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Protein

Regulator of the glycerol channel 1

Gene

RGC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of FPS1 glycerol channel required for the glycerol efflux.2 Publications

GO - Molecular functioni

  • channel regulator activity Source: SGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • positive regulation of glycerol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-34254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of the glycerol channel 1
Gene namesi
Name:RGC1
Ordered Locus Names:YPR115W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR115W.
SGDiS000006319. RGC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10831083Regulator of the glycerol channel 1PRO_0000242488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei136 – 1361PhosphoserineCombined sources
Modified residuei249 – 2491PhosphoserineCombined sources
Modified residuei252 – 2521PhosphoserineCombined sources
Modified residuei481 – 4811PhosphoserineCombined sources
Modified residuei537 – 5371PhosphoserineCombined sources
Modified residuei652 – 6521PhosphoserineCombined sources
Modified residuei765 – 7651PhosphoserineCombined sources
Modified residuei813 – 8131PhosphoserineCombined sources
Modified residuei817 – 8171PhosphothreonineCombined sources
Modified residuei857 – 8571PhosphothreonineCombined sources
Modified residuei866 – 8661PhosphoserineCombined sources
Modified residuei879 – 8791PhosphoserineCombined sources
Modified residuei918 – 9181PhosphoserineCombined sources
Modified residuei966 – 9661PhosphoserineCombined sources
Modified residuei969 – 9691PhosphoserineCombined sources
Modified residuei975 – 9751PhosphoserineCombined sources
Modified residuei1059 – 10591PhosphoserineCombined sources
Modified residuei1081 – 10811PhosphoserineCombined sources
Modified residuei1082 – 10821PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06108.

PTM databases

iPTMnetiQ06108.

Interactioni

Protein-protein interaction databases

BioGridi36282. 57 interactions.
DIPiDIP-1970N.
IntActiQ06108. 32 interactions.
MINTiMINT-410152.

Structurei

3D structure databases

ProteinModelPortaliQ06108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini495 – 606112PHAdd
BLAST

Sequence similaritiesi

Belongs to the RGC1 family.Curated
Contains 1 PH domain.Curated

Phylogenomic databases

GeneTreeiENSGT00390000002928.
InParanoidiQ06108.
OrthoDBiEOG7FZ06S.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYFTFPKQ ENGGISKQPA TPGSTRSSSR NLELPKNYRS FGGSSDELAS
60 70 80 90 100
MYSADSQYLM DMIPDSLTLK NEPASGNTQM NGPDGKENKD IKLDEYILPK
110 120 130 140 150
TDPRSPYYIN MPIPKKLPKS EGKARAKQKV NRADPSDLDV ENIYETSGEF
160 170 180 190 200
VREYPTDILI DRFHKWKKIL KSLIAYFREA AYSQEQIARI NYQMKNAVKF
210 220 230 240 250
AFLTDLEDET NKLVDPSISK LPTKKPQPVP LAAQKLDSKY DTDVEQPQSI
260 270 280 290 300
QSVPSEEVAS ASSGFMKFGS GSIQDIQVIL KKYHLSLGSQ QYKISKEILA
310 320 330 340 350
YIIPKLTDLR KDLTTKMKEI KELNGDFKTN IGEHIKITSR LLNKYIASVK
360 370 380 390 400
LLDEASTSGD KQGEKLKPKH DPYLLKLQLD LQLKRQLLEE NYLREAFLNL
410 420 430 440 450
QSAALQLEKI VYSKIQSALQ RYSALIDSEA RLMIKNLCHE LQQGILSRPP
460 470 480 490 500
AVEWDNFVSH HPTCLMNLKS TDPPPQPRRL SDIVYPNMKS PLAKCIRVGY
510 520 530 540 550
LLKKTESSKS FTKGYFVLTT NYLHEFKSSD FFLDSKSPRS KNKPVVEQSD
560 570 580 590 600
ISRVNKDGTN AGSHPSSKGT QDPKLTKRRK GLSSSNLYPI SSLSLNDCSL
610 620 630 640 650
KDSTDSTFVL QGYASYHSPE DTCTKESSTT SDLACPTKTL ASNKGKHQRT
660 670 680 690 700
PSALSMVSVP KFLKSSSVPK EQKKAKEEAN INKKSICEKR VEWTFKIFSA
710 720 730 740 750
SLEPTPEESK NFKKWVQDIK ALTSFNSTQE RSNFIEEKIL KSRNHNNGKS
760 770 780 790 800
SQRSKNSTYI TPVDSFVNLS EKVTPSSSVT TLNTRKRANR PRYIDIPKSA
810 820 830 840 850
NMNAGAMNSV YRSKVNTPAI DENGNLAIVG ETKNSAPQNG MSYTIRTPCK
860 870 880 890 900
SPYSPYTGEG MLYNRSADNL MASSSRKASA PGEVPQIAVS NHGDEAIIPA
910 920 930 940 950
SAYSDSSHKS SRASSVASIH NQRVDFYPSP LMNLPGVSPS CLALDGNANG
960 970 980 990 1000
YFGIPLNCNS EARRGSDLSP FEMESPLFEE NRTQNCSGSR KSSACHIPHQ
1010 1020 1030 1040 1050
CGPRKEGNDS RLIYGNEKGA SQSRLTLKEP LTSKGVEAPY SSLKKTYSAE
1060 1070 1080
NVPLTSTVSN DKSLHSRKEG STNTVPATSA SSK
Length:1,083
Mass (Da):120,395
Last modified:November 1, 1996 - v1
Checksum:i28D63D32843BFE08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32445 Genomic DNA. Translation: AAB68085.1.
BK006949 Genomic DNA. Translation: DAA11530.1.
PIRiS59780.
RefSeqiNP_015440.1. NM_001184212.1.

Genome annotation databases

EnsemblFungiiYPR115W; YPR115W; YPR115W.
GeneIDi856231.
KEGGisce:YPR115W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32445 Genomic DNA. Translation: AAB68085.1.
BK006949 Genomic DNA. Translation: DAA11530.1.
PIRiS59780.
RefSeqiNP_015440.1. NM_001184212.1.

3D structure databases

ProteinModelPortaliQ06108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36282. 57 interactions.
DIPiDIP-1970N.
IntActiQ06108. 32 interactions.
MINTiMINT-410152.

PTM databases

iPTMnetiQ06108.

Proteomic databases

MaxQBiQ06108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR115W; YPR115W; YPR115W.
GeneIDi856231.
KEGGisce:YPR115W.

Organism-specific databases

EuPathDBiFungiDB:YPR115W.
SGDiS000006319. RGC1.

Phylogenomic databases

GeneTreeiENSGT00390000002928.
InParanoidiQ06108.
OrthoDBiEOG7FZ06S.

Enzyme and pathway databases

BioCyciYEAST:G3O-34254-MONOMER.

Miscellaneous databases

NextBioi981479.
PROiQ06108.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The budding index of Saccharomyces cerevisiae deletion strains identifies genes important for cell cycle progression."
    Zettel M.F., Garza L.R., Cass A.M., Myhre R.A., Haizlip L.A., Osadebe S.N., Sudimack D.W., Pathak R., Stone T.L., Polymenis M.
    FEMS Microbiol. Lett. 223:253-258(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Genome-wide analysis of membrane targeting by S.cerevisiae pleckstrin homology domains."
    Yu J.W., Mendrola J.M., Audhya A., Singh S., Keleti D., DeWald D.B., Murray D., Emr S.D., Lemmon M.A.
    Mol. Cell 13:677-688(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481; SER-652; THR-817; SER-866; SER-918 AND SER-1059, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Identification of positive regulators of the yeast fps1 glycerol channel."
    Beese S.E., Negishi T., Levin D.E.
    PLoS Genet. 5:E1000738-E1000738(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-249; SER-252; SER-481; SER-537; SER-652; SER-765; SER-813; THR-817; THR-857; SER-866; SER-879; SER-966; SER-969; SER-975; SER-1059; SER-1081 AND SER-1082, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRGC1_YEAST
AccessioniPrimary (citable) accession number: Q06108
Secondary accession number(s): D6W4B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication
Does not bind efficiently to phosphoinositides and does not associate with membranes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.