule annotationAdd
BLAST
Domaini644 – 781138MIPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CWC22 family.Curated
Contains 1 MI domain.PROSITE-ProRule annotation
Contains 1 MIF4G domain.Curated

Phylogenomic databases

GeneTreeiENSGT00550000075087.
HOGENOMiHOG000248855.
InParanoidiQ06132.
KOiK17583.
OMAiKNNRLKP.
OrthoDBiEOG7CCC10.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
[Graphical view]
SMARTiSM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51366. MI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKTDGIRIP GVILDELKTL DYSQDERFSI SEGKKRRRGN GKHLSRKEKR
60 70 80 90 100
KMERADKKRK IISTREINSS RLKSAPTSEK RSANAGVKNV GKQANGKNPI
110 120 130 140 150
SSDESESNEN WDSDEVLTDE VAEESGEQAM SAEETMKKLE SLKRKAKGIQ
160 170 180 190 200
GAENSGEIKG NSYEKKHIRN RDTNENFVSY PLAPSDRSAF ERDEMDMQYY
210 220 230 240 250
AKKLGLKGER KAIHAKDEFD AIGGLLEGLE YFENYGKSDE EYGDFATETN
260 270 280 290 300
SMRKDDEASE KAFSSDDDLS ASDFEDSDGL SESDNDSVAD SDDNYRREKE
310 320 330 340 350
NPYVAPTQSV ESYVPPSLRK KLDDSENNST LSEISKKVNS SLNKLSDSNI
360 370 380 390 400
TIIITDLNRL YDSLPRQYVT ESLTKGILNI ISQNQKLLDG FIMNYAALAY
410 420 430 440 450
TLSKLRGIEV GAFFIQKTVE AFLHHYEEEM ENILKDQQSK ISSKICINIA
460 470 480 490 500
TLLSYCYNFG FVSCRLIYDI IRIFVADPNE FTTELLLRII SISGQLIRGD
510 520 530 540 550
DPSALRDIRS ELLKNAKNLK EQSPRLRFLM DTMSDLKNNR LKPSILATDH
560 570 580 590 600
HPLKKNLQSI LNSSSSWEPL QVSLEDIKNI DSKGKWWLVG ASWRGNMENA
610 620 630 640 650
FEVSINNEND ASKSKKSKIS IEDDLLDDIP DWNIIARQQR MNTDIRRAIF
660 670 680 690 700
ISIMSAQDYL DAFSKLEKLS LKNKQVLEIP RIVLHCLLAD SGSNGYNHYY
710 720 730 740 750
ALVANKICER YSHLSKSFQF LFWDVIKKFE DKEFDSESDT DEEDDLDDKE
760 770 780 790 800
KLLRISNQGR FFGSLLANDI LKLDVFKHVP FMGGLNTEGM LFMEILLFQL
810 820 830 840 850
FLTVAKKSEK KLKMDESGNK RIIYSDDYLR DVLTKNVKSE NMLFILKGLK
860 870 880 890
WFINKKFRYH NFLAGKKGDK AFDRDERRLA WASKAAKSII DKELENIDS
Length:899
Mass (Da):102,853
Last modified:November 1, 1996 - v1
Checksum:i8EEFDB8258407FF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19028 Genomic DNA. Translation: AAB67262.1.
BK006945 Genomic DNA. Translation: DAA09642.1.
PIRiS51341.
RefSeqiNP_013440.1. NM_001182225.1.

Genome annotation databases

EnsemblFungiiYLR336C; YLR336C; YLR336C.
GeneIDi851049.
KEGGisce:YLR336C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19028 Genomic DNA. Translation: AAB67262.1.
BK006945 Genomic DNA. Translation: DAA09642.1.
PIRiS51341.
RefSeqiNP_013440.1. NM_001182225.1.

3D structure databases

ProteinModelPortaliQ06132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31600. 51 interactions.
DIPiDIP-6333N.
IntActiQ06132. 7 interactions.
MINTiMINT-709404.

PTM databases

iPTMnetiQ06132.

Proteomic databases

MaxQBiQ06132.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR336C; YLR336C; YLR336C.
GeneIDi851049.
KEGGisce:YLR336C.

Organism-specific databases

EuPathDBiFungiDB:YLR336C.
SGDiS000004328. SGD1.

Phylogenomic databases

GeneTreeiENSGT00550000075087.
HOGENOMiHOG000248855.
InParanoidiQ06132.
KOiK17583.
OMAiKNNRLKP.
OrthoDBiEOG7CCC10.

Enzyme and pathway databases

BioCyciYEAST:G3O-32415-MONOMER.

Miscellaneous databases

PROiQ06132.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
[Graphical view]
SMARTiSM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51366. MI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "SGD1 encodes an essential nuclear protein of Saccharomyces cerevisiae that affects expression of the GPD1 gene for glycerol 3-phosphate dehydrogenase."
    Akhtar N., Paahlman A.-K., Larsson K., Corbett A.H., Adler L.
    FEBS Lett. 483:87-92(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "Phospholipase C interacts with Sgd1p and is required for expression of GPD1 and osmoresistance in Saccharomyces cerevisiae."
    Lin H., Nguyen P.H., Vancura A.
    Mol. Genet. Genomics 267:313-320(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PLC1.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-736, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSGD1_YEAST
AccessioniPrimary (citable) accession number: Q06132
Secondary accession number(s): D6VYX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3060 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.