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Q06108

- RGC1_YEAST

UniProt

Q06108 - RGC1_YEAST

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Protein

Regulator of the glycerol channel 1

Gene

RGC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Positive regulator of FPS1 glycerol channel required for the glycerol efflux.2 Publications

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. positive regulation of glycerol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-34254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of the glycerol channel 1
Gene namesi
Name:RGC1
Ordered Locus Names:YPR115W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR115w.
SGDiS000006319. RGC1.

Subcellular locationi

Cytoplasm 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10831083Regulator of the glycerol channel 1PRO_0000242488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei136 – 1361Phosphoserine1 Publication
Modified residuei249 – 2491Phosphoserine1 Publication
Modified residuei252 – 2521Phosphoserine1 Publication
Modified residuei481 – 4811Phosphoserine3 Publications
Modified residuei537 – 5371Phosphoserine1 Publication
Modified residuei652 – 6521Phosphoserine2 Publications
Modified residuei765 – 7651Phosphoserine1 Publication
Modified residuei813 – 8131Phosphoserine1 Publication
Modified residuei817 – 8171Phosphothreonine2 Publications
Modified residuei857 – 8571Phosphothreonine1 Publication
Modified residuei866 – 8661Phosphoserine2 Publications
Modified residuei879 – 8791Phosphoserine1 Publication
Modified residuei918 – 9181Phosphoserine1 Publication
Modified residuei966 – 9661Phosphoserine1 Publication
Modified residuei969 – 9691Phosphoserine1 Publication
Modified residuei975 – 9751Phosphoserine1 Publication
Modified residuei1059 – 10591Phosphoserine2 Publications
Modified residuei1081 – 10811Phosphoserine1 Publication
Modified residuei1082 – 10821Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06108.
PaxDbiQ06108.

Expressioni

Gene expression databases

GenevestigatoriQ06108.

Interactioni

Protein-protein interaction databases

BioGridi36282. 57 interactions.
DIPiDIP-1970N.
IntActiQ06108. 32 interactions.
MINTiMINT-410152.
STRINGi4932.YPR115W.

Structurei

3D structure databases

ProteinModelPortaliQ06108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini495 – 606112PHAdd
BLAST

Sequence similaritiesi

Belongs to the RGC1 family.Curated
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiNOG41793.
GeneTreeiENSGT00390000002928.
InParanoidiQ06108.
OMAiKSSACHI.
OrthoDBiEOG7FZ06S.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06108-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDYFTFPKQ ENGGISKQPA TPGSTRSSSR NLELPKNYRS FGGSSDELAS
60 70 80 90 100
MYSADSQYLM DMIPDSLTLK NEPASGNTQM NGPDGKENKD IKLDEYILPK
110 120 130 140 150
TDPRSPYYIN MPIPKKLPKS EGKARAKQKV NRADPSDLDV ENIYETSGEF
160 170 180 190 200
VREYPTDILI DRFHKWKKIL KSLIAYFREA AYSQEQIARI NYQMKNAVKF
210 220 230 240 250
AFLTDLEDET NKLVDPSISK LPTKKPQPVP LAAQKLDSKY DTDVEQPQSI
260 270 280 290 300
QSVPSEEVAS ASSGFMKFGS GSIQDIQVIL KKYHLSLGSQ QYKISKEILA
310 320 330 340 350
YIIPKLTDLR KDLTTKMKEI KELNGDFKTN IGEHIKITSR LLNKYIASVK
360 370 380 390 400
LLDEASTSGD KQGEKLKPKH DPYLLKLQLD LQLKRQLLEE NYLREAFLNL
410 420 430 440 450
QSAALQLEKI VYSKIQSALQ RYSALIDSEA RLMIKNLCHE LQQGILSRPP
460 470 480 490 500
AVEWDNFVSH HPTCLMNLKS TDPPPQPRRL SDIVYPNMKS PLAKCIRVGY
510 520 530 540 550
LLKKTESSKS FTKGYFVLTT NYLHEFKSSD FFLDSKSPRS KNKPVVEQSD
560 570 580 590 600
ISRVNKDGTN AGSHPSSKGT QDPKLTKRRK GLSSSNLYPI SSLSLNDCSL
610 620 630 640 650
KDSTDSTFVL QGYASYHSPE DTCTKESSTT SDLACPTKTL ASNKGKHQRT
660 670 680 690 700
PSALSMVSVP KFLKSSSVPK EQKKAKEEAN INKKSICEKR VEWTFKIFSA
710 720 730 740 750
SLEPTPEESK NFKKWVQDIK ALTSFNSTQE RSNFIEEKIL KSRNHNNGKS
760 770 780 790 800
SQRSKNSTYI TPVDSFVNLS EKVTPSSSVT TLNTRKRANR PRYIDIPKSA
810 820 830 840 850
NMNAGAMNSV YRSKVNTPAI DENGNLAIVG ETKNSAPQNG MSYTIRTPCK
860 870 880 890 900
SPYSPYTGEG MLYNRSADNL MASSSRKASA PGEVPQIAVS NHGDEAIIPA
910 920 930 940 950
SAYSDSSHKS SRASSVASIH NQRVDFYPSP LMNLPGVSPS CLALDGNANG
960 970 980 990 1000
YFGIPLNCNS EARRGSDLSP FEMESPLFEE NRTQNCSGSR KSSACHIPHQ
1010 1020 1030 1040 1050
CGPRKEGNDS RLIYGNEKGA SQSRLTLKEP LTSKGVEAPY SSLKKTYSAE
1060 1070 1080
NVPLTSTVSN DKSLHSRKEG STNTVPATSA SSK
Length:1,083
Mass (Da):120,395
Last modified:November 1, 1996 - v1
Checksum:i28D63D32843BFE08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32445 Genomic DNA. Translation: AAB68085.1.
BK006949 Genomic DNA. Translation: DAA11530.1.
PIRiS59780.
RefSeqiNP_015440.1. NM_001184212.1.

Genome annotation databases

EnsemblFungiiYPR115W; YPR115W; YPR115W.
GeneIDi856231.
KEGGisce:YPR115W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32445 Genomic DNA. Translation: AAB68085.1 .
BK006949 Genomic DNA. Translation: DAA11530.1 .
PIRi S59780.
RefSeqi NP_015440.1. NM_001184212.1.

3D structure databases

ProteinModelPortali Q06108.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36282. 57 interactions.
DIPi DIP-1970N.
IntActi Q06108. 32 interactions.
MINTi MINT-410152.
STRINGi 4932.YPR115W.

Proteomic databases

MaxQBi Q06108.
PaxDbi Q06108.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR115W ; YPR115W ; YPR115W .
GeneIDi 856231.
KEGGi sce:YPR115W.

Organism-specific databases

CYGDi YPR115w.
SGDi S000006319. RGC1.

Phylogenomic databases

eggNOGi NOG41793.
GeneTreei ENSGT00390000002928.
InParanoidi Q06108.
OMAi KSSACHI.
OrthoDBi EOG7FZ06S.

Enzyme and pathway databases

BioCyci YEAST:G3O-34254-MONOMER.

Miscellaneous databases

NextBioi 981479.

Gene expression databases

Genevestigatori Q06108.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The budding index of Saccharomyces cerevisiae deletion strains identifies genes important for cell cycle progression."
    Zettel M.F., Garza L.R., Cass A.M., Myhre R.A., Haizlip L.A., Osadebe S.N., Sudimack D.W., Pathak R., Stone T.L., Polymenis M.
    FEMS Microbiol. Lett. 223:253-258(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Genome-wide analysis of membrane targeting by S.cerevisiae pleckstrin homology domains."
    Yu J.W., Mendrola J.M., Audhya A., Singh S., Keleti D., DeWald D.B., Murray D., Emr S.D., Lemmon M.A.
    Mol. Cell 13:677-688(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481; SER-652; THR-817; SER-866; SER-918 AND SER-1059, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Identification of positive regulators of the yeast fps1 glycerol channel."
    Beese S.E., Negishi T., Levin D.E.
    PLoS Genet. 5:E1000738-E1000738(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-249; SER-252; SER-481; SER-537; SER-652; SER-765; SER-813; THR-817; THR-857; SER-866; SER-879; SER-966; SER-969; SER-975; SER-1059; SER-1081 AND SER-1082, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRGC1_YEAST
AccessioniPrimary (citable) accession number: Q06108
Secondary accession number(s): D6W4B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication
Does not bind efficiently to phosphoinositides and does not associate with membranes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3