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Protein

Multidrug resistance protein 1

Gene

MDR1

Organism
Leishmania enriettii
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Confers vinblastine resistance.

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi426 – 433ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1071 – 1078ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein 1 (EC:3.6.3.44)
Alternative name(s):
P-glycoprotein 1
Gene namesi
Name:MDR1
OrganismiLeishmania enriettii
Taxonomic identifieri5663 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72CytoplasmicSequence analysisAdd BLAST72
Transmembranei73 – 93HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei120 – 140HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei189 – 209HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei216 – 236HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei297 – 317HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei326 – 345HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini346 – 712CytoplasmicSequence analysisAdd BLAST367
Transmembranei713 – 733HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei762 – 781HelicalPROSITE-ProRule annotationAdd BLAST20
Transmembranei837 – 857HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei858 – 878HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei938 – 958HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei976 – 996HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933451 – 1280Multidrug resistance protein 1Add BLAST1280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi1113N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ06034.
SMRiQ06034.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 357ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST286
Domaini391 – 634ABC transporter 1PROSITE-ProRule annotationAdd BLAST244
Domaini713 – 1002ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST290
Domaini1036 – 1274ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q06034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAHAAYAN EGWSAPEGGI AGKDGSTRDC SGYGSQGPLF SAEEEVKGTV
60 70 80 90 100
VRETVGPIEI FRYADATDRV LMIAGTAFAV ACGAGMPVFS FIFGRIAMDL
110 120 130 140 150
MSGVGSAEEK AAKTSLIMVY VGIAMLIACA GHVMCWTVAA CRQVARIRLL
160 170 180 190 200
FFRAVLRQDI GWHDEHSPGA LTARMTGDTR VIQNGINDKL SQGIMNGSMG
210 220 230 240 250
VIGYIAGFVF SWELTLMMIG MMPFIIVMAA IIGSIVSKIT ESSRKYFAKA
260 270 280 290 300
GSLATEVMEN IRTVQAFGRE DYELERFTKA VLYAQGRGIR KELASNLSAA
310 320 330 340 350
VIMALMYVSY TVAFFFGSYL VEWGRRDMAD IISTFLAVLM GSFGLGFVAP
360 370 380 390 400
SRTAFTESRA AAYEIFKAID RVPPVDIDAG GVPVPGFKES IEFRNVRFAY
410 420 430 440 450
PTRPGMILFR DLSLKIKCGQ KVAFSGASGC GKSSVIGLIQ RFYDPIGGAV
460 470 480 490 500
LVDGVRMREL CLREWRDQIG IVSQEPNLFA GTMMENVRMG KPNATDEEVV
510 520 530 540 550
EACRQANIHD TIMALPDRYD TPVGPVGSLL SGGQKQRIAI ARALVKRPPI
560 570 580 590 600
LLLDEATSAL DRKSEMEVQA ALDQLIQRGG TTVVVIAHRL ATIRDMDRIY
610 620 630 640 650
YVKHDGAEGS RITESGTFDE LLELDGEFAA VAKMQGVLAG DAKSGASVRD
660 670 680 690 700
AKKASGHLGV ILDEADLAQL DEDVPRTARQ NVPIDELAKW EVKHAKVGFL
710 720 730 740 750
RLMRMNKDKA WAVALGILSS VVIGSARPAS SIVMGHMLRV LGEYSATKDV
760 770 780 790 800
EALRSGTNLY APLFIVFAVA NFSGWILHGF YGYAGEHLTT KIRVLLFRQI
810 820 830 840 850
MRQDINFFDI PGRDAGTLAG MLSGDCEAVH QLWGPSIGLK VQTMCIIASG
860 870 880 890 900
LVVGFIYQWK LALVALACMP LMIGCSLTRR LMINGYTKSR EGDTDDTIVT
910 920 930 940 950
EALSNVRTVT SLNMKEDCVE AFQAALREEA PRSVRKGIIA GGIYGITQFI
960 970 980 990 1000
FYGVYALCFW YGSKLIDKGE AEFKDVMIAS MSILFGAQNA GEAGAFATKL
1010 1020 1030 1040 1050
ADAEASAKRV FSVIDRVPDV DIEQAGNKDL GEGCDIEYRN VQFIYSARPK
1060 1070 1080 1090 1100
QVVLASVNMR FGDATSNGLI GQTGCGKSTV IQMLARFYER RSGLISVNGR
1110 1120 1130 1140 1150
DLSSLDIAEW RRNISIVLQE PNLFSGTVRE NIRYAREGAT DEEVEEAARL
1160 1170 1180 1190 1200
AHIHHEIIKW TDGYDTEVGY KGRALSGGQK QRIAIARGLL RRPRLLLLDE
1210 1220 1230 1240 1250
ATSALDSVTE AKVQEGIEAF QAKYKVTTVS IAHRLTTIRH CDQIILLDSG
1260 1270 1280
CIIEQGSHEE LMALGGEYKT RYDLYMSALS
Length:1,280
Mass (Da):139,729
Last modified:February 1, 1995 - v1
Checksum:i76B65C82CE5E4043
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti286G → D. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08091 Unassigned DNA. Translation: AAA16255.1.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMDR1_LEIEN
AccessioniPrimary (citable) accession number: Q06034
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 10, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families