Indole-3-glycerol phosphate synthase - Sulfolobus solfataricus

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Reviewed, UniProtKB/Swiss-Prot Q06121 (TRPC_SULSO)

Last modified November 24, 2009. Version 77. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	SSO0895

Organism

Sulfolobus solfataricus [Complete proteome] [HAMAP]

Taxonomic identifier

2287 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

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Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO₂ + H₂O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Subunit structure	Monomer. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

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Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 248

248

Indole-3-glycerol phosphate synthase HAMAP MF_00134

PRO_0000154302

Secondary structure

248

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q06121-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 919E2AEEE68DDF65
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FASTA

248

28,588

        10         20         30         40         50         60 
MPRYLKGWLK DVVQLSLRRP SFRASRQRPI ISLNERILEF NKRNITAIIA EYKRKSPSGL 

        70         80         90        100        110        120 
DVERDPIEYS KFMERYAVGL SILTEEKYFN GSYETLRKIA SSVSIPILMK DFIVKESQID 

       130        140        150        160        170        180 
DAYNLGADTV LLIVKILTER ELESLLEYAR SYGMEPLIEI NDENDLDIAL RIGARFIGIN 

       190        200        210        220        230        240 
SRDLETLEIN KENQRKLISM IPSNVVKVAE SGISERNEIE ELRKLGVNAF LIGSSLMRNP 


EKIKEFIL

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tryptophan biosynthesis genes trpEGC in the thermoacidophilic archaebacterium Sulfolobus solfataricus." Tutino M.L., Scarano G., Marino G., Sannia G., Cubellis M.V. J. Bacteriol. 175:299-302(1993) [PubMed: 8416906] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 5833 / MT-4.
[2]	"The tryptophan operon in Sulfolobus solfataricus." Tutino M.L., Cubellis M., Sannia G., Marino G. Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 5833 / MT-4.
[3]	"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[4]	"2.0-A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability." Hennig M., Darimont B., Kirschner K., Jansonius J.N. Structure 3:1295-1306(1995) [PubMed: 8747456] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
[5]	"The crystal structure of indole-3-glycerol phosphate synthase from the hyperthermophilic archaeon Sulfolobus solfataricus in three different crystal forms: effects of ionic strength." Knoechel T.R., Hennig M., Merz A., Darimont B., Kirschner K., Jansonius J.N. J. Mol. Biol. 262:502-515(1996) [PubMed: 8893859] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
[6]	"The catalytic mechanism of indole-3-glycerolphosphate synthase: crystal structure of substrate, product and substrate analogue bound to the enzyme from Sulfolobus solfataricus." Hennig M., Darimont B., Kirschner K., Jansonius J.N. Submitted (FEB-1998) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+	Additional computationally mapped references.

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Cross-references

Sequence databases

M98048 Genomic DNA. Translation: AAA73381.1.
Z50014 Genomic DNA. Translation: CAA90313.1.
AE006641 Genomic DNA. Translation: AAK41177.1.

PIR

C40635.
S50179.

RefSeq

NP_342387.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A53	X-ray	2.00	A	2-248	[»]
1IGS	X-ray	2.00	A	1-248	[»]
1JUK	X-ray	2.50	A	1-248	[»]
1JUL	X-ray	2.00	A	1-248	[»]
1LBF	X-ray	2.05	A	2-248	[»]
1LBL	X-ray	2.40	A	2-248	[»]
2C3Z	X-ray	2.80	A	27-248	[»]

ModBase

Search...

Genome annotation databases

GeneID

1455144.

GenomeReviews

Gene locus SSO0895 in contig AE006641_GR.

KEGG

sso:SSO0895.

NMPDR

fig|273057.1.peg.810.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

Q06121.

OMA

PLVEVHT

Enzyme and pathway databases

BioCyc

MetaCyc:MONOMER-3602.
SSOL273057:SSO0895-MON.

BRENDA

4.1.1.48. 2070.

Family and domain databases

HAMAP

MF_00134.
[Tree]

InterPro

IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GPS_central.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]

Gene3D

G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.

Pfam

PF00218. IGPS. 1 hit.
[Graphical view]

PROSITE

PS00614. IGPS. 1 hit.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

TRPC_SULSO

Accession

Primary (citable) accession number: Q06121
Secondary accession number(s): P50385

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	November 24, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families