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Q06078 (UTP21_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U3 small nucleolar RNA-associated protein 21

Short name=U3 snoRNA-associated protein 21
Alternative name(s):
U three protein 21
Gene names
Name:UTP21
Ordered Locus Names:YLR409C
ORF Names:L8084.22
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length939 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Ref.5

Subunit structure

Interacts with snoRNA U3. Interacts with MPP10. Interacts (via WD repeats) with UTP18. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Ref.5 Ref.8

Subcellular location

Nucleusnucleolus Ref.3 Ref.5.

Domain

The WD repeats are grouped into two tandem seven-bladed beta-propeller regions.

Miscellaneous

Present with 2020 molecules/cell in log phase SD medium.

Sequence similarities

Contains 14 WD repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PWP2P256357EBI-359,EBI-14332
UTP18P403626EBI-359,EBI-4534

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 939938U3 small nucleolar RNA-associated protein 21
PRO_0000051480

Regions

Repeat40 – 7132WD 1
Repeat81 – 11131WD 2
Repeat119 – 15840WD 3
Repeat168 – 20134WD 4
Repeat208 – 24538WD 5
Repeat252 – 28736WD 6
Repeat295 – 34753WD 7
Repeat354 – 38835WD 8
Repeat415 – 45440WD 9
Repeat463 – 49735WD 10
Repeat505 – 54137WD 11
Repeat546 – 58136WD 12
Repeat583 – 62442WD 13
Repeat626 – 66439WD 14

Amino acid modifications

Modified residue21N-acetylserine Ref.7
Modified residue7721Phosphoserine Ref.6

Secondary structure

................................................................................................................................... 939
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q06078 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F1F856EF28369351

FASTA939104,791
        10         20         30         40         50         60 
MSIDLKKRKV EEDVRSRGKN SKIFSPFRII GNVSNGVPFA TGTLGSTFYI VTCVGKTFQI 

        70         80         90        100        110        120 
YDANTLHLLF VSEKETPSSI VALSAHFHYV YAAYENKVGI YKRGIEEHLL ELETDANVEH 

       130        140        150        160        170        180 
LCIFGDYLCA STDDNSIFIY KKSDPQDKYP SEFYTKLTVT EIQGGEIVSL QHLATYLNKL 

       190        200        210        220        230        240 
TVVTKSNVLL FNVRTGKLVF TSNEFPDQIT TAEPAPVLDI IALGTVTGEV IMFNMRKGKR 

       250        260        270        280        290        300 
IRTIKIPQSR ISSLSFRTDG SSHLSVGTSS GDLIFYDLDR RSRIHVLKNI HRESYGGVTQ 

       310        320        330        340        350        360 
ATFLNGQPII VTSGGDNSLK EYVFDPSLSQ GSGDVVVQPP RYLRSRGGHS QPPSYIAFAD 

       370        380        390        400        410        420 
SQSHFMLSAS KDRSLWSFSL RKDAQSQEMS QRLHKKQDGG RVGGSTIKSK FPEIVALAIE 

       430        440        450        460        470        480 
NARIGEWENI ITAHKDEKFA RTWDMRNKRV GRWTFDTTDD GFVKSVAMSQ CGNFGFIGSS 

       490        500        510        520        530        540 
NGSITIYNMQ SGILRKKYKL HKRAVTGISL DGMNRKMVSC GLDGIVGFYD FNKSTLLGKL 

       550        560        570        580        590        600 
KLDAPITAMV YHRSSDLFAL ALDDLSIVVI DAVTQRVVRQ LWGHSNRITA FDFSPEGRWI 

       610        620        630        640        650        660 
VSASLDSTIR TWDLPTGGCI DGIIVDNVAT NVKFSPNGDL LATTHVTGNG ICIWTNRAQF 

       670        680        690        700        710        720 
KTVSTRTIDE SEFARMALPS TSVRGNDSML SGALESNGGE DLNDIDFNTY TSLEQIDKEL 

       730        740        750        760        770        780 
LTLSIGPRSK MNTLLHLDVI RKRSKPKEAP KKSEKLPFFL QLSGEKVGDE ASVREGIAHE 

       790        800        810        820        830        840 
TPEEIHRRDQ EAQKKLDAEE QMNKFKVTGR LGFESHFTKQ LREGSQSKDY SSLLATLINF 

       850        860        870        880        890        900 
SPAAVDLEIR SLNSFEPFDE IVWFIDALTQ GLKSNKNFEL YETFMSLLFK AHGDVIHANN 

       910        920        930 
KNQDIASALQ NWEDVHKKED RLDDLVKFCM GVAAFVTTA 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"The small-subunit processome is a ribosome assembly intermediate."
Bernstein K.A., Gallagher J.E.G., Mitchell B.M., Granneman S., Baserga S.J.
Eukaryot. Cell 3:1619-1626(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME, SUBCELLULAR LOCATION.
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-772, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[8]"Structure of Utp21 tandem WD domain provides insight into the organization of the UTPB complex involved in ribosome synthesis."
Zhang C., Lin J., Liu W., Chen X., Chen R., Ye K.
PLoS ONE 9:E86540-E86540(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-684, SUBUNIT, WD REPEATS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19729 Genomic DNA. Translation: AAB82361.1.
BK006945 Genomic DNA. Translation: DAA09709.1.
PIRS55965.
RefSeqNP_013513.3. NM_001182297.3.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HNXX-ray2.10A1-684[»]
4NSXX-ray2.10A1-684[»]
ProteinModelPortalQ06078.
SMRQ06078. Positions 20-684.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31666. 56 interactions.
DIPDIP-6416N.
IntActQ06078. 19 interactions.
MINTMINT-561636.
STRING4932.YLR409C.

Proteomic databases

MaxQBQ06078.
PaxDbQ06078.
PeptideAtlasQ06078.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR409C; YLR409C; YLR409C.
GeneID851125.
KEGGsce:YLR409C.

Organism-specific databases

CYGDYLR409c.
SGDS000004401. UTP21.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00390000004976.
HOGENOMHOG000217777.
KOK14554.
OMAHVPTRQI.
OrthoDBEOG7MSMX8.

Enzyme and pathway databases

BioCycYEAST:G3O-32471-MONOMER.

Gene expression databases

GenevestigatorQ06078.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
InterProIPR011047. Quinonprotein_ADH-like_supfam.
IPR007319. SSU_processome_Utp21.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF04192. Utp21. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTSM00320. WD40. 9 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 2 hits.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio967857.
PROQ06078.

Entry information

Entry nameUTP21_YEAST
AccessionPrimary (citable) accession number: Q06078
Secondary accession number(s): D6VZ43
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references