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Q06095

- DUT_HHV6U

UniProt

Q06095 - DUT_HHV6U

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
U45, BHLF3
Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:U45
Synonyms:BHLF3
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009295: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182959Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ06095.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

Q06095-1 [UniParc]FASTAAdd to Basket

« Hide

MYSAISEKIS ETITLQRQTS SRYIEFFVFR NVDINELWTT DISEDKTHDV    50
WPAVNEKSFK KFLENELTSY QRPIPLLGIP QNGTVSKTCK KEKQRETDCV 100
NYERKRGNPV TFYPRHRAKR NANTDTCISE EPSILVSHHR NSKMDVFMDT 150
NKITLVNREL IWVPHDQVRI VKLDISLYIP DGFFGVITGH SNDVFCECVT 200
EIITDETDIS VFLMNLSEHS LMLLPGDVEF SINFLPCYIP EPWEMINLSP 250
PEFAIFHLKA SREFIAKPNS YTIQYFDAMY VCADELKALM IPSKEIAKLG 300
LLIETYIWNK DTIPSIKIFN STRKTIYIPT GICIARIIFT CGHFCLSLMP 350
ERAINRLQVL DANSSFLFHY AASNNA 376
Length:376
Mass (Da):43,398
Last modified:November 1, 1995 - v1
Checksum:i81B3CE9C817D27D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64320 Genomic DNA. Translation: CAA45600.1.
X83413 Genomic DNA. Translation: CAA58379.1.
X92436 Genomic DNA. Translation: CAA63171.1.
PIRiA56653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64320 Genomic DNA. Translation: CAA45600.1 .
X83413 Genomic DNA. Translation: CAA58379.1 .
X92436 Genomic DNA. Translation: CAA63171.1 .
PIRi A56653.

3D structure databases

ProteinModelPortali Q06095.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Infectivity determinants encoded in a conserved gene block of human herpesvirus-6."
    Gompels U.A., Carss A.L., Sun N., Arrand J.R.
    DNA Seq. 3:25-39(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution."
    Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J., Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.
    Virology 209:29-51(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_HHV6U
AccessioniPrimary (citable) accession number: Q06095
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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