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Protein

Sorbitol dehydrogenase

Gene

gutB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduces glucitol to fructose.

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Zinc 1; catalyticBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi156Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBSUB:BSU06150-MONOMER
MetaCyc:BSU06150-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase (EC:1.1.1.14)
Alternative name(s):
Glucitol dehydrogenase
L-iditol 2-dehydrogenase
Gene namesi
Name:gutB
Ordered Locus Names:BSU06150
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001608252 – 353Sorbitol dehydrogenaseAdd BLAST352

Proteomic databases

PaxDbiQ06004
PRIDEiQ06004

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100003458

Structurei

3D structure databases

ProteinModelPortaliQ06004
SMRiQ06004
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CPQ Bacteria
COG1063 LUCA
HOGENOMiHOG000294670
InParanoidiQ06004
KOiK00008
OMAiFILGHEC
PhylomeDBiQ06004

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHTVPQNMK AAVMHNTREI KIETLPVPDI NHDEVLIKVM AVGICGSDLH
60 70 80 90 100
YYTNGRIGNY VVEKPFILGH ECAGEIAAVG SSVDQFKVGD RVAVEPGVTC
110 120 130 140 150
GRCEACKEGR YNLCPDVQFL ATPPVDGAFV QYIKMRQDFV FLIPDSLSYE
160 170 180 190 200
EAALIEPFSV GIHAAARTKL QPGSTIAIMG MGPVGLMAVA AAKAFGAGTI
210 220 230 240 250
IVTDLEPLRL EAAKKMGATH IINIREQDAL EEIKTITNDR GVDVAWETAG
260 270 280 290 300
NPAALQSALA SVRRGGKLAI VGLPSQNEIP LNVPFIADNE IDIYGIFRYA
310 320 330 340 350
NTYPKGIEFL ASGIVDTKHL VTDQYSLEQT QDAMERALQF KNECLKVMVY

PNR
Length:353
Mass (Da):38,390
Last modified:January 23, 2007 - v3
Checksum:iC87DD26E6DCA74C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96947 Genomic DNA Translation: AAA22508.1
AL009126 Genomic DNA Translation: CAB12434.1
L16626 Genomic DNA Translation: AAA20875.1
PIRiA45052
RefSeqiNP_388496.1, NC_000964.3
WP_003244156.1, NZ_JNCM01000032.1

Genome annotation databases

EnsemblBacteriaiCAB12434; CAB12434; BSU06150
GeneIDi939495
KEGGibsu:BSU06150
PATRICifig|224308.179.peg.666

Similar proteinsi

Entry informationi

Entry nameiDHSO_BACSU
AccessioniPrimary (citable) accession number: Q06004
Secondary accession number(s): Q45615
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health