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Protein

Regulator of the glycerol channel 1

Gene

RGC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of FPS1 glycerol channel required for the glycerol efflux.2 Publications

GO - Molecular functioni

  • channel regulator activity Source: SGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • positive regulation of glycerol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-34254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of the glycerol channel 1
Gene namesi
Name:RGC1
Ordered Locus Names:YPR115W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR115W.
SGDiS000006319. RGC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002424881 – 1083Regulator of the glycerol channel 1Add BLAST1083

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei765PhosphoserineCombined sources1
Modified residuei813PhosphoserineCombined sources1
Modified residuei817PhosphothreonineCombined sources1
Modified residuei857PhosphothreonineCombined sources1
Modified residuei866PhosphoserineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Modified residuei918PhosphoserineCombined sources1
Modified residuei966PhosphoserineCombined sources1
Modified residuei969PhosphoserineCombined sources1
Modified residuei975PhosphoserineCombined sources1
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1081PhosphoserineCombined sources1
Modified residuei1082PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06108.
PRIDEiQ06108.

PTM databases

iPTMnetiQ06108.

Interactioni

Protein-protein interaction databases

BioGridi36282. 61 interactors.
DIPiDIP-1970N.
IntActiQ06108. 33 interactors.
MINTiMINT-410152.

Structurei

3D structure databases

ProteinModelPortaliQ06108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini495 – 606PHAdd BLAST112

Sequence similaritiesi

Belongs to the RGC1 family.Curated
Contains 1 PH domain.Curated

Phylogenomic databases

GeneTreeiENSGT00390000002928.
InParanoidiQ06108.
OMAiFVREYPT.
OrthoDBiEOG092C2NCC.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYFTFPKQ ENGGISKQPA TPGSTRSSSR NLELPKNYRS FGGSSDELAS
60 70 80 90 100
MYSADSQYLM DMIPDSLTLK NEPASGNTQM NGPDGKENKD IKLDEYILPK
110 120 130 140 150
TDPRSPYYIN MPIPKKLPKS EGKARAKQKV NRADPSDLDV ENIYETSGEF
160 170 180 190 200
VREYPTDILI DRFHKWKKIL KSLIAYFREA AYSQEQIARI NYQMKNAVKF
210 220 230 240 250
AFLTDLEDET NKLVDPSISK LPTKKPQPVP LAAQKLDSKY DTDVEQPQSI
260 270 280 290 300
QSVPSEEVAS ASSGFMKFGS GSIQDIQVIL KKYHLSLGSQ QYKISKEILA
310 320 330 340 350
YIIPKLTDLR KDLTTKMKEI KELNGDFKTN IGEHIKITSR LLNKYIASVK
360 370 380 390 400
LLDEASTSGD KQGEKLKPKH DPYLLKLQLD LQLKRQLLEE NYLREAFLNL
410 420 430 440 450
QSAALQLEKI VYSKIQSALQ RYSALIDSEA RLMIKNLCHE LQQGILSRPP
460 470 480 490 500
AVEWDNFVSH HPTCLMNLKS TDPPPQPRRL SDIVYPNMKS PLAKCIRVGY
510 520 530 540 550
LLKKTESSKS FTKGYFVLTT NYLHEFKSSD FFLDSKSPRS KNKPVVEQSD
560 570 580 590 600
ISRVNKDGTN AGSHPSSKGT QDPKLTKRRK GLSSSNLYPI SSLSLNDCSL
610 620 630 640 650
KDSTDSTFVL QGYASYHSPE DTCTKESSTT SDLACPTKTL ASNKGKHQRT
660 670 680 690 700
PSALSMVSVP KFLKSSSVPK EQKKAKEEAN INKKSICEKR VEWTFKIFSA
710 720 730 740 750
SLEPTPEESK NFKKWVQDIK ALTSFNSTQE RSNFIEEKIL KSRNHNNGKS
760 770 780 790 800
SQRSKNSTYI TPVDSFVNLS EKVTPSSSVT TLNTRKRANR PRYIDIPKSA
810 820 830 840 850
NMNAGAMNSV YRSKVNTPAI DENGNLAIVG ETKNSAPQNG MSYTIRTPCK
860 870 880 890 900
SPYSPYTGEG MLYNRSADNL MASSSRKASA PGEVPQIAVS NHGDEAIIPA
910 920 930 940 950
SAYSDSSHKS SRASSVASIH NQRVDFYPSP LMNLPGVSPS CLALDGNANG
960 970 980 990 1000
YFGIPLNCNS EARRGSDLSP FEMESPLFEE NRTQNCSGSR KSSACHIPHQ
1010 1020 1030 1040 1050
CGPRKEGNDS RLIYGNEKGA SQSRLTLKEP LTSKGVEAPY SSLKKTYSAE
1060 1070 1080
NVPLTSTVSN DKSLHSRKEG STNTVPATSA SSK
Length:1,083
Mass (Da):120,395
Last modified:November 1, 1996 - v1
Checksum:i28D63D32843BFE08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32445 Genomic DNA. Translation: AAB68085.1.
BK006949 Genomic DNA. Translation: DAA11530.1.
PIRiS59780.
RefSeqiNP_015440.1. NM_001184212.1.

Genome annotation databases

EnsemblFungiiYPR115W; YPR115W; YPR115W.
GeneIDi856231.
KEGGisce:YPR115W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32445 Genomic DNA. Translation: AAB68085.1.
BK006949 Genomic DNA. Translation: DAA11530.1.
PIRiS59780.
RefSeqiNP_015440.1. NM_001184212.1.

3D structure databases

ProteinModelPortaliQ06108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36282. 61 interactors.
DIPiDIP-1970N.
IntActiQ06108. 33 interactors.
MINTiMINT-410152.

PTM databases

iPTMnetiQ06108.

Proteomic databases

MaxQBiQ06108.
PRIDEiQ06108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR115W; YPR115W; YPR115W.
GeneIDi856231.
KEGGisce:YPR115W.

Organism-specific databases

EuPathDBiFungiDB:YPR115W.
SGDiS000006319. RGC1.

Phylogenomic databases

GeneTreeiENSGT00390000002928.
InParanoidiQ06108.
OMAiFVREYPT.
OrthoDBiEOG092C2NCC.

Enzyme and pathway databases

BioCyciYEAST:G3O-34254-MONOMER.

Miscellaneous databases

PROiQ06108.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRGC1_YEAST
AccessioniPrimary (citable) accession number: Q06108
Secondary accession number(s): D6W4B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication
Does not bind efficiently to phosphoinositides and does not associate with membranes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.