Reviewed, UniProtKB/Swiss-Prot Q06099 (FADH_CANMA)

Names and origin

Protein names

Recommended name:
    S-(hydroxymethyl)glutathione dehydrogenase
    EC=1.1.1.284
Alternative name(s):
    Glutathione-dependent formaldehyde dehydrogenase
      Short name=GSH-FDH
      Short name=FALDH
      Short name=FDH
      Short name=FLD
    EC=1.1.1.-

Gene names

Name:	FDH1
Synonyms:	ADH1

Organism

Candida maltosa (Yeast)

Taxonomic identifier

5479 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Confers resistance to formaldehyde.
Catalytic activity	S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	ethanol oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	S-(hydroxymethyl)glutathione dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	S-(hydroxymethyl)glutathione dehydrogenase		PRO_0000160781
Sites
	Metal binding	49	1	Zinc 1; catalytic By similarity
	Metal binding	71	1	Zinc 1; catalytic By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 2 By similarity
	Metal binding	107	1	Zinc 2 By similarity
	Metal binding	115	1	Zinc 2 By similarity
	Metal binding	178	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q06099-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: F09E01BC65DAD0C7	FASTA	381	40,075
	10 20 30 40 50 60 MSESTVGKPI TCKAAVAWEA AKPLSIEDVT VAPPKRHEVR IKLYDTGVCH TDAYTLSGVD 70 80 90 100 110 120 PEGAFPVILG HEGAGIVESI GEGVTNVKVG DHVIALYTPE CGECKFCKSG KTNLCGKIRA 130 140 150 160 170 180 TQGKGVMPDG TSRFTCKGKE ILHFMGCSTF SQYTVVADIS VVAINPKAEF DKACLLGCGI 190 200 210 220 230 240 TTGYGAATIT ANVQKGDNVA VFGGGIVGLS VIQGCAERGA AQIILVDISD KKEEWGQKLG 250 260 270 280 290 300 ATAFVNPTKL PEGTTIVDKL IEMTDGGCDF TFDCTGNVGV MRNALEACHK GWGTSVIIGV 310 320 330 340 350 360 AAAGKEISTR PFQLVTGRTW KGAAFGGVKG RSQLPGIVNN YLDGKLKVEE FITHREPLAA 370 380 INKAFEEMHA GDCIRAVVDL S

References

[1]

"Cloning and analysis of a Candida maltosa gene which confers resistance to formaldehyde in Saccharomyces cerevisiae." Sasnauskas K., Jomantiene R., Januska A., Lebediene E., Lebedys J., Janulaitis A. Gene 122:207-211(1992) [PubMed: 1339376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 899.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M58332 Genomic DNA. Translation: AAA34344.1.
PIR	JN0447.
3D structure databases
HSSP	HSSP built from PDB template 1M6H based on UniProtKB P11766.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.284. 3846.
Family and domain databases
InterPro	IPR014183. ADH_3. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR02818. adh_III_F_hyde. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FADH_CANMA

Accession

Primary (citable) accession number: Q06099

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)