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Q06128 (TRPE_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anthranilate synthase component 1
EC=4.1.3.27
Alternative name(s):
Anthranilate synthase component I
Gene names
Name:trpE
Ordered Locus Names:SSO0893
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Anthranilate synthase component 1
PRO_0000154132

Experimental info

Sequence conflict3371A → R Ref.1
Sequence conflict3371A → R Ref.2

Secondary structure

1 ......................................................................... 421
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q06128 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: BD49BD7771ECC6EE

FASTA42147,652
        10         20         30         40         50         60 
MEVHPISEFA SPFEVFKCIE RDFKVAGLLE SIGGPQYKAR YSVIAWSTNG YLKIHDDPVN 

        70         80         90        100        110        120 
ILNGYLKDLK LADIPGLFKG GMIGYISYDA VRFWEKIRDL KPAAEDWPYA EFFTPDNIII 

       130        140        150        160        170        180 
YDHNEGKVYV NADLSSVGGC GDIGEFKVSF YDESLNKNSY ERIVSESLEY IRSGYIFQVV 

       190        200        210        220        230        240 
LSRFYRYIFS GDPLRIYYNL RRINPSPYMF YLKFDEKYLI GSSPELLFRV QDNIVETYPI 

       250        260        270        280        290        300 
AGTRPRGADQ EEDLKLELEL MNSEKDKAEH LMLVDLARND LGKVCVPGTV KVPELMYVEK 

       310        320        330        340        350        360 
YSHVQHIVSK VIGTLKKKYN ALNVLSATFP AGTVSGAPKP MAMNIIETLE EYKRGPYAGA 

       370        380        390        400        410        420 
VGFISADGNA EFAIAIRTAF LNKELLRIHA GAGIVYDSNP ESEYFETEHK LKALKTAIGV 


R

« Hide

References

« Hide 'large scale' references
[1]"Tryptophan biosynthesis genes trpEGC in the thermoacidophilic archaebacterium Sulfolobus solfataricus."
Tutino M.L., Scarano G., Marino G., Sannia G., Cubellis M.V.
J. Bacteriol. 175:299-302(1993) [PubMed: 8416906] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 5833 / MT-4.
[2]"Expression of Sulfolobus solfataricus trpE and trpG genes in E. coli."
Tutino M.L., Tosco A., Marino G., Sannia G.
Biochem. Biophys. Res. Commun. 230:306-310(1997) [PubMed: 9016772] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 5833 / MT-4.
[3]"The complete genome of the crenarchaeon Sulfolobus solfataricus P2."
She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. expand/collapse author list , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.
Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[4]"The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications."
Knoechel T., Ivens A., Hester G., Gonzalez A., Bauerle R., Wilmanns M., Kirschner K., Jansonius J.N.
Proc. Natl. Acad. Sci. U.S.A. 96:9479-9484(1999) [PubMed: 10449718] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M98048 Genomic DNA. Translation: AAA73379.1.
Z50014 Genomic DNA. Translation: CAA90311.1.
AE006641 Genomic DNA. Translation: AAK41175.1.
PIRH90239.
JC5323.
RefSeqNP_342385.1. NC_002754.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QDLX-ray2.50A1-421[»]
ProteinModelPortalQ06128.
SMRQ06128. Positions 1-421.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-6202N.
IntActQ06128. 1 interaction.
MINTMINT-102245.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1455142.
GenomeReviewsGene locus SSO0893 in contig AE006641_GR.
KEGGsso:SSO0893.
NMPDRfig|273057.1.peg.808.

Phylogenomic databases

HOGENOMHBG507440.
OMAIRDYMAR.
ProtClustDBPRK13574.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-3603.
SSOL273057:SSO0893-MONOMER.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I.
IPR006805. Anth_synth_I_N.
IPR010116. Anthranilate_synth_I_arc.
IPR015890. Chorismate-bd_C.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KOK01657.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMsTIGR01820. TrpE-arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE_SULSO
AccessionPrimary (citable) accession number: Q06128
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 20, 2001
Last modified: December 14, 2011
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents