Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q06034 (MDR1_LEIEN) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance protein 1
EC=3.6.3.44
Alternative name(s):
P-glycoprotein 1
Gene names
Name:MDR1
OrganismLeishmania enriettii
Taxonomic identifier5663 [NCBI]
Taxonomic lineageEukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length1280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Confers vinblastine resistance.

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Ontologies

Keywords
   Biological processAntibiotic resistance
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12801280Multidrug resistance protein 1
PRO_0000093345

Regions

Topological domain1 – 7272Cytoplasmic Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane297 – 31721Helical; Potential
Transmembrane326 – 34520Helical; Potential
Topological domain346 – 712367Cytoplasmic Potential
Transmembrane713 – 73321Helical; Potential
Transmembrane762 – 78120Helical; Potential
Transmembrane837 – 85721Helical; Potential
Transmembrane858 – 87821Helical; Potential
Transmembrane938 – 95821Helical; Potential
Transmembrane976 – 99621Helical; Potential
Domain72 – 357286ABC transmembrane type-1 1
Domain391 – 634244ABC transporter 1
Domain713 – 1002290ABC transmembrane type-1 2
Domain1036 – 1274239ABC transporter 2
Nucleotide binding426 – 4338ATP 1 Potential
Nucleotide binding1071 – 10788ATP 2 Potential

Amino acid modifications

Glycosylation11131N-linked (GlcNAc...) Potential

Natural variations

Natural variant2861G → D.

Sequences

Sequence LengthMass (Da)Tools
Q06034 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 76B65C82CE5E4043

FASTA1,280139,729
        10         20         30         40         50         60 
MSRAHAAYAN EGWSAPEGGI AGKDGSTRDC SGYGSQGPLF SAEEEVKGTV VRETVGPIEI 

        70         80         90        100        110        120 
FRYADATDRV LMIAGTAFAV ACGAGMPVFS FIFGRIAMDL MSGVGSAEEK AAKTSLIMVY 

       130        140        150        160        170        180 
VGIAMLIACA GHVMCWTVAA CRQVARIRLL FFRAVLRQDI GWHDEHSPGA LTARMTGDTR 

       190        200        210        220        230        240 
VIQNGINDKL SQGIMNGSMG VIGYIAGFVF SWELTLMMIG MMPFIIVMAA IIGSIVSKIT 

       250        260        270        280        290        300 
ESSRKYFAKA GSLATEVMEN IRTVQAFGRE DYELERFTKA VLYAQGRGIR KELASNLSAA 

       310        320        330        340        350        360 
VIMALMYVSY TVAFFFGSYL VEWGRRDMAD IISTFLAVLM GSFGLGFVAP SRTAFTESRA 

       370        380        390        400        410        420 
AAYEIFKAID RVPPVDIDAG GVPVPGFKES IEFRNVRFAY PTRPGMILFR DLSLKIKCGQ 

       430        440        450        460        470        480 
KVAFSGASGC GKSSVIGLIQ RFYDPIGGAV LVDGVRMREL CLREWRDQIG IVSQEPNLFA 

       490        500        510        520        530        540 
GTMMENVRMG KPNATDEEVV EACRQANIHD TIMALPDRYD TPVGPVGSLL SGGQKQRIAI 

       550        560        570        580        590        600 
ARALVKRPPI LLLDEATSAL DRKSEMEVQA ALDQLIQRGG TTVVVIAHRL ATIRDMDRIY 

       610        620        630        640        650        660 
YVKHDGAEGS RITESGTFDE LLELDGEFAA VAKMQGVLAG DAKSGASVRD AKKASGHLGV 

       670        680        690        700        710        720 
ILDEADLAQL DEDVPRTARQ NVPIDELAKW EVKHAKVGFL RLMRMNKDKA WAVALGILSS 

       730        740        750        760        770        780 
VVIGSARPAS SIVMGHMLRV LGEYSATKDV EALRSGTNLY APLFIVFAVA NFSGWILHGF 

       790        800        810        820        830        840 
YGYAGEHLTT KIRVLLFRQI MRQDINFFDI PGRDAGTLAG MLSGDCEAVH QLWGPSIGLK 

       850        860        870        880        890        900 
VQTMCIIASG LVVGFIYQWK LALVALACMP LMIGCSLTRR LMINGYTKSR EGDTDDTIVT 

       910        920        930        940        950        960 
EALSNVRTVT SLNMKEDCVE AFQAALREEA PRSVRKGIIA GGIYGITQFI FYGVYALCFW 

       970        980        990       1000       1010       1020 
YGSKLIDKGE AEFKDVMIAS MSILFGAQNA GEAGAFATKL ADAEASAKRV FSVIDRVPDV 

      1030       1040       1050       1060       1070       1080 
DIEQAGNKDL GEGCDIEYRN VQFIYSARPK QVVLASVNMR FGDATSNGLI GQTGCGKSTV 

      1090       1100       1110       1120       1130       1140 
IQMLARFYER RSGLISVNGR DLSSLDIAEW RRNISIVLQE PNLFSGTVRE NIRYAREGAT 

      1150       1160       1170       1180       1190       1200 
DEEVEEAARL AHIHHEIIKW TDGYDTEVGY KGRALSGGQK QRIAIARGLL RRPRLLLLDE 

      1210       1220       1230       1240       1250       1260 
ATSALDSVTE AKVQEGIEAF QAKYKVTTVS IAHRLTTIRH CDQIILLDSG CIIEQGSHEE 

      1270       1280 
LMALGGEYKT RYDLYMSALS

« Hide

References

[1]"Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii."
Chow L.M.C., Wong A.K.C., Ullman B., Wirth D.F.
Mol. Biochem. Parasitol. 60:195-208(1993) [PubMed: 8232412] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L08091 Unassigned DNA. Translation: AAA16255.1.

3D structure databases

ProteinModelPortalQ06034.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF90123. ABC_TM_1. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDR1_LEIEN
AccessionPrimary (citable) accession number: Q06034
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 21, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents