Q06009 (PP2A_MEDSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit
EC=3.1.3.16

Gene names

Name:

PP2A

Organism

Medicago sativa (Alfalfa)

Taxonomic identifier

3879 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Trifolieae › Medicago

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in cell cycle regulation.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Tissue specificity	Predominantly expressed in stems, moderate in roots, nodes, leaves and flower buds.
Sequence similarities	Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Keywords
Biological process	Cell cycle
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Serine/threonine-protein phosphatase PP2A catalytic subunit		PRO_0000058860
Sites
	Active site	122	1	Proton donor By similarity
	Metal binding	61	1	Iron By similarity
	Metal binding	63	1	Iron By similarity
	Metal binding	89	1	Iron By similarity
	Metal binding	89	1	Manganese By similarity
	Metal binding	121	1	Manganese By similarity
	Metal binding	171	1	Manganese By similarity
	Metal binding	245	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q06009 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 08230261A0110431	FASTA	313	35,711
	10 20 30 40 50 60 MGANSMIADV THDLNEQISQ LMQCKPLSEQ QVKELCEKAK EILMDESNVQ PVKSPVTICG 70 80 90 100 110 120 DIHGQFHDLA ELFRIGGKCP DTNYLFMGDY VDRGYYSVET VTLLVALKVR YPQRITILRG 130 140 150 160 170 180 NHESRQITQV YGFYDECLRK YGSANVWKIF TDLFDFFPLT ALVESEIFCL HGGLSPSIET 190 200 210 220 230 240 LDNIRNFDRV QEVPHEGPMC DLLWSDPDDR CGWGISPRGA GYTFGQDISE QFNHTNSLKL 250 260 270 280 290 300 IARAHQLVMD GFNWAHEQKV VTIFSAPNYC YRCGNMASIL EVDDCKGHTF IQFEPAPRRG 310 EPDVTRRTPD YFL

References

[1]	"Isolation and characterization of a phosphoprotein phosphatase type 2A gene from alfalfa." Pirck M., Pay A., Heberle-Bors E., Hirt H. Mol. Gen. Genet. 240:126-131(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70399 mRNA. Translation: CAA49849.1.
PIR	S35502.
3D structure databases
ProteinModelPortal	Q06009.
SMR	Q06009. Positions 11-313.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PP2A_MEDSA

Accession

Primary (citable) accession number: Q06009

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program