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Q06066

- YBOX1_CHICK

UniProt

Q06066 - YBOX1_CHICK

Protein

Nuclease-sensitive element-binding protein 1

Gene

YBX1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'). Regulates the transcription of numerous genes By similarity. Component of the coding region determinant (CRD)-mediated complex that promotes mRNA stability By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. RNA splicing Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    mRNA processing, mRNA splicing, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclease-sensitive element-binding protein 1
    Alternative name(s):
    Y-box transcription factor
    Y-box-binding protein 1
    Short name:
    YB-1
    Gene namesi
    Name:YBX1
    Synonyms:NSEP1, YB-1, YB1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm. Nucleus. Cytoplasmic granule By similarity
    Note: Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Probably localized in cytoplasmic mRNP granules containing untranslated mRNAs By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. histone pre-mRNA 3'end processing complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Nuclease-sensitive element-binding protein 1PRO_0000100222Add
    BLAST

    Proteomic databases

    PaxDbiQ06066.
    PRIDEiQ06066.

    Interactioni

    Subunit structurei

    Component of the CRD-mediated complex. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Can bind to DNA as a homomultimer By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000038395.

    Structurei

    3D structure databases

    ProteinModelPortaliQ06066.
    SMRiQ06066. Positions 49-126.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 12265CSDAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 6854Interaction with ss-DNABy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CSD (cold-shock) domain.Curated

    Phylogenomic databases

    eggNOGiNOG326255.
    HOGENOMiHOG000116439.
    HOVERGENiHBG008757.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    InterProiIPR019844. Cold-shock_CS.
    IPR011129. Cold_shock_prot.
    IPR002059. CSP_DNA-bd.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF00313. CSD. 1 hit.
    [Graphical view]
    PRINTSiPR00050. COLDSHOCK.
    SMARTiSM00357. CSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    PROSITEiPS00352. COLD_SHOCK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q06066-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEAETQPP AAPVPAAPAA APADSKPNGG SGNGSSGLAS AAPPAGGDKK    50
    VIATKVLGTV KWFNVRNGYG FINRNDTKED VFVHQTAIKK NNPRKYLRSV 100
    GDGETVEFDV VEGEKGAEAA NVTGPGGVPV QGSKYAADRN HYRRYPRRRG 150
    PPRNYQQNYQ NSESGEKNEG AENIPEGQAQ QRRPYRRRRY PPYYMRRPYG 200
    RRPQYSNPPV QGEIVEGADN QGAGEQGRPV RQNMYRGYRP RFRRGPPRQR 250
    QPREDGNEED KENQGDETQG QQPPQRRYRR NFNYRRRRPE NPKPQDGKET 300
    KTAEPPAENT SAPEAEQGGA E 321
    Length:321
    Mass (Da):35,799
    Last modified:February 1, 1994 - v1
    Checksum:i6496F306C1432274
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13032 mRNA. Translation: AAA02573.1.
    PIRiA48136.
    UniGeneiGga.4145.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13032 mRNA. Translation: AAA02573.1 .
    PIRi A48136.
    UniGenei Gga.4145.

    3D structure databases

    ProteinModelPortali Q06066.
    SMRi Q06066. Positions 49-126.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000038395.

    Proteomic databases

    PaxDbi Q06066.
    PRIDEi Q06066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG326255.
    HOGENOMi HOG000116439.
    HOVERGENi HBG008757.

    Miscellaneous databases

    PROi Q06066.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    InterProi IPR019844. Cold-shock_CS.
    IPR011129. Cold_shock_prot.
    IPR002059. CSP_DNA-bd.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF00313. CSD. 1 hit.
    [Graphical view ]
    PRINTSi PR00050. COLDSHOCK.
    SMARTi SM00357. CSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    PROSITEi PS00352. COLD_SHOCK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of chicken YB-1: regulation of expression in the liver."
      Grant C.E., Deeley R.G.
      Mol. Cell. Biol. 13:4186-4196(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Embryonic liver.

    Entry informationi

    Entry nameiYBOX1_CHICK
    AccessioniPrimary (citable) accession number: Q06066
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3