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Protein

Factor arrest protein 10

Gene

FAR10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the control of the reentry into the cell cycle following pheromone treatment.1 Publication

GO - Biological processi

  • re-entry into mitotic cell cycle after pheromone arrest Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-32347-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Factor arrest protein 10
Gene namesi
Name:FAR10
Ordered Locus Names:YLR238W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR238W.
SGDiS000004228. FAR10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 454454CytoplasmicSequence analysisAdd
BLAST
Transmembranei455 – 47521Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini476 – 4783ExtracellularSequence analysis

GO - Cellular componenti

  • endoplasmic reticulum Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Factor arrest protein 10PRO_0000087189Add
BLAST

Proteomic databases

MaxQBiQ06001.

PTM databases

iPTMnetiQ06001.

Interactioni

Subunit structurei

Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.

Protein-protein interaction databases

BioGridi31505. 116 interactions.
DIPiDIP-1572N.
IntActiQ06001. 3 interactions.
MINTiMINT-395934.

Structurei

3D structure databases

ProteinModelPortaliQ06001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 17661FHAPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili342 – 42685Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi108 – 1158Poly-Ser

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000068298.
HOGENOMiHOG000065944.
InParanoidiQ06001.
OMAiGTKHKPD.
OrthoDBiEOG7DFXN1.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q06001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGPGPEINK EEHPSSPGKK QITYNSIPKN ANLIDGSTNS SKRPIEKYDK
60 70 80 90 100
RIADPTKSYF PHSISRTPRR KYTYILVLTS LNGTFESKHV VIPFKPDGLK
110 120 130 140 150
LGRPVANSNS SSSSSLRGGK RVDSHTFSQV RSDNGNFDSR VLSRNHALLS
160 170 180 190 200
CDPLTGKVYI RDLKSSNGTF INGQRIGSND VEIKVGDVID LGTDIDTKIE
210 220 230 240 250
HRKISATVEE LFVQPLLESP IFENEDSDDC HTITEKEEAA AITSHIYGDS
260 270 280 290 300
NNLELEEVIL GSDTEILSGI FINNCIGTSP TLSNIIKTLA MEIPFSKCDN
310 320 330 340 350
FKLQSMENFL INYTTHLEYT NKLLVEKNDQ QLVKLQNGLR RKLSGKYEKI
360 370 380 390 400
IEQNRNQVKQ LERDHMFFKK SFEVKKRRNN EKQKSMEREI EDLKTRLEVE
410 420 430 440 450
RYKNSQMMKK NKQKEQELST ASKKKTTEHD TRGVPGMNPK GTDKFSIKNT
460 470
LCNHFTLLTF GTISIGIIAI VFKILSPN
Length:478
Mass (Da):54,092
Last modified:November 1, 1996 - v1
Checksum:iA3A4B2B83C967DD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19027 Genomic DNA. Translation: AAB67404.1.
BK006945 Genomic DNA. Translation: DAA09552.1.
PIRiS51457.
RefSeqiNP_013339.1. NM_001182125.1.

Genome annotation databases

EnsemblFungiiYLR238W; YLR238W; YLR238W.
GeneIDi850939.
KEGGisce:YLR238W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19027 Genomic DNA. Translation: AAB67404.1.
BK006945 Genomic DNA. Translation: DAA09552.1.
PIRiS51457.
RefSeqiNP_013339.1. NM_001182125.1.

3D structure databases

ProteinModelPortaliQ06001.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31505. 116 interactions.
DIPiDIP-1572N.
IntActiQ06001. 3 interactions.
MINTiMINT-395934.

PTM databases

iPTMnetiQ06001.

Proteomic databases

MaxQBiQ06001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR238W; YLR238W; YLR238W.
GeneIDi850939.
KEGGisce:YLR238W.

Organism-specific databases

EuPathDBiFungiDB:YLR238W.
SGDiS000004228. FAR10.

Phylogenomic databases

GeneTreeiENSGT00530000068298.
HOGENOMiHOG000065944.
InParanoidiQ06001.
OMAiGTKHKPD.
OrthoDBiEOG7DFXN1.

Enzyme and pathway databases

BioCyciYEAST:G3O-32347-MONOMER.

Miscellaneous databases

NextBioi967384.
PROiQ06001.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae."
    Beilharz T., Egan B., Silver P.A., Hofmann K., Lithgow T.
    J. Biol. Chem. 278:8219-8223(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. "Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae."
    Kemp H.A., Sprague G.F. Jr.
    Mol. Cell. Biol. 23:1750-1763(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FAR3; FAR7; FAR8; FAR11 AND VPS64.

Entry informationi

Entry nameiFAR10_YEAST
AccessioniPrimary (citable) accession number: Q06001
Secondary accession number(s): D6VYN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.