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Protein

U3 small nucleolar RNA-associated protein 21

Gene

UTP21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.1 Publication

GO - Biological processi

  • ribosomal small subunit biogenesis Source: SGD
  • rRNA methylation Source: Reactome
  • rRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32471-MONOMER.
ReactomeiR-SCE-6790901. rRNA modification in the nucleus and cytosol.
R-SCE-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 21
Short name:
U3 snoRNA-associated protein 21
Alternative name(s):
U three protein 21
Gene namesi
Name:UTP21
Ordered Locus Names:YLR409C
ORF Names:L8084.22
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR409C.
SGDiS000004401. UTP21.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
  • nucleoplasm Source: Reactome
  • Pwp2p-containing subcomplex of 90S preribosome Source: SGD
  • small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000514802 – 939U3 small nucleolar RNA-associated protein 21Add BLAST938

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei772PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ06078.
PRIDEiQ06078.

PTM databases

iPTMnetiQ06078.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Interacts (via WD repeats) with UTP18. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PWP2P256359EBI-359,EBI-14332
UTP18P403627EBI-359,EBI-4534
UTP6Q023549EBI-359,EBI-22119

Protein-protein interaction databases

BioGridi31666. 50 interactors.
DIPiDIP-6416N.
IntActiQ06078. 25 interactors.
MINTiMINT-561636.

Structurei

Secondary structure

1939
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 31Combined sources10
Beta strandi40 – 44Combined sources5
Beta strandi47 – 53Combined sources7
Beta strandi58 – 62Combined sources5
Turni63 – 65Combined sources3
Beta strandi68 – 71Combined sources4
Beta strandi82 – 86Combined sources5
Beta strandi89 – 94Combined sources6
Beta strandi97 – 102Combined sources6
Beta strandi105 – 111Combined sources7
Beta strandi113 – 116Combined sources4
Beta strandi118 – 124Combined sources7
Beta strandi127 – 132Combined sources6
Beta strandi135 – 141Combined sources7
Beta strandi147 – 149Combined sources3
Beta strandi152 – 158Combined sources7
Turni161 – 163Combined sources3
Beta strandi165 – 171Combined sources7
Beta strandi179 – 186Combined sources8
Beta strandi188 – 192Combined sources5
Turni193 – 195Combined sources3
Beta strandi198 – 201Combined sources4
Beta strandi209 – 214Combined sources6
Beta strandi220 – 234Combined sources15
Turni235 – 238Combined sources4
Beta strandi239 – 245Combined sources7
Beta strandi251 – 256Combined sources6
Beta strandi259 – 261Combined sources3
Beta strandi263 – 268Combined sources6
Beta strandi273 – 277Combined sources5
Turni278 – 281Combined sources4
Beta strandi282 – 287Combined sources6
Helixi293 – 295Combined sources3
Beta strandi299 – 303Combined sources5
Beta strandi307 – 313Combined sources7
Beta strandi315 – 323Combined sources9
Beta strandi341 – 347Combined sources7
Beta strandi353 – 358Combined sources6
Beta strandi365 – 370Combined sources6
Beta strandi375 – 379Combined sources5
Beta strandi386 – 388Combined sources3
Beta strandi414 – 419Combined sources6
Turni422 – 426Combined sources5
Beta strandi430 – 434Combined sources5
Beta strandi438 – 444Combined sources7
Turni445 – 448Combined sources4
Beta strandi449 – 456Combined sources8
Beta strandi458 – 460Combined sources3
Beta strandi463 – 468Combined sources6
Beta strandi474 – 479Combined sources6
Beta strandi482 – 488Combined sources7
Turni489 – 491Combined sources3
Beta strandi494 – 499Combined sources6
Beta strandi505 – 510Combined sources6
Beta strandi516 – 521Combined sources6
Beta strandi524 – 533Combined sources10
Beta strandi536 – 541Combined sources6
Beta strandi546 – 551Combined sources6
Turni553 – 555Combined sources3
Beta strandi557 – 562Combined sources6
Beta strandi567 – 571Combined sources5
Turni572 – 575Combined sources4
Beta strandi576 – 581Combined sources6
Beta strandi588 – 593Combined sources6
Beta strandi597 – 604Combined sources8
Beta strandi607 – 613Combined sources7
Turni614 – 616Combined sources3
Beta strandi619 – 624Combined sources6
Beta strandi629 – 634Combined sources6
Beta strandi640 – 647Combined sources8
Beta strandi649 – 656Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HNXX-ray2.10A1-684[»]
4NSXX-ray2.10A1-684[»]
5JPQelectron microscopy7.30I1-939[»]
ProteinModelPortaliQ06078.
SMRiQ06078.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati40 – 71WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST32
Repeati81 – 111WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST31
Repeati119 – 158WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati168 – 201WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST34
Repeati208 – 245WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati252 – 287WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati295 – 347WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST53
Repeati354 – 388WD 8PROSITE-ProRule annotation1 PublicationAdd BLAST35
Repeati415 – 454WD 9PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati463 – 497WD 10PROSITE-ProRule annotation1 PublicationAdd BLAST35
Repeati505 – 541WD 11PROSITE-ProRule annotation1 PublicationAdd BLAST37
Repeati546 – 581WD 12PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati583 – 624WD 13PROSITE-ProRule annotation1 PublicationAdd BLAST42
Repeati626 – 664WD 14PROSITE-ProRule annotation1 PublicationAdd BLAST39

Domaini

The WD repeats are grouped into two tandem seven-bladed beta-propeller regions.

Sequence similaritiesi

Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000004976.
HOGENOMiHOG000217777.
InParanoidiQ06078.
KOiK14554.
OMAiHVPTRQI.
OrthoDBiEOG092C0JIX.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR007319. SSU_processome_Utp21.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF04192. Utp21. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 9 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIDLKKRKV EEDVRSRGKN SKIFSPFRII GNVSNGVPFA TGTLGSTFYI
60 70 80 90 100
VTCVGKTFQI YDANTLHLLF VSEKETPSSI VALSAHFHYV YAAYENKVGI
110 120 130 140 150
YKRGIEEHLL ELETDANVEH LCIFGDYLCA STDDNSIFIY KKSDPQDKYP
160 170 180 190 200
SEFYTKLTVT EIQGGEIVSL QHLATYLNKL TVVTKSNVLL FNVRTGKLVF
210 220 230 240 250
TSNEFPDQIT TAEPAPVLDI IALGTVTGEV IMFNMRKGKR IRTIKIPQSR
260 270 280 290 300
ISSLSFRTDG SSHLSVGTSS GDLIFYDLDR RSRIHVLKNI HRESYGGVTQ
310 320 330 340 350
ATFLNGQPII VTSGGDNSLK EYVFDPSLSQ GSGDVVVQPP RYLRSRGGHS
360 370 380 390 400
QPPSYIAFAD SQSHFMLSAS KDRSLWSFSL RKDAQSQEMS QRLHKKQDGG
410 420 430 440 450
RVGGSTIKSK FPEIVALAIE NARIGEWENI ITAHKDEKFA RTWDMRNKRV
460 470 480 490 500
GRWTFDTTDD GFVKSVAMSQ CGNFGFIGSS NGSITIYNMQ SGILRKKYKL
510 520 530 540 550
HKRAVTGISL DGMNRKMVSC GLDGIVGFYD FNKSTLLGKL KLDAPITAMV
560 570 580 590 600
YHRSSDLFAL ALDDLSIVVI DAVTQRVVRQ LWGHSNRITA FDFSPEGRWI
610 620 630 640 650
VSASLDSTIR TWDLPTGGCI DGIIVDNVAT NVKFSPNGDL LATTHVTGNG
660 670 680 690 700
ICIWTNRAQF KTVSTRTIDE SEFARMALPS TSVRGNDSML SGALESNGGE
710 720 730 740 750
DLNDIDFNTY TSLEQIDKEL LTLSIGPRSK MNTLLHLDVI RKRSKPKEAP
760 770 780 790 800
KKSEKLPFFL QLSGEKVGDE ASVREGIAHE TPEEIHRRDQ EAQKKLDAEE
810 820 830 840 850
QMNKFKVTGR LGFESHFTKQ LREGSQSKDY SSLLATLINF SPAAVDLEIR
860 870 880 890 900
SLNSFEPFDE IVWFIDALTQ GLKSNKNFEL YETFMSLLFK AHGDVIHANN
910 920 930
KNQDIASALQ NWEDVHKKED RLDDLVKFCM GVAAFVTTA
Length:939
Mass (Da):104,791
Last modified:November 1, 1996 - v1
Checksum:iF1F856EF28369351
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19729 Genomic DNA. Translation: AAB82361.1.
BK006945 Genomic DNA. Translation: DAA09709.1.
PIRiS55965.
RefSeqiNP_013513.3. NM_001182297.3.

Genome annotation databases

EnsemblFungiiYLR409C; YLR409C; YLR409C.
GeneIDi851125.
KEGGisce:YLR409C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19729 Genomic DNA. Translation: AAB82361.1.
BK006945 Genomic DNA. Translation: DAA09709.1.
PIRiS55965.
RefSeqiNP_013513.3. NM_001182297.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HNXX-ray2.10A1-684[»]
4NSXX-ray2.10A1-684[»]
5JPQelectron microscopy7.30I1-939[»]
ProteinModelPortaliQ06078.
SMRiQ06078.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31666. 50 interactors.
DIPiDIP-6416N.
IntActiQ06078. 25 interactors.
MINTiMINT-561636.

PTM databases

iPTMnetiQ06078.

Proteomic databases

MaxQBiQ06078.
PRIDEiQ06078.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR409C; YLR409C; YLR409C.
GeneIDi851125.
KEGGisce:YLR409C.

Organism-specific databases

EuPathDBiFungiDB:YLR409C.
SGDiS000004401. UTP21.

Phylogenomic databases

GeneTreeiENSGT00390000004976.
HOGENOMiHOG000217777.
InParanoidiQ06078.
KOiK14554.
OMAiHVPTRQI.
OrthoDBiEOG092C0JIX.

Enzyme and pathway databases

BioCyciYEAST:G3O-32471-MONOMER.
ReactomeiR-SCE-6790901. rRNA modification in the nucleus and cytosol.
R-SCE-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiQ06078.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR007319. SSU_processome_Utp21.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF04192. Utp21. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 9 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUTP21_YEAST
AccessioniPrimary (citable) accession number: Q06078
Secondary accession number(s): D6VZ43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2020 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.