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Protein

Multiple RNA-binding domain-containing protein 1

Gene

MRD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-rRNA processing. Required for maintaining steady-state levels of 40S ribosomal subunit. Required for the initial processing of pre-rRNA at the A0 to A2 sites, leading to the processing of the 23S pre-rRNA intermediate to the 18S rRNA.1 Publication

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • rRNA primary transcript binding Source: SGD

GO - Biological processi

  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • small-subunit processome assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34252-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple RNA-binding domain-containing protein 1
Gene namesi
Name:MRD1
Ordered Locus Names:YPR112C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR112C.
SGDiS000006316. MRD1.

Subcellular locationi

GO - Cellular componenti

  • 90S preribosome Source: SGD
  • nucleolus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Multiple RNA-binding domain-containing protein 1PRO_0000081647Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201PhosphoserineCombined sources
Modified residuei264 – 2641PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06106.

PTM databases

iPTMnetiQ06106.

Interactioni

Subunit structurei

Interacts with NOP1. Binds to the 35S pre-rRNA and the U3 snoRNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UTP22P532543EBI-34383,EBI-1878

Protein-protein interaction databases

BioGridi36279. 57 interactions.
DIPiDIP-6281N.
IntActiQ06106. 53 interactions.
MINTiMINT-600745.

Structurei

3D structure databases

ProteinModelPortaliQ06106.
SMRiQ06106. Positions 346-425, 533-628, 662-838.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 9493RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini345 – 42379RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini532 – 60473RRM 3PROSITE-ProRule annotationAdd
BLAST
Domaini663 – 74684RRM 4PROSITE-ProRule annotationAdd
BLAST
Domaini763 – 84078RRM 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RRM MRD1 family.Curated
Contains 5 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00840000129953.
HOGENOMiHOG000211156.
InParanoidiQ06106.
KOiK14787.
OMAiDQIMESG.
OrthoDBiEOG092C1UL3.

Family and domain databases

Gene3Di3.30.70.330. 6 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 5 hits.
[Graphical view]
SMARTiSM00360. RRM. 5 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 4 hits.
PROSITEiPS50102. RRM. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIIVKGLP VYLTDDNLRE HFTKRLRQKH SHQAVNGSGP DLITDVKILR
60 70 80 90 100
DRNGESRRFG FIGYRNEEDA FDAVEYFNGS FINTSKIEVS MAKSFADPRV
110 120 130 140 150
PQPMKEKRRE ALKRFREKEE KLLQEENRKK KKVDENKHSN IDDEIRKNKQ
160 170 180 190 200
LQEFMETMKP SSQVTSWEKV GIDKSIEDEK LKREEEDSSV QGNSLLAHAL
210 220 230 240 250
ALKEENNKDE APNLVIENES DDEYSALNRN RDEDQEDAGE EEKMISISNL
260 270 280 290 300
KDTDIGLVND DANSDEKENE KRRNLAQDEK VSDLDWFKQR RVRIKESEAE
310 320 330 340 350
TREKSSSYAT EQNESLDTKK EEQPERAVPQ KTDEELAIEK INQTGRLFLR
360 370 380 390 400
NILYTSKEED FRKLFSPFGE LEEVHVALDT RTGQSKGFAY VLFKDSKNAV
410 420 430 440 450
NAYVELDKQI FQGRLLHILP GEEKKSHRLD EFDLKNMPLK KQKELKRKAA
460 470 480 490 500
ASRQTFSWNS LYMNQDAVLG SVAAKLGLEK SQLIDAENSS SAVKQALAEA
510 520 530 540 550
HVIGDVRKYF ESKGVDLTKF SQLKSTNQRD DKVILVKNFP FGTTREELGE
560 570 580 590 600
MFLPYGKLER LLMPPAGTIA IVQFRDTTSA RAAFTKLSYK RFKDGIIYLE
610 620 630 640 650
RGPKDCFTKP AEADDLINNT SAKEEENPVE VKPSSNDLME ANKDVTEGSS
660 670 680 690 700
NAHDEDVIDG PTVSIFIKNL NFSTTNQNLT DRFKVFTGFV VAQVKTKPDP
710 720 730 740 750
KHQGKTLSMG FGFVEFRTKE QANAVIAAMD GTVIDGHKIQ LKLSHRQASQ
760 770 780 790 800
SGNTKTKSNK KSGKIIVKNL PFEATRKDVF ELFNSFGQLK SVRVPKKFDK
810 820 830 840 850
SARGFAFVEF LLPKEAENAM DQLHGVHLLG RRLVMQYAEE DAVDAEEEIA
860 870 880
RMTKKVRKQV ATNEMAALRN GGGRKKLDVD DEENEGF
Length:887
Mass (Da):101,120
Last modified:November 1, 1996 - v1
Checksum:i1E34816BD486DEA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32445 Genomic DNA. Translation: AAB68082.1.
BK006949 Genomic DNA. Translation: DAA11527.1.
PIRiS59777.
RefSeqiNP_015437.1. NM_001184209.1.

Genome annotation databases

EnsemblFungiiYPR112C; YPR112C; YPR112C.
GeneIDi856228.
KEGGisce:YPR112C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32445 Genomic DNA. Translation: AAB68082.1.
BK006949 Genomic DNA. Translation: DAA11527.1.
PIRiS59777.
RefSeqiNP_015437.1. NM_001184209.1.

3D structure databases

ProteinModelPortaliQ06106.
SMRiQ06106. Positions 346-425, 533-628, 662-838.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36279. 57 interactions.
DIPiDIP-6281N.
IntActiQ06106. 53 interactions.
MINTiMINT-600745.

PTM databases

iPTMnetiQ06106.

Proteomic databases

MaxQBiQ06106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR112C; YPR112C; YPR112C.
GeneIDi856228.
KEGGisce:YPR112C.

Organism-specific databases

EuPathDBiFungiDB:YPR112C.
SGDiS000006316. MRD1.

Phylogenomic databases

GeneTreeiENSGT00840000129953.
HOGENOMiHOG000211156.
InParanoidiQ06106.
KOiK14787.
OMAiDQIMESG.
OrthoDBiEOG092C1UL3.

Enzyme and pathway databases

BioCyciYEAST:G3O-34252-MONOMER.

Miscellaneous databases

PROiQ06106.

Family and domain databases

Gene3Di3.30.70.330. 6 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 5 hits.
[Graphical view]
SMARTiSM00360. RRM. 5 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 4 hits.
PROSITEiPS50102. RRM. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRD1_YEAST
AccessioniPrimary (citable) accession number: Q06106
Secondary accession number(s): D6W4B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2220 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.