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Q06095

- DUT_HHV6U

UniProt

Q06095 - DUT_HHV6U

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

U45

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:U45
    Synonyms:BHLF3
    OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
    Taxonomic identifieri10370 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009295: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182959Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ06095.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q06095-1 [UniParc]FASTAAdd to Basket

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    MYSAISEKIS ETITLQRQTS SRYIEFFVFR NVDINELWTT DISEDKTHDV    50
    WPAVNEKSFK KFLENELTSY QRPIPLLGIP QNGTVSKTCK KEKQRETDCV 100
    NYERKRGNPV TFYPRHRAKR NANTDTCISE EPSILVSHHR NSKMDVFMDT 150
    NKITLVNREL IWVPHDQVRI VKLDISLYIP DGFFGVITGH SNDVFCECVT 200
    EIITDETDIS VFLMNLSEHS LMLLPGDVEF SINFLPCYIP EPWEMINLSP 250
    PEFAIFHLKA SREFIAKPNS YTIQYFDAMY VCADELKALM IPSKEIAKLG 300
    LLIETYIWNK DTIPSIKIFN STRKTIYIPT GICIARIIFT CGHFCLSLMP 350
    ERAINRLQVL DANSSFLFHY AASNNA 376
    Length:376
    Mass (Da):43,398
    Last modified:November 1, 1995 - v1
    Checksum:i81B3CE9C817D27D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64320 Genomic DNA. Translation: CAA45600.1.
    X83413 Genomic DNA. Translation: CAA58379.1.
    X92436 Genomic DNA. Translation: CAA63171.1.
    PIRiA56653.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64320 Genomic DNA. Translation: CAA45600.1 .
    X83413 Genomic DNA. Translation: CAA58379.1 .
    X92436 Genomic DNA. Translation: CAA63171.1 .
    PIRi A56653.

    3D structure databases

    ProteinModelPortali Q06095.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Infectivity determinants encoded in a conserved gene block of human herpesvirus-6."
      Gompels U.A., Carss A.L., Sun N., Arrand J.R.
      DNA Seq. 3:25-39(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution."
      Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J., Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.
      Virology 209:29-51(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_HHV6U
    AccessioniPrimary (citable) accession number: Q06095
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3