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Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE), Anthranilate synthase component 2 (trpG)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain 2 (trpB2), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3602.
SSOL273057:GCH2-851-MONOMER.
BRENDAi4.1.1.48. 6163.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
Gene namesi
Name:trpC
Ordered Locus Names:SSO0895
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Indole-3-glycerol phosphate synthasePRO_0000154302Add
BLAST

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi273057.SSO0895.

Structurei

Secondary structure

1
248
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 1711Combined sources
Beta strandi21 – 233Combined sources
Helixi33 – 4210Combined sources
Beta strandi48 – 525Combined sources
Beta strandi57 – 593Combined sources
Helixi66 – 738Combined sources
Turni74 – 763Combined sources
Beta strandi78 – 836Combined sources
Turni87 – 893Combined sources
Helixi93 – 1008Combined sources
Beta strandi107 – 1115Combined sources
Helixi116 – 12510Combined sources
Beta strandi128 – 1336Combined sources
Helixi134 – 1363Combined sources
Helixi139 – 15113Combined sources
Beta strandi157 – 1626Combined sources
Helixi163 – 1719Combined sources
Beta strandi175 – 1795Combined sources
Turni184 – 1863Combined sources
Helixi191 – 1988Combined sources
Beta strandi205 – 2139Combined sources
Helixi216 – 2249Combined sources
Beta strandi229 – 2324Combined sources
Helixi234 – 2385Combined sources
Helixi242 – 2476Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A53X-ray2.00A2-248[»]
1IGSX-ray2.00A1-248[»]
1JUKX-ray2.50A1-248[»]
1JULX-ray2.00A1-248[»]
1LBFX-ray2.05A2-248[»]
1LBLX-ray2.40A2-248[»]
2C3ZX-ray2.80A27-248[»]
3NYZX-ray1.51A/B1-248[»]
3NZ1X-ray1.56A1-248[»]
3TC6X-ray1.60A1-245[»]
3TC7X-ray1.50A1-245[»]
4A29X-ray1.10A1-247[»]
4A2RX-ray1.30A1-245[»]
4A2SX-ray1.40A1-245[»]
4IWWX-ray2.30A/B2-248[»]
4IX0X-ray2.50A2-248[»]
4LNYX-ray1.93A1-247[»]
4OU1X-ray1.25A1-247[»]
ProteinModelPortaliQ06121.
SMRiQ06121. Positions 2-248.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06121.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpC family.Curated

Phylogenomic databases

eggNOGiarCOG01088. Archaea.
COG0134. LUCA.
HOGENOMiHOG000230462.
InParanoidiQ06121.
KOiK01609.
OMAiKRYISAG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_A. IGPS_A.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRYLKGWLK DVVQLSLRRP SFRASRQRPI ISLNERILEF NKRNITAIIA
60 70 80 90 100
EYKRKSPSGL DVERDPIEYS KFMERYAVGL SILTEEKYFN GSYETLRKIA
110 120 130 140 150
SSVSIPILMK DFIVKESQID DAYNLGADTV LLIVKILTER ELESLLEYAR
160 170 180 190 200
SYGMEPLIEI NDENDLDIAL RIGARFIGIN SRDLETLEIN KENQRKLISM
210 220 230 240
IPSNVVKVAE SGISERNEIE ELRKLGVNAF LIGSSLMRNP EKIKEFIL
Length:248
Mass (Da):28,588
Last modified:June 1, 1994 - v1
Checksum:i919E2AEEE68DDF65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98048 Genomic DNA. Translation: AAA73381.1.
Z50014 Genomic DNA. Translation: CAA90313.1.
AE006641 Genomic DNA. Translation: AAK41177.1.
PIRiC40635.
S50179.
RefSeqiWP_009992313.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK41177; AAK41177; SSO0895.
GeneIDi27427215.
KEGGisso:SSO0895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98048 Genomic DNA. Translation: AAA73381.1.
Z50014 Genomic DNA. Translation: CAA90313.1.
AE006641 Genomic DNA. Translation: AAK41177.1.
PIRiC40635.
S50179.
RefSeqiWP_009992313.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A53X-ray2.00A2-248[»]
1IGSX-ray2.00A1-248[»]
1JUKX-ray2.50A1-248[»]
1JULX-ray2.00A1-248[»]
1LBFX-ray2.05A2-248[»]
1LBLX-ray2.40A2-248[»]
2C3ZX-ray2.80A27-248[»]
3NYZX-ray1.51A/B1-248[»]
3NZ1X-ray1.56A1-248[»]
3TC6X-ray1.60A1-245[»]
3TC7X-ray1.50A1-245[»]
4A29X-ray1.10A1-247[»]
4A2RX-ray1.30A1-245[»]
4A2SX-ray1.40A1-245[»]
4IWWX-ray2.30A/B2-248[»]
4IX0X-ray2.50A2-248[»]
4LNYX-ray1.93A1-247[»]
4OU1X-ray1.25A1-247[»]
ProteinModelPortaliQ06121.
SMRiQ06121. Positions 2-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0895.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41177; AAK41177; SSO0895.
GeneIDi27427215.
KEGGisso:SSO0895.

Phylogenomic databases

eggNOGiarCOG01088. Archaea.
COG0134. LUCA.
HOGENOMiHOG000230462.
InParanoidiQ06121.
KOiK01609.
OMAiKRYISAG.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00043.
BioCyciMetaCyc:MONOMER-3602.
SSOL273057:GCH2-851-MONOMER.
BRENDAi4.1.1.48. 6163.

Miscellaneous databases

EvolutionaryTraceiQ06121.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_A. IGPS_A.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tryptophan biosynthesis genes trpEGC in the thermoacidophilic archaebacterium Sulfolobus solfataricus."
    Tutino M.L., Scarano G., Marino G., Sannia G., Cubellis M.V.
    J. Bacteriol. 175:299-302(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 5833 / MT-4.
  2. "The tryptophan operon in Sulfolobus solfataricus."
    Tutino M.L., Cubellis M., Sannia G., Marino G.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 5833 / MT-4.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  4. "2.0-A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability."
    Hennig M., Darimont B., Kirschner K., Jansonius J.N.
    Structure 3:1295-1306(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
  5. "The crystal structure of indole-3-glycerol phosphate synthase from the hyperthermophilic archaeon Sulfolobus solfataricus in three different crystal forms: effects of ionic strength."
    Knoechel T.R., Hennig M., Merz A., Darimont B., Kirschner K., Jansonius J.N.
    J. Mol. Biol. 262:502-515(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
  6. "The catalytic mechanism of indole-3-glycerolphosphate synthase: crystal structure of substrate, product and substrate analogue bound to the enzyme from Sulfolobus solfataricus."
    Hennig M., Darimont B., Kirschner K., Jansonius J.N.
    Submitted (FEB-1998) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiTRPC_SULSO
AccessioniPrimary (citable) accession number: Q06121
Secondary accession number(s): P50385
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.