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Q06095 (DUT_HHV6U) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:U45
Synonyms:BHLF3
OrganismHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) [Reference proteome]
Taxonomic identifier10370 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182959

Sequences

Sequence LengthMass (Da)Tools
Q06095 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 81B3CE9C817D27D5

FASTA37643,398
        10         20         30         40         50         60 
MYSAISEKIS ETITLQRQTS SRYIEFFVFR NVDINELWTT DISEDKTHDV WPAVNEKSFK 

        70         80         90        100        110        120 
KFLENELTSY QRPIPLLGIP QNGTVSKTCK KEKQRETDCV NYERKRGNPV TFYPRHRAKR 

       130        140        150        160        170        180 
NANTDTCISE EPSILVSHHR NSKMDVFMDT NKITLVNREL IWVPHDQVRI VKLDISLYIP 

       190        200        210        220        230        240 
DGFFGVITGH SNDVFCECVT EIITDETDIS VFLMNLSEHS LMLLPGDVEF SINFLPCYIP 

       250        260        270        280        290        300 
EPWEMINLSP PEFAIFHLKA SREFIAKPNS YTIQYFDAMY VCADELKALM IPSKEIAKLG 

       310        320        330        340        350        360 
LLIETYIWNK DTIPSIKIFN STRKTIYIPT GICIARIIFT CGHFCLSLMP ERAINRLQVL 

       370 
DANSSFLFHY AASNNA 

« Hide

References

« Hide 'large scale' references
[1]"Infectivity determinants encoded in a conserved gene block of human herpesvirus-6."
Gompels U.A., Carss A.L., Sun N., Arrand J.R.
DNA Seq. 3:25-39(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution."
Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J., Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.
Virology 209:29-51(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64320 Genomic DNA. Translation: CAA45600.1.
X83413 Genomic DNA. Translation: CAA58379.1.
X92436 Genomic DNA. Translation: CAA63171.1.
PIRA56653.

3D structure databases

ProteinModelPortalQ06095.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMSSF51283. SSF51283. 2 hits.
ProtoNetSearch...

Entry information

Entry nameDUT_HHV6U
AccessionPrimary (citable) accession number: Q06095
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families