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Q06009 (PP2A_MEDSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit

EC=3.1.3.16
Gene names
Name:PP2A
OrganismMedicago sativa (Alfalfa)
Taxonomic identifier3879 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in cell cycle regulation.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Tissue specificity

Predominantly expressed in stems, moderate in roots, nodes, leaves and flower buds.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Keywords
   Biological processCell cycle
   LigandIron
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Serine/threonine-protein phosphatase PP2A catalytic subunit
PRO_0000058860

Sites

Active site1221Proton donor By similarity
Metal binding611Iron By similarity
Metal binding631Iron By similarity
Metal binding891Iron By similarity
Metal binding891Manganese By similarity
Metal binding1211Manganese By similarity
Metal binding1711Manganese By similarity
Metal binding2451Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q06009 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 08230261A0110431

FASTA31335,711
        10         20         30         40         50         60 
MGANSMIADV THDLNEQISQ LMQCKPLSEQ QVKELCEKAK EILMDESNVQ PVKSPVTICG 

        70         80         90        100        110        120 
DIHGQFHDLA ELFRIGGKCP DTNYLFMGDY VDRGYYSVET VTLLVALKVR YPQRITILRG 

       130        140        150        160        170        180 
NHESRQITQV YGFYDECLRK YGSANVWKIF TDLFDFFPLT ALVESEIFCL HGGLSPSIET 

       190        200        210        220        230        240 
LDNIRNFDRV QEVPHEGPMC DLLWSDPDDR CGWGISPRGA GYTFGQDISE QFNHTNSLKL 

       250        260        270        280        290        300 
IARAHQLVMD GFNWAHEQKV VTIFSAPNYC YRCGNMASIL EVDDCKGHTF IQFEPAPRRG 

       310 
EPDVTRRTPD YFL 

« Hide

References

[1]"Isolation and characterization of a phosphoprotein phosphatase type 2A gene from alfalfa."
Pirck M., Pay A., Heberle-Bors E., Hirt H.
Mol. Gen. Genet. 240:126-131(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70399 mRNA. Translation: CAA49849.1.
PIRS35502.

3D structure databases

ProteinModelPortalQ06009.
SMRQ06009. Positions 11-313.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ06009.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A_MEDSA
AccessionPrimary (citable) accession number: Q06009
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families