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Protein

Nuclease-sensitive element-binding protein 1

Gene

YBX1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'). Regulates the transcription of numerous genes (By similarity). Component of the coding region determinant (CRD)-mediated complex that promotes mRNA stability (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor, RNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclease-sensitive element-binding protein 1
Alternative name(s):
Y-box transcription factor
Y-box-binding protein 1
Short name:
YB-1
Gene namesi
Name:YBX1
Synonyms:NSEP1, YB-1, YB1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm
  • Nucleus
  • Cytoplasmic granule By similarity

  • Note: Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Probably localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001002221 – 321Nuclease-sensitive element-binding protein 1Add BLAST321

Proteomic databases

PRIDEiQ06066.

Expressioni

Gene expression databases

BgeeiENSGALG00000004848.

Interactioni

Subunit structurei

Component of the CRD-mediated complex. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Can bind to DNA as a homomultimer (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ06066.
SMRiQ06066.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 122CSDAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 68Interaction with ss-DNABy similarityAdd BLAST54

Phylogenomic databases

HOGENOMiHOG000116439.
HOVERGENiHBG008757.
InParanoidiQ06066.

Family and domain databases

CDDicd04458. CSP_CDS. 1 hit.
InterProiView protein in InterPro
IPR019844. Cold-shock_CS.
IPR011129. CSD.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
PfamiView protein in Pfam
PF00313. CSD. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiView protein in SMART
SM00357. CSP. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiView protein in PROSITE
PS00352. COLD_SHOCK. 1 hit.

Sequencei

Sequence statusi: Complete.

Q06066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEAETQPP AAPVPAAPAA APADSKPNGG SGNGSSGLAS AAPPAGGDKK
60 70 80 90 100
VIATKVLGTV KWFNVRNGYG FINRNDTKED VFVHQTAIKK NNPRKYLRSV
110 120 130 140 150
GDGETVEFDV VEGEKGAEAA NVTGPGGVPV QGSKYAADRN HYRRYPRRRG
160 170 180 190 200
PPRNYQQNYQ NSESGEKNEG AENIPEGQAQ QRRPYRRRRY PPYYMRRPYG
210 220 230 240 250
RRPQYSNPPV QGEIVEGADN QGAGEQGRPV RQNMYRGYRP RFRRGPPRQR
260 270 280 290 300
QPREDGNEED KENQGDETQG QQPPQRRYRR NFNYRRRRPE NPKPQDGKET
310 320
KTAEPPAENT SAPEAEQGGA E
Length:321
Mass (Da):35,799
Last modified:February 1, 1994 - v1
Checksum:i6496F306C1432274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13032 mRNA. Translation: AAA02573.1.
PIRiA48136.
UniGeneiGga.4145.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiYBOX1_CHICK
AccessioniPrimary (citable) accession number: Q06066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 15, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome