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Protein

Multiple RNA-binding domain-containing protein 1

Gene

MRD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-rRNA processing. Required for maintaining steady-state levels of 40S ribosomal subunit. Required for the initial processing of pre-rRNA at the A0 to A2 sites, leading to the processing of the 23S pre-rRNA intermediate to the 18S rRNA.1 Publication

Miscellaneous

Present with 2220 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • rRNA primary transcript binding Source: SGD

GO - Biological processi

  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • small-subunit processome assembly Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processrRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-34252-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple RNA-binding domain-containing protein 1
Gene namesi
Name:MRD1
Ordered Locus Names:YPR112C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR112C
SGDiS000006316 MRD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816471 – 887Multiple RNA-binding domain-containing protein 1Add BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06106
PaxDbiQ06106
PRIDEiQ06106

PTM databases

iPTMnetiQ06106

Interactioni

Subunit structurei

Interacts with NOP1. Binds to the 35S pre-rRNA and the U3 snoRNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UTP22P532543EBI-34383,EBI-1878

Protein-protein interaction databases

BioGridi36279, 287 interactors
DIPiDIP-6281N
IntActiQ06106, 53 interactors
MINTiQ06106
STRINGi4932.YPR112C

Structurei

3D structure databases

ProteinModelPortaliQ06106
SMRiQ06106
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 94RRM 1PROSITE-ProRule annotationAdd BLAST93
Domaini345 – 423RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini532 – 604RRM 3PROSITE-ProRule annotationAdd BLAST73
Domaini663 – 746RRM 4PROSITE-ProRule annotationAdd BLAST84
Domaini763 – 840RRM 5PROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the RRM MRD1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00840000129953
HOGENOMiHOG000211156
InParanoidiQ06106
KOiK14787
OMAiCKSFGDP
OrthoDBiEOG092C1UL3

Family and domain databases

CDDicd12568 RRM3_MRD1, 1 hit
Gene3Di3.30.70.330, 5 hits
InterProiView protein in InterPro
IPR034482 Mrd1_RRM3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 5 hits
SMARTiView protein in SMART
SM00360 RRM, 5 hits
SUPFAMiSSF54928 SSF54928, 4 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 5 hits

Sequencei

Sequence statusi: Complete.

Q06106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIIVKGLP VYLTDDNLRE HFTKRLRQKH SHQAVNGSGP DLITDVKILR
60 70 80 90 100
DRNGESRRFG FIGYRNEEDA FDAVEYFNGS FINTSKIEVS MAKSFADPRV
110 120 130 140 150
PQPMKEKRRE ALKRFREKEE KLLQEENRKK KKVDENKHSN IDDEIRKNKQ
160 170 180 190 200
LQEFMETMKP SSQVTSWEKV GIDKSIEDEK LKREEEDSSV QGNSLLAHAL
210 220 230 240 250
ALKEENNKDE APNLVIENES DDEYSALNRN RDEDQEDAGE EEKMISISNL
260 270 280 290 300
KDTDIGLVND DANSDEKENE KRRNLAQDEK VSDLDWFKQR RVRIKESEAE
310 320 330 340 350
TREKSSSYAT EQNESLDTKK EEQPERAVPQ KTDEELAIEK INQTGRLFLR
360 370 380 390 400
NILYTSKEED FRKLFSPFGE LEEVHVALDT RTGQSKGFAY VLFKDSKNAV
410 420 430 440 450
NAYVELDKQI FQGRLLHILP GEEKKSHRLD EFDLKNMPLK KQKELKRKAA
460 470 480 490 500
ASRQTFSWNS LYMNQDAVLG SVAAKLGLEK SQLIDAENSS SAVKQALAEA
510 520 530 540 550
HVIGDVRKYF ESKGVDLTKF SQLKSTNQRD DKVILVKNFP FGTTREELGE
560 570 580 590 600
MFLPYGKLER LLMPPAGTIA IVQFRDTTSA RAAFTKLSYK RFKDGIIYLE
610 620 630 640 650
RGPKDCFTKP AEADDLINNT SAKEEENPVE VKPSSNDLME ANKDVTEGSS
660 670 680 690 700
NAHDEDVIDG PTVSIFIKNL NFSTTNQNLT DRFKVFTGFV VAQVKTKPDP
710 720 730 740 750
KHQGKTLSMG FGFVEFRTKE QANAVIAAMD GTVIDGHKIQ LKLSHRQASQ
760 770 780 790 800
SGNTKTKSNK KSGKIIVKNL PFEATRKDVF ELFNSFGQLK SVRVPKKFDK
810 820 830 840 850
SARGFAFVEF LLPKEAENAM DQLHGVHLLG RRLVMQYAEE DAVDAEEEIA
860 870 880
RMTKKVRKQV ATNEMAALRN GGGRKKLDVD DEENEGF
Length:887
Mass (Da):101,120
Last modified:November 1, 1996 - v1
Checksum:i1E34816BD486DEA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32445 Genomic DNA Translation: AAB68082.1
BK006949 Genomic DNA Translation: DAA11527.1
PIRiS59777
RefSeqiNP_015437.1, NM_001184209.1

Genome annotation databases

EnsemblFungiiYPR112C; YPR112C; YPR112C
GeneIDi856228
KEGGisce:YPR112C

Similar proteinsi

Entry informationi

Entry nameiMRD1_YEAST
AccessioniPrimary (citable) accession number: Q06106
Secondary accession number(s): D6W4B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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