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Q06108

- RGC1_YEAST

UniProt

Q06108 - RGC1_YEAST

Protein

Regulator of the glycerol channel 1

Gene

RGC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Positive regulator of FPS1 glycerol channel required for the glycerol efflux.2 Publications

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. positive regulation of glycerol transport Source: SGD

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34254-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of the glycerol channel 1
    Gene namesi
    Name:RGC1
    Ordered Locus Names:YPR115W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPR115w.
    SGDiS000006319. RGC1.

    Subcellular locationi

    Cytoplasm 2 Publications

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10831083Regulator of the glycerol channel 1PRO_0000242488Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei136 – 1361Phosphoserine1 Publication
    Modified residuei249 – 2491Phosphoserine1 Publication
    Modified residuei252 – 2521Phosphoserine1 Publication
    Modified residuei481 – 4811Phosphoserine3 Publications
    Modified residuei537 – 5371Phosphoserine1 Publication
    Modified residuei652 – 6521Phosphoserine2 Publications
    Modified residuei765 – 7651Phosphoserine1 Publication
    Modified residuei813 – 8131Phosphoserine1 Publication
    Modified residuei817 – 8171Phosphothreonine2 Publications
    Modified residuei857 – 8571Phosphothreonine1 Publication
    Modified residuei866 – 8661Phosphoserine2 Publications
    Modified residuei879 – 8791Phosphoserine1 Publication
    Modified residuei918 – 9181Phosphoserine1 Publication
    Modified residuei966 – 9661Phosphoserine1 Publication
    Modified residuei969 – 9691Phosphoserine1 Publication
    Modified residuei975 – 9751Phosphoserine1 Publication
    Modified residuei1059 – 10591Phosphoserine2 Publications
    Modified residuei1081 – 10811Phosphoserine1 Publication
    Modified residuei1082 – 10821Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ06108.
    PaxDbiQ06108.

    Expressioni

    Gene expression databases

    GenevestigatoriQ06108.

    Interactioni

    Protein-protein interaction databases

    BioGridi36282. 56 interactions.
    DIPiDIP-1970N.
    IntActiQ06108. 32 interactions.
    MINTiMINT-410152.
    STRINGi4932.YPR115W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06108.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini495 – 606112PHAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RGC1 family.Curated
    Contains 1 PH domain.Curated

    Phylogenomic databases

    eggNOGiNOG41793.
    GeneTreeiENSGT00390000002928.
    OMAiKSSACHI.
    OrthoDBiEOG7FZ06S.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06108-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDYFTFPKQ ENGGISKQPA TPGSTRSSSR NLELPKNYRS FGGSSDELAS     50
    MYSADSQYLM DMIPDSLTLK NEPASGNTQM NGPDGKENKD IKLDEYILPK 100
    TDPRSPYYIN MPIPKKLPKS EGKARAKQKV NRADPSDLDV ENIYETSGEF 150
    VREYPTDILI DRFHKWKKIL KSLIAYFREA AYSQEQIARI NYQMKNAVKF 200
    AFLTDLEDET NKLVDPSISK LPTKKPQPVP LAAQKLDSKY DTDVEQPQSI 250
    QSVPSEEVAS ASSGFMKFGS GSIQDIQVIL KKYHLSLGSQ QYKISKEILA 300
    YIIPKLTDLR KDLTTKMKEI KELNGDFKTN IGEHIKITSR LLNKYIASVK 350
    LLDEASTSGD KQGEKLKPKH DPYLLKLQLD LQLKRQLLEE NYLREAFLNL 400
    QSAALQLEKI VYSKIQSALQ RYSALIDSEA RLMIKNLCHE LQQGILSRPP 450
    AVEWDNFVSH HPTCLMNLKS TDPPPQPRRL SDIVYPNMKS PLAKCIRVGY 500
    LLKKTESSKS FTKGYFVLTT NYLHEFKSSD FFLDSKSPRS KNKPVVEQSD 550
    ISRVNKDGTN AGSHPSSKGT QDPKLTKRRK GLSSSNLYPI SSLSLNDCSL 600
    KDSTDSTFVL QGYASYHSPE DTCTKESSTT SDLACPTKTL ASNKGKHQRT 650
    PSALSMVSVP KFLKSSSVPK EQKKAKEEAN INKKSICEKR VEWTFKIFSA 700
    SLEPTPEESK NFKKWVQDIK ALTSFNSTQE RSNFIEEKIL KSRNHNNGKS 750
    SQRSKNSTYI TPVDSFVNLS EKVTPSSSVT TLNTRKRANR PRYIDIPKSA 800
    NMNAGAMNSV YRSKVNTPAI DENGNLAIVG ETKNSAPQNG MSYTIRTPCK 850
    SPYSPYTGEG MLYNRSADNL MASSSRKASA PGEVPQIAVS NHGDEAIIPA 900
    SAYSDSSHKS SRASSVASIH NQRVDFYPSP LMNLPGVSPS CLALDGNANG 950
    YFGIPLNCNS EARRGSDLSP FEMESPLFEE NRTQNCSGSR KSSACHIPHQ 1000
    CGPRKEGNDS RLIYGNEKGA SQSRLTLKEP LTSKGVEAPY SSLKKTYSAE 1050
    NVPLTSTVSN DKSLHSRKEG STNTVPATSA SSK 1083
    Length:1,083
    Mass (Da):120,395
    Last modified:November 1, 1996 - v1
    Checksum:i28D63D32843BFE08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32445 Genomic DNA. Translation: AAB68085.1.
    BK006949 Genomic DNA. Translation: DAA11530.1.
    PIRiS59780.
    RefSeqiNP_015440.1. NM_001184212.1.

    Genome annotation databases

    EnsemblFungiiYPR115W; YPR115W; YPR115W.
    GeneIDi856231.
    KEGGisce:YPR115W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32445 Genomic DNA. Translation: AAB68085.1 .
    BK006949 Genomic DNA. Translation: DAA11530.1 .
    PIRi S59780.
    RefSeqi NP_015440.1. NM_001184212.1.

    3D structure databases

    ProteinModelPortali Q06108.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36282. 56 interactions.
    DIPi DIP-1970N.
    IntActi Q06108. 32 interactions.
    MINTi MINT-410152.
    STRINGi 4932.YPR115W.

    Proteomic databases

    MaxQBi Q06108.
    PaxDbi Q06108.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR115W ; YPR115W ; YPR115W .
    GeneIDi 856231.
    KEGGi sce:YPR115W.

    Organism-specific databases

    CYGDi YPR115w.
    SGDi S000006319. RGC1.

    Phylogenomic databases

    eggNOGi NOG41793.
    GeneTreei ENSGT00390000002928.
    OMAi KSSACHI.
    OrthoDBi EOG7FZ06S.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34254-MONOMER.

    Miscellaneous databases

    NextBioi 981479.

    Gene expression databases

    Genevestigatori Q06108.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The budding index of Saccharomyces cerevisiae deletion strains identifies genes important for cell cycle progression."
      Zettel M.F., Garza L.R., Cass A.M., Myhre R.A., Haizlip L.A., Osadebe S.N., Sudimack D.W., Pathak R., Stone T.L., Polymenis M.
      FEMS Microbiol. Lett. 223:253-258(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Genome-wide analysis of membrane targeting by S.cerevisiae pleckstrin homology domains."
      Yu J.W., Mendrola J.M., Audhya A., Singh S., Keleti D., DeWald D.B., Murray D., Emr S.D., Lemmon M.A.
      Mol. Cell 13:677-688(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481; SER-652; THR-817; SER-866; SER-918 AND SER-1059, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Identification of positive regulators of the yeast fps1 glycerol channel."
      Beese S.E., Negishi T., Levin D.E.
      PLoS Genet. 5:E1000738-E1000738(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-249; SER-252; SER-481; SER-537; SER-652; SER-765; SER-813; THR-817; THR-857; SER-866; SER-879; SER-966; SER-969; SER-975; SER-1059; SER-1081 AND SER-1082, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRGC1_YEAST
    AccessioniPrimary (citable) accession number: Q06108
    Secondary accession number(s): D6W4B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 300 molecules/cell in log phase SD medium.1 Publication
    Does not bind efficiently to phosphoinositides and does not associate with membranes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3