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Protein

Acetoacetate metabolism regulatory protein AtoC

Gene

atoC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi236 – 245ATPPROSITE-ProRule annotation10
DNA bindingi433 – 452H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ornithine decarboxylase inhibitor activity Source: EcoCyc
  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:ATOC-MONOMER.
ECOL316407:JW2214-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetoacetate metabolism regulatory protein AtoC
Alternative name(s):
Ornithine decarboxylase antizyme
Ornithine/arginine decarboxylase inhibitor
Gene namesi
Name:atoC
Synonyms:az
Ordered Locus Names:b2220, JW2214
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11668. atoC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810201 – 461Acetoacetate metabolism regulatory protein AtoCAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by AtoS.Curated
The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ06065.
PRIDEiQ06065.

Interactioni

Protein-protein interaction databases

DIPiDIP-9190N.
IntActiQ06065. 10 interactors.
STRINGi511145.b2220.

Structurei

3D structure databases

ProteinModelPortaliQ06065.
SMRiQ06065.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 120Response regulatoryPROSITE-ProRule annotationAdd BLAST115
Domaini145 – 374Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST230

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation
Contains 1 sigma-54 factor interaction domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C1W. Bacteria.
COG2204. LUCA.
HOGENOMiHOG000058489.
InParanoidiQ06065.
KOiK07714.
OMAiIAEMPLQ.
PhylomeDBiQ06065.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAINRILIV DDEDNVRRML STAFALQGFE THCANNGRTA LHLFADIHPD
60 70 80 90 100
VVLMDIRMPE MDGIKALKEM RSHETRTPVI LMTAYAEVET AVEALRCGAF
110 120 130 140 150
DYVIKPFDLD ELNLIVQRAL QLQSMKKEIR HLHQALSTSW QWGHILTNSP
160 170 180 190 200
AMMDICKDTA KIALSQASVL ISGESGTGKE LIARAIHYNS RRAKGPFIKV
210 220 230 240 250
NCAALPESLL ESELFGHEKG AFTGAQTLRQ GLFERANEGT LLLDEIGEMP
260 270 280 290 300
LVLQAKLLRI LQEREFERIG GHQTIKVDIR IIAATNRDLQ AMVKEGTFRE
310 320 330 340 350
DLFYRLNVIH LILPPLRDRR EDISLLANHF LQKFSSENQR DIIDIDPMAM
360 370 380 390 400
SLLTAWSWPG NIRELSNVIE RAVVMNSGPI IFSEDLPPQI RQPVCNAGEV
410 420 430 440 450
KTAPVGERNL KEEIKRVEKR IIMEVLEQQE GNRTRTALML GISRRALMYK
460
LQEYGIDPAD V
Length:461
Mass (Da):52,176
Last modified:November 1, 1995 - v2
Checksum:i478D5795790E339A
GO

Sequence cautioni

The sequence AAA23450 differs from that shown. Reason: Frameshift at position 92.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99A → R in AAA23450 (PubMed:8346225).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17902 Genomic DNA. Translation: AAA60332.1.
U00096 Genomic DNA. Translation: AAC75280.1.
AP009048 Genomic DNA. Translation: BAA16016.1.
L13078 Genomic DNA. Translation: AAA23450.1. Frameshift.
PIRiB64992.
RefSeqiNP_416724.1. NC_000913.3.
WP_000125282.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75280; AAC75280; b2220.
BAA16016; BAA16016; BAA16016.
GeneIDi947444.
KEGGiecj:JW2214.
eco:b2220.
PATRICi32119799. VBIEscCol129921_2309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17902 Genomic DNA. Translation: AAA60332.1.
U00096 Genomic DNA. Translation: AAC75280.1.
AP009048 Genomic DNA. Translation: BAA16016.1.
L13078 Genomic DNA. Translation: AAA23450.1. Frameshift.
PIRiB64992.
RefSeqiNP_416724.1. NC_000913.3.
WP_000125282.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ06065.
SMRiQ06065.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9190N.
IntActiQ06065. 10 interactors.
STRINGi511145.b2220.

Proteomic databases

PaxDbiQ06065.
PRIDEiQ06065.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75280; AAC75280; b2220.
BAA16016; BAA16016; BAA16016.
GeneIDi947444.
KEGGiecj:JW2214.
eco:b2220.
PATRICi32119799. VBIEscCol129921_2309.

Organism-specific databases

EchoBASEiEB1619.
EcoGeneiEG11668. atoC.

Phylogenomic databases

eggNOGiENOG4105C1W. Bacteria.
COG2204. LUCA.
HOGENOMiHOG000058489.
InParanoidiQ06065.
KOiK07714.
OMAiIAEMPLQ.
PhylomeDBiQ06065.

Enzyme and pathway databases

BioCyciEcoCyc:ATOC-MONOMER.
ECOL316407:JW2214-MONOMER.

Miscellaneous databases

PROiQ06065.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATOC_ECOLI
AccessioniPrimary (citable) accession number: Q06065
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.