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Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE), Anthranilate synthase component 2 (trpG)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain 2 (trpB2), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3602.
BRENDAi4.1.1.48. 6163.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
Gene namesi
Name:trpC
Ordered Locus Names:SSO0895
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001543021 – 248Indole-3-glycerol phosphate synthaseAdd BLAST248

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi273057.SSO0895.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 17Combined sources11
Beta strandi21 – 23Combined sources3
Helixi33 – 42Combined sources10
Beta strandi48 – 52Combined sources5
Beta strandi57 – 59Combined sources3
Helixi66 – 73Combined sources8
Turni74 – 76Combined sources3
Beta strandi78 – 83Combined sources6
Turni87 – 89Combined sources3
Helixi93 – 100Combined sources8
Beta strandi107 – 111Combined sources5
Helixi116 – 125Combined sources10
Beta strandi128 – 133Combined sources6
Helixi134 – 136Combined sources3
Helixi139 – 151Combined sources13
Beta strandi157 – 162Combined sources6
Helixi163 – 171Combined sources9
Beta strandi175 – 179Combined sources5
Turni184 – 186Combined sources3
Helixi191 – 198Combined sources8
Beta strandi205 – 213Combined sources9
Helixi216 – 224Combined sources9
Beta strandi229 – 232Combined sources4
Helixi234 – 238Combined sources5
Helixi242 – 247Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A53X-ray2.00A2-248[»]
1IGSX-ray2.00A1-248[»]
1JUKX-ray2.50A1-248[»]
1JULX-ray2.00A1-248[»]
1LBFX-ray2.05A2-248[»]
1LBLX-ray2.40A2-248[»]
2C3ZX-ray2.80A27-248[»]
3NYZX-ray1.51A/B1-248[»]
3NZ1X-ray1.56A1-248[»]
3TC6X-ray1.60A1-245[»]
3TC7X-ray1.50A1-245[»]
4A29X-ray1.10A1-247[»]
4A2RX-ray1.30A1-245[»]
4A2SX-ray1.40A1-245[»]
4IWWX-ray2.30A/B2-248[»]
4IX0X-ray2.50A2-248[»]
4LNYX-ray1.93A1-247[»]
4OU1X-ray1.25A1-247[»]
5AN7X-ray1.10A1-247[»]
5AOUX-ray1.10A1-245[»]
5K7JX-ray1.39A/B2-248[»]
ProteinModelPortaliQ06121.
SMRiQ06121.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06121.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpC family.Curated

Phylogenomic databases

eggNOGiarCOG01088. Archaea.
COG0134. LUCA.
HOGENOMiHOG000230462.
InParanoidiQ06121.
KOiK01609.
OMAiKRYISAG.

Family and domain databases

CDDicd00331. IGPS. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_A. IGPS_A. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRYLKGWLK DVVQLSLRRP SFRASRQRPI ISLNERILEF NKRNITAIIA
60 70 80 90 100
EYKRKSPSGL DVERDPIEYS KFMERYAVGL SILTEEKYFN GSYETLRKIA
110 120 130 140 150
SSVSIPILMK DFIVKESQID DAYNLGADTV LLIVKILTER ELESLLEYAR
160 170 180 190 200
SYGMEPLIEI NDENDLDIAL RIGARFIGIN SRDLETLEIN KENQRKLISM
210 220 230 240
IPSNVVKVAE SGISERNEIE ELRKLGVNAF LIGSSLMRNP EKIKEFIL
Length:248
Mass (Da):28,588
Last modified:June 1, 1994 - v1
Checksum:i919E2AEEE68DDF65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98048 Genomic DNA. Translation: AAA73381.1.
Z50014 Genomic DNA. Translation: CAA90313.1.
AE006641 Genomic DNA. Translation: AAK41177.1.
PIRiC40635.
S50179.
RefSeqiWP_009992313.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK41177; AAK41177; SSO0895.
GeneIDi27427215.
KEGGisso:SSO0895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98048 Genomic DNA. Translation: AAA73381.1.
Z50014 Genomic DNA. Translation: CAA90313.1.
AE006641 Genomic DNA. Translation: AAK41177.1.
PIRiC40635.
S50179.
RefSeqiWP_009992313.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A53X-ray2.00A2-248[»]
1IGSX-ray2.00A1-248[»]
1JUKX-ray2.50A1-248[»]
1JULX-ray2.00A1-248[»]
1LBFX-ray2.05A2-248[»]
1LBLX-ray2.40A2-248[»]
2C3ZX-ray2.80A27-248[»]
3NYZX-ray1.51A/B1-248[»]
3NZ1X-ray1.56A1-248[»]
3TC6X-ray1.60A1-245[»]
3TC7X-ray1.50A1-245[»]
4A29X-ray1.10A1-247[»]
4A2RX-ray1.30A1-245[»]
4A2SX-ray1.40A1-245[»]
4IWWX-ray2.30A/B2-248[»]
4IX0X-ray2.50A2-248[»]
4LNYX-ray1.93A1-247[»]
4OU1X-ray1.25A1-247[»]
5AN7X-ray1.10A1-247[»]
5AOUX-ray1.10A1-245[»]
5K7JX-ray1.39A/B2-248[»]
ProteinModelPortaliQ06121.
SMRiQ06121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0895.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41177; AAK41177; SSO0895.
GeneIDi27427215.
KEGGisso:SSO0895.

Phylogenomic databases

eggNOGiarCOG01088. Archaea.
COG0134. LUCA.
HOGENOMiHOG000230462.
InParanoidiQ06121.
KOiK01609.
OMAiKRYISAG.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00043.
BioCyciMetaCyc:MONOMER-3602.
BRENDAi4.1.1.48. 6163.

Miscellaneous databases

EvolutionaryTraceiQ06121.

Family and domain databases

CDDicd00331. IGPS. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_A. IGPS_A. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC_SULSO
AccessioniPrimary (citable) accession number: Q06121
Secondary accession number(s): P50385
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.