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Protein

Sorbitol dehydrogenase

Gene

gutB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Reduces glucitol to fructose.

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Zinc 1; catalyticBy similarity
Metal bindingi70 – 701Zinc 1; catalyticBy similarity
Metal bindingi100 – 1001Zinc 2By similarity
Metal bindingi103 – 1031Zinc 2By similarity
Metal bindingi106 – 1061Zinc 2By similarity
Metal bindingi114 – 1141Zinc 2By similarity
Metal bindingi156 – 1561Zinc 1; catalyticBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBSUB:BSU06150-MONOMER.
MetaCyc:BSU06150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase (EC:1.1.1.14)
Alternative name(s):
Glucitol dehydrogenase
L-iditol 2-dehydrogenase
Gene namesi
Name:gutB
Ordered Locus Names:BSU06150
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 353352Sorbitol dehydrogenasePRO_0000160825Add
BLAST

Proteomic databases

PaxDbiQ06004.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100003458.

Structurei

3D structure databases

ProteinModelPortaliQ06004.
SMRiQ06004. Positions 7-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CPQ. Bacteria.
COG1063. LUCA.
HOGENOMiHOG000294670.
InParanoidiQ06004.
KOiK00008.
OMAiMHNTREI.
PhylomeDBiQ06004.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHTVPQNMK AAVMHNTREI KIETLPVPDI NHDEVLIKVM AVGICGSDLH
60 70 80 90 100
YYTNGRIGNY VVEKPFILGH ECAGEIAAVG SSVDQFKVGD RVAVEPGVTC
110 120 130 140 150
GRCEACKEGR YNLCPDVQFL ATPPVDGAFV QYIKMRQDFV FLIPDSLSYE
160 170 180 190 200
EAALIEPFSV GIHAAARTKL QPGSTIAIMG MGPVGLMAVA AAKAFGAGTI
210 220 230 240 250
IVTDLEPLRL EAAKKMGATH IINIREQDAL EEIKTITNDR GVDVAWETAG
260 270 280 290 300
NPAALQSALA SVRRGGKLAI VGLPSQNEIP LNVPFIADNE IDIYGIFRYA
310 320 330 340 350
NTYPKGIEFL ASGIVDTKHL VTDQYSLEQT QDAMERALQF KNECLKVMVY

PNR
Length:353
Mass (Da):38,390
Last modified:January 23, 2007 - v3
Checksum:iC87DD26E6DCA74C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96947 Genomic DNA. Translation: AAA22508.1.
AL009126 Genomic DNA. Translation: CAB12434.1.
L16626 Genomic DNA. Translation: AAA20875.1.
PIRiA45052.
RefSeqiNP_388496.1. NC_000964.3.
WP_003244156.1. NZ_JNCM01000032.1.

Genome annotation databases

EnsemblBacteriaiCAB12434; CAB12434; BSU06150.
GeneIDi939495.
KEGGibsu:BSU06150.
PATRICi18972866. VBIBacSub10457_0647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96947 Genomic DNA. Translation: AAA22508.1.
AL009126 Genomic DNA. Translation: CAB12434.1.
L16626 Genomic DNA. Translation: AAA20875.1.
PIRiA45052.
RefSeqiNP_388496.1. NC_000964.3.
WP_003244156.1. NZ_JNCM01000032.1.

3D structure databases

ProteinModelPortaliQ06004.
SMRiQ06004. Positions 7-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100003458.

Proteomic databases

PaxDbiQ06004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12434; CAB12434; BSU06150.
GeneIDi939495.
KEGGibsu:BSU06150.
PATRICi18972866. VBIBacSub10457_0647.

Phylogenomic databases

eggNOGiENOG4105CPQ. Bacteria.
COG1063. LUCA.
HOGENOMiHOG000294670.
InParanoidiQ06004.
KOiK00008.
OMAiMHNTREI.
PhylomeDBiQ06004.

Enzyme and pathway databases

BioCyciBSUB:BSU06150-MONOMER.
MetaCyc:BSU06150-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHSO_BACSU
AccessioniPrimary (citable) accession number: Q06004
Secondary accession number(s): Q45615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.