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Q06009

- PP2A_MEDSA

UniProt

Q06009 - PP2A_MEDSA

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Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene

PP2A

Organism
Medicago sativa (Alfalfa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in cell cycle regulation.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Manganese 1By similarity
Metal bindingi63 – 631Manganese 1By similarity
Metal bindingi89 – 891Manganese 1By similarity
Metal bindingi89 – 891Manganese 2By similarity
Metal bindingi121 – 1211Manganese 2By similarity
Active sitei122 – 1221Proton donorBy similarity
Metal bindingi171 – 1711Manganese 2By similarity
Metal bindingi245 – 2451Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A
OrganismiMedicago sativa (Alfalfa)
Taxonomic identifieri3879 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Serine/threonine-protein phosphatase PP2A catalytic subunitPRO_0000058860Add
BLAST

Proteomic databases

PRIDEiQ06009.

Expressioni

Tissue specificityi

Predominantly expressed in stems, moderate in roots, nodes, leaves and flower buds.

Structurei

3D structure databases

ProteinModelPortaliQ06009.
SMRiQ06009. Positions 11-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06009-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGANSMIADV THDLNEQISQ LMQCKPLSEQ QVKELCEKAK EILMDESNVQ
60 70 80 90 100
PVKSPVTICG DIHGQFHDLA ELFRIGGKCP DTNYLFMGDY VDRGYYSVET
110 120 130 140 150
VTLLVALKVR YPQRITILRG NHESRQITQV YGFYDECLRK YGSANVWKIF
160 170 180 190 200
TDLFDFFPLT ALVESEIFCL HGGLSPSIET LDNIRNFDRV QEVPHEGPMC
210 220 230 240 250
DLLWSDPDDR CGWGISPRGA GYTFGQDISE QFNHTNSLKL IARAHQLVMD
260 270 280 290 300
GFNWAHEQKV VTIFSAPNYC YRCGNMASIL EVDDCKGHTF IQFEPAPRRG
310
EPDVTRRTPD YFL
Length:313
Mass (Da):35,711
Last modified:June 1, 1994 - v1
Checksum:i08230261A0110431
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70399 mRNA. Translation: CAA49849.1.
PIRiS35502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70399 mRNA. Translation: CAA49849.1 .
PIRi S35502.

3D structure databases

ProteinModelPortali Q06009.
SMRi Q06009. Positions 11-313.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q06009.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a phosphoprotein phosphatase type 2A gene from alfalfa."
    Pirck M., Pay A., Heberle-Bors E., Hirt H.
    Mol. Gen. Genet. 240:126-131(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPP2A_MEDSA
AccessioniPrimary (citable) accession number: Q06009
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3