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Q06066 (YBOX1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclease-sensitive element-binding protein 1
Alternative name(s):
Y-box transcription factor
Y-box-binding protein 1
Short name=YB-1
Gene names
Name:YBX1
Synonyms:NSEP1, YB-1, YB1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'). Regulates the transcription of numerous genes By similarity. Component of the coding region determinant (CRD)-mediated complex that promotes mRNA stability By similarity. Ref.1

Subunit structure

Component of the CRD-mediated complex. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Can bind to DNA as a homomultimer By similarity.

Subcellular location

Cytoplasm. Nucleus. Cytoplasmic granule By similarity. Note: Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Probably localized in cytoplasmic mRNP granules containing untranslated mRNAs By similarity.

Sequence similarities

Contains 1 CSD (cold-shock) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Nuclease-sensitive element-binding protein 1
PRO_0000100222

Regions

Domain58 – 12265CSD
Region15 – 6854Interaction with ss-DNA By similarity

Sequences

Sequence LengthMass (Da)Tools
Q06066 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 6496F306C1432274

FASTA32135,799
        10         20         30         40         50         60 
MSSEAETQPP AAPVPAAPAA APADSKPNGG SGNGSSGLAS AAPPAGGDKK VIATKVLGTV 

        70         80         90        100        110        120 
KWFNVRNGYG FINRNDTKED VFVHQTAIKK NNPRKYLRSV GDGETVEFDV VEGEKGAEAA 

       130        140        150        160        170        180 
NVTGPGGVPV QGSKYAADRN HYRRYPRRRG PPRNYQQNYQ NSESGEKNEG AENIPEGQAQ 

       190        200        210        220        230        240 
QRRPYRRRRY PPYYMRRPYG RRPQYSNPPV QGEIVEGADN QGAGEQGRPV RQNMYRGYRP 

       250        260        270        280        290        300 
RFRRGPPRQR QPREDGNEED KENQGDETQG QQPPQRRYRR NFNYRRRRPE NPKPQDGKET 

       310        320 
KTAEPPAENT SAPEAEQGGA E 

« Hide

References

[1]"Cloning and characterization of chicken YB-1: regulation of expression in the liver."
Grant C.E., Deeley R.G.
Mol. Cell. Biol. 13:4186-4196(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Tissue: Embryonic liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13032 mRNA. Translation: AAA02573.1.
PIRA48136.
UniGeneGga.4145.

3D structure databases

ProteinModelPortalQ06066.
SMRQ06066. Positions 49-126.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000038395.

Proteomic databases

PaxDbQ06066.
PRIDEQ06066.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG326255.
HOGENOMHOG000116439.
HOVERGENHBG008757.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
InterProIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF00313. CSD. 1 hit.
[Graphical view]
PRINTSPR00050. COLDSHOCK.
SMARTSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMSSF50249. SSF50249. 1 hit.
PROSITEPS00352. COLD_SHOCK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ06066.

Entry information

Entry nameYBOX1_CHICK
AccessionPrimary (citable) accession number: Q06066
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families