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Q06078

- UTP21_YEAST

UniProt

Q06078 - UTP21_YEAST

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Protein
U3 small nucleolar RNA-associated protein 21
Gene
UTP21, YLR409C, L8084.22
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. rRNA processing Source: SGD
  2. ribosomal small subunit biogenesis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32471-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 21
Short name:
U3 snoRNA-associated protein 21
Alternative name(s):
U three protein 21
Gene namesi
Name:UTP21
Ordered Locus Names:YLR409C
ORF Names:L8084.22
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR409c.
SGDiS000004401. UTP21.

Subcellular locationi

Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. Pwp2p-containing subcomplex of 90S preribosome Source: SGD
  2. nucleolus Source: SGD
  3. small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 939938U3 small nucleolar RNA-associated protein 21
PRO_0000051480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei772 – 7721Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ06078.
PaxDbiQ06078.
PeptideAtlasiQ06078.

Expressioni

Gene expression databases

GenevestigatoriQ06078.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Interacts (via WD repeats) with UTP18. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PWP2P256357EBI-359,EBI-14332
UTP18P403626EBI-359,EBI-4534

Protein-protein interaction databases

BioGridi31666. 56 interactions.
DIPiDIP-6416N.
IntActiQ06078. 19 interactions.
MINTiMINT-561636.
STRINGi4932.YLR409C.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 3110
Beta strandi40 – 445
Beta strandi47 – 537
Beta strandi58 – 625
Turni63 – 653
Beta strandi68 – 714
Beta strandi82 – 865
Beta strandi89 – 946
Beta strandi97 – 1026
Beta strandi105 – 1117
Beta strandi113 – 1164
Beta strandi118 – 1247
Beta strandi127 – 1326
Beta strandi135 – 1417
Beta strandi147 – 1493
Beta strandi152 – 1587
Turni161 – 1633
Beta strandi165 – 1717
Beta strandi179 – 1868
Beta strandi188 – 1925
Turni193 – 1953
Beta strandi198 – 2014
Beta strandi209 – 2146
Beta strandi220 – 23415
Turni235 – 2384
Beta strandi239 – 2457
Beta strandi251 – 2566
Beta strandi259 – 2613
Beta strandi263 – 2686
Beta strandi273 – 2775
Turni278 – 2814
Beta strandi282 – 2876
Helixi293 – 2953
Beta strandi299 – 3035
Beta strandi307 – 3137
Beta strandi315 – 3239
Beta strandi341 – 3477
Beta strandi353 – 3586
Beta strandi365 – 3706
Beta strandi375 – 3795
Beta strandi386 – 3883
Beta strandi414 – 4196
Turni422 – 4265
Beta strandi430 – 4345
Beta strandi438 – 4447
Turni445 – 4484
Beta strandi449 – 4568
Beta strandi458 – 4603
Beta strandi463 – 4686
Beta strandi474 – 4796
Beta strandi482 – 4887
Turni489 – 4913
Beta strandi494 – 4996
Beta strandi505 – 5106
Beta strandi516 – 5216
Beta strandi524 – 53310
Beta strandi536 – 5416
Beta strandi546 – 5516
Turni553 – 5553
Beta strandi557 – 5626
Beta strandi567 – 5715
Turni572 – 5754
Beta strandi576 – 5816
Beta strandi588 – 5936
Beta strandi597 – 6048
Beta strandi607 – 6137
Turni614 – 6163
Beta strandi619 – 6246
Beta strandi629 – 6346
Beta strandi640 – 6478
Beta strandi649 – 6568

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HNXX-ray2.10A1-684[»]
4NSXX-ray2.10A1-684[»]
ProteinModelPortaliQ06078.
SMRiQ06078. Positions 20-684.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati40 – 7132WD 1
Add
BLAST
Repeati81 – 11131WD 2
Add
BLAST
Repeati119 – 15840WD 3
Add
BLAST
Repeati168 – 20134WD 4
Add
BLAST
Repeati208 – 24538WD 5
Add
BLAST
Repeati252 – 28736WD 6
Add
BLAST
Repeati295 – 34753WD 7
Add
BLAST
Repeati354 – 38835WD 8
Add
BLAST
Repeati415 – 45440WD 9
Add
BLAST
Repeati463 – 49735WD 10
Add
BLAST
Repeati505 – 54137WD 11
Add
BLAST
Repeati546 – 58136WD 12
Add
BLAST
Repeati583 – 62442WD 13
Add
BLAST
Repeati626 – 66439WD 14
Add
BLAST

Domaini

The WD repeats are grouped into two tandem seven-bladed beta-propeller regions.

Sequence similaritiesi

Contains 14 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000004976.
HOGENOMiHOG000217777.
KOiK14554.
OMAiHVPTRQI.
OrthoDBiEOG7MSMX8.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR011047. Quinonprotein_ADH-like_supfam.
IPR007319. SSU_processome_Utp21.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04192. Utp21. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 9 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06078-1 [UniParc]FASTAAdd to Basket

« Hide

MSIDLKKRKV EEDVRSRGKN SKIFSPFRII GNVSNGVPFA TGTLGSTFYI    50
VTCVGKTFQI YDANTLHLLF VSEKETPSSI VALSAHFHYV YAAYENKVGI 100
YKRGIEEHLL ELETDANVEH LCIFGDYLCA STDDNSIFIY KKSDPQDKYP 150
SEFYTKLTVT EIQGGEIVSL QHLATYLNKL TVVTKSNVLL FNVRTGKLVF 200
TSNEFPDQIT TAEPAPVLDI IALGTVTGEV IMFNMRKGKR IRTIKIPQSR 250
ISSLSFRTDG SSHLSVGTSS GDLIFYDLDR RSRIHVLKNI HRESYGGVTQ 300
ATFLNGQPII VTSGGDNSLK EYVFDPSLSQ GSGDVVVQPP RYLRSRGGHS 350
QPPSYIAFAD SQSHFMLSAS KDRSLWSFSL RKDAQSQEMS QRLHKKQDGG 400
RVGGSTIKSK FPEIVALAIE NARIGEWENI ITAHKDEKFA RTWDMRNKRV 450
GRWTFDTTDD GFVKSVAMSQ CGNFGFIGSS NGSITIYNMQ SGILRKKYKL 500
HKRAVTGISL DGMNRKMVSC GLDGIVGFYD FNKSTLLGKL KLDAPITAMV 550
YHRSSDLFAL ALDDLSIVVI DAVTQRVVRQ LWGHSNRITA FDFSPEGRWI 600
VSASLDSTIR TWDLPTGGCI DGIIVDNVAT NVKFSPNGDL LATTHVTGNG 650
ICIWTNRAQF KTVSTRTIDE SEFARMALPS TSVRGNDSML SGALESNGGE 700
DLNDIDFNTY TSLEQIDKEL LTLSIGPRSK MNTLLHLDVI RKRSKPKEAP 750
KKSEKLPFFL QLSGEKVGDE ASVREGIAHE TPEEIHRRDQ EAQKKLDAEE 800
QMNKFKVTGR LGFESHFTKQ LREGSQSKDY SSLLATLINF SPAAVDLEIR 850
SLNSFEPFDE IVWFIDALTQ GLKSNKNFEL YETFMSLLFK AHGDVIHANN 900
KNQDIASALQ NWEDVHKKED RLDDLVKFCM GVAAFVTTA 939
Length:939
Mass (Da):104,791
Last modified:November 1, 1996 - v1
Checksum:iF1F856EF28369351
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19729 Genomic DNA. Translation: AAB82361.1.
BK006945 Genomic DNA. Translation: DAA09709.1.
PIRiS55965.
RefSeqiNP_013513.3. NM_001182297.3.

Genome annotation databases

EnsemblFungiiYLR409C; YLR409C; YLR409C.
GeneIDi851125.
KEGGisce:YLR409C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19729 Genomic DNA. Translation: AAB82361.1 .
BK006945 Genomic DNA. Translation: DAA09709.1 .
PIRi S55965.
RefSeqi NP_013513.3. NM_001182297.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HNX X-ray 2.10 A 1-684 [» ]
4NSX X-ray 2.10 A 1-684 [» ]
ProteinModelPortali Q06078.
SMRi Q06078. Positions 20-684.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31666. 56 interactions.
DIPi DIP-6416N.
IntActi Q06078. 19 interactions.
MINTi MINT-561636.
STRINGi 4932.YLR409C.

Proteomic databases

MaxQBi Q06078.
PaxDbi Q06078.
PeptideAtlasi Q06078.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR409C ; YLR409C ; YLR409C .
GeneIDi 851125.
KEGGi sce:YLR409C.

Organism-specific databases

CYGDi YLR409c.
SGDi S000004401. UTP21.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00390000004976.
HOGENOMi HOG000217777.
KOi K14554.
OMAi HVPTRQI.
OrthoDBi EOG7MSMX8.

Enzyme and pathway databases

BioCyci YEAST:G3O-32471-MONOMER.

Miscellaneous databases

NextBioi 967857.
PROi Q06078.

Gene expression databases

Genevestigatori Q06078.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR011047. Quinonprotein_ADH-like_supfam.
IPR007319. SSU_processome_Utp21.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF04192. Utp21. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 9 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 2 hits.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "The small-subunit processome is a ribosome assembly intermediate."
    Bernstein K.A., Gallagher J.E.G., Mitchell B.M., Granneman S., Baserga S.J.
    Eukaryot. Cell 3:1619-1626(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME, SUBCELLULAR LOCATION.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-772, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. "Structure of Utp21 tandem WD domain provides insight into the organization of the UTPB complex involved in ribosome synthesis."
    Zhang C., Lin J., Liu W., Chen X., Chen R., Ye K.
    PLoS ONE 9:E86540-E86540(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-684, SUBUNIT, WD REPEATS.

Entry informationi

Entry nameiUTP21_YEAST
AccessioniPrimary (citable) accession number: Q06078
Secondary accession number(s): D6VZ43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2020 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

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