Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q06129 (TRPG_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anthranilate synthase component II
EC=4.1.3.27
Alternative name(s):
Glutamine amido-transferase
Gene names
Name:trpG
Ordered Locus Names:SSO0894
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 195195Anthranilate synthase component II
PRO_0000056900

Regions

Domain3 – 195193Glutamine amidotransferase type-1

Sites

Active site841 By similarity
Active site1751 By similarity
Active site1771 By similarity

Experimental info

Sequence conflict491I → L in AAA73380. Ref.1
Sequence conflict491I → L in CAA90312. Ref.1

Secondary structure

1 ................................. 195
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q06129 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 155B62933E9CD33E

FASTA19521,909
        10         20         30         40         50         60 
MDLTLIIDNY DSFVYNIAQI VGELGSYPIV IRNDEISIKG IERIDPDRII ISPGPGTPEK 

        70         80         90        100        110        120 
REDIGVSLDV IKYLGKRTPI LGVCLGHQAI GYAFGAKIRR ARKVFHGKIS NIILVNNSPL 

       130        140        150        160        170        180 
SLYYGIAKEF KATRYHSLVV DEVHRPLIVD AISAEDNEIM AIHHEEYPIY GVQFHPESVG 

       190 
TSLGYKILYN FLNRV

« Hide

References

« Hide 'large scale' references
[1]"Tryptophan biosynthesis genes trpEGC in the thermoacidophilic archaebacterium Sulfolobus solfataricus."
Tutino M.L., Scarano G., Marino G., Sannia G., Cubellis M.V.
J. Bacteriol. 175:299-302(1993) [PubMed: 8416906] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 5833 / MT-4.
[2]"The complete genome of the crenarchaeon Sulfolobus solfataricus P2."
She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. expand/collapse author list , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.
Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[3]"The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications."
Knoechel T., Ivens A., Hester G., Gonzalez A., Bauerle R., Wilmanns M., Kirschner K., Jansonius J.N.
Proc. Natl. Acad. Sci. U.S.A. 96:9479-9484(1999) [PubMed: 10449718] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M98048 Genomic DNA. Translation: AAA73380.1.
Z50014 Genomic DNA. Translation: CAA90312.1.
AE006641 Genomic DNA. Translation: AAK41176.1.
PIRA99240.
B40635.
RefSeqNP_342386.1. NC_002754.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QDLX-ray2.50B1-195[»]
ProteinModelPortalQ06129.
SMRQ06129. Positions 1-195.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-6203N.
IntActQ06129. 1 interaction.
MINTMINT-102261.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1455143.
GenomeReviewsGene locus SSO0894 in contig AE006641_GR.
KEGGsso:SSO0894.
NMPDRfig|273057.1.peg.809.

Phylogenomic databases

HOGENOMHBG292341.
OMALAHQVMH.
ProtClustDBPRK05670.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-3604.
SSOL273057:SSO0894-MONOMER.

Family and domain databases

InterProIPR017926. GATASE_1.
IPR006221. TrpG_papA.
[Graphical view]
KOK01658.
PfamPF00117. GATase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00566. TrpG_papA. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPG_SULSO
AccessionPrimary (citable) accession number: Q06129
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents