Q06109 (RRG8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Required for respiratory growth protein 8, mitochondrial

Gene names

Name:	RRG8
Ordered Locus Names:	YPR116W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for respiratory activity and maintenance and expression of the mitochondrial genome. Ref.6
Subcellular location	Mitochondrion Ref.3.
Disruption phenotype	Decrease in plasma membrane electron transport. Ref.5
Miscellaneous	Present with 2140 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Belongs to the RRG8 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	mitochondrial genome maintenance Inferred from mutant phenotype Ref.6. Source: SGD
Cellular component	mitochondrion Inferred from direct assay Ref.3. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Required for respiratory growth protein 8, mitochondrial		PRO_0000242626

Sequences

	Sequence		Length	Mass (Da)
	Q06109 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 429821FA1CA256C8	FASTA	277	31,133
	10 20 30 40 50 60 MGLPKSAYKK LLIDCPTRVI NKNCAQRVKD VSPLITNFEK WSDKRKKLYF KDEEEMVGQF 70 80 90 100 110 120 HLENFNLKNN LYGRLLASPM RAEKISKLKS CRELLIPLKV VPSTGKDQHA DKDKLKLVPT 130 140 150 160 170 180 LDYSKSYKSS YVLNSASIVQ DNLAAATSWF PISVLQTSTP KSLEVDSSTF ITEYNANLHA 190 200 210 220 230 240 FIKARLSVIP NVGPSSINRV LLICDKRKTP PIEIQVVSHG KGLPITQSVF NLGYLHEPTL 250 260 270 EAIVSKDAVT NGIYLDADND KDLIKHLYST LLFHSVN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits." Herst P.M., Perrone G.G., Dawes I.W., Bircham P.W., Berridge M.V. FEMS Yeast Res. 8:897-905(2008) [PubMed: 18657191] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[6]	"Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae." Merz S., Westermann B. Genome Biol. 10:R95.1-R95.18(2009) [PubMed: 19751518] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32445 Genomic DNA. Translation: AAB68086.1. BK006949 Genomic DNA. Translation: DAA11531.1.
PIR	S59781.
RefSeq	NP_015441.1. NM_001184213.1.
3D structure databases
ProteinModelPortal	Q06109.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q06109. 2 interactions.
MINT	MINT-2492489.
STRING	Q06109.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YPR116W; YPR116W; YPR116W.
GeneID	856232.
KEGG	sce:YPR116W.
NMPDR	fig|4932.3.peg.6578.
Organism-specific databases
CYGD	YPR116w.
SGD	S000006320. RRG8.
Phylogenomic databases
eggNOG	fuNOG12791.
OMA	FHRWAGK.
OrthoDB	EOG4X9BSZ.
Gene expression databases
ArrayExpress	Q06109.
Genevestigator	Q06109.
GermOnline	YPR116W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	981482.

Entry information

Entry name

RRG8_YEAST

Accession

Primary (citable) accession number: Q06109
Secondary accession number(s): D6W4B5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program