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Protein

Signal transduction histidine-protein kinase AtoS

Gene

atoS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  • ATP binding Source: EcoCyc
  • phosphorelay sensor kinase activity Source: EcoCyc

GO - Biological processi

  • phosphorelay signal transduction system Source: EcoCyc
  • protein autophosphorylation Source: EcoCyc
  • regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:ATOS-MONOMER.
ECOL316407:JW2213-MONOMER.
BRENDAi2.7.13.3. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transduction histidine-protein kinase AtoS (EC:2.7.13.3)
Gene namesi
Name:atoS
Ordered Locus Names:b2219, JW2213
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11667. atoS.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Transmembranei584 – 60421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608Signal transduction histidine-protein kinase AtoSPRO_0000074695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei398 – 3981Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ06067.
PRIDEiQ06067.

Interactioni

Protein-protein interaction databases

BioGridi4262011. 13 interactions.
IntActiQ06067. 2 interactions.
STRINGi511145.b2219.

Structurei

3D structure databases

ProteinModelPortaliQ06067.
SMRiQ06067. Positions 263-603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 25948HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini260 – 32566PASPROSITE-ProRule annotationAdd
BLAST
Domaini326 – 38257PACPROSITE-ProRule annotationAdd
BLAST
Domaini395 – 602208Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation
Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
COG0642. LUCA.
COG2202. LUCA.
HOGENOMiHOG000122301.
InParanoidiQ06067.
KOiK07710.
OMAiEIAITCA.
PhylomeDBiQ06067.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013767. PAS_fold.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYMKWIYPR RLRNQMILMA ILMVIVPTLT IGYIVETEGR SAVLSEKEKK
60 70 80 90 100
LSAVVNLLNQ ALGDRYDLYI DLPREERIRA LNAELAPITE NITHAFPGIG
110 120 130 140 150
AGYYNKMLDA IITYAPSALY QNNVGVTIAA DHPGREVMRT NTPLVYSGRQ
160 170 180 190 200
VRGDILNSML PIERNGEILG YIWANELTED IRRQAWKMDV RIIIVLTAGL
210 220 230 240 250
LISLLLIVLF SRRLSANIDI ITDGLSTLAQ NIPTRLPQLP GEMGQISQSV
260 270 280 290 300
NNLAQALRET RTLNDLIIEN AADGVIAIDR QGDVTTMNPA AEVITGYQRH
310 320 330 340 350
ELVGQPYSML FDNTQFYSPV LDTLEHGTEH VALEISFPGR DRTIELSVTT
360 370 380 390 400
SRIHNTHGEM IGALVIFSDL TARKETQRRM AQAERLATLG ELMAGVAHEV
410 420 430 440 450
RNPLTAIRGY VQILRQQTSD PIHQEYLSVV LKEIDSINKV IQQLLEFSRP
460 470 480 490 500
RHSQWQQVSL NALVEETLVL VQTAGVQARV DFISELDNEL SPINADRELL
510 520 530 540 550
KQVLLNILIN AVQAISARGK IRIQTWQYSD SQQAISIEDN GCGIDLSLQK
560 570 580 590 600
KIFDPFFTTK ASGTGLGLAL SQRIINAHQG DIRVASLPGY GATFTLILPI

NPQGNQTV
Length:608
Mass (Da):67,790
Last modified:February 1, 1995 - v1
Checksum:i4669888F98985C9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13078 Genomic DNA. Translation: AAA23449.1.
U00096 Genomic DNA. Translation: AAC75279.1.
AP009048 Genomic DNA. Translation: BAA16015.1.
PIRiA64992.
RefSeqiNP_416723.1. NC_000913.3.
WP_000559125.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75279; AAC75279; b2219.
BAA16015; BAA16015; BAA16015.
GeneIDi949011.
KEGGiecj:JW2213.
eco:b2219.
PATRICi32119797. VBIEscCol129921_2308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13078 Genomic DNA. Translation: AAA23449.1.
U00096 Genomic DNA. Translation: AAC75279.1.
AP009048 Genomic DNA. Translation: BAA16015.1.
PIRiA64992.
RefSeqiNP_416723.1. NC_000913.3.
WP_000559125.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ06067.
SMRiQ06067. Positions 263-603.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262011. 13 interactions.
IntActiQ06067. 2 interactions.
STRINGi511145.b2219.

Proteomic databases

PaxDbiQ06067.
PRIDEiQ06067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75279; AAC75279; b2219.
BAA16015; BAA16015; BAA16015.
GeneIDi949011.
KEGGiecj:JW2213.
eco:b2219.
PATRICi32119797. VBIEscCol129921_2308.

Organism-specific databases

EchoBASEiEB1618.
EcoGeneiEG11667. atoS.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
COG0642. LUCA.
COG2202. LUCA.
HOGENOMiHOG000122301.
InParanoidiQ06067.
KOiK07710.
OMAiEIAITCA.
PhylomeDBiQ06067.

Enzyme and pathway databases

BioCyciEcoCyc:ATOS-MONOMER.
ECOL316407:JW2213-MONOMER.
BRENDAi2.7.13.3. 2026.

Miscellaneous databases

PROiQ06067.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013767. PAS_fold.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATOS_ECOLI
AccessioniPrimary (citable) accession number: Q06067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.