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Protein

26S proteasome regulatory subunit RPN7

Gene

RPN7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

Miscellaneous

Present with 51900 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • enzyme regulator activity Source: InterPro
  • structural molecule activity Source: SGD

GO - Biological processi

Enzyme and pathway databases

BioCyciYEAST:G3O-34248-MONOMER.
ReactomeiR-SCE-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SCE-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SCE-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-SCE-382556. ABC-family proteins mediated transport.
R-SCE-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-SCE-5668541. TNFR2 non-canonical NF-kB pathway.
R-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-5689880. Ub-specific processing proteases.
R-SCE-6798695. Neutrophil degranulation.
R-SCE-68949. Orc1 removal from chromatin.
R-SCE-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SCE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SCE-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SCE-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SCE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit RPN7
Gene namesi
Name:RPN7
Ordered Locus Names:YPR108W
ORF Names:P8283.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR108W.
SGDiS000006312. RPN7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001738452 – 42926S proteasome regulatory subunit RPN7Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06103.
PRIDEiQ06103.

PTM databases

iPTMnetiQ06103.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36274. 458 interactors.
DIPiDIP-2880N.
IntActiQ06103. 43 interactors.
MINTiMINT-531082.
STRINGi4932.YPR108W.

Structurei

Secondary structure

1429
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 34Combined sources10
Beta strandi36 – 38Combined sources3
Helixi40 – 55Combined sources16
Turni56 – 58Combined sources3
Helixi60 – 71Combined sources12
Helixi96 – 122Combined sources27
Helixi127 – 143Combined sources17
Helixi147 – 157Combined sources11
Helixi164 – 167Combined sources4
Helixi169 – 181Combined sources13
Helixi184 – 200Combined sources17
Helixi204 – 220Combined sources17
Helixi224 – 234Combined sources11
Turni240 – 242Combined sources3
Helixi246 – 260Combined sources15
Helixi263 – 269Combined sources7
Helixi276 – 279Combined sources4
Helixi280 – 282Combined sources3
Beta strandi283 – 285Combined sources3
Helixi286 – 297Combined sources12
Helixi301 – 314Combined sources14
Turni315 – 318Combined sources4
Turni320 – 322Combined sources3
Helixi323 – 325Combined sources3
Helixi326 – 342Combined sources17
Beta strandi345 – 349Combined sources5
Helixi350 – 357Combined sources8
Helixi361 – 371Combined sources11
Helixi372 – 374Combined sources3
Beta strandi379 – 382Combined sources4
Turni383 – 386Combined sources4
Beta strandi387 – 390Combined sources4
Helixi396 – 423Combined sources28

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J47electron microscopy-R397-422[»]
3JCKelectron microscopy3.50D1-429[»]
3JCOelectron microscopy4.80R1-429[»]
3JCPelectron microscopy4.60R1-429[»]
4CR2electron microscopy7.70R1-429[»]
4CR3electron microscopy9.30R1-429[»]
4CR4electron microscopy8.80R1-429[»]
5A5Belectron microscopy9.50R1-429[»]
5MPBelectron microscopy7.80R1-429[»]
5MPCelectron microscopy7.70R1-429[»]
5MPDelectron microscopy4.10R1-429[»]
5MPEelectron microscopy4.50R1-429[»]
5WVIelectron microscopy6.30R1-429[»]
5WVKelectron microscopy4.20R1-429[»]
ProteinModelPortaliQ06103.
SMRiQ06103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati131 – 164TPRAdd BLAST34
Domaini221 – 392PCIAdd BLAST172

Keywords - Domaini

TPR repeat

Phylogenomic databases

GeneTreeiENSGT00510000046608.
HOGENOMiHOG000214998.
InParanoidiQ06103.
KOiK03037.
OMAiVDYIDQE.
OrthoDBiEOG092C33JO.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR035268. PSMD6.
IPR019585. Rpn7/CSN1.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR14145:SF6. PTHR14145:SF6. 1 hit.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
PF10602. RPN7. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDVEEKSQE VEYVDPTVNR VPNYEVSEKA FLLTQSKVSI EQRKEAAEFV
60 70 80 90 100
LAKIKEEEMA PYYKYLCEEY LVNNGQSDLE HDEKSDSLNE WIKFDQELYN
110 120 130 140 150
ELCKKNESKI KELNEKIQKL EEDDEGELEQ AQAWINLGEY YAQIGDKDNA
160 170 180 190 200
EKTLGKSLSK AISTGAKIDV MLTIARLGFF YNDQLYVKEK LEAVNSMIEK
210 220 230 240 250
GGDWERRNRY KTYYGIHCLA VRNFKEAAKL LVDSLATFTS IELTSYESIA
260 270 280 290 300
TYASVTGLFT LERTDLKSKV IDSPELLSLI STTAALQSIS SLTISLYASD
310 320 330 340 350
YASYFPYLLE TYANVLIPCK YLNRHADFFV REMRRKVYAQ LLESYKTLSL
360 370 380 390 400
KSMASAFGVS VAFLDNDLGK FIPNKQLNCV IDRVNGIVET NRPDNKNAQY
410 420
HLLVKQGDGL LTKLQKYGAA VRLTGSDRV
Length:429
Mass (Da):48,959
Last modified:January 23, 2007 - v3
Checksum:iB21B66CD818E636D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8S → G in AAT92788 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32445 Genomic DNA. Translation: AAB68078.1.
AY692769 Genomic DNA. Translation: AAT92788.1.
BK006949 Genomic DNA. Translation: DAA11522.1.
PIRiS59773.
RefSeqiNP_015433.1. NM_001184205.1.

Genome annotation databases

EnsemblFungiiYPR108W; YPR108W; YPR108W.
GeneIDi856223.
KEGGisce:YPR108W.

Similar proteinsi

Entry informationi

Entry nameiRPN7_YEAST
AccessioniPrimary (citable) accession number: Q06103
Secondary accession number(s): D6W4A6, E9P8W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names