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Protein

Propionyl-CoA carboxylase beta chain

Gene

pccB

Organism
Rhodococcus erythropolis (Arthrobacter picolinophilus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Propionyl-CoA carboxylase beta chain (pccB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00945; UER00908.

Names & Taxonomyi

Protein namesi
Recommended name:
Propionyl-CoA carboxylase beta chain (EC:6.4.1.3)
Short name:
PCCase
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase
Gene namesi
Name:pccB
OrganismiRhodococcus erythropolis (Arthrobacter picolinophilus)
Taxonomic identifieri1833 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998021 – 476Propionyl-CoA carboxylase beta chainAdd BLAST476

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.

Structurei

3D structure databases

ProteinModelPortaliQ06101.
SMRiQ06101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 225CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST225
Domaini226 – 476CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST251

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 476CarboxyltransferasePROSITE-ProRule annotationAdd BLAST476

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated

Phylogenomic databases

eggNOGiENOG4106H22. Bacteria.
COG4799. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06101-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILAPVTKS ESSTDPRDPL ARLENLFDPG TTVPLHARDK SGVLAASGNI
60 70 80 90 100
DGVRTIAYCS DATVMGGAMG VDGCKHLVKA IDTAIEEESP IVGLWHSGGA
110 120 130 140 150
RLAEGVEALH AVGLVFEAMV RASGLIPQIS VVLGFAAGGA AYGPALTDVV
160 170 180 190 200
IMAPEGRVFV TGPDVVRSVT GEQVDMVSLG GPDTHTKKSG VAHIAAHDEA
210 220 230 240 250
DALHRARRLV SMMCEQGEFD QRAAELGDSD LRAMMPASAK RAYDVRPIVH
260 270 280 290 300
EMLDNVEGES SFEELQGNYA RSIVTGFGRM AGRTVGVIAN NPLRLGCLNS
310 320 330 340 350
ESAEKAARFV RLCNAFGVPL VVVVDVPGYL PGVSMEWEGV VRRGAKLLHA
360 370 380 390 400
FAEATVPRVT VVTRKIYGGA YIAMNSRALG ATAVFAWPNS EVAVMGAKAA
410 420 430 440 450
VGILHKRALA AAPDDEREAL HDRLAAEHEA IAGGVDRRCR NRRRRRGNRP
460 470
GEDSQHRHAA LASAPSVRAR HKNIPL
Length:476
Mass (Da):50,450
Last modified:February 1, 1995 - v1
Checksum:i7D1EFD1C0C77478B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95713 Genomic DNA. Translation: AAB80770.1.
PIRiJQ1943.

Similar proteinsi

Entry informationi

Entry nameiPCCB_RHOER
AccessioniPrimary (citable) accession number: Q06101
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 5, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families